f862d6b01ac969950abd905b16743bd2 303902.pdf 447dfc2b3bec86f21e500cca676952061572f65d 303902.pdf 6cf57c48e7d8d49b681b1c6a327ccdb6580ef59af32a45f64ec89df1655c117a 303902.pdf Title: Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma Subject: Journal of Allergy and Clinical Immunology Global, 2 (2023) 100134. doi:10.1016/j.jacig.2023.100134 Author: José Antonio Castillo MD PhD Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Aug 28 18:11:38 2023 CEST ModDate: Mon Aug 28 18:12:13 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 690121 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EEMJLF+AdvPS-UVBL Type 1C WinAnsi yes yes no 732 0 EEMJLG+AdvPSA35F Type 1C MacRoman yes yes no 734 0 EEMJLH+AdvP4C4E59 Type 1C Custom yes yes yes 739 0 EEMJLI+AdvPSA88C Type 1C WinAnsi yes yes no 741 0 EEMJLJ+AdvPSA88B Type 1C MacRoman yes yes no 743 0 EEMJLK+AdvPSA88D Type 1C WinAnsi yes yes no 745 0 EEMJML+AdvPS7DED Type 1C WinAnsi yes yes no 747 0 EEMJMM+AdvPSA88A Type 1C MacRoman yes yes no 751 0 EEMJMN+AdvPS586B Type 1C WinAnsi yes yes no 755 0 EEMJNN+AdvPSSym Type 1C Custom yes yes no 760 0 EEMJPP+AdvPSA35D Type 1C MacRoman yes yes no 466 0 EEMKAA+AdvP2A83 Type 1C WinAnsi yes yes no 460 0 EEMJPO+AdvPS7DA6 Type 1C WinAnsi yes yes no 464 0 EEMKBA+AdvPSA360 Type 1C WinAnsi yes yes no 470 0 EEMLDK+AdvPSA35E Type 1C WinAnsi yes yes no 476 0 EEMLPH+AdvPSMPi6 Type 1C WinAnsi yes yes no 484 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-18 02:50:58 CET RepresentationInformation: 303902.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-17 08:31:18 CET Size: 690121 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'tbl1fnlowastlowastlowas' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl1fnlowastlowas' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl1fnlowas' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnlowastlowas' cannot be found ID: PDF-HUL-122 Offset: 661014 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnlowas' cannot be found ID: PDF-HUL-122 Offset: 661014 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 661014 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1fnlowastlowastlowas' cannot be found ID: PDF-HUL-122 Offset: 661014 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 827 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma Destination: Title Children: Item: Title: Methods Destination: first0 Children: Item: Title: Ethics approval Destination: second1 Item: Title: Study population Destination: second2 Item: Title: Study design Destination: second3 Children: Item: Title: Asthma characteristic severity and control Destination: third1 Item: Title: Lung function Destination: third2 Item: Title: Atopic status Destination: third3 Item: Title: Inflammatory status Destination: third4 Item: Title: Sinonasal phenotypes Destination: third5 Item: Title: Analysis Destination: second4 Children: Item: Title: Sample size Destination: third6 Item: Title: Statistical analysis Destination: third7 Item: Title: Results Destination: first1 Children: Item: Title: Population and demographic characteristics Destination: second5 Item: Title: Atopy Destination: second6 Item: Title: Inflammatory biomarkers Destination: second7 Item: Title: NSAID sensitivity Destination: second8 Item: Title: Sinonasal phenotypes Destination: second9 Item: Title: Asthma severity and control Destination: second10 Children: Item: Title: Asthma severity Destination: third8 Item: Title: Impact of rhinitis and CRS in asthma severity and control Destination: third9 Item: Title: Factors associated with severe asthma (multivariate