fbd4692def6ad6e28b8e631ce181582a  303869.pdf
f4a9a6b55ee2ded3e1994e4c479ae5df518bfb27  303869.pdf
aeceea0e56a3491093d529cb88ae9a3e6b14824fc493673495660cbaa60000a6  303869.pdf

Title:           Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resected Stage IB to IIIA EGFR-Mutated NSCLC: Updated Analysis From the Phase 3 ADAURA Trial
Subject:         Journal of Thoracic Oncology, 18 (2023) 1209-1221. doi:10.1016/j.jtho.2023.05.015
Author:          Thomas John M.B.B.S. PhD
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    16th August 2023
ModDate:         Wed Aug 16 21:29:16 2023 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       584.957 x 782.986 pts
Page rot:        0
File size:       459385 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
NJCJFC+AdvTTc9c3bd71                 Type 1C           WinAnsi          yes yes no     720  0
NJCJHC+AdvTTda6f6cb8.B               Type 1C           WinAnsi          yes yes no     726  0
NJCJHD+AdvTT43930a72.BI              Type 1C           WinAnsi          yes yes no     729  0
NJCJHE+AdvTT43930a72.BI+fb           Type 1C           Custom           yes yes yes    727  0
NJCJHF+AdvPSSym                      Type 1C           Custom           yes yes yes    740  0
NJCJIG+AdvTT7f5838b0.I               Type 1C           WinAnsi          yes yes no     743  0
NJCJIH+AdvTT7f5838b0.I+20            Type 1C           WinAnsi          yes yes no     745  0
NJCJKL+AdvP4C4E74                    Type 1C           Custom           yes yes yes    408  0
NJCJKM+AdvTT08640291+20              Type 1C           WinAnsi          yes yes no     403  0
NJCJKN+AdvTT9cc80a3e.I               Type 1C           WinAnsi          yes yes no     427  0
NJCJKH+AdvTT7f5838b0.I+fb            Type 1C           Custom           yes yes yes    428  0
NJCJKI+AdvTT0eeac7f7.B               Type 1C           WinAnsi          yes yes no     415  0
NJCJKJ+AdvTT08640291                 Type 1C           WinAnsi          yes yes no     419  0
NJCJKK+AdvTT08640291+fb              Type 1C           Custom           yes yes yes    413  0
NJCJLO+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     429  0
NJCJNO+AdvTTc9c3bd71+fb              Type 1C           Custom           yes yes yes    435  0
NJCKAA+AdvTTc9c3bd71+20              Type 1C           WinAnsi          yes yes no     436  0
NJCJOP+Arial-BoldMT                  CID TrueType      Identity-H       yes yes yes    437  0
NJCJPA+ArialMT                       CID TrueType      Identity-H       yes yes yes    449  0
NJCKKN+AdvTT275472e6+20              Type 1C           Custom           yes yes yes    461  0
NJCKLO+AdvTT5843c571                 Type 1C           WinAnsi          yes yes no     468  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-12-11 02:55:28 CET
 RepresentationInformation: 303869.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-10 11:14:03 CET
  Size: 459385
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'cor1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found
   ID: PDF-HUL-122
   Offset: 427901
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-122
   Offset: 427901
  ErrorMessage: Improperly formed date
   ID: PDF-HUL-133
   Offset: 446172
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 803
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resec ...
