fe5d5a0a8869bd19b05b97838c2e8f9e 1-s2.0-S1359644622004342-main.pdf 006f63f7b4cf4d1a574c326e763e09f201892e84 1-s2.0-S1359644622004342-main.pdf e42f682eb85e8ed0fbbdb7e18ff94236d26362f8edbe75f66ece82dc7d515d78 1-s2.0-S1359644622004342-main.pdf Title: Allosteric binding cooperativity in a kinetic context Subject: Drug Discovery Today, 28 (2023) 103441. doi:10.1016/j.drudis.2022.103441 Author: Óscar Díaz Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Wed Jan 25 17:34:11 2023 CET ModDate: Wed Jan 25 17:34:57 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 612.283 x 793.701 pts Page rot: 0 File size: 537431 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JMGOGJ+AdvPSSym Type 1C Custom yes yes no 596 0 JMGOGK+AdvPSMy-R Type 1C WinAnsi yes yes no 595 0 JMGMOH+AdvOT46dcae81 Type 1C WinAnsi yes yes no 560 0 JMGMOI+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 561 0 JMGMOJ+AdvCORRESAST Type 1C Custom yes yes yes 562 0 JMGMOK+AdvOTa554f99f.B Type 1C WinAnsi yes yes no 563 0 JMGMPK+AdvOTa554f99f.B+fb Type 1C Custom yes yes yes 564 0 JMGMPL+AdvOTf8f9f135 Type 1C WinAnsi yes yes no 565 0 JMGMPM+AdvOTf8f9f135+fb Type 1C Custom yes yes yes 576 0 JMGMPN+AdvPSMP13 Type 1C WinAnsi yes yes no 577 0 JMGNAO+AdvP4C4E74 Type 1C Custom yes yes no 586 0 JMGNAP+AdvOTc243060c Type 1C WinAnsi yes yes no 587 0 JMGNBA+AdvPSMPi6 Type 1C WinAnsi yes yes no 588 0 JMGOHK+AdvOTf8f9f135+20 Type 1C WinAnsi yes yes no 359 0 JMGOLK+AdvPSHEL-O Type 1C WinAnsi yes yes no 356 0 JMGPEH+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 362 0 JMGPIH+AdvPi1 Type 1C WinAnsi yes yes no 363 0 JMHEMI+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 366 0 JMHEPI+AdvOT46dcae81+fb Type 1C Custom yes yes yes 373 0 JMHFAI+AdvTTdf37bfe4+20 Type 1C Custom yes yes yes 372 0 JMHFCI+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 374 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-24 02:43:41 CET RepresentationInformation: 1-s2.0-S1359644622004342-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-23 14:40:56 CET Size: 537431 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-122 Offset: 515506 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-122 Offset: 515506 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 638 FreeObjects: 37 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: atl0 Destination: 1 Children: Item: Title: Allosteric modulation at equilibrium conditions Destination: 1 Item: Title: From equilibrium constants to rate constants: including the kinetic context Destination: 1 Item: Title: Allostery in a heteromeric context Destination: 1 Item: Title: Residence time, agonist efficacy, and allosteric interactions Destination: 1 Item: Title: Concluding remarks Destination: 1 Item: Title: ack6 Destination: 1 Item: Title: Acknowledgments Destination: 1 Item: Title: Declaration of interests Destination: 1 Item: Title: References Destination: 1 Info: Title: Allosteric binding cooperativity in a kinetic context Author: Óscar Díaz Subject: Drug Discovery Today, 28 (2023) 103441. doi:10.1016/j.drudis.2022.103441 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Wed Jan 25 18:04:11 CET 2023 ModDate: Wed Jan 25 18:04:57 CET 2023 ID: 0xcf04bb3d6cc609f0e200e098e2ba171a, 0x50d9d7b4f95d8142a1a0e626b541b448 Filters: FilterPipeline: FlateDecode FilterPipeline: CCITTFaxDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 571 ImageHeight: 631 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 993 ImageHeight: 345 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 993 ImageHeight: 391 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 993 ImageHeight: 391 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 997 ImageHeight: 378 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 993 ImageHeight: 735 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: JMGMPM+AdvOTf8f9f135+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JMGMPM+AdvOTf8f9f135+fb Flags: Symbolic FontBBox: 19, 0, 583, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMGMPN+AdvPSMP13 FontSubset: true FirstChar: 97 LastChar: 100 FontDescriptor: FontName: JMGMPN+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGOLK+AdvPSHEL-O FontSubset: true FirstChar: 68 LastChar: 121 FontDescriptor: FontName: JMGOLK+AdvPSHEL-O Flags: Nonsymbolic FontBBox: -166, -218, 1114, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGOHK+AdvOTf8f9f135+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: JMGOHK+AdvOTf8f9f135+20 Flags: Nonsymbolic FontBBox: -197, -187, 