analysis) Destination: second11 Item: Title: Factors associated with severe and uncontrolled asthma Destination: second12 Item: Title: Discussion Destination: first2 Item: Title: Disclosure statement Destination: first3 Item: Title: References Destination: refer Info: Title: Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma Author: José Antonio Castillo MD PhD Subject: Journal of Allergy and Clinical Immunology Global, 2 (2023) 100134. doi:10.1016/j.jacig.2023.100134 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Aug 28 18:41:38 CEST 2023 ModDate: Mon Aug 28 18:42:13 CEST 2023 ID: 0x0c2397c00766d58ca128a06b57df8fd6, 0x20fd69a974626b42b0fceb6e5bbe4d5c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 972 ImageHeight: 1287 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1749 ImageHeight: 561 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1749 ImageHeight: 510 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1006 ImageHeight: 759 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: EEMJLH+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: EEMJLH+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EEMLPH+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: EEMLPH+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJLI+AdvPSA88C FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: EEMJLI+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJLJ+AdvPSA88B FontSubset: true FirstChar: 37 LastChar: 223 FontDescriptor: FontName: EEMJLJ+AdvPSA88B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEMJLK+AdvPSA88D FontSubset: true FirstChar: 58 LastChar: 121 FontDescriptor: FontName: EEMJLK+AdvPSA88D Flags: Nonsymbolic FontBBox: -197, -208, 989, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJML+AdvPS7DED FontSubset: true FirstChar: 53 LastChar: 53 FontDescriptor: FontName: EEMJML+AdvPS7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMKAA+AdvP2A83 FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: EEMKAA+AdvP2A83 Flags: Nonsymbolic FontBBox: -156, -229, 1000, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJMM+AdvPSA88A FontSubset: true FirstChar: 34 LastChar: 252 FontDescriptor: FontName: EEMJMM+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEMJPO+AdvPS7DA6 FontSubset: true FirstChar: 109 LastChar: 109 FontDescriptor: FontName: EEMJPO+AdvPS7DA6 Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJPP+AdvPSA35D FontSubset: true FirstChar: 37 LastChar: 222 FontDescriptor: FontName: EEMJPP+AdvPSA35D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EEMJMN+AdvPS586B FontSubset: true FirstChar: 53 LastChar: 56 FontDescriptor: FontName: EEMJMN+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMKBA+AdvPSA360 FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: EEMKBA+AdvPSA360 Flags: Nonsymbolic FontBBox: -166, -239, 1145, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJNN+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: EEMJNN+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: EEMJLF+AdvPS-UVBL FontSubset: true FirstChar: 67 LastChar: 121 FontDescriptor: FontName: EEMJLF+AdvPS-UVBL Flags: Nonsymbolic FontBBox: -145, -208, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMLDK+AdvPSA35E FontSubset: true FirstChar: 46 LastChar: 114 FontDescriptor: FontName: EEMLDK+AdvPSA35E Flags: Nonsymbolic FontBBox: -166, -239, 1145, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EEMJLG+AdvPSA35F FontSubset: true FirstChar: 37 LastChar: 223 FontDescriptor: FontName: EEMJLG+AdvPSA35F Flags: Nonsymbolic FontBBox: -156, -239, 989, 770 FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf doi:10.1016/j.jacig.2023.100134 Chronic rhinosinusitis with nasal polyps and allergic rhinitis as different multimorbid treatable traits in asthma José Antonio Castillo MD PhD Vicente Plaza MD PhD Gustavo Rodrigo MD PhD Berta Juliá MD PhD César Picado MD PhD Cristina Fernández MD PhD Joaquim Mullol MD PhD FAAAAI Asthma allergic rhinitis chronic rhinosinusitis with nasal polyps united airway disease asthma severity asthma control Journal of Allergy and Clinical Immunology Global, 2 (2023) 100134. doi:10.1016/j.jacig.2023.100134 Merck Sharp & Dohme LLC., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, The Author(s) journal Journal of Allergy and Clinical Immunology Global © 2023 Merck Sharp & Dohme LLC., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and The Author(s). Published by Elsevier Inc. on behalf of American Academy of Allergy, Asthma & Immunology 2772-8293 2 4 November 2023 100134 100134 10.1016/j.jacig.2023.100134 https://doi.org/10.1016/j.jacig.2023.100134 2010-04-23 true 10.1016/j.jacig.2023.100134 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.jacig.2023.100134 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-08-28T21:41:38+05:30 2023-08-28T21:42:13+05:30 2023-08-28T21:42:13+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:1571d898-be02-4aef-8d64-8e76eb1be989 uuid:97f9aae4-11f8-4599-b8d0-4247a2ae91df http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 133, 637, 133, 639 Annotation: Subtype: Link Rect: 253, 637, 253, 639 Annotation: Subtype: Link Rect: 378, 637, 378, 639 Annotation: Subtype: Link Rect: 476, 637, 476, 639 Annotation: Subtype: Link Rect: 96, 624, 96, 626 Annotation: Subtype: Link Rect: 234, 624, 234, 626 Annotation: Subtype: Link Rect: 372, 624, 372, 626 Annotation: Subtype: Link Rect: 535, 455, 538, 464 Destination: 127 Annotation: Subtype: Link Rect: 538, 444, 541, 453 Destination: 127 Annotation: Subtype: Link Rect: 543, 444, 546, 453 Destination: 127 Annotation: Subtype: Link Rect: 408, 411, 412, 421 Destination: 127 Annotation: Subtype: Link Rect: 414, 411, 417, 421 Destination: 127 Annotation: Subtype: Link Rect: 515, 378, 519, 388 Destination: 127 Annotation: Subtype: Link Rect: 476, 345, 479, 355 Destination: 127 Annotation: Subtype: Link Rect: 478, 323, 481, 333 Destination: 127 Annotation: Subtype: Link Rect: 485, 291, 489, 300 Destination: 127 Annotation: Subtype: Link Rect: 490, 291, 494, 300 Destination: 127 Annotation: Subtype: Link Rect: 328, 258, 331, 267 Destination: 127 Annotation: Subtype: Link Rect: 333, 258, 340, 267 Destination: 127 Annotation: Subtype: Link Rect: 376, 258, 383, 267 Destination: 127 Annotation: Subtype: Link Rect: 436, 247, 443, 256 Destination: 127 Annotation: Subtype: Link Rect: 444, 247, 451, 256 Destination: 127 Annotation: Subtype: Link Rect: 501, 214, 508, 223 Destination: 127 Annotation: Subtype: Link Rect: 397, 181, 404, 190 Destination: 127 Annotation: Subtype: Link Rect: 406, 181, 413, 190 Destination: 127 Annotation: Subtype: Link Rect: 531, 181, 538, 190 Destination: 127 Annotation: Subtype: Link Rect: 539, 181, 546, 190 Destination: 127 Annotation: Subtype: Link Rect: 505, 148, 512, 158 Destination: 127 Annotation: Subtype: Link Rect: 514, 148, 521, 158 Destination: 127 Annotation: Subtype: Link Rect: 384, 137, 391, 147 Destination: 127 Annotation: Subtype: Link Rect: 392, 137, 399, 147 Destination: 127 Annotation: Subtype: Link Rect: 539, 137, 546, 147 Destination: 127 Annotation: Subtype: Link Rect: 113, 132, 195, 139 Annotation: Subtype: Link Rect: 224, 123, 276, 130 Annotation: Subtype: Link Rect: 