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Materials and Methods
        Destination: flink2
        Children: 
         Item: 
          Title: Trial Design and Patients
          Destination: slink1
         Item: 
          Title: Safety and HRQoL Assessments
          Destination: slink2
         Item: 
          Title: Statistical Methods
          Destination: slink3
          Children: 
           Item: 
            Title: Safety
            Destination: thirlink1
           Item: 
            Title: HRQoL
            Destination: thirlink2
       Item: 
        Title: Results
        Destination: flink3
        Children: 
         Item: 
          Title: Patient Demographics and Treatment
          Destination: slink4
         Item: 
          Title: Safety
          Destination: slink5
          Children: 
           Item: 
            Title: Safety Summary
            Destination: thirlink3
           Item: 
            Title: Grade Greater Than or Equal to 3 AEs
            Destination: thirlink4
           Item: 
            Title: Causally Related AEs
            Destination: thirlink5
           Item: 
            Title: Serious AEs
            Destination: thirlink6
           Item: 
            Title: AEs Leading to Discontinuation, Dose Interruption, and Dose Reduction
            Destination: thirlink7
           Item: 
            Title: AEs Leading to Death
            Destination: thirlink8
           Item: 
            Title: Safety Summary by Sex
            Destination: thirlink9
           Item: 
            Title: Safety Summary by Age
            Destination: thirlink10
           Item: 
            Title: Time to Onset and Duration of Most Common AEs and Selected AEs of Clinical Interest
            Destination: thirlink11
           Item: 
            Title: ILD
            Destination: thirlink12
           Item: 
            Title: Cardiac Events
            Destination: thirlink13
           Item: 
            Title: HRQoL
            Destination: thirlink14
       Item: 
        Title: Discussion
        Destination: flink4
       Item: 
        Title: Credit Authorship Contribution Statement
        Destination: flink5
       Item: 
        Title: flink6
        Destination: flink6
       Item: 
        Title: Data Sharing Statement
        Destination: flink7
       Item: 
        Title: Supplementary Data
        Destination: flink8
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resected Stage IB to IIIA EGFR-Mutated NSCLC: Updated Analysis From the Phase 3 ADAURA Trial
    Author: Thomas John M.B.B.S. PhD
    Subject: Journal of Thoracic Oncology, 18 (2023) 1209-1221. doi:10.1016/j.jtho.2023.05.015
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
   ID: 0xe8f93abe8f614728052b4a2d53c0586f, 0x03661f1e1ce4514dabbec1ff6ac22576
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: NJCJPA+ArialMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: NJCJOP+Arial-BoldMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NJCJKJ+AdvTT08640291
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: NJCJKJ+AdvTT08640291
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -208, 916, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJHF+AdvPSSym
      FontSubset: true
      FirstChar: 2
      LastChar: 170
      FontDescriptor: 
       FontName: NJCJHF+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJIG+AdvTT7f5838b0.I
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: NJCJIG+AdvTT7f5838b0.I
       Flags: Nonsymbolic
       FontBBox: -62, -218, 927, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJIH+AdvTT7f5838b0.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: NJCJIH+AdvTT7f5838b0.I+20
       Flags: Nonsymbolic
       FontBBox: -10, -239, 1104, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJKN+AdvTT9cc80a3e.I
      FontSubset: true
      FirstChar: 49
      LastChar: 121
      FontDescriptor: 
       FontName: NJCJKN+AdvTT9cc80a3e.I
       Flags: Nonsymbolic
       FontBBox: -125, -208, 979, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJKH+AdvTT7f5838b0.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: NJCJKH+AdvTT7f5838b0.I+fb
       Flags: Symbolic
       FontBBox: -41, -197, 1354, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJLO+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: NJCJLO+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCKKN+AdvTT275472e6+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: NJCKKN+AdvTT275472e6+20
       Flags: Symbolic
       FontBBox: -510, -250, 1552, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJFC+AdvTTc9c3bd71
      FontSubset: true
      FirstChar: 37
      LastChar: 233
      FontDescriptor: 
       FontName: NJCJFC+AdvTTc9c3bd71
       Flags: Nonsymbolic
