c02e4a6df125f2f418df68b797e8bf14 303916.pdf 355273178e0184e3ff33209dbf2fb8668826735a 303916.pdf 5fc617cc46a25319fd5dc1dcb716887ebc8ea076bd5f3e7675af3964bdc99898 303916.pdf Title: Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature Subject: Background: Gout is the most common type of inflammatory arthritis. Keywords: gout, anakinra, IL-1 inhibition, gout flare, biological therapies, gouty arthritis, IL-1 blocking agents, IL-1 blockade Author: Sicylle Jeria-Navarro Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jan 7 12:37:51 2023 CET ModDate: Sat Jan 7 15:24:48 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 352681 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ESZFBY+MuseoSans-700 Type 1C Custom yes yes yes 39 0 TWZRAN+MuseoSans-300 Type 1C Custom yes yes yes 42 0 WIKMWX+MuseoSans-300Italic Type 1C WinAnsi yes yes no 55 0 NPYRSX+MinionPro-Regular Type 1C Custom yes yes no 58 0 ZEAOCL+MuseoSans-500 Type 1C Custom yes yes yes 65 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 68 0 QASLBY+MTGU Type 1C Custom yes yes no 87 0 MRSSEI+MTSY Type 1C Custom yes yes no 108 0 TZODUQ+MinionPro-It Type 1C Custom yes yes no 141 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-20 02:49:01 CET RepresentationInformation: 303916.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-19 11:43:59 CET Size: 352681 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 336 FreeObjects: 14 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature Destination: ariclecounter.1 Children: Item: Title: Highlights Destination: section*.2 Item: Title: Introduction Destination: section*.3 Item: Title: Materials and methods Destination: section*.4 Children: Item: Title: Case series Destination: section*.5 Item: Title: Scoping review Destination: section*.6 Children: Item: Title: Eligibility criteria Destination: section*.7 Item: Title: Article selection and data synthesis Destination: section*.8 Item: Title: Results Destination: section*.9 Children: Item: Title: Case series Destination: section*.10 Item: Title: Scoping review Destination: section*.11 Children: Item: Title: Studies' characteristics Destination: section*.12 Item: Title: Patients' characteristics Destination: section*.13 Item: Title: Treatment characteristics Destination: section*.14 Item: Title: Effectiveness Destination: section*.15 Item: Title: Anakinra in clinical complex scenarios Destination: section*.16 Children: Item: Title: Active infection Destination: section*.17 Item: Title: Organ or stem cell transplantation Destination: section*.18 Item: Title: Dialysis Destination: section*.19 Item: Title: Safety Destination: section*.20 Item: Title: Discussion Destination: section*.21 Item: Title: Data availability statement Destination: section*.22 Item: Title: Author contributions Destination: section*.23 Item: Title: Conflict of interest Destination: section*.24 Item: Title: Publisher's note Destination: section*.25 Item: Title: Supplementary material Destination: section*.26 Item: Title: References Destination: section*.27 Info: Title: Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature Author: Sicylle Jeria-Navarro Subject: Background: Gout is the most common type of inflammatory arthritis. Keywords: gout, anakinra, IL-1 inhibition, gout flare, biological therapies, gouty arthritis, IL-1 blocking agents, IL-1 blockade Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jan 07 13:07:51 CET 2023 ModDate: Sat Jan 07 15:54:48 CET 2023 ID: 0xf7df575937a1c28394ed2039b5db3095, 0x49533f2f7493e4469dd0f68651838549 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 128 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 827 ImageHeight: 1454 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: ZEAOCL+MuseoSans-500 FontSubset: true