68, 60, 191, 67 Annotation: Subtype: Link Rect: 41, 51, 163, 58 Annotation: Subtype: Link Rect: 468, 702, 546, 718 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 145, 438, 152, 447 Destination: 127 Annotation: Subtype: Link Rect: 155, 318, 223, 327 Annotation: Subtype: Link Rect: 276, 207, 283, 217 Destination: 127 Annotation: Subtype: Link Rect: 222, 196, 229, 206 Destination: 127 Annotation: Subtype: Link Rect: 375, 613, 382, 622 Destination: 127 Annotation: Subtype: Link Rect: 409, 602, 416, 611 Destination: 127 Annotation: Subtype: Link Rect: 367, 547, 371, 556 Destination: 127 Annotation: Subtype: Link Rect: 534, 448, 541, 458 Destination: 127 Annotation: Subtype: Link Rect: 398, 350, 405, 359 Destination: 127 Annotation: Subtype: Link Rect: 317, 328, 324, 337 Destination: 127 Annotation: Subtype: Link Rect: 349, 317, 356, 326 Destination: 127 Annotation: Subtype: Link Rect: 536, 295, 543, 304 Destination: 127 Annotation: Subtype: Link Rect: 384, 207, 391, 217 Destination: 127 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 502, 191, 529, 200 Destination: 19 Annotation: Subtype: Link Rect: 482, 115, 517, 125 Destination: null Annotation: Subtype: Link Rect: 417, 104, 494, 114 Annotation: Subtype: Link Rect: 512, 51, 541, 60 Destination: 19 Annotation: Subtype: Link Rect: 500, 651, 512, 659 Destination: null Annotation: Subtype: Link Rect: 500, 641, 512, 649 Destination: null Annotation: Subtype: Link Rect: 500, 621, 504, 629 Destination: null Annotation: Subtype: Link Rect: 496, 551, 508, 559 Destination: null Annotation: Subtype: Link Rect: 500, 541, 512, 549 Destination: null Annotation: Subtype: Link Rect: 496, 512, 508, 520 Destination: null Annotation: Subtype: Link Rect: 496, 492, 500, 500 Destination: null Annotation: Subtype: Link Rect: 496, 452, 508, 460 Destination: null Annotation: Subtype: Link Rect: 500, 412, 512, 420 Destination: null Annotation: Subtype: Link Rect: 504, 402, 508, 410 Destination: null Annotation: Subtype: Link Rect: 496, 392, 508, 400 Destination: null Annotation: Subtype: Link Rect: 496, 372, 504, 380 Destination: null Annotation: Subtype: Link Rect: 492, 363, 500, 371 Destination: null Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 92, 271, 128, 280 Destination: null Annotation: Subtype: Link Rect: 37, 260, 115, 269 Annotation: Subtype: Link Rect: 56, 207, 63, 217 Destination: 127 Annotation: Subtype: Link Rect: 64, 207, 71, 217 Destination: 127 Annotation: Subtype: Link Rect: 228, 181, 254, 190 Destination: 19 Annotation: Subtype: Link Rect: 247, 138, 267, 148 Destination: 41 Annotation: Subtype: Link Rect: 37, 127, 64, 137 Destination: null Annotation: Subtype: Link Rect: 217, 127, 283, 137 Annotation: Subtype: Link Rect: 37, 116, 50, 126 Annotation: Subtype: Link Rect: 298, 489, 332, 498 Destination: null Annotation: Subtype: Link Rect: 477, 489, 543, 498 Annotation: Subtype: Link Rect: 298, 478, 310, 487 Annotation: Subtype: Link Rect: 518, 346, 537, 356 Destination: 68 Annotation: Subtype: Link Rect: 476, 171, 512, 181 Destination: null Annotation: Subtype: Link Rect: 413, 160, 490, 170 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 149, 233, 168, 242 Destination: 68 Annotation: Subtype: Link Rect: 100, 123, 120, 132 Destination: 68 Annotation: Subtype: Link Rect: 478, 233, 498, 242 Destination: 82 Annotation: Subtype: Link Rect: 476, 179, 509, 189 Destination: null Annotation: Subtype: Link Rect: 411, 169, 489, 178 Annotation: Subtype: Link Rect: 399, 158, 430, 167 Destination: 120 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 69, 351, 76, 360 Destination: 