       FontBBox: -31, -218, 843, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJKM+AdvTT08640291+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: NJCJKM+AdvTT08640291+20
       Flags: Nonsymbolic
       FontBBox: -187, -197, 1208, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJNO+AdvTTc9c3bd71+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: NJCJNO+AdvTTc9c3bd71+fb
       Flags: Symbolic
       FontBBox: 9, -197, 1302, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCKAA+AdvTTc9c3bd71+20
      FontSubset: true
      FirstChar: 134
      LastChar: 151
      FontDescriptor: 
       FontName: NJCKAA+AdvTTc9c3bd71+20
       Flags: Nonsymbolic
       FontBBox: 0, -239, 1072, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCKLO+AdvTT5843c571
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: NJCKLO+AdvTT5843c571
       Flags: Nonsymbolic
       FontBBox: -72, -208, 927, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJHC+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 42
      LastChar: 121
      FontDescriptor: 
       FontName: NJCJHC+AdvTTda6f6cb8.B
       Flags: Nonsymbolic
       FontBBox: -72, -218, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJHE+AdvTT43930a72.BI+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: NJCJHE+AdvTT43930a72.BI+fb
       Flags: Symbolic
       FontBBox: -52, -197, 1406, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJKL+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: NJCJKL+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJHD+AdvTT43930a72.BI
      FontSubset: true
      FirstChar: 38
      LastChar: 233
      FontDescriptor: 
       FontName: NJCJHD+AdvTT43930a72.BI
       Flags: Nonsymbolic
       FontBBox: -72, -218, 979, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NJCJKK+AdvTT08640291+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: NJCJKK+AdvTT08640291+fb
       Flags: Symbolic
       FontBBox: 30, 0, 843, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NJCJKI+AdvTT0eeac7f7.B
      FontSubset: true
      FirstChar: 44
      LastChar: 233
      FontDescriptor: 
       FontName: NJCJKI+AdvTT0eeac7f7.B
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -218, 958, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: NJCJOP+Arial-BoldMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: NJCJOP+Arial-BoldMT
       Flags: Symbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile2: true
     Font: 
      BaseFont: NJCJPA+ArialMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: NJCJPA+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jtho.2023.05.015</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resected Stage IB to IIIA EGFR-Mutated NSCLC: Updated Analysis From the Phase 3 ADAURA Trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Thomas John M.B.B.S. PhD</rdf:li>
               <rdf:li>Christian Grohé MD</rdf:li>
               <rdf:li>Jonathan W. Goldman MD</rdf:li>
               <rdf:li>Frances A. Shepherd MD FRCPC</rdf:li>
               <rdf:li>Filippo de Marinis MD PhD</rdf:li>
               <rdf:li>Terufumi Kato MD</rdf:li>
               <rdf:li>Qun Wang MD PhD</rdf:li>
               <rdf:li>Wu-Chou Su MD</rdf:li>
               <rdf:li>Jin Hyuk Choi MD PhD</rdf:li>
               <rdf:li>Virote Sriuranpong MD PhD</rdf:li>
               <rdf:li>Barbara Melotti MD</rdf:li>
               <rdf:li>Mary J. Fidler MD</rdf:li>
               <rdf:li>Jun Chen MD PhD</rdf:li>
               <rdf:li>Muna Albayaty MbChB. FFPM MSc</rdf:li>
               <rdf:li>Marta Stachowiak MPharm</rdf:li>
               <rdf:li>Sarah Taggart Msci</rdf:li>
               <rdf:li>Yi-Long Wu MD</rdf:li>
               <rdf:li>Masahiro Tsuboi MD PhD</rdf:li>
               <rdf:li>Roy S. Herbst MD PhD</rdf:li>
               <rdf:li>Margarita Majem MD PhD</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Osimertinib</rdf:li>
               <rdf:li>Adjuvant</rdf:li>
               <rdf:li>EGFR</rdf:li>
               <rdf:li>Non–small cell lung cancer</rdf:li>
               <rdf:li>Safety</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Thoracic Oncology, 18 (2023) 1209-1221. doi:10.1016/j.jtho.2023.05.015</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>International Association for the Study of Lung Cancer</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Thoracic Oncology</prism:publicationName>
         <prism:copyright>© 2023 International Association for the Study of Lung Cancer. Published by Elsevier Inc.</prism:copyright>
         <prism:issn>1556-0864</prism:issn>
         <prism:volume>18</prism:volume>
         <prism:number>9</prism:number>
         <prism:coverDisplayDate>September 2023</prism:coverDisplayDate>
         <prism:pageRange>1209-1221</prism:pageRange>