FirstChar: 0 LastChar: 122 FontDescriptor: FontName: ZEAOCL+MuseoSans-500 Flags: Symbolic FontBBox: -55, -210, 845, 744 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WIKMWX+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: WIKMWX+MuseoSans-300Italic Flags: Nonsymbolic, SmallCap FontBBox: -53, -12, 796, 703 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ESZFBY+MuseoSans-700 FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: ESZFBY+MuseoSans-700 Flags: Symbolic FontBBox: -55, -210, 941, 722 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QASLBY+MTGU FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: QASLBY+MTGU Flags: Symbolic FontBBox: 0, -196, 456, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TWZRAN+MuseoSans-300 FontSubset: true FirstChar: 0 LastChar: 122 FontDescriptor: FontName: TWZRAN+MuseoSans-300 Flags: Symbolic FontBBox: -55, -210, 841, 742 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NPYRSX+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: NPYRSX+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 799 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MRSSEI+MTSY FontSubset: true FirstChar: 6 LastChar: 68 FontDescriptor: FontName: MRSSEI+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TZODUQ+MinionPro-It FontSubset: true FirstChar: 3 LastChar: 237 FontDescriptor: FontName: TZODUQ+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2023-01-07T17:07:51+05:30 LaTeX with hyperref package + hypdvips 2023-01-07T19:54:48+05:30 2023-01-07T19:54:48+05:30 application/pdf Background: Gout is the most common type of inflammatory arthritis. Sicylle Jeria-Navarro Alejandro Gomez-Gomez Hye Sang Park Enrique Calvo-Aranda Hector Corominas Maria Antonia Pou Cesar Diaz-Torne Effectiveness and safety of anakinra in gouty arthritis: A case series and review of the literature gout anakinra IL-1 inhibition gout flare biological therapies gouty arthritis IL-1 blocking agents IL-1 blockade gout, anakinra, IL-1 inhibition, gout flare, biological therapies, gouty arthritis, IL-1 blocking agents, IL-1 blockade dvips + MiKTeX GPL Ghostscript 9.0 uuid:4015a4e8-66a0-4eb2-adc6-1ff693bc5a03 uuid:48f2d4fd-d573-4746-965c-3ae29de1d9d2 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 55, 781, 225, 798 Annotation: Subtype: Link Rect: 449, 792, 507, 800 Annotation: Subtype: Link Rect: 466, 783, 476, 791 Annotation: Subtype: Link Rect: 475, 783, 503, 791 Annotation: Subtype: Link Rect: 502, 783, 520, 791 Annotation: Subtype: Link Rect: 446, 774, 539, 783 Annotation: Subtype: Link Rect: 55, 705, 131, 722 Annotation: Subtype: Link Rect: 64, 556, 152, 564 Annotation: Subtype: Link Rect: 69, 391, 163, 398 Annotation: Subtype: Link Rect: 129, 332, 157, 339 Annotation: Subtype: Link Rect: 55, 323, 91, 330 Annotation: Subtype: Link Rect: 91, 323, 127, 330 Annotation: Subtype: Link Rect: 126, 323, 152, 330 Annotation: Subtype: Link Rect: 152, 322, 179, 330 Annotation: Subtype: Link Rect: 221, 630, 539, 722 Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 85, 505, 91, 518 Destination: External Annotation: Subtype: Link Rect: 96, 505, 102, 518 Destination: External Annotation: Subtype: Link Rect: 186, 480, 193, 493 Destination: External Annotation: Subtype: Link Rect: 100, 356, 106, 368 Destination: External Annotation: Subtype: Link Rect: 152, 169, 158, 182 Destination: External Annotation: Subtype: Link Rect: 213, 107, 220, 119 Destination: External Annotation: Subtype: Link Rect: 362, 692, 369, 705 Destination: External Annotation: Subtype: Link Rect: 371, 692, 378, 705 Destination: External Annotation: Subtype: Link Rect: 409, 680, 416, 692 Destination: External Annotation: Subtype: Link Rect: 523, 667, 534, 680 Destination: External Annotation: Subtype: Link Rect: 367, 