127 Annotation: Subtype: Link Rect: 78, 351, 85, 360 Destination: 127 Annotation: Subtype: Link Rect: 64, 329, 71, 338 Destination: 127 Annotation: Subtype: Link Rect: 73, 329, 80, 338 Destination: 127 Annotation: Subtype: Link Rect: 67, 307, 74, 316 Destination: 127 Annotation: Subtype: Link Rect: 88, 263, 105, 272 Destination: 127 Annotation: Subtype: Link Rect: 222, 241, 229, 251 Destination: 127 Annotation: Subtype: Link Rect: 119, 164, 126, 174 Destination: 127 Annotation: Subtype: Link Rect: 421, 690, 425, 700 Destination: 127 Annotation: Subtype: Link Rect: 427, 690, 434, 700 Destination: 127 Annotation: Subtype: Link Rect: 435, 690, 443, 700 Destination: 395 Annotation: Subtype: Link Rect: 374, 614, 381, 623 Destination: 395 Annotation: Subtype: Link Rect: 417, 570, 421, 579 Destination: 127 Annotation: Subtype: Link Rect: 422, 570, 430, 579 Destination: 127 Annotation: Subtype: Link Rect: 357, 559, 364, 568 Destination: 395 Annotation: Subtype: Link Rect: 418, 548, 421, 557 Destination: 127 Annotation: Subtype: Link Rect: 423, 548, 430, 557 Destination: 127 Annotation: Subtype: Link Rect: 375, 493, 382, 503 Destination: 127 Annotation: Subtype: Link Rect: 384, 493, 391, 503 Destination: 127 Annotation: Subtype: Link Rect: 393, 493, 400, 503 Destination: 127 Annotation: Subtype: Link Rect: 397, 395, 404, 404 Destination: 395 Annotation: Subtype: Link Rect: 406, 395, 413, 404 Destination: 395 Annotation: Subtype: Link Rect: 427, 329, 434, 338 Destination: 127 Annotation: Subtype: Link Rect: 357, 263, 364, 272 Destination: 395 Annotation: Subtype: Link Rect: 366, 263, 373, 272 Destination: 395 Annotation: Subtype: Link Rect: 317, 219, 324, 229 Destination: 395 Annotation: Subtype: Link Rect: 335, 186, 338, 196 Destination: 127 Annotation: Subtype: Link Rect: 340, 186, 347, 196 Destination: 395 Annotation: Subtype: Link Rect: 461, 131, 468, 141 Destination: 127 Annotation: Subtype: Link Rect: 470, 131, 477, 141 Destination: 395 Annotation: Subtype: Link Rect: 444, 110, 452, 119 Destination: 395 Annotation: Subtype: Link Rect: 444, 55, 451, 64 Destination: 395 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 70, 450, 77, 460 Destination: 395 Annotation: Subtype: Link Rect: 241, 428, 248, 438 Destination: 127 Annotation: Subtype: Link Rect: 249, 428, 256, 438 Destination: 395 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 50, 414, 283, 421 Annotation: Subtype: Link Rect: 50, 405, 283, 412 Annotation: Subtype: Link Rect: 50, 396, 157, 403 Annotation: Subtype: Link Rect: 50, 387, 146, 394 Annotation: Subtype: Link Rect: 149, 387, 283, 394 Annotation: Subtype: Link Rect: 50, 378, 283, 385 Annotation: Subtype: Link Rect: 50, 369, 257, 376 Annotation: Subtype: Link Rect: 50, 360, 283, 367 Annotation: Subtype: Link Rect: 50, 351, 265, 358 Annotation: Subtype: Link Rect: 50, 342, 283, 349 Annotation: Subtype: Link Rect: 50, 333, 132, 340 Annotation: Subtype: Link Rect: 50, 333, 176, 340 Annotation: Subtype: Link Rect: 50, 333, 281, 340 Annotation: Subtype: Link Rect: 50, 324, 283, 331 Annotation: Subtype: Link Rect: 50, 315, 283, 322 Annotation: Subtype: Link Rect: 50, 306, 128, 313 Annotation: Subtype: Link Rect: 50, 297, 283, 304 Annotation: Subtype: Link Rect: 50, 288, 283, 295 Annotation: Subtype: Link Rect: 50, 279, 126, 286 Annotation: Subtype: Link Rect: 50, 270, 283, 277 Annotation: Subtype: Link Rect: 50, 261, 283, 268 Annotation: Subtype: Link Rect: 50, 252, 110, 259 Annotation: Subtype: Link Rect: 50, 243, 283, 250 Annotation: Subtype: Link Rect: 50, 234, 229, 241 Annotation: Subtype: Link Rect: 50, 225, 