         <prism:startingPage>1209</prism:startingPage>
         <prism:endingPage>1221</prism:endingPage>
         <prism:doi>10.1016/j.jtho.2023.05.015</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jtho.2023.05.015</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jtho.2023.05.015</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jtho.2023.05.015</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>16th August 2023</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2023-08-17T00:59:16+05:30</xap:ModifyDate>
         <xap:MetadataDate>2023-08-17T00:59:16+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>16th August 2023</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:886ed21c-7113-4469-9fbb-4d62088fbdfc</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:8b34467c-08f8-4980-bb42-cad1e56dd748</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1209
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 197, 561, 202, 572
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 205, 561, 210, 572
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 213, 561, 213, 572
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 213, 561, 213, 572
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 213, 561, 217, 572
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 330, 561, 334, 572
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 480, 561, 485, 572
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 219, 547, 224, 559
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 373, 547, 376, 559
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 480, 547, 485, 559
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 154, 533, 159, 545
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 254, 533, 257, 545
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 390, 533, 393, 545
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 496, 126, 532, 133
      Annotation: 
       Subtype: Link
       Rect: 303, 118, 347, 125
      Annotation: 
       Subtype: Link
       Rect: 355, 90, 503, 97
      Annotation: 
       Subtype: Link
       Rect: 303, 67, 446, 73
      Annotation: 
       Subtype: Link
       Rect: 460, 662, 538, 677
    Page: 
     Label: 1210
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 201, 718, 206, 730
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 321, 718, 323, 730
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 428, 718, 435, 730
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 151, 704, 156, 716
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 353, 704, 357, 716
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 194, 690, 199, 702
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 310, 690, 315, 702
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 406, 690, 410, 702
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 185, 676, 189, 688
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 321, 676, 324, 688
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 470, 676, 475, 688
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 438, 169, 539, 179
      Annotation: 
       Subtype: Link
       Rect: 298, 157, 384, 167
    Page: 
     Label: 1211
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 707, 104, 716
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 78, 632, 82, 642
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 83, 632, 88, 642
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 83, 570, 87, 579
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 242, 495, 258, 505
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 77, 420, 85, 430
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 87, 420, 95, 430
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 183, 333, 187, 343
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 75, 308, 79, 318
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 80, 308, 84, 318
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 86, 308, 94, 318
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 95, 308, 104, 318
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 83, 221, 87, 231
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 89, 221, 93, 231
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 94, 221, 98, 231
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 100, 221, 108, 231
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 110, 221, 130, 231
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 186, 146, 190, 156
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 277, 96, 285, 106
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 342, 676, 346, 686
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 352, 671, 455, 681
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 474, 671, 538, 681