617, 374, 630 Destination: External Annotation: Subtype: Link Rect: 375, 617, 386, 630 Destination: External Annotation: Subtype: Link Rect: 389, 617, 399, 630 Destination: External Annotation: Subtype: Link Rect: 383, 605, 393, 617 Destination: External Annotation: Subtype: Link Rect: 395, 605, 406, 617 Destination: External Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 55, 515, 144, 526 Destination: External Annotation: Subtype: Link Rect: 55, 403, 144, 414 Destination: External Annotation: Subtype: Link Rect: 69, 391, 157, 401 Destination: External Annotation: Subtype: Link Rect: 158, 207, 169, 219 Destination: External Annotation: Subtype: Link Rect: 509, 596, 537, 604 Destination: External Annotation: Subtype: Link Rect: 319, 279, 351, 289 Destination: External Annotation: Subtype: Link Rect: 436, 182, 447, 194 Destination: External Annotation: Subtype: Link Rect: 450, 182, 461, 194 Destination: External Annotation: Subtype: Link Rect: 311, 157, 317, 169 Destination: External Annotation: Subtype: Link Rect: 319, 157, 330, 169 Destination: External Annotation: Subtype: Link Rect: 332, 157, 343, 169 Destination: External Annotation: Subtype: Link Rect: 345, 157, 356, 169 Destination: External Annotation: Subtype: Link Rect: 359, 157, 369, 169 Destination: External Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Rotate: 90 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 104, 169, 115, 182 Destination: External Annotation: Subtype: Link Rect: 119, 169, 130, 182 Destination: External Annotation: Subtype: Link Rect: 253, 169, 264, 182 Destination: External Annotation: Subtype: Link Rect: 173, 157, 183, 169 Destination: External Annotation: Subtype: Link Rect: 252, 132, 280, 140 Destination: External Annotation: Subtype: Link Rect: 494, 312, 505, 324 Destination: External Annotation: Subtype: Link Rect: 508, 312, 519, 324 Destination: External Annotation: Subtype: Link Rect: 307, 299, 335, 308 Destination: External Annotation: Subtype: Link Rect: 420, 157, 431, 169 Destination: External Annotation: Subtype: Link Rect: 434, 132, 445, 144 Destination: External Annotation: Subtype: Link Rect: 441, 92, 530, 103 Destination: External Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 126, 700, 134, 709 Destination: External Annotation: Subtype: Link Rect: 112, 684, 121, 693 Destination: External Annotation: Subtype: Link Rect: 94, 561, 102, 570 Destination: External Annotation: Subtype: Link Rect: 107, 465, 116, 474 Destination: External Annotation: Subtype: Link Rect: 99, 449, 108, 458 Destination: External Annotation: Subtype: Link Rect: 101, 416, 110, 425 Destination: External Annotation: Subtype: Link Rect: 133, 231, 221, 241 Destination: External Annotation: Subtype: Link Rect: 192, 119, 203, 132 Destination: External Annotation: Subtype: Link Rect: 209, 119, 219, 132 Destination: External Annotation: Subtype: Link Rect: 225, 119, 235, 132 Destination: External Annotation: Subtype: Link Rect: 241, 119, 251, 132 Destination: External Annotation: Subtype: Link Rect: 257, 119, 268, 132 Destination: External Annotation: Subtype: Link Rect: 273, 119, 284, 132 Destination: External Annotation: Subtype: Link Rect: 58, 107, 86, 115 Destination: External Annotation: Subtype: Link Rect: 330, 655, 340, 668 Destination: External Annotation: Subtype: Link Rect: 385, 655, 396, 668 Destination: External Annotation: Subtype: Link Rect: 403, 655, 413, 668 Destination: External Annotation: Subtype: Link Rect: 420, 655, 431, 668 Destination: External Annotation: Subtype: Link Rect: 438, 655, 449, 668 Destination: External Annotation: Subtype: Link Rect: 456, 655, 466, 668 Destination: External Annotation: Subtype: Link Rect: 503, 655, 513, 668 Destination: External Annotation: Subtype: Link Rect: 396, 