143083fff802c683a72f73da63adae89  303861.pdf
86eff57cc62e3e4c4f7b213012193dbd72215ca1  303861.pdf
4cdfa502696e1f1e27c404a7b61548b52e170f39ef213a42bbbb72d9d68fe91a  303861.pdf

Title:           Economic burden of locoregional and metastatic relapses in resectable early-stage non-small cell lung cancer in Spain
Subject:         BMC Pulmonary Medicine, https://doi.org/10.1186/s12890-023-02356-0
Keywords:        Economic burden;Early-stage NSCLC;Locorregional relapse;Metastatic relapse
Author:           Javier De Castro
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Sat Feb 18 06:34:03 2023 CET
ModDate:         Tue Feb 21 11:35:03 2023 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       2525340 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     50  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     51  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     52  0
NUJTEY+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     53  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  no     363  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes    105  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     58  0
WarnockPro-LightIt                   Type 1C           WinAnsi          yes no  yes     54  0
CXCHVA+WarnockPro-It                 Type 1C           WinAnsi          yes yes yes     55  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     56  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes     57  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     67  0
GOJFOH+MTSY                          Type 1C           Custom           yes yes yes     68  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    301  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes    130  0
QPLXAS+TimesNewRomanPS-ItalicMT      TrueType          WinAnsi          yes yes yes    155  0
QPLXAS+STIXMath-Regular              Type 1C           Custom           yes yes yes    179  0
MyriadPro-Regular4                   Type 1C           WinAnsi          yes no  yes    268  0
HRFNNK+OpenSans-Light                Type 1C           Custom           yes yes no     275  0
HRFNNK+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     271  0
HRFNNK+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     281  0
HRFNNK+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     278  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-12-06 02:45:26 CET
 RepresentationInformation: 303861.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-05 11:47:23 CET
  Size: 2525340
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 464
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Economic burden of locoregional and metastatic relapses in resectable early-stage non-small cell lung cancer in Spain
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Materials and methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Background
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Model design
         Item: 
          Title: Data collection
         Item: 
          Title: Characterization of the metastases
         Item: 
          Title: Direct medical costs (healthcare resource utilisation and unit costs)
          Children: 
           Item: 
            Title: Relapse diagnosis
           Item: 
            Title: Treatment costs
           Item: 
            Title: Healthcare resource use
           Item: 
            Title: Unit costs
         Item: 
          Title: Indirect costs
         Item: 
          Title: Sensitivity analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Total cost per 100 relapses
         Item: 
          Title: Average relapse cost
         Item: 
          Title: Sensitivity analysis results
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Economic burden of locoregional and metastatic relapses in resectable early-stage non-small cell lung cancer in Spain
    Author:  Javier De Castro
    Subject: BMC Pulmonary Medicine, https://doi.org/10.1186/s12890-023-02356-0
    Keywords: Economic burden;Early-stage NSCLC;Locorregional relapse;Metastatic relapse
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Feb 18 06:34:03 CET 2023
    ModDate: Tue Feb 21 11:35:03 CET 2023
   ID: 0x55d528972d2d5a8012daad09b3285e2f, 0x127e5975c322af604087f76dfee44ef7
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 42
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 82
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 898
      ImageHeight: 833
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1414
      ImageHeight: 2481
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1961
      ImageHeight: 1282
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 755
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GOJFOH+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GOJFOH+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QPLXAS+STIXMath-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: QPLXAS+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-LightIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -223, -515, 1437, 929
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: CXCHVA+WarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: CXCHVA+WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -175, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: NUJTEY+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 128
      LastChar: 128
      FontDescriptor: 
       FontName: NUJTEY+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: QPLXAS+TimesNewRomanPS-ItalicMT
      FontSubset: true
      FirstChar: 128
      LastChar: 128
      FontDescriptor: 
       FontName: QPLXAS+TimesNewRomanPS-ItalicMT
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-02-18T05:34:03</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2023-02-21T11:35:03+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-02-21T11:35:03+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Economic burden;Early-stage NSCLC;Locorregional relapse;Metastatic relapse</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12890-023-02356-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Pulmonary Medicine, https://doi.org/10.1186/s12890-023-02356-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Economic burden</rdf:li>
               <rdf:li>Early-stage NSCLC</rdf:li>
               <rdf:li>Locorregional relapse</rdf:li>
               <rdf:li>Metastatic relapse</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Economic burden of locoregional and metastatic relapses in resectable early-stage non-small cell lung cancer in Spain</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Javier De Castro</rdf:li>
               <rdf:li> Amelia Insa</rdf:li>
               <rdf:li> Roberto Collado-Borrell</rdf:li>
               <rdf:li> Vicente Escudero-Vilaplana</rdf:li>
               <rdf:li> Alex Martínez</rdf:li>
               <rdf:li> Elena Fernandez</rdf:li>
               <rdf:li> Ivana Sullivan</rdf:li>
               <rdf:li> Natalia Arrabal</rdf:li>
               <rdf:li> David Carcedo Rodriguez</rdf:li>
               <rdf:li> Alba Manzaneque</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12890-023-02356-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12890-023-02356-0</prism:url>
         <prism:doi>10.1186/s12890-023-02356-0</prism:doi>
         <prism:issn>1471-2466</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Pulmonary Medicine</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12890-023-02356-0</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:2f2b0942-b2d7-4625-b650-43b23e816699</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:a82d81c9-6a95-4a93-afbe-329ed178108b</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:2f2b0942-b2d7-4625-b650-43b23e816699</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-02-21T09:55:26Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 68, 330, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 68, 530, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 60, 276, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 186, 586, 199, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 586, 319, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 442, 586, 454, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 130, 572, 143, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 354, 572, 367, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 469, 572, 481, 560
