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Keywords: psoriasis; genetics; epigenomics Author: Laura Mateu-Arrom and Lluis Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Aug 24 03:25:05 2023 CEST ModDate: Thu Aug 24 03:30:33 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 845272 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ICJAXV+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 NABXUW+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 FNAHBL+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 OLCJGJ+VnURWPalladioL Type 1 Custom yes yes no 23 0 KONDUX+EuphemiaUCAS-Bold Type 1C WinAnsi yes yes no 42 0 HIZBRM+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 45 0 SARRKW+EURM10 Type 1 Builtin yes yes no 70 0 IOLAWT+PazoMath-Italic Type 1 Builtin yes yes no 80 0 GPNGBC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 93 0 GPNGBD+PalatinoLinotype CID TrueType Identity-H yes yes yes 96 0 GPNGBE+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 GPNGBG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 GPNGKE+PalatinoLinotype TrueType MacRoman yes yes no 108 0 AOPHAZ+CMSY10 Type 1 Builtin yes yes no 118 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-12 02:49:28 CET RepresentationInformation: 303880.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-11 13:42:33 CET Size: 845272 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 575 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Genetics Destination: subsection.3.1 Children: Item: Title: Antigen Presentation Destination: subsubsection.3.1.1 Item: Title: Th1 Signaling Pathway Destination: subsubsection.3.1.2 Item: Title: Th17 Signaling Pathway Destination: subsubsection.3.1.3 Item: Title: Innate Immunity Destination: subsubsection.3.1.4 Item: Title: Skin Barrier Function Destination: subsubsection.3.1.5 Item: Title: Genetics of Generalized Pustular Psoriasis Destination: subsubsection.3.1.6 Item: Title: Genetics in Psoriatic Arthritis Destination: subsubsection.3.1.7 Item: Title: Genetics and Psoriasis Treatment Destination: subsubsection.3.1.8 Item: Title: Epigenetics Destination: subsection.3.2 Children: Item: Title: Non Coding RNA Destination: subsubsection.3.2.1 Item: Title: DNA Methylation Destination: subsubsection.3.2.2 Item: Title: Histone Modification Destination: subsubsection.3.2.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Genetic and Epigenetic Mechanisms of Psoriasis Author: Laura Mateu-Arrom and Lluis Puig Subject: Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis. 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