1270, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGNAO+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JMGNAO+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: JMGPEH+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JMGPEH+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMGNAP+AdvOTc243060c FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JMGNAP+AdvOTc243060c Flags: Nonsymbolic FontBBox: -31, -250, 875, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGPIH+AdvPi1 FontSubset: true FirstChar: 101 LastChar: 119 FontDescriptor: FontName: JMGPIH+AdvPi1 Flags: Nonsymbolic FontBBox: 13, -323, 958, 824 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGNBA+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: JMGNBA+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMHEMI+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JMHEMI+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGMOH+AdvOT46dcae81 FontSubset: true FirstChar: 40 LastChar: 252 FontDescriptor: FontName: JMGMOH+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGMOI+AdvOT3b30f6db.B FontSubset: true FirstChar: 40 LastChar: 250 FontDescriptor: FontName: JMGMOI+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGMOJ+AdvCORRESAST FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JMGMOJ+AdvCORRESAST Flags: Symbolic FontBBox: 0, -947, 1041, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMGOGK+AdvPSMy-R FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: JMGOGK+AdvPSMy-R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGMOK+AdvOTa554f99f.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JMGMOK+AdvOTa554f99f.B Flags: Serif, Nonsymbolic FontBBox: -93, -250, 1072, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMGOGJ+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JMGOGJ+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: JMGMPK+AdvOTa554f99f.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JMGMPK+AdvOTa554f99f.B+fb Flags: Symbolic FontBBox: 19, 0, 645, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMHFAI+AdvTTdf37bfe4+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JMHFAI+AdvTTdf37bfe4+20 Flags: Symbolic FontBBox: -968, -239, 1416, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMGMPL+AdvOTf8f9f135 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: JMGMPL+AdvOTf8f9f135 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 1041, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JMHEPI+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JMHEPI+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JMHFCI+AdvOT65f8a23b.I FontSubset: true FirstChar: 58 LastChar: 117 FontDescriptor: FontName: JMHFCI+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.drudis.2022.103441 Allosteric binding cooperativity in a kinetic context Óscar Díaz Victor Martín Pedro Renault David Romero Antoni Guillamon Jesús Giraldo allosteric modulation binding kinetics binding cooperativity rate constant cooperativity rate constant residence time GPCRs heterodimer receptor Drug Discovery Today, 28 (2023) 103441. doi:10.1016/j.drudis.2022.103441 The Authors journal Drug Discovery Today © 2022 The Authors. Published by Elsevier Ltd. 1359-6446 28 2 February 2023 103441 103441 10.1016/j.drudis.2022.103441 https://doi.org/10.1016/j.drudis.2022.103441 2010-04-23 true 10.1016/j.drudis.2022.103441 elsevier.com sciencedirect.com VoR 10.1016/j.drudis.2022.103441 noindex 2010-04-23 true elsevier.com sciencedirect.com sciencedirect.com elsevier.com Elsevier 2023-01-25T22:04:57+05:30 2023-01-25T22:04:11+05:30 2023-01-25T22:04:57+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:b053c8ce-399a-462a-a2b8-3ff835d738e3 uuid:22c03cce-22a4-4168-8b9c-713622961883 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 103441 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 42, 525, 43, 585 Destination: null Annotation: Subtype: Link Rect: 42, 497, 42, 517 Destination: null Annotation: Subtype: Link Rect: 42, 444, 42, 452 Destination: null Annotation: Subtype: Link Rect: 81, 448, 85, 456 Destination: 295 Annotation: Subtype: Link Rect: 86, 448, 89, 456 Destination: 295 Annotation: Subtype: Link Rect: 91, 448, 94, 456 Destination: 295 Annotation: Subtype: Link Rect: 147, 448, 151, 456 Destination: 295 Annotation: Subtype: Link Rect: 152, 448, 156, 456 Destination: 295 Annotation: Subtype: Link Rect: 212, 448, 216, 456 Destination: 295 Annotation: Subtype: Link Rect: 217, 448, 220, 456 Destination: 295 Annotation: Subtype: Link Rect: 222, 448, 225, 456 Destination: 295 Annotation: Subtype: Link Rect: 282, 448, 285, 456 Destination: 295 Annotation: