e45981c5fe4a7ae501a773918d5d35fc  303900.pdf
f2f00c5708ae1797e2793d4f91f3f361688e03f5  303900.pdf
f39a93e72423cc316a7b95ad1fa82433cfb1fcdd53a801586fc361c92db6db02  303900.pdf

Title:           Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes
Subject:         JACC: Basic to Translational Science, 8 (2023) 1-15. doi:10.1016/j.jacbts.2022.07.013
Author:          Carmen Tarifa PhD
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Sun Jan  8 01:28:01 2023 CET
ModDate:         Sun Jan  8 01:28:53 2023 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           15
Encrypted:       no
Page size:       576 x 773.972 pts
Page rot:        0
File size:       3492897 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MKGNMK+AdvOT5b669f61                 Type 1C           WinAnsi          yes yes no     878  0
MKGNML+AdvOTa2a4c9ce                 Type 1C           WinAnsi          yes yes no     880  0
MKGNNM+AdvOTe81213fa                 Type 1C           WinAnsi          yes yes no     884  0
MKGPOB+AdvOT2986fa51                 Type 1C           WinAnsi          yes yes no     890  0
MKGPOC+AdvOT2986fa51+20              Type 1C           WinAnsi          yes yes no     892  0
MKGPOD+AdvOT8f503d4a                 Type 1C           WinAnsi          yes yes no     894  0
MKGPOE+AdvP4C4E74                    Type 1C           Custom           yes yes yes    899  0
MKGPOF+AdvOTc3f2c111.B               Type 1C           WinAnsi          yes yes no     888  0
MKGPOG+AdvOT61751f86                 Type 1C           WinAnsi          yes yes no     903  0
MKHAAG+AdvPSSym                      Type 1C           WinAnsi          yes yes no     905  0
MKHABH+AdvOT78d326c7                 Type 1C           WinAnsi          yes yes no     562  0
MKHABI+AdvOTe81213fa+fb              Type 1C           Custom           yes yes yes    563  0
MKHABJ+AdvOTe81213fa+20              Type 1C           WinAnsi          yes yes no     564  0
MKHABK+AdvOTc3f2c111.B+fb            Type 1C           Custom           yes yes yes    566  0
MKHACL+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no     567  0
MKHACM+AdvOTd9ad3ae4.I               Type 1C           WinAnsi          yes yes no     550  0
MKHACN+AdvOT61751f86+20              Type 1C           WinAnsi          yes yes no     553  0
MKHABG+AdvOT2986fa51+fb              Type 1C           Custom           yes yes yes    554  0
MKHAEN+AdvOT1a97e067.I               Type 1C           WinAnsi          yes yes no     581  0
MKHAEO+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     580  0
MKHAEP+AdvPS3F4C13                   Type 1C           WinAnsi          yes yes no     584  0
MKHAGA+AdvOTe60b6cd3.B               Type 1C           WinAnsi          yes yes no     589  0
MKHODM+AdvOT8e266094.B               Type 1C           WinAnsi          yes yes no     601  0
MKIJOF+AdvOTd9ad3ae4.I+fb            Type 1C           Custom           yes yes yes    622  0
MKIJPG+AdvOTf2345705                 Type 1C           WinAnsi          yes yes no     623  0
MKIJPH+AdvOTf2345705+fb              Type 1C           Custom           yes yes yes    619  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-12-18 02:51:03 CET
 RepresentationInformation: 303900.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-12-17 08:31:04 CET
  Size: 3492897
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 976
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes
      Destination: titlink1
      Children: 
       Item: 
        Title: Methods
        Destination: flink1
        Children: 
         Item: 
          Title: Myocyte isolation
          Destination: slink1
         Item: 
          Title: Patch-clamp technique
          Destination: slink2
         Item: 
          Title: Protein expression and distribution
          Destination: slink3
         Item: 
          Title: Detection and characterization of calcium sparks
          Destination: slink4
         Item: 
          Title: Mathematical model
          Destination: slink5
         Item: 
          Title: Data analysis and statistical methods
          Destination: slink6
       Item: 
        Title: Results
        Destination: flink2
        Children: 
         Item: 
          Title: Properties, frequency, and distribution of calcium sparks in patients with AF
          Destination: slink7
         Item: 
          Title: Mechanisms underlying changes in calcium spark distribution and dynamics in AF
          Destination: slink8
         Item: 
          Title: Functional consequences of subsarcolemmal calcium release in patients with AF
          Destination: slink9
       Item: 
        Title: Discussion
        Destination: flink3
        Children: 
         Item: 
          Title: Main findings
          Destination: slink10
         Item: 
          Title: Influence of calcium regulatory proteins on the spatial distribution of calcium sparks in human atrial myocytes