283, 232 Annotation: Subtype: Link Rect: 50, 216, 151, 223 Annotation: Subtype: Link Rect: 50, 208, 283, 214 Annotation: Subtype: Link Rect: 50, 199, 210, 206 Annotation: Subtype: Link Rect: 50, 190, 92, 197 Annotation: Subtype: Link Rect: 95, 190, 283, 197 Annotation: Subtype: Link Rect: 50, 181, 236, 188 Annotation: Subtype: Link Rect: 50, 172, 283, 179 Annotation: Subtype: Link Rect: 50, 163, 283, 170 Annotation: Subtype: Link Rect: 50, 154, 199, 161 Annotation: Subtype: Link Rect: 50, 145, 283, 152 Annotation: Subtype: Link Rect: 50, 136, 283, 143 Annotation: Subtype: Link Rect: 50, 127, 222, 134 Annotation: Subtype: Link Rect: 50, 118, 63, 125 Annotation: Subtype: Link Rect: 65, 118, 75, 125 Annotation: Subtype: Link Rect: 77, 118, 283, 125 Annotation: Subtype: Link Rect: 50, 109, 283, 116 Annotation: Subtype: Link Rect: 50, 100, 94, 107 Annotation: Subtype: Link Rect: 50, 91, 283, 98 Annotation: Subtype: Link Rect: 50, 82, 283, 89 Annotation: Subtype: Link Rect: 50, 73, 187, 80 Annotation: Subtype: Link Rect: 50, 64, 283, 71 Annotation: Subtype: Link Rect: 50, 55, 283, 62 Annotation: Subtype: Link Rect: 310, 710, 543, 717 Annotation: Subtype: Link Rect: 310, 701, 382, 708 Annotation: Subtype: Link Rect: 310, 692, 543, 699 Annotation: Subtype: Link Rect: 310, 683, 354, 690 Annotation: Subtype: Link Rect: 310, 674, 543, 681 Annotation: Subtype: Link Rect: 310, 665, 490, 672 Annotation: Subtype: Link Rect: 310, 656, 543, 663 Annotation: Subtype: Link Rect: 310, 648, 543, 654 Annotation: Subtype: Link Rect: 310, 639, 447, 646 Annotation: Subtype: Link Rect: 310, 630, 543, 637 Annotation: Subtype: Link Rect: 310, 621, 543, 628 Annotation: Subtype: Link Rect: 310, 612, 405, 619 Annotation: Subtype: Link Rect: 310, 603, 543, 610 Annotation: Subtype: Link Rect: 310, 594, 472, 601 Annotation: Subtype: Link Rect: 310, 585, 543, 592 Annotation: Subtype: Link Rect: 310, 576, 543, 583 Annotation: Subtype: Link Rect: 310, 567, 436, 574 Annotation: Subtype: Link Rect: 310, 558, 543, 565 Annotation: Subtype: Link Rect: 310, 549, 543, 556 Annotation: Subtype: Link Rect: 310, 540, 432, 547 Annotation: Subtype: Link Rect: 310, 531, 543, 538 Annotation: Subtype: Link Rect: 310, 522, 543, 529 Annotation: Subtype: Link Rect: 310, 513, 334, 520 Annotation: Subtype: Link Rect: 406, 495, 482, 502 Annotation: Subtype: Link Rect: 498, 477, 543, 484 Annotation: Subtype: Link Rect: 310, 468, 316, 475 Annotation: Subtype: Link Rect: 310, 459, 543, 466 Annotation: Subtype: Link Rect: 310, 450, 543, 457 Annotation: Subtype: Link Rect: 310, 441, 543, 448 Annotation: Subtype: Link Rect: 310, 432, 347, 439 Annotation: Subtype: Link Rect: 310, 423, 320, 430 Annotation: Subtype: Link Rect: 323, 423, 543, 430 Annotation: Subtype: Link Rect: 310, 414, 543, 421 Annotation: Subtype: Link Rect: 310, 405, 425, 412 Annotation: Subtype: Link Rect: 310, 396, 543, 403 Annotation: Subtype: Link Rect: 310, 387, 535, 394 Annotation: Subtype: Link Rect: 310, 378, 482, 385 Annotation: Subtype: Link Rect: 484, 378, 504, 385 Annotation: Subtype: Link Rect: 508, 378, 543, 385 Annotation: Subtype: Link Rect: 310, 370, 543, 377 Annotation: Subtype: Link Rect: 310, 361, 543, 368 Annotation: Subtype: Link Rect: 310, 352, 543, 359 Annotation: Subtype: Link Rect: 310, 343, 330, 350 Annotation: Subtype: Link Rect: 310, 334, 543, 341 Annotation: Subtype: Link Rect: 310, 325, 538, 332 Annotation: Subtype: Link Rect: 310, 316, 520, 323 Annotation: Subtype: Link Rect: 310, 307, 543, 314 Annotation: Subtype: Link Rect: 310, 298, 541, 305 Annotation: Subtype: Link Rect: 310, 289, 382, 296 