643, 406, 655 Destination: External Annotation: Subtype: Link Rect: 412, 643, 422, 655 Destination: External Annotation: Subtype: Link Rect: 428, 643, 439, 655 Destination: External Annotation: Subtype: Link Rect: 493, 630, 503, 643 Destination: External Annotation: Subtype: Link Rect: 347, 568, 357, 581 Destination: External Annotation: Subtype: Link Rect: 457, 506, 467, 519 Destination: External Annotation: Subtype: Link Rect: 471, 506, 482, 519 Destination: External Annotation: Subtype: Link Rect: 486, 506, 496, 519 Destination: External Annotation: Subtype: Link Rect: 500, 506, 511, 519 Destination: External Annotation: Subtype: Link Rect: 410, 481, 421, 494 Destination: External Annotation: Subtype: Link Rect: 494, 368, 505, 381 Destination: External Annotation: Subtype: Link Rect: 509, 368, 519, 381 Destination: External Annotation: Subtype: Link Rect: 523, 368, 534, 381 Destination: External Annotation: Subtype: Link Rect: 494, 331, 504, 344 Destination: External Annotation: Subtype: Link Rect: 509, 331, 519, 344 Destination: External Annotation: Subtype: Link Rect: 523, 331, 534, 344 Destination: External Annotation: Subtype: Link Rect: 391, 306, 401, 319 Destination: External Annotation: Subtype: Link Rect: 461, 306, 471, 319 Destination: External Annotation: Subtype: Link Rect: 523, 306, 534, 319 Destination: External Annotation: Subtype: Link Rect: 380, 294, 391, 306 Destination: External Annotation: Subtype: Link Rect: 512, 294, 523, 306 Destination: External Annotation: Subtype: Link Rect: 480, 244, 491, 256 Destination: External Annotation: Subtype: Link Rect: 381, 144, 392, 157 Destination: External Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 58, 742, 69, 754 Destination: External Annotation: Subtype: Link Rect: 71, 742, 82, 754 Destination: External Annotation: Subtype: Link Rect: 84, 742, 95, 754 Destination: External Annotation: Subtype: Link Rect: 97, 742, 108, 754 Destination: External Annotation: Subtype: Link Rect: 110, 742, 121, 754 Destination: External Annotation: Subtype: Link Rect: 123, 742, 134, 754 Destination: External Annotation: Subtype: Link Rect: 225, 742, 236, 754 Destination: External Annotation: Subtype: Link Rect: 200, 730, 206, 742 Destination: External Annotation: Subtype: Link Rect: 208, 730, 218, 742 Destination: External Annotation: Subtype: Link Rect: 221, 730, 231, 742 Destination: External Annotation: Subtype: Link Rect: 233, 730, 244, 742 Destination: External Annotation: Subtype: Link Rect: 246, 730, 256, 742 Destination: External Annotation: Subtype: Link Rect: 258, 730, 269, 742 Destination: External Annotation: Subtype: Link Rect: 271, 730, 282, 742 Destination: External Annotation: Subtype: Link Rect: 103, 702, 191, 713 Destination: External Annotation: Subtype: Link Rect: 206, 406, 217, 418 Destination: External Annotation: Subtype: Link Rect: 89, 94, 100, 107 Destination: External Annotation: Subtype: Link Rect: 523, 667, 534, 680 Destination: External Annotation: Subtype: Link Rect: 414, 642, 424, 655 Destination: External Annotation: Subtype: Link Rect: 311, 568, 321, 580 Destination: External Annotation: Subtype: Link Rect: 388, 518, 399, 530 Destination: External Annotation: Subtype: Link Rect: 404, 518, 415, 530 Destination: External Annotation: Subtype: Link Rect: 523, 431, 534, 443 Destination: External Annotation: Subtype: Link Rect: 523, 319, 534, 331 Destination: External Annotation: Subtype: Link Rect: 465, 281, 476, 294 Destination: External Annotation: Subtype: Link Rect: 478, 119, 489, 132 Destination: External Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 234, 717, 245, 730 Destination: External Annotation: Subtype: Link Rect: 131, 630, 142, 642 Destination: External Annotation: Subtype: Link Rect: 149, 630, 160, 642 