          Destination: slink11
         Item: 
          Title: Calcium release at the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in AF
          Destination: slink12
         Item: 
          Title: Study limitations
          Destination: slink13
       Item: 
        Title: Conclusions
        Destination: flink4
       Item: 
        Title: Acknowledgments
        Destination: acklink1
       Item: 
        Title: Funding Support and Author Disclosures
        Destination: flink5
       Item: 
        Title: References
        Destination: blink2
   Info: 
    Title: Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes
    Author: Carmen Tarifa PhD
    Subject: JACC: Basic to Translational Science, 8 (2023) 1-15. doi:10.1016/j.jacbts.2022.07.013
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Sun Jan 08 01:58:01 CET 2023
    ModDate: Sun Jan 08 01:58:53 CET 2023
   ID: 0x628d560b312afee10f868b0d9fb8ce10, 0xed2b5f2236f52641b611e8f2af563d8a
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1046
      ImageHeight: 1331
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1495
      ImageHeight: 2044
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 1127
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 1958
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 1896
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1445
      ImageHeight: 2134
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 1637
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1346
      ImageHeight: 1175
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1595
      ImageHeight: 954
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MKGPOE+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: MKGPOE+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKHAEO+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 60
      FontDescriptor: 
       FontName: MKHAEO+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHAEN+AdvOT1a97e067.I
      FontSubset: true
      FirstChar: 40
      LastChar: 116
      FontDescriptor: 
       FontName: MKHAEN+AdvOT1a97e067.I
       Flags: Nonsymbolic
       FontBBox: -156, -239, 1062, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGPOG+AdvOT61751f86
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: MKGPOG+AdvOT61751f86
       Flags: Nonsymbolic
       FontBBox: -10, -197, 916, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHAEP+AdvPS3F4C13
      FontSubset: true
      FirstChar: 68
      LastChar: 109
      FontDescriptor: 
       FontName: MKHAEP+AdvPS3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHAAG+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: MKHAAG+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHAGA+AdvOTe60b6cd3.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: MKHAGA+AdvOTe60b6cd3.B
       Flags: Nonsymbolic
       FontBBox: -52, -250, 947, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHODM+AdvOT8e266094.B
      FontSubset: true
      FirstChar: 46
      LastChar: 46
      FontDescriptor: 
       FontName: MKHODM+AdvOT8e266094.B
       Flags: Nonsymbolic
       FontBBox: -52, -239, 989, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHACM+AdvOTd9ad3ae4.I
      FontSubset: true
      FirstChar: 45
      LastChar: 252
      FontDescriptor: 
       FontName: MKHACM+AdvOTd9ad3ae4.I
       Flags: Nonsymbolic
       FontBBox: -135, -239, 927, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHACN+AdvOT61751f86+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: MKHACN+AdvOT61751f86+20
       Flags: Nonsymbolic
       FontBBox: -187, -197, 1031, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHABG+AdvOT2986fa51+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MKHABG+AdvOT2986fa51+fb
       Flags: Symbolic
       FontBBox: 19, 0, 916, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKIJPH+AdvOTf2345705+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MKIJPH+AdvOTf2345705+fb
       Flags: Symbolic
       FontBBox: 9, 0, 906, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKGNMK+AdvOT5b669f61
      FontSubset: true
      FirstChar: 44
      LastChar: 90
      FontDescriptor: 
       FontName: MKGNMK+AdvOT5b669f61
       Flags: Nonsymbolic
       FontBBox: -41, -197, 1083, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKIJOF+AdvOTd9ad3ae4.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MKIJOF+AdvOTd9ad3ae4.I+fb
       Flags: Symbolic
       FontBBox: 40, -156, 854, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKIJPG+AdvOTf2345705
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: MKIJPG+AdvOTf2345705
       Flags: Nonsymbolic
       FontBBox: -62, -239, 895, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGNML+AdvOTa2a4c9ce
      FontSubset: true
      FirstChar: 65
      LastChar: 122
      FontDescriptor: 