Annotation: Subtype: Link Rect: 383, 289, 543, 296 Annotation: Subtype: Link Rect: 310, 280, 539, 287 Annotation: Subtype: Link Rect: 310, 271, 543, 278 Annotation: Subtype: Link Rect: 310, 262, 543, 269 Annotation: Subtype: Link Rect: 310, 253, 489, 260 Annotation: Subtype: Link Rect: 310, 244, 543, 251 Annotation: Subtype: Link Rect: 310, 235, 454, 242 Annotation: Subtype: Link Rect: 310, 226, 481, 233 Annotation: Subtype: Link Rect: 485, 226, 543, 233 Annotation: Subtype: Link Rect: 310, 217, 411, 224 Annotation: Subtype: Link Rect: 310, 208, 382, 215 Annotation: Subtype: Link Rect: 385, 208, 543, 215 Annotation: Subtype: Link Rect: 310, 199, 543, 206 Annotation: Subtype: Link Rect: 310, 190, 377, 197 Annotation: Subtype: Link Rect: 310, 181, 543, 188 Annotation: Subtype: Link Rect: 310, 172, 543, 179 Annotation: Subtype: Link Rect: 310, 163, 383, 170 Annotation: Subtype: Link Rect: 310, 154, 446, 161 Annotation: Subtype: Link Rect: 448, 154, 543, 161 Annotation: Subtype: Link Rect: 310, 145, 361, 152 Annotation: Subtype: Link Rect: 363, 145, 468, 152 Annotation: Subtype: Link Rect: 471, 145, 543, 152 Annotation: Subtype: Link Rect: 310, 136, 327, 143 Annotation: Subtype: Link Rect: 330, 136, 390, 143 Annotation: Subtype: Link Rect: 392, 136, 432, 143 Annotation: Subtype: Link Rect: 434, 136, 462, 143 Annotation: Subtype: Link Rect: 465, 136, 543, 143 Annotation: Subtype: Link Rect: 310, 127, 375, 134 Annotation: Subtype: Link Rect: 310, 118, 543, 125 Annotation: Subtype: Link Rect: 310, 109, 543, 116 Annotation: Subtype: Link Rect: 310, 101, 466, 108 Annotation: Subtype: Link Rect: 310, 92, 543, 99 Annotation: Subtype: Link Rect: 310, 83, 543, 90 Annotation: Subtype: Link Rect: 310, 74, 330, 81 Annotation: Subtype: Link Rect: 310, 65, 543, 72 Annotation: Subtype: Link Rect: 310, 56, 535, 63 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 54, 710, 286, 717 Annotation: Subtype: Link Rect: 54, 701, 270, 708 Annotation: Subtype: Link Rect: 54, 692, 286, 699 Annotation: Subtype: Link Rect: 54, 683, 286, 690 Annotation: Subtype: Link Rect: 54, 674, 77, 681 Annotation: Subtype: Link Rect: 54, 665, 286, 672 Annotation: Subtype: Link Rect: 54, 656, 285, 663 Annotation: Subtype: Link Rect: 54, 648, 286, 654 Annotation: Subtype: Link Rect: 54, 639, 286, 646 Annotation: Subtype: Link Rect: 54, 630, 196, 637 Annotation: Subtype: Link Rect: 54, 621, 286, 628 Annotation: Subtype: Link Rect: 54, 612, 232, 619 Annotation: Subtype: Link Rect: 54, 603, 286, 610 Annotation: Subtype: Link Rect: 54, 594, 286, 601 Annotation: Subtype: Link Rect: 54, 585, 181, 592 Annotation: Subtype: Link Rect: 314, 710, 546, 717 Annotation: Subtype: Link Rect: 314, 701, 546, 708 Annotation: Subtype: Link Rect: 314, 692, 439, 699 Annotation: Subtype: Link Rect: 314, 683, 546, 690 Annotation: Subtype: Link Rect: 314, 674, 546, 681 Annotation: Subtype: Link Rect: 314, 665, 462, 672 Annotation: Subtype: Link Rect: 314, 656, 546, 663 Annotation: Subtype: Link Rect: 314, 648, 546, 654 Annotation: Subtype: Link Rect: 314, 639, 539, 646 Annotation: Subtype: Link Rect: 314, 630, 546, 637 Annotation: Subtype: Link Rect: 314, 621, 546, 628 Annotation: Subtype: Link Rect: 314, 612, 408, 619 Annotation: Subtype: Link Rect: 314, 603, 546, 610 Annotation: Subtype: Link Rect: 314, 594, 546, 601 Annotation: Subtype: Link Rect: 314, 585, 449, 592 Checksum: be994d74 Type: CRC32 Checksum: f862d6b01ac969950abd905b16743bd2 Type: MD5 Checksum: 447dfc2b3bec86f21e500cca676952061572f65d Type: SHA-1 Checksum: 6cf57c48e7d8d49b681b1c6a327ccdb6580ef59af32a45f64ec89df1655c117a Type: SHA-256