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 297, 659, 320, 669
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 403, 392, 412, 402
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 301, 363, 393, 373
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 439, 330, 447, 340
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 433, 238, 533, 248
       Destination: null
    Page: 
     Label: 1212
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 79, 619, 83, 629
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 122, 607, 126, 617
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 128, 607, 132, 617
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 134, 607, 142, 617
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 143, 607, 152, 617
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 135, 468, 143, 478
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 144, 468, 153, 478
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 160, 463, 264, 473
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 270, 368, 278, 378
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 45, 339, 150, 349
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 202, 234, 206, 244
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 222, 229, 286, 239
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 217, 78, 227
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 162, 72, 166, 82
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 358, 615, 457, 625
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 329, 534, 428, 544
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 434, 538, 438, 548
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 302, 471, 325, 481
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 352, 471, 451, 481
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 457, 476, 461, 486
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 331, 422, 354, 432
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 431, 358, 534, 368
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 302, 195, 334, 205
       Destination: 80
      Annotation: 
       Subtype: Link
       Rect: 399, 145, 506, 155
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 354, 107, 386, 117
       Destination: 92
    Page: 
     Label: 1213
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 406, 145, 416
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 347, 419, 369, 428
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 161, 295, 164, 303
       Destination: 80
    Page: 
     Label: 1214
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 49, 455, 148, 465
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 188, 405, 212, 415
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 241, 380, 264, 390
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 178, 343, 281, 353
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 171, 281, 194, 291
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 49, 205, 159, 215
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 435, 677, 534, 687
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 475, 615, 539, 625
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 298, 602, 334, 612
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 373, 428, 473, 438
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 422, 354, 448, 364
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 475, 354, 539, 364
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 298, 341, 323, 351
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 369, 329, 392, 339
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 336, 292, 428, 302
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 302, 180, 328, 190
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 338, 117, 362, 127
       Destination: 124
      Annotation: 
       Subtype: Link
       Rect: 457, 59, 461, 69
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 61, 662, 64, 670
       Destination: 92
    Page: 
     Label: 1215
     Sequence: 7
    Page: 
     Label: 1216
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 129, 188, 139
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 298, 279, 394, 289
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 345, 258, 353, 268
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 302, 179, 393, 189
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 429, 54, 452, 64
       Destination: 138
    Page: 
     Label: 1217
     Sequence: 9
    Page: 
     Label: 1218
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 545, 149, 555
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 150, 545, 158, 555
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 116, 345, 120, 355
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 195, 283, 200, 293