       FontName: MKGNML+AdvOTa2a4c9ce
       Flags: Nonsymbolic
       FontBBox: -20, -197, 1072, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHABH+AdvOT78d326c7
      FontSubset: true
      FirstChar: 65
      LastChar: 65
      FontDescriptor: 
       FontName: MKHABH+AdvOT78d326c7
       Flags: Nonsymbolic
       FontBBox: -41, -260, 979, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHABI+AdvOTe81213fa+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MKHABI+AdvOTe81213fa+fb
       Flags: Symbolic
       FontBBox: 19, 0, 947, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKGNNM+AdvOTe81213fa
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: MKGNNM+AdvOTe81213fa
       Flags: Serif, Nonsymbolic
       FontBBox: -31, -239, 989, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHABJ+AdvOTe81213fa+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: MKHABJ+AdvOTe81213fa+20
       Flags: Nonsymbolic
       FontBBox: -187, -125, 1250, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKHABK+AdvOTc3f2c111.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MKHABK+AdvOTc3f2c111.B+fb
       Flags: Symbolic
       FontBBox: 19, 0, 937, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MKHACL+AdvPS44A44B
      FontSubset: true
      FirstChar: 68
      LastChar: 68
      FontDescriptor: 
       FontName: MKHACL+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGPOF+AdvOTc3f2c111.B
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: MKGPOF+AdvOTc3f2c111.B
       Flags: Nonsymbolic
       FontBBox: -52, -250, 927, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGPOB+AdvOT2986fa51
      FontSubset: true
      FirstChar: 40
      LastChar: 252
      FontDescriptor: 
       FontName: MKGPOB+AdvOT2986fa51
       Flags: Nonsymbolic
       FontBBox: -52, -239, 885, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGPOC+AdvOT2986fa51+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: MKGPOC+AdvOT2986fa51+20
       Flags: Nonsymbolic
       FontBBox: -145, -114, 1270, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MKGPOD+AdvOT8f503d4a
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: MKGPOD+AdvOT8f503d4a
       Flags: Nonsymbolic
       FontBBox: -52, -197, 1093, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jacbts.2022.07.013</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Spatial Distribution of Calcium Sparks Determines Their Ability to Induce&amp;nbsp;Afterdepolarizations in Human Atrial Myocytes</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Carmen Tarifa PhD</rdf:li>
               <rdf:li>Alexander Vallmitjana PhD</rdf:li>
               <rdf:li>Verónica Jiménez-Sábado PhD</rdf:li>
               <rdf:li>Miquel Marchena PhD</rdf:li>
               <rdf:li>Anna Llach PhD</rdf:li>
               <rdf:li>Adela Herraiz-Martínez PhD</rdf:li>
               <rdf:li>Héctor Godoy-Marín PhD</rdf:li>
               <rdf:li>Carme Nolla-Colomer PhD</rdf:li>
               <rdf:li>Antonino Ginel MD</rdf:li>
               <rdf:li>Xavier Viñolas MD</rdf:li>
               <rdf:li>José Montiel MD</rdf:li>
               <rdf:li>Francisco Ciruela PhD</rdf:li>
               <rdf:li>Blas Echebarria PhD</rdf:li>
               <rdf:li>Raúl Benítez PhD</rdf:li>
               <rdf:li>Juan Cinca MD</rdf:li>
               <rdf:li>Leif Hove-Madsen PhD</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>atrial fibrillation</rdf:li>
               <rdf:li>human atrial myocyte</rdf:li>
               <rdf:li>ryanodine receptor</rdf:li>
               <rdf:li>sarcoplasmic reticulum</rdf:li>
               <rdf:li>transient inward currents</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">JACC: Basic to Translational Science, 8 (2023) 1-15. doi:10.1016/j.jacbts.2022.07.013</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>JACC: Basic to Translational Science</prism:publicationName>
         <prism:copyright>© 2023 Published by Elsevier on behalf of the American College of Cardiology Foundation.</prism:copyright>
         <prism:issn>2452-302X</prism:issn>
         <prism:volume>8</prism:volume>
         <prism:number>1</prism:number>
         <prism:coverDisplayDate>January 2023</prism:coverDisplayDate>
         <prism:pageRange>1-15</prism:pageRange>
         <prism:startingPage>1</prism:startingPage>
         <prism:endingPage>15</prism:endingPage>
         <prism:doi>10.1016/j.jacbts.2022.07.013</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jacbts.2022.07.013</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jacbts.2022.07.013</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jacbts.2022.07.013</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2023-01-08T05:58:01+05:30</xap:CreateDate>
         <xap:ModifyDate>2023-01-08T05:58:53+05:30</xap:ModifyDate>
