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Title:           Arginine reprograms metabolism in liver cancer via RBM39
Subject:         Cell, 186 (2023) 5068-5106. doi:10.1016/j.cell.2023.09.011
Author:          Dirk Mossmann
Creator:         Elsevier
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      Title: Arginine reprograms metabolism in liver cancer via RBM39
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Elevated arginine levels are necessary for liver tumorigenesis
          Destination: slink3
         Item: 
          Title: Loss of ARG1 and AGMAT preserves oncogenic arginine levels
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         Item: 
          Title: Arginine determines expression of metabolic genes
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         Item: 
          Title: Arginine-dependent ASNS expression further enhances arginine uptake
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         Item: 
          Title: Arginine specifically binds RBM39
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         Item: 
          Title: Arginine-bound RBM39 controls transcription of metabolic genes
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         Item: 
          Title: RBM39 promotes tumorigenesis
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         Item: 
          Title: RBM39 is required for metabolic reprograming and tumor progression in HCC
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       Item: 
        Title: Discussion
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         Item: 
          Title: Limitations of the study
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       Item: 
        Title: Supplemental information
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Declaration of interests
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       Item: 
        Title: References
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       Item: 
        Title: STAR★Methods
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        Children: 
         Item: 
          Title: Key resources table
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         Item: 
          Title: Resource availability
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           Item: 
            Title: Lead contact
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           Item: 
            Title: Materials availability
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           Item: 
            Title: Data and code availability
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         Item: 
          Title: Experimental model and study participant details
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           Item: 
            Title: Animals
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           Item: 
            Title: Human cell lines
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           Item: 
            Title: Patient material and ethics
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           Item: 
            Title: HCC organoid culture
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         Item: 
          Title: Method details
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           Item: 
            Title: Arginine-modified diets
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           Item: 
            Title: AAV administration
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           Item: 
            Title: Indisulam treatment of mice
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           Item: 
            Title: HCC organoid drug treatment
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           Item: 
            Title: Generation of stable cell lines
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           Item: 
            Title: Growth under arginine restricted conditions and indisulam treatment
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           Item: 
            Title: siRNA-mediated knockdown
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           Item: 
            Title: Luciferase reporter assay
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           Item: 
            Title: Clonogenic growth assays and crystal violet staining
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           Item: 
            Title: Hepatosphere formation assay
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           Item: 
            Title: Cellular fractionation
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           Item: 
            Title: Immunoblots
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           Item: 
            Title: RNA isolation, quantitative reverse transcription and endpoint PCR
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           Item: 
            Title: Metabolomics of mouse liver tissues and human liver biopsies
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           Item: 
            Title: Statistical analysis untargeted metabolomics data
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           Item: 
            Title: Arginine enzyme-linked immunosorbent assay(ELISA)
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           Item: 
            Title: Total polyamine measurement
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           Item: 
            Title: 3H-arginine and 3H-putrescine uptake
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           Item: 
            Title: Pulldown of potential arginine-binding proteins from SNU-449 cells, mouse L-dKO, and human liver tumor tissues
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           Item: 
            Title: Identification of potential arginine-binding proteins from SNU-449 cells, mouse L-dKO, and human liver tumor tissues by MS
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           Item: 
            Title: Downstream processing of MS data from pull-down experiments
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           Item: 
            Title: Expression of RBM39-FLAG, CASTOR1-FLAG, and eGFP-FLAG in HEK293 cells and anti-FLAG purification
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           Item: 
            Title: Expression of RBM39-Strep in E. coli cells and anti-strep purification
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           Item: 
            Title: 3H-arginine binding to purified RBM39-FLAG and RBM39-Strep
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           Item: 
            Title: Proteome of HCC patients
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           Item: 
            Title: Transcriptome/RNA-sequencing (RNA-seq) of HCC patients
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           Item: 
            Title: RNA-seq of cell lines
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           Item: 
            Title: Statistical analysis of cell line RNA-seq
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           Item: 
            Title: Comparison of RNA-seq data of ARG1/AGMAT expressing and RBM39 depleted SNU-449 cells
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            Title: Differential alternative splicing analysis
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            Title: Histopathology and immunohistochemistry
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            Title: Kaplan-Meier survival curve
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         Item: 
          Title: Quantification and statistical analysis
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               <rdf:li>Christoph Müller</rdf:li>
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