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 123, 208, 127, 218
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 128, 208, 136, 218
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 471, 707, 475, 716
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 477, 707, 485, 716
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 422, 607, 430, 617
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 531, 570, 539, 579
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 498, 520, 503, 530
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 332, 495, 336, 505
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 401, 445, 409, 455
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 397, 408, 401, 418
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 454, 395, 459, 405
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 460, 395, 468, 405
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 421, 296, 425, 306
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 427, 296, 431, 306
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 426, 59, 434, 69
       Destination: 370
    Page: 
     Label: 1219
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 167, 694, 175, 704
       Destination: 370
      Annotation: 
       Subtype: Link
       Rect: 114, 532, 123, 542
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 114, 433, 123, 442
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 183, 246, 187, 256
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 188, 246, 192, 256
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 194, 246, 202, 256
       Destination: 182
      Annotation: 
       Subtype: Link
       Rect: 128, 171, 132, 181
       Destination: 182
    Page: 
     Label: 1220
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 133, 615, 281, 625
      Annotation: 
       Subtype: Link
       Rect: 252, 544, 286, 554
      Annotation: 
       Subtype: Link
       Rect: 45, 531, 283, 541
      Annotation: 
       Subtype: Link
       Rect: 45, 519, 90, 529
      Annotation: 
       Subtype: Link
       Rect: 144, 449, 197, 458
      Annotation: 
       Subtype: Link
       Rect: 237, 449, 286, 458
      Annotation: 
       Subtype: Link
       Rect: 45, 436, 181, 446
      Annotation: 
       Subtype: Link
       Rect: 62, 397, 286, 406
      Annotation: 
       Subtype: Link
       Rect: 62, 387, 286, 396
      Annotation: 
       Subtype: Link
       Rect: 62, 376, 286, 385
      Annotation: 
       Subtype: Link
       Rect: 62, 365, 163, 374
      Annotation: 
       Subtype: Link
       Rect: 62, 354, 286, 363
      Annotation: 
       Subtype: Link
       Rect: 62, 343, 286, 352
      Annotation: 
       Subtype: Link
       Rect: 62, 332, 191, 341
      Annotation: 
       Subtype: Link
       Rect: 62, 321, 286, 330
      Annotation: 
       Subtype: Link
       Rect: 62, 310, 286, 319
      Annotation: 
       Subtype: Link
       Rect: 62, 299, 283, 308
      Annotation: 
       Subtype: Link
       Rect: 62, 288, 286, 297
      Annotation: 
       Subtype: Link
       Rect: 62, 277, 286, 286
      Annotation: 
       Subtype: Link
       Rect: 62, 266, 286, 275
      Annotation: 
       Subtype: Link
       Rect: 62, 255, 286, 264
      Annotation: 
       Subtype: Link
       Rect: 62, 244, 283, 253
      Annotation: 
       Subtype: Link
       Rect: 62, 233, 286, 242
      Annotation: 
       Subtype: Link
       Rect: 62, 222, 286, 231
      Annotation: 
       Subtype: Link
       Rect: 62, 211, 286, 220
      Annotation: 
       Subtype: Link
       Rect: 62, 200, 283, 209
      Annotation: 
       Subtype: Link
       Rect: 171, 178, 283, 187
      Annotation: 
       Subtype: Link
       Rect: 62, 123, 286, 132
      Annotation: 
       Subtype: Link
       Rect: 62, 113, 286, 122
      Annotation: 
       Subtype: Link
       Rect: 62, 102, 142, 111
      Annotation: 
       Subtype: Link
       Rect: 62, 91, 286, 100
      Annotation: 
       Subtype: Link
       Rect: 62, 80, 286, 89
      Annotation: 
       Subtype: Link
       Rect: 62, 69, 286, 78
      Annotation: 
       Subtype: Link
       Rect: 62, 58, 192, 67
      Annotation: 
       Subtype: Link
       Rect: 315, 715, 540, 724
      Annotation: 
       Subtype: Link
       Rect: 315, 704, 540, 713
      Annotation: 
       Subtype: Link
       Rect: 315, 694, 540, 702
      Annotation: 
       Subtype: Link
       Rect: 315, 683, 540, 692
      Annotation: 
       Subtype: Link
       Rect: 315, 672, 439, 681
      Annotation: 
       Subtype: Link
       Rect: 315, 661, 540, 670
      Annotation: 
       Subtype: Link
       Rect: 315, 650, 539, 659
      Annotation: 
       Subtype: Link
       Rect: 315, 639, 540, 648
      Annotation: 
       Subtype: Link
       Rect: 315, 628, 540, 637