         <xap:MetadataDate>2023-01-08T05:58:53+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:7b9e5633-ac4a-4457-b9c4-92d2c91a7b5a</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:575922b3-db3a-4e5c-900f-3c9e63967877</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 166, 510, 166, 511
      Annotation: 
       Subtype: Link
       Rect: 187, 512, 190, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 192, 512, 195, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 280, 510, 280, 511
      Annotation: 
       Subtype: Link
       Rect: 302, 512, 305, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 401, 510, 401, 511
      Annotation: 
       Subtype: Link
       Rect: 423, 512, 426, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 428, 512, 431, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 433, 512, 437, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 503, 510, 503, 511
      Annotation: 
       Subtype: Link
       Rect: 525, 512, 528, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 155, 498, 155, 499
      Annotation: 
       Subtype: Link
       Rect: 176, 500, 180, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 268, 498, 268, 499
      Annotation: 
       Subtype: Link
       Rect: 289, 500, 293, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 294, 500, 298, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 375, 498, 375, 499
      Annotation: 
       Subtype: Link
       Rect: 397, 500, 399, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 401, 500, 404, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 486, 498, 486, 499
      Annotation: 
       Subtype: Link
       Rect: 508, 500, 510, 508
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 169, 486, 169, 487
      Annotation: 
       Subtype: Link
       Rect: 189, 488, 193, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 249, 486, 249, 487
      Annotation: 
       Subtype: Link
       Rect: 269, 488, 270, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 320, 486, 320, 487
      Annotation: 
       Subtype: Link
       Rect: 339, 488, 343, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 409, 486, 409, 487
      Annotation: 
       Subtype: Link
       Rect: 431, 488, 433, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 435, 488, 438, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 497, 486, 497, 487
      Annotation: 
       Subtype: Link
       Rect: 518, 488, 522, 496
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 160, 474, 160, 475
      Annotation: 
       Subtype: Link
       Rect: 181, 476, 184, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 227, 474, 227, 475
      Annotation: 
       Subtype: Link
       Rect: 247, 476, 250, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 252, 476, 256, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 257, 476, 259, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 329, 474, 329, 475
      Annotation: 
       Subtype: Link
       Rect: 348, 476, 351, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 353, 476, 357, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 358, 476, 362, 484
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 409, 20, 537, 27
      Annotation: 
       Subtype: Link
       Rect: 513, 597, 537, 621
      Annotation: 
       Subtype: Link
       Rect: 202, 703, 364, 708
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 153, 533, 330, 541
      Annotation: 
       Subtype: Link
       Rect: 131, 463, 139, 471
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 213, 451, 217, 459
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 219, 451, 222, 459
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 192, 439, 196, 447
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 136, 427, 139, 435
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 226, 391, 229, 399
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 231, 391, 240, 399
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 155, 379, 161, 387
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 285, 343, 289, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 291, 343, 294, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 296, 343, 300, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 302, 343, 315, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 264, 296, 267, 303
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 269, 296, 275, 303
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 221, 224, 224, 232
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 226, 224, 232, 232
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 294, 176, 296, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 431, 487, 435, 495
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 437, 487, 441, 495
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 464, 439, 470, 447
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 395, 367, 398, 375
