f99ba5d40291c03bedd94a1564a2b2c4 303887.pdf 6bd4713e77521a61678e94f50ef527df9279c071 303887.pdf 3b2822f7dce03073e81bd093d7fb16811d706f60dc4716f144cd5a1e2d8e3fda 303887.pdf Title: Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry Subject: DOI: 10.1093/ehjopen/oead003; European Heart Journal Open, 3, 1, 2023-01-24.; Abstract: Aims: Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting. Methods and results: In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4–18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission l Keywords: Cardiogenic shock; GEIST; IABP; In-hospital complications; Intra-aortic balloon counter-pulsation; Stress cardiomyopathy; Takotsubo syndrome Author: Francesco Santoro Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Fri Feb 10 03:17:10 2023 CET ModDate: Fri Dec 13 12:11:25 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 748850 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UPENBT+STIXGeneral-Regular Type 1C Custom yes yes yes 23 0 QLJIHZ+ArialMT TrueType WinAnsi yes yes no 1 0 SNIGXG+GillSansNova-Heavy CID TrueType Identity-H yes yes yes 25 0 TZAEVH+GillSansNova-BookItalic CID TrueType Identity-H yes yes yes 26 0 UDMROI+GillSansNova-Bold CID TrueType Identity-H yes yes yes 28 0 NTFMMJ+GillSansNova-Book CID TrueType Identity-H yes yes yes 27 0 GGPIVG+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 24 0 HLAHFY+STIXGeneral-Bold Type 1C Custom yes yes yes 72 0 KEHFLG+GillSansNova-BoldItalic CID TrueType Identity-H yes yes yes 73 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-14 02:48:20 CET RepresentationInformation: 303887.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-13 12:11:54 CET Size: 748850 Format: PDF Version: 1.5 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'figoead003_ga1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'figoead003_ga1' cannot be found ID: PDF-HUL-122 Offset: 640758 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 920 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry Destination: head1 Children: Item: Title: Introduction Destination: secoead003-s0 Item: Title: Methods Destination: secoead003-s1 Children: Item: Title: Study population Destination: secoead003-s1.1 Item: Title: Inclusion criteria Destination: secoead003-s1.2 Item: Title: Clinical and echocardiographic examination Destination: secoead003-s1.3 Item: Title: Cardiogenic shock management Destination: secoead003-s1.4 Item: Title: Heart failure management Destination: secoead003-s1.5 Item: Title: Definition of outcome Destination: secoead003-s1.6 Item: Title: Statistical analysis Destination: secoead003-s1.7 Item: Title: Results Destination: secoead003-s2 Children: Item: Title: Clinical features of cardiogenic shock in Takotsubo syndrome Destination: secoead003-s2.1 Item: Title: Intra-aortic balloon pump use in cardiogenic shock Destination: secoead003-s2.2 Item: Title: Long-term follow-up Destination: secoead003-s2.3 Item: Title: Discussion Destination: secoead003-s3 Children: Item: Title: Limitations Destination: secoead003-s3.1 Item: Title: Conclusions Destination: secoead003-s4 Item: Title: Lead author biography Destination: secoead003-s5 Item: Title: Data availability Destination: secoead003-s6 Item: Title: Supplementary material Destination: secoead003-s7 Item: Title: Acknowledgements Destination: acknow Item: Title: Funding Destination: secoead003-s17 Item: Title: References Destination: reflist Info: Title: Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry Author: Francesco Santoro Subject: DOI: 10.1093/ehjopen/oead003; European Heart Journal Open, 3, 1, 2023-01-24.; Abstract: Aims: Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting. Methods and results: In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4–18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission l Keywords: Cardiogenic shock; GEIST; IABP; In-hospital complications; Intra-aortic balloon counter-pulsation; Stress cardiomyopathy; Takotsubo syndrome Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Fri Feb 10 03:47:10 CET 2023 ModDate: Fri Dec 13 12:11:25 CET 2024 ID: 0x68624dfede87132e1218403c4af81e2b, 0x42d5a8fe79f9caac91c6b161f04cb4cc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 650 ImageHeight: 605 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 650 ImageHeight: 449 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 275 ImageHeight: 354 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: GGPIVG+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: SNIGXG+GillSansNova-Heavy Encoding: Identity-H ToUnicode: true Font: BaseFont: KEHFLG+GillSansNova-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: TZAEVH+GillSansNova-BookItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: NTFMMJ+GillSansNova-Book Encoding: Identity-H ToUnicode: true Font: BaseFont: UDMROI+GillSansNova-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: UPENBT+STIXGeneral-Regular FontSubset: true FirstChar: 1 LastChar: 7 FontDescriptor: FontName: UPENBT+STIXGeneral-Regular Flags: Nonsymbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HLAHFY+STIXGeneral-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HLAHFY+STIXGeneral-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1030, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: QLJIHZ+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: QLJIHZ+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: GGPIVG+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GGPIVG+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: NTFMMJ+GillSansNova-Book CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NTFMMJ+GillSansNova-Book Flags: Nonsymbolic FontBBox: -420, -251, 1219, 950 FontFile2: true Font: BaseFont: UDMROI+GillSansNova-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UDMROI+GillSansNova-Bold Flags: Nonsymbolic, ForceBold FontBBox: -476, -276, 1276, 961 FontFile2: true Font: BaseFont: KEHFLG+GillSansNova-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KEHFLG+GillSansNova-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -404, -250, 1219, 960 FontFile2: true Font: BaseFont: TZAEVH+GillSansNova-BookItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: TZAEVH+GillSansNova-BookItalic Flags: Nonsymbolic, Italic FontBBox: -316, -235, 1219, 950 FontFile2: true Font: BaseFont: SNIGXG+GillSansNova-Heavy CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SNIGXG+GillSansNova-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -504, -287, 1375, 966 FontFile2: true XMP: uuid:db861f81-16c6-45df-98e9-a3ce37bce0e3 uuid:602CF176-89D0-8250-7699-E777C398F774 True Cardiogenic shock; GEIST; IABP; In-hospital complications; Intra-aortic balloon counter-pulsation; Stress cardiomyopathy; Takotsubo syndrome PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp 4.1.6 by 1T3XT application/pdf 10.1093/ehjopen/oead003 en Oxford University Press Impact of intra-aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: results from the German-Italian-Spanish (GEIST) registry Francesco Santoro Iván J Núñez Gil Thomas Stiermaier Ibrahim El-Battrawy Christian Moeller Federico Guerra Giuseppina Novo Luca Arcari Beatrice Musumeci Luca Cacciotti Enrica Mariano Francesco Romeo Michele Cannone Pasquale Caldarola Irene Giannini Adriana Mallardi Alessandra Leopizzi Enrica Vitale Roberta Montisci Luigi Meloni Pasquale Raimondo Matteo Di Biase Manuel Almendro-Delia Alessandro Sionis Aitor Uribarri Ibrahim Akin Holger Thiele Ingo Eitel Natale Daniele Brunetti DOI: 10.1093/ehjopen/oead003; European Heart Journal Open, 3, 1, 2023-01-24.; Abstract: Aims: Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short- and long-term impact of intra-aortic balloon pumping (IABP) on mortality in this setting. Methods and results: In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0.01 in all cases). Forty-three patients with CS (20% of 212) received IABP within 8 h (interquartile range 4–18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission l © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. Cardiogenic shock GEIST IABP In-hospital complications Intra-aortic balloon counter-pulsation Stress cardiomyopathy Takotsubo syndrome Journal European Heart Journal Open © The Author(s) 2023. 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