      Annotation: 
       Subtype: Link
       Rect: 315, 617, 410, 626
      Annotation: 
       Subtype: Link
       Rect: 315, 606, 540, 615
      Annotation: 
       Subtype: Link
       Rect: 315, 595, 540, 604
      Annotation: 
       Subtype: Link
       Rect: 315, 584, 416, 593
      Annotation: 
       Subtype: Link
       Rect: 315, 573, 540, 582
      Annotation: 
       Subtype: Link
       Rect: 315, 562, 540, 571
      Annotation: 
       Subtype: Link
       Rect: 315, 551, 540, 560
      Annotation: 
       Subtype: Link
       Rect: 315, 540, 540, 549
      Annotation: 
       Subtype: Link
       Rect: 315, 529, 540, 538
      Annotation: 
       Subtype: Link
       Rect: 315, 518, 347, 527
      Annotation: 
       Subtype: Link
       Rect: 315, 507, 540, 516
      Annotation: 
       Subtype: Link
       Rect: 315, 496, 540, 505
      Annotation: 
       Subtype: Link
       Rect: 315, 485, 540, 494
      Annotation: 
       Subtype: Link
       Rect: 315, 474, 479, 483
      Annotation: 
       Subtype: Link
       Rect: 315, 463, 540, 472
      Annotation: 
       Subtype: Link
       Rect: 315, 452, 540, 461
      Annotation: 
       Subtype: Link
       Rect: 315, 441, 512, 450
      Annotation: 
       Subtype: Link
       Rect: 315, 430, 540, 439
      Annotation: 
       Subtype: Link
       Rect: 315, 420, 540, 428
      Annotation: 
       Subtype: Link
       Rect: 315, 409, 539, 418
      Annotation: 
       Subtype: Link
       Rect: 315, 398, 540, 407
      Annotation: 
       Subtype: Link
       Rect: 315, 387, 364, 396
      Annotation: 
       Subtype: Link
       Rect: 315, 376, 540, 385
      Annotation: 
       Subtype: Link
       Rect: 315, 365, 540, 374
      Annotation: 
       Subtype: Link
       Rect: 315, 354, 540, 363
      Annotation: 
       Subtype: Link
       Rect: 315, 343, 540, 352
      Annotation: 
       Subtype: Link
       Rect: 315, 332, 474, 341
      Annotation: 
       Subtype: Link
       Rect: 315, 321, 540, 330
      Annotation: 
       Subtype: Link
       Rect: 315, 310, 540, 319
      Annotation: 
       Subtype: Link
       Rect: 315, 299, 476, 308
      Annotation: 
       Subtype: Link
       Rect: 464, 277, 540, 286
      Annotation: 
       Subtype: Link
       Rect: 315, 266, 539, 275
      Annotation: 
       Subtype: Link
       Rect: 315, 255, 446, 264
      Annotation: 
       Subtype: Link
       Rect: 504, 222, 540, 231
      Annotation: 
       Subtype: Link
       Rect: 315, 211, 534, 220
      Annotation: 
       Subtype: Link
       Rect: 315, 200, 414, 209
      Annotation: 
       Subtype: Link
       Rect: 315, 189, 540, 198
      Annotation: 
       Subtype: Link
       Rect: 315, 178, 540, 187
      Annotation: 
       Subtype: Link
       Rect: 315, 167, 540, 176
      Annotation: 
       Subtype: Link
       Rect: 315, 157, 540, 165
      Annotation: 
       Subtype: Link
       Rect: 315, 146, 540, 155
      Annotation: 
       Subtype: Link
       Rect: 315, 135, 390, 144
      Annotation: 
       Subtype: Link
       Rect: 315, 124, 540, 133
      Annotation: 
       Subtype: Link
       Rect: 315, 113, 540, 122
      Annotation: 
       Subtype: Link
       Rect: 315, 102, 380, 111
      Annotation: 
       Subtype: Link
       Rect: 315, 91, 540, 100
      Annotation: 
       Subtype: Link
       Rect: 315, 80, 540, 89
      Annotation: 
       Subtype: Link
       Rect: 315, 69, 540, 78
      Annotation: 
       Subtype: Link
       Rect: 315, 58, 507, 67
    Page: 
     Label: 1221
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 61, 715, 285, 724
      Annotation: 
       Subtype: Link
       Rect: 61, 704, 285, 713
      Annotation: 
       Subtype: Link
       Rect: 61, 694, 285, 702
      Annotation: 
       Subtype: Link
       Rect: 61, 683, 285, 692
      Annotation: 
       Subtype: Link
       Rect: 61, 672, 102, 681
      Annotation: 
       Subtype: Link
       Rect: 61, 661, 285, 670
      Annotation: 
       Subtype: Link
       Rect: 61, 650, 285, 659
      Annotation: 
       Subtype: Link
       Rect: 314, 715, 538, 724
      Annotation: 
       Subtype: Link
       Rect: 314, 704, 538, 713
      Annotation: 
       Subtype: Link
       Rect: 314, 694, 380, 702
      Annotation: 
       Subtype: Link
       Rect: 314, 683, 538, 692
      Annotation: 
       Subtype: Link
       Rect: 314, 672, 538, 681
      Annotation: 
       Subtype: Link
       Rect: 314, 661, 538, 670
      Annotation: 
       Subtype: Link
       Rect: 314, 650, 532, 659
  Checksum: 03d5ac7d
   Type: CRC32
  Checksum: fbd4692def6ad6e28b8e631ce181582a
   Type: MD5
  Checksum: f4a9a6b55ee2ded3e1994e4c479ae5df518bfb27
   Type: SHA-1
  Checksum: aeceea0e56a3491093d529cb88ae9a3e6b14824fc493673495660cbaa60000a6
   Type: SHA-256