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 483, 355, 486, 363
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 510, 343, 513, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 514, 343, 518, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 520, 343, 526, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 528, 343, 534, 351
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 394, 296, 400, 303
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 379, 272, 382, 279
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 384, 272, 387, 279
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 389, 272, 395, 279
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 396, 260, 402, 267
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 510, 176, 517, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 519, 176, 526, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 528, 176, 534, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 134, 52, 175, 58
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 218, 626, 225, 634
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 227, 626, 232, 634
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 140, 390, 230, 397
      Annotation: 
       Subtype: Link
       Rect: 41, 330, 128, 338
      Annotation: 
       Subtype: Link
       Rect: 141, 199, 147, 206
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 149, 199, 155, 206
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 41, 183, 131, 191
      Annotation: 
       Subtype: Link
       Rect: 57, 136, 148, 143
      Annotation: 
       Subtype: Link
       Rect: 106, 97, 196, 104
      Annotation: 
       Subtype: Link
       Rect: 443, 363, 449, 371
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 376, 252, 466, 260
      Annotation: 
       Subtype: Link
       Rect: 412, 204, 466, 212
      Annotation: 
       Subtype: Link
       Rect: 260, 192, 296, 200
      Annotation: 
       Subtype: Link
       Rect: 355, 37, 448, 44
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 148, 611, 246, 618
      Annotation: 
       Subtype: Link
       Rect: 300, 506, 306, 514
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 153, 432, 159, 439
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 161, 432, 168, 439
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 137, 372, 144, 380
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 146, 372, 152, 380
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 133, 348, 139, 356
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 145, 333, 284, 340
      Annotation: 
       Subtype: Link
       Rect: 177, 285, 315, 292
      Annotation: 
       Subtype: Link
       Rect: 109, 273, 191, 281
      Annotation: 
       Subtype: Link
       Rect: 215, 264, 221, 272
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 496, 449, 534, 457
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 327, 437, 354, 445
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 463, 425, 498, 433
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 427, 390, 461, 397
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 495, 318, 531, 326
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 357, 282, 395, 290
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 330, 210, 421, 218
      Annotation: 
       Subtype: Link
       Rect: 404, 174, 493, 182
      Annotation: 
       Subtype: Link
       Rect: 401, 55, 439, 63
       Destination: 106
    Page: 
     Label: 5
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 179, 277, 214, 285
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 148, 122, 280, 129
      Annotation: 
       Subtype: Link
       Rect: 112, 86, 207, 94
      Annotation: 
       Subtype: Link
       Rect: 218, 50, 315, 58
      Annotation: 
       Subtype: Link
       Rect: 109, 38, 138, 46
      Annotation: 
       Subtype: Link
       Rect: 381, 253, 519, 261
      Annotation: 
       Subtype: Link
       Rect: 421, 229, 528, 237
      Annotation: 
       Subtype: Link
       Rect: 369, 122, 402, 129
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 357, 110, 437, 118
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 330, 98, 399, 106
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 430, 86, 469, 94
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 382, 74, 420, 82
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 492, 38, 534, 46
       Destination: 143
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 85, 69, 92
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 75, 85, 165, 92
      Annotation: 
       Subtype: Link
       Rect: 262, 73, 331, 80
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 336, 73, 425, 80
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 80, 178, 87
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 182, 80, 269, 87
      Annotation: 
       Subtype: Link
