87f3fffbb1f5d845a942f9220c467730 303893.pdf 6be75fa552e7779ffdb52b0c7166052c8f5a3a71 303893.pdf 803796efc28e2f6b8d71596d57a204964c3b848fde5ba5e9f0edcd00dafa3293 303893.pdf Title: Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project Subject: There is controversial information about the accumulation of advanced glycation end-products (AGEs) in obesity. We assessed the impact of total and abdominal adiposity on AGE levels via a cross-sectional investigation with 4254 middle-aged subjects from the ILERVAS project. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Total adiposity indices (BMI and Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE)) and abdominal adiposity (waist circumference and body roundness index (BRI)) were assessed. Lean mass was estimated using the Hume index. The area under the receiver operating characteristic (ROC) curve was evaluated for each index. Different cardiovascular risk factors (smoking, prediabetes, hypertension and dyslipidemia) were evaluated. In the study population, 26.2% showed elevated SAF values. No differences in total body fat, visceral adiposity and lean body mass were detected between patients with normal and high SAF values. SAF levels showed a very slight but positive correlation with total body fat percentage (estimated by the CUN-BAE formula) and abdominal adiposity (estimated by the BRI). However, none of them had sufficient power to identify patients with high SAF levels (area under the ROC curve <0.52 in all cases). Finally, a progressive increase in SAF levels was observed in parallel with cardiovascular risk factors in the entire population and when patients with normal weight, overweight and obesity were evaluated separately. In conclusion, total obesity and visceral adiposity are not associated with a greater deposit of AGE. The elevation of AGE in obesity is related to the presence of cardiometabolic risk. Keywords: adipose tissue; advanced glycation end-products; body composition; cardiometabolic risk; cardiovascular risk factors; novel targets; obesity; skin autofluorescence Author: Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández and Albert Lecube Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jan 6 02:41:15 2023 CET ModDate: Fri Jan 6 02:45:46 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 924574 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YJKOBO+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 TEYLQO+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 JKISFU+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 AEPYJE+VnURWPalladioL Type 1 Custom yes yes no 23 0 UQZHSH+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 SSJMKU+CMSY10 Type 1 Builtin yes yes no 71 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 KEHJKK+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 88 0 KEHJKL+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 94 0 KEHJKM+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 100 0 KEHJKN+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 106 0 KEHJKO+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 109 0 KEHJLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 112 0 KEHLGG+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 115 0 KEHLMF+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 118 0 KEHJKK+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 133 0 KEHJKL+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 139 0 KEHJKM+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 145 0 KEHJKN+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 151 0 KEHJKO+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 154 0 KEHJLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 157 0 KEHLGF+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 160 0 KEHLGG+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 166 0 KEHJKK+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 178 0 KEHJKL+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 184 0 KEHJKM+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 190 0 KEHJKN+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 196 0 KEHJKO+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 199 0 KEHJLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 202 0 KEHLGF+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 205 0 KEHLGG+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 211 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 224 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-14 02:48:07 CET RepresentationInformation: 303893.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-13 12:03:38 CET Size: 924574 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 357 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Definition of Cardiovascular Risk Factors Destination: subsection.2.2 Item: Title: Anthropometric Measures Destination: subsection.2.3 Item: Title: Skin Autofluorescence Destination: subsection.2.4 Item: Title: Statistical Methods Destination: subsection.2.5 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project Author: Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández and Albert Lecube Subject: There is controversial information about the accumulation of advanced glycation end-products (AGEs) in obesity. We assessed the impact of total and abdominal adiposity on AGE levels via a cross-sectional investigation with 4254 middle-aged subjects from the ILERVAS project. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Total adiposity indices (BMI and Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE)) and abdominal adiposity (waist circumference and body roundness index (BRI)) were assessed. Lean mass was estimated using the Hume index. The area under the receiver operating characteristic (ROC) curve was evaluated for each index. Different cardiovascular risk factors (smoking, prediabetes, hypertension and dyslipidemia) were evaluated. In the study population, 26.2% showed elevated SAF values. No differences in total body fat, visceral adiposity and lean body mass were detected between patients with normal and high SAF values. SAF levels showed a very slight but positive correlation with total body fat percentage (estimated by the CUN-BAE formula) and abdominal adiposity (estimated by the BRI). However, none of them had sufficient power to identify patients with high SAF levels (area under the ROC curve <0.52 in all cases). Finally, a progressive increase in SAF levels was observed in parallel with cardiovascular risk factors in the entire population and when patients with normal weight, overweight and obesity were evaluated separately. In conclusion, total obesity and visceral adiposity are not associated with a greater deposit of AGE. The elevation of AGE in obesity is related to the presence of cardiometabolic risk. 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