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 679, 110, 667
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 280, 667, 285, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 187, 631, 192, 619
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 89, 595, 93, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 116, 559, 121, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 127, 559, 132, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 220, 511, 225, 499
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 231, 511, 236, 499
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 243, 511, 248, 499
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 237, 439, 242, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 253, 367, 258, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 264, 367, 269, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 275, 367, 285, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 147, 319, 151, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 258, 271, 263, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 268, 271, 273, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 278, 271, 288, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 56, 259, 66, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 196, 223, 206, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 211, 223, 221, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 258, 199, 268, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 275, 199, 285, 187
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 172, 175, 182, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 143, 127, 153, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 400, 704, 410, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 403, 668, 413, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 451, 608, 461, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 466, 608, 476, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 390, 572, 400, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 413, 548, 423, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
     Thumb: true
    Page: 
     Sequence: 3
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 380, 77, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 114, 151, 119, 139
       Flags: Print
       AppearanceDictionary: true
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 369, 693, 374, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 378, 693, 383, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 388, 693, 392, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 397, 693, 402, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 406, 693, 411, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 416, 693, 421, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 321, 657, 331, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 364, 633, 374, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 380, 633, 390, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 399, 381, 404, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 523, 345, 528, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 533, 225, 538, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 357, 153, 367, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 373, 153, 383, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 390, 153, 400, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 407, 153, 417, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 424, 153, 433, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 440, 153, 450, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 457, 153, 467, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 474, 153, 483, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 490, 153, 500, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 507, 153, 517, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 523, 153, 533, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 609, 288, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 56, 597, 66, 585
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 146, 573, 156, 561
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 97, 561, 102, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 186
      Annotation: 
       Subtype: Link
       Rect: 85, 489, 95, 477
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 307, 669, 317, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
      Annotation: 
       Subtype: Link
       Rect: 374, 537, 384, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 232
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 198, 561, 203, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 91, 549, 96, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 212, 537, 217, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 151
      Annotation: 
       Subtype: Link
       Rect: 285, 394, 290, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 71, 237, 76, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 486, 668, 496, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 325, 500, 335, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 373, 356, 378, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 383, 356, 388, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 393, 356, 403, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 408, 356, 418, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 335, 320, 345, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 349, 320, 359, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 333, 212, 343, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 244, 396, 253, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 275, 323, 285, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 224, 239, 234, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 191, 119, 201, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 512, 468, 522, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 199
      Annotation: 
       Subtype: Link
       Rect: 345, 383, 355, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 526, 347, 536, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 304, 335, 314, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 319, 335, 328, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 333, 335, 343, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 367, 179, 377, 167
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 465, 201, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 200, 369, 210, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 215, 369, 225, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 496, 242, 529, 234
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 233, 404, 225
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 505, 250, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 244, 496, 279, 488
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 487, 142, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 186, 469, 238, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 93, 208, 85
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 470, 703, 523, 695
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 694, 493, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 337, 631, 484, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 586, 459, 578
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 694, 282, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 685, 84, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 577, 274, 569
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 568, 117, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 118, 448, 110
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 447, 109, 506, 101
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 354, 82, 526, 74
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 658, 208, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 72d5fda6
   Type: CRC32
  Checksum: 143083fff802c683a72f73da63adae89
   Type: MD5
  Checksum: 86eff57cc62e3e4c4f7b213012193dbd72215ca1
   Type: SHA-1
  Checksum: 4cdfa502696e1f1e27c404a7b61548b52e170f39ef213a42bbbb72d9d68fe91a
   Type: SHA-256