       Rect: 148, 44, 183, 52
       Destination: 143
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 190, 650, 197, 658
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 101, 587, 137, 594
       Destination: 131
      Annotation: 
       Subtype: Link
       Rect: 143, 587, 180, 594
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 102, 551, 133, 558
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 182, 539, 217, 547
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 192, 527, 229, 535
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 80, 515, 117, 523
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 137, 431, 174, 439
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 87, 395, 144, 403
      Annotation: 
       Subtype: Link
       Rect: 139, 383, 177, 391
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 207, 360, 242, 367
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 142, 264, 213, 272
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 141, 156, 178, 164
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 75, 144, 112, 152
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 260, 587, 325, 594
       Destination: 192
      Annotation: 
       Subtype: Link
       Rect: 330, 491, 397, 499
       Destination: 192
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 364, 63, 391, 70
       Destination: 143
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 356, 145, 362, 153
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 447, 109, 453, 117
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 344, 86, 350, 93
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 352, 86, 358, 93
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 360, 86, 366, 93
       Destination: 241
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 208, 146, 215
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 148, 208, 154, 215
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 156, 208, 162, 215
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 168, 172, 171, 179
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 173, 172, 178, 179
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 285, 64, 292, 72
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 294, 64, 301, 72
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 215, 52, 220, 60
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 380, 172, 386, 179
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 367, 76, 373, 84
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 363, 52, 369, 60
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 371, 52, 378, 60
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 380, 52, 387, 60
       Destination: 241
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 79, 177, 82, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 84, 177, 87, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 89, 177, 95, 184
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 415, 287, 422, 295
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 389, 263, 396, 271
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 415, 120, 422, 128
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 424, 120, 430, 128
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 346, 54, 436, 61
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 435, 196, 442
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 309, 339, 315, 347
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 301, 315, 307, 323
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 309, 315, 315, 323
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 109, 133, 142, 140
       Destination: 211
      Annotation: 
       Subtype: Link
       Rect: 288, 88, 295, 96
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 297, 88, 303, 96
       Destination: 241
      Annotation: 
       Subtype: Link
       Rect: 519, 422, 534, 430
      Annotation: 
       Subtype: Link
       Rect: 327, 411, 396, 418
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 644, 175, 650
      Annotation: 
       Subtype: Link
       Rect: 41, 635, 175, 641
      Annotation: 
       Subtype: Link
       Rect: 41, 626, 175, 632
      Annotation: 
       Subtype: Link
       Rect: 41, 618, 175, 623
      Annotation: 
       Subtype: Link
       Rect: 41, 608, 130, 615
      Annotation: 
       Subtype: Link
       Rect: 48, 595, 175, 601
      Annotation: 
       Subtype: Link
       Rect: 41, 586, 175, 592
      Annotation: 
       Subtype: Link
       Rect: 41, 577, 53, 583
      Annotation: 
       Subtype: Link
       Rect: 58, 577, 175, 583
      Annotation: 
       Subtype: Link
       Rect: 41, 568, 175, 574
      Annotation: 
       Subtype: Link
       Rect: 41, 559, 175, 565
      Annotation: 
       Subtype: Link
       Rect: 41, 550, 175, 556
      Annotation: 
       Subtype: Link
       Rect: 41, 541, 175, 547