Destination: External Annotation: Subtype: Link Rect: 166, 630, 177, 642 Destination: External Annotation: Subtype: Link Rect: 184, 630, 194, 642 Destination: External Annotation: Subtype: Link Rect: 201, 630, 212, 642 Destination: External Annotation: Subtype: Link Rect: 219, 630, 229, 642 Destination: External Annotation: Subtype: Link Rect: 236, 630, 247, 642 Destination: External Annotation: Subtype: Link Rect: 254, 630, 264, 642 Destination: External Annotation: Subtype: Link Rect: 271, 630, 282, 642 Destination: External Annotation: Subtype: Link Rect: 540, 358, 306, 383 Annotation: Subtype: Link Rect: 86, 250, 165, 257 Annotation: Subtype: Link Rect: 139, 229, 232, 237 Annotation: Subtype: Link Rect: 77, 202, 157, 209 Annotation: Subtype: Link Rect: 77, 181, 170, 190 Annotation: Subtype: Link Rect: 154, 162, 233, 169 Annotation: Subtype: Link Rect: 77, 134, 138, 141 Annotation: Subtype: Link Rect: 195, 107, 248, 114 Annotation: Subtype: Link Rect: 540, 257, 306, 274 Annotation: Subtype: Link Rect: 330, 222, 412, 229 Annotation: Subtype: Link Rect: 436, 199, 523, 208 Annotation: Subtype: Link Rect: 368, 164, 430, 171 Annotation: Subtype: Link Rect: 368, 134, 464, 141 Annotation: Subtype: Link Rect: 348, 105, 442, 114 Annotation: Subtype: Link Rect: 55, 42, 124, 49 Annotation: Subtype: Link Rect: 491, 40, 539, 49 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 444, 792, 539, 799 Annotation: Subtype: Link Rect: 179, 724, 247, 733 Annotation: Subtype: Link Rect: 212, 704, 280, 713 Annotation: Subtype: Link Rect: 137, 669, 219, 677 Annotation: Subtype: Link Rect: 113, 642, 158, 649 Annotation: Subtype: Link Rect: 86, 606, 165, 613 Annotation: Subtype: Link Rect: 89, 578, 185, 586 Annotation: Subtype: Link Rect: 225, 558, 270, 565 Annotation: Subtype: Link Rect: 74, 529, 168, 538 Annotation: Subtype: Link Rect: 180, 493, 267, 502 Annotation: Subtype: Link Rect: 77, 459, 130, 466 Annotation: Subtype: Link Rect: 99, 423, 151, 430 Annotation: Subtype: Link Rect: 99, 402, 187, 410 Annotation: Subtype: Link Rect: 103, 375, 199, 382 Annotation: Subtype: Link Rect: 171, 346, 266, 355 Annotation: Subtype: Link Rect: 182, 311, 261, 318 Annotation: Subtype: Link Rect: 96, 283, 154, 291 Annotation: Subtype: Link Rect: 162, 264, 235, 271 Annotation: Subtype: Link Rect: 89, 226, 171, 235 Annotation: Subtype: Link Rect: 99, 192, 182, 199 Annotation: Subtype: Link Rect: 96, 170, 164, 179 Annotation: Subtype: Link Rect: 460, 726, 525, 733 Annotation: Subtype: Link Rect: 451, 694, 538, 703 Annotation: Subtype: Link Rect: 326, 660, 379, 667 Annotation: Subtype: Link Rect: 487, 640, 539, 647 Annotation: Subtype: Link Rect: 430, 620, 526, 627 Annotation: Subtype: Link Rect: 326, 584, 398, 592 Annotation: Subtype: Link Rect: 341, 553, 420, 562 Annotation: Subtype: Link Rect: 352, 525, 433, 534 Annotation: Subtype: Link Rect: 341, 499, 437, 506 Annotation: Subtype: Link Rect: 326, 470, 420, 478 Annotation: Subtype: Link Rect: 401, 435, 481, 442 Annotation: Subtype: Link Rect: 401, 405, 499, 414 Annotation: Subtype: Link Rect: 431, 387, 524, 394 Annotation: Subtype: Link Rect: 326, 359, 406, 366 Annotation: Subtype: Link Rect: 326, 330, 417, 339 Annotation: Subtype: Link Rect: 449, 302, 522, 310 Annotation: Subtype: Link Rect: 540, 249, 306, 268 Annotation: Subtype: Link Rect: 482, 222, 539, 231 Annotation: Subtype: Link Rect: 307, 214, 527, 223 Annotation: Subtype: Link Rect: 307, 206, 457, 215 Annotation: Subtype: Link Rect: 55, 43, 124, 50 Annotation: Subtype: Link Rect: 491, 41, 539, 50 Checksum: dd31aa98 Type: CRC32 Checksum: c02e4a6df125f2f418df68b797e8bf14 Type: MD5 Checksum: 355273178e0184e3ff33209dbf2fb8668826735a Type: SHA-1 Checksum: 5fc617cc46a25319fd5dc1dcb716887ebc8ea076bd5f3e7675af3964bdc99898 Type: SHA-256