      Annotation: 
       Subtype: Link
       Rect: 41, 532, 83, 538
      Annotation: 
       Subtype: Link
       Rect: 48, 519, 175, 525
      Annotation: 
       Subtype: Link
       Rect: 41, 510, 175, 516
      Annotation: 
       Subtype: Link
       Rect: 41, 501, 65, 507
      Annotation: 
       Subtype: Link
       Rect: 70, 501, 175, 507
      Annotation: 
       Subtype: Link
       Rect: 41, 492, 121, 498
      Annotation: 
       Subtype: Link
       Rect: 49, 479, 175, 485
      Annotation: 
       Subtype: Link
       Rect: 41, 470, 175, 476
      Annotation: 
       Subtype: Link
       Rect: 41, 461, 169, 467
      Annotation: 
       Subtype: Link
       Rect: 48, 448, 175, 454
      Annotation: 
       Subtype: Link
       Rect: 41, 439, 117, 445
      Annotation: 
       Subtype: Link
       Rect: 121, 439, 175, 445
      Annotation: 
       Subtype: Link
       Rect: 41, 430, 49, 436
      Annotation: 
       Subtype: Link
       Rect: 53, 430, 66, 436
      Annotation: 
       Subtype: Link
       Rect: 70, 430, 175, 436
      Annotation: 
       Subtype: Link
       Rect: 41, 421, 175, 427
      Annotation: 
       Subtype: Link
       Rect: 41, 412, 175, 418
      Annotation: 
       Subtype: Link
       Rect: 41, 403, 56, 409
      Annotation: 
       Subtype: Link
       Rect: 49, 389, 175, 395
      Annotation: 
       Subtype: Link
       Rect: 41, 381, 175, 386
      Annotation: 
       Subtype: Link
       Rect: 41, 372, 175, 378
      Annotation: 
       Subtype: Link
       Rect: 41, 363, 121, 369
      Annotation: 
       Subtype: Link
       Rect: 48, 349, 175, 355
      Annotation: 
       Subtype: Link
       Rect: 41, 340, 175, 346
      Annotation: 
       Subtype: Link
       Rect: 41, 331, 175, 337
      Annotation: 
       Subtype: Link
       Rect: 41, 322, 175, 328
      Annotation: 
       Subtype: Link
       Rect: 41, 313, 64, 319
      Annotation: 
       Subtype: Link
       Rect: 49, 299, 175, 305
      Annotation: 
       Subtype: Link
       Rect: 41, 290, 158, 296
      Annotation: 
       Subtype: Link
       Rect: 49, 276, 175, 282
      Annotation: 
       Subtype: Link
       Rect: 41, 267, 175, 273
      Annotation: 
       Subtype: Link
       Rect: 41, 258, 175, 264
      Annotation: 
       Subtype: Link
       Rect: 41, 249, 104, 255
      Annotation: 
       Subtype: Link
       Rect: 51, 235, 175, 241
      Annotation: 
       Subtype: Link
       Rect: 41, 226, 175, 232
      Annotation: 
       Subtype: Link
       Rect: 41, 219, 87, 225
      Annotation: 
       Subtype: Link
       Rect: 91, 217, 175, 223
      Annotation: 
       Subtype: Link
       Rect: 41, 208, 175, 214
      Annotation: 
       Subtype: Link
       Rect: 41, 199, 175, 205
      Annotation: 
       Subtype: Link
       Rect: 41, 190, 70, 196
      Annotation: 
       Subtype: Link
       Rect: 50, 175, 175, 181
      Annotation: 
       Subtype: Link
       Rect: 41, 166, 145, 172
      Annotation: 
       Subtype: Link
       Rect: 150, 166, 175, 172
      Annotation: 
       Subtype: Link
       Rect: 41, 158, 175, 163
      Annotation: 
       Subtype: Link
       Rect: 41, 149, 101, 154
      Annotation: 
       Subtype: Link
       Rect: 51, 134, 175, 140
      Annotation: 
       Subtype: Link
       Rect: 41, 125, 175, 131
      Annotation: 
       Subtype: Link
       Rect: 41, 116, 175, 122
      Annotation: 
       Subtype: Link
       Rect: 187, 644, 320, 650
      Annotation: 
       Subtype: Link
       Rect: 187, 635, 308, 641
      Annotation: 
       Subtype: Link
       Rect: 196, 622, 320, 628
      Annotation: 
       Subtype: Link
       Rect: 187, 613, 320, 619
      Annotation: 
       Subtype: Link
       Rect: 187, 604, 265, 610
      Annotation: 
       Subtype: Link
       Rect: 270, 604, 320, 610
      Annotation: 
       Subtype: Link
       Rect: 187, 596, 320, 601
      Annotation: 
       Subtype: Link
       Rect: 187, 586, 228, 593
      Annotation: 
       Subtype: Link
       Rect: 197, 573, 320, 579
      Annotation: 
       Subtype: Link
       Rect: 187, 565, 320, 571
      Annotation: 
       Subtype: Link
       Rect: 187, 556, 320, 562
      Annotation: 
       Subtype: Link
       Rect: 187, 547, 293, 553
      Annotation: 
       Subtype: Link
       Rect: 196, 534, 320, 540
      Annotation: 
       Subtype: Link
       Rect: 187, 525, 286, 531
      Annotation: 
       Subtype: Link
       Rect: 290, 525, 320, 531
      Annotation: 
       Subtype: Link
       Rect: 187, 516, 320, 522
      Annotation: 
       Subtype: Link
       Rect: 187, 507, 320, 513
      Annotation: 
       Subtype: Link
       Rect: 187, 498, 208, 504
      Annotation: 
       Subtype: Link
       Rect: 197, 485, 320, 491
      Annotation: 
       Subtype: Link
       Rect: 187, 476, 320, 482
      Annotation: 
       Subtype: Link
       Rect: 187, 467, 320, 473
      Annotation: 
       Subtype: Link
       Rect: 187, 458, 285, 464
      Annotation: 
       Subtype: Link
       Rect: 196, 445, 320, 451
      Annotation: 
       Subtype: Link
       Rect: 187, 436, 263, 442
      Annotation: 
       Subtype: Link
       Rect: 268, 436, 320, 442
      Annotation: 
       Subtype: Link
       Rect: 187, 427, 220, 433
      Annotation: 
       Subtype: Link
       Rect: 225, 427, 320, 433
      Annotation: 
       Subtype: Link
       Rect: 187, 418, 320, 424
      Annotation: 
       Subtype: Link
       Rect: 187, 409, 249, 415
      Annotation: 
       Subtype: Link
       Rect: 187, 360, 299, 366
      Annotation: 
       Subtype: Link
       Rect: 197, 347, 320, 353
      Annotation: 
       Subtype: Link
       Rect: 187, 338, 320, 344
      Annotation: 
       Subtype: Link
       Rect: 187, 329, 320, 335
      Annotation: 
       Subtype: Link
       Rect: 187, 320, 311, 326
      Annotation: 
       Subtype: Link
       Rect: 198, 307, 320, 313
      Annotation: 
       Subtype: Link
       Rect: 187, 298, 320, 304
      Annotation: 
       Subtype: Link
       Rect: 187, 289, 320, 295
      Annotation: 
       Subtype: Link
       Rect: 187, 280, 217, 286
      Annotation: 
       Subtype: Link
       Rect: 196, 267, 320, 273
      Annotation: 
       Subtype: Link
       Rect: 187, 258, 320, 264
      Annotation: 
       Subtype: Link
       Rect: 187, 249, 320, 255
      Annotation: 
       Subtype: Link
       Rect: 187, 240, 309, 246
      Annotation: 
       Subtype: Link
       Rect: 197, 227, 313, 233
      Annotation: 
       Subtype: Link
       Rect: 257, 187, 320, 193
      Annotation: 
       Subtype: Link
       Rect: 187, 178, 246, 184
      Annotation: 
       Subtype: Link
       Rect: 187, 138, 301, 144
      Annotation: 
       Subtype: Link
       Rect: 197, 125, 320, 131
      Annotation: 
       Subtype: Link
       Rect: 187, 116, 320, 122
      Annotation: 
       Subtype: Link
       Rect: 332, 644, 466, 650
      Annotation: 
       Subtype: Link
       Rect: 332, 635, 459, 641
      Annotation: 
       Subtype: Link
       Rect: 343, 623, 466, 629
      Annotation: 
       Subtype: Link
       Rect: 332, 614, 466, 620
      Annotation: 
       Subtype: Link
       Rect: 332, 605, 466, 611
      Annotation: 
       Subtype: Link
       Rect: 332, 596, 417, 602
      Annotation: 
       Subtype: Link
       Rect: 342, 584, 430, 590
      Annotation: 
       Subtype: Link
       Rect: 343, 571, 466, 577
      Annotation: 
       Subtype: Link
       Rect: 332, 563, 461, 568
      Annotation: 
       Subtype: Link
       Rect: 332, 554, 466, 560
      Annotation: 
       Subtype: Link
       Rect: 332, 545, 414, 551
      Annotation: 
       Subtype: Link
       Rect: 343, 532, 466, 538
      Annotation: 
       Subtype: Link
       Rect: 332, 523, 461, 529
      Annotation: 
       Subtype: Link
       Rect: 332, 514, 466, 520
      Annotation: 
       Subtype: Link
       Rect: 332, 505, 466, 511
      Annotation: 
       Subtype: Link
       Rect: 332, 496, 385, 502
      Annotation: 
       Subtype: Link
       Rect: 343, 484, 466, 490
      Annotation: 
       Subtype: Link
       Rect: 332, 475, 466, 481
      Annotation: 
       Subtype: Link
       Rect: 332, 466, 466, 472
      Annotation: 
       Subtype: Link
       Rect: 332, 457, 385, 463
      Annotation: 
       Subtype: Link
       Rect: 332, 400, 424, 406
      Annotation: 
       Subtype: Link
       Rect: 342, 388, 466, 394
      Annotation: 
       Subtype: Link
       Rect: 332, 381, 415, 387
      Annotation: 
       Subtype: Link
       Rect: 418, 379, 466, 385
      Annotation: 
       Subtype: Link
       Rect: 332, 370, 466, 376
      Annotation: 
       Subtype: Link
       Rect: 332, 361, 400, 367
      Annotation: 
       Subtype: Link
       Rect: 342, 348, 466, 354
      Annotation: 
       Subtype: Link
       Rect: 332, 339, 466, 345
      Annotation: 
       Subtype: Link
       Rect: 332, 330, 466, 336
      Annotation: 
       Subtype: Link
       Rect: 332, 321, 416, 327
      Annotation: 
       Subtype: Link
       Rect: 343, 309, 466, 315
      Annotation: 
       Subtype: Link
       Rect: 332, 300, 466, 306
      Annotation: 
       Subtype: Link
       Rect: 332, 291, 444, 297
      Annotation: 
       Subtype: Link
       Rect: 342, 279, 466, 285
      Annotation: 
       Subtype: Link
       Rect: 332, 270, 466, 276
      Annotation: 
       Subtype: Link
       Rect: 332, 261, 428, 267
      Annotation: 
       Subtype: Link
       Rect: 332, 213, 453, 219
  Checksum: 7cc6f695
   Type: CRC32
  Checksum: e45981c5fe4a7ae501a773918d5d35fc
   Type: MD5
  Checksum: f2f00c5708ae1797e2793d4f91f3f361688e03f5
   Type: SHA-1
  Checksum: f39a93e72423cc316a7b95ad1fa82433cfb1fcdd53a801586fc361c92db6db02
   Type: SHA-256