Subtype: Link Rect: 354, 448, 358, 456 Destination: 295 Annotation: Subtype: Link Rect: 359, 448, 363, 456 Destination: 295 Annotation: Subtype: Link Rect: 416, 448, 419, 456 Destination: 295 Annotation: Subtype: Link Rect: 421, 448, 424, 456 Destination: 295 Annotation: Subtype: Link Rect: 426, 448, 429, 456 Destination: 295 Annotation: Subtype: Link Rect: 430, 447, 435, 460 Destination: 295 Annotation: Subtype: Link Rect: 42, 226, 42, 236 Destination: null Annotation: Subtype: Link Rect: 42, 204, 42, 212 Destination: null Annotation: Subtype: Link Rect: 208, 124, 212, 133 Destination: 126 Annotation: Subtype: Link Rect: 148, 64, 157, 73 Destination: 126 Annotation: Subtype: Link Rect: 235, 178, 235, 187 Destination: null Annotation: Subtype: Link Rect: 226, 130, 250, 139 Destination: 1 Annotation: Subtype: Link Rect: 259, 134, 269, 142 Destination: 126 Annotation: Subtype: Link Rect: 300, 106, 322, 115 Destination: 1 Annotation: Subtype: Link Rect: 529, 86, 533, 95 Destination: 126 Annotation: Subtype: Link Rect: 537, 713, 549, 721 Annotation: Subtype: Link Rect: 537, 713, 549, 721 Annotation: Subtype: Link Rect: 549, 707, 579, 737 Annotation: Subtype: Link Rect: 340, 26, 452, 31 Annotation: Subtype: Link Rect: 42, 17, 162, 23 Page: Label: 103442 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 36, 336, 36, 344 Destination: null Annotation: Subtype: Link Rect: 36, 313, 36, 321 Destination: null Annotation: Subtype: Link Rect: 133, 301, 154, 309 Destination: 1 Annotation: Subtype: Link Rect: 253, 477, 262, 485 Destination: 126 Annotation: Subtype: Link Rect: 238, 461, 259, 470 Destination: 1 Annotation: Subtype: Link Rect: 241, 437, 263, 446 Destination: 1 Annotation: Subtype: Link Rect: 221, 389, 243, 398 Destination: 1 Annotation: Subtype: Link Rect: 229, 342, 230, 350 Destination: null Annotation: Subtype: Link Rect: 411, 413, 411, 422 Destination: null Annotation: Subtype: Link Rect: 36, 128, 36, 140 Destination: null Annotation: Subtype: Link Rect: 542, 113, 561, 121 Destination: 1 Annotation: Subtype: Link Rect: 460, 74, 479, 82 Destination: 1 Annotation: Subtype: Link Rect: 234, 57, 237, 65 Destination: 126 Annotation: Subtype: Link Rect: 36, 609, 36, 621 Destination: null Annotation: Subtype: Link Rect: 280, 558, 283, 566 Destination: 126 Page: Label: 103443 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 54, 542, 54, 551 Destination: null Annotation: Subtype: Link Rect: 132, 355, 136, 363 Destination: 126 Annotation: Subtype: Link Rect: 54, 303, 54, 312 Destination: null Annotation: Subtype: Link Rect: 115, 307, 119, 315 Destination: 126 Annotation: Subtype: Link Rect: 390, 665, 394, 674 Destination: 126 Annotation: Subtype: Link Rect: 276, 630, 285, 638 Destination: 126 Annotation: Subtype: Link Rect: 250, 582, 259, 590 Destination: 126 Annotation: Subtype: Link Rect: 257, 546, 261, 554 Destination: 126 Annotation: Subtype: Link Rect: 290, 414, 298, 423 Destination: 126 Annotation: Subtype: Link Rect: 235, 363, 235, 371 Destination: null Annotation: Subtype: Link Rect: 313, 367, 316, 375 Destination: 126 Annotation: Subtype: Link Rect: 405, 720, 405, 729 Destination: null Annotation: Subtype: Link Rect: 405, 709, 405, 717 Destination: null Annotation: Subtype: Link Rect: 429, 605, 436, 613 Destination: 126 Annotation: Subtype: Link Rect: 405, 577, 426, 585 Destination: 21 Annotation: Subtype: Link Rect: 445, 517, 497, 526 Destination: 1 Annotation: Subtype: Link Rect: 416, 326, 417, 334 Destination: null Annotation: Subtype: Link Rect: 42, 105, 42, 117 Destination: null Annotation: Subtype: Link Rect: 407, 70, 426, 78 Destination: 1 Annotation: Subtype: Link Rect: 61, 54, 67, 62 Destination: 126 Page: Label: 103444 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 74, 480, 82, 489 Destination: 126 Annotation: Subtype: Link Rect: 150, 408, 157, 417 Destination: 126 Annotation: Subtype: Link Rect: 163, 405, 185, 413 Destination: 45 Annotation: Subtype: Link Rect: 48, 393, 48, 401 Destination: null Annotation: Subtype: Link Rect: 168, 169, 175, 178 Destination: 126 Annotation: Subtype: Link Rect: 48, 142, 48, 150 Destination: null Annotation: Subtype: Link Rect: 60, 145, 68, 154 Destination: 126 Annotation: Subtype: Link Rect: 334, 396, 341, 405 Destination: 126 Annotation: Subtype: Link Rect: 381, 277, 388, 285 Destination: 126 Annotation: Subtype: Link Rect: 343, 265, 350, 273 Destination: 126 Annotation: Subtype: Link Rect: 263, 241, 270, 249 Destination: 126 Annotation: Subtype: Link Rect: 234, 157, 241, 166 Destination: 126 Annotation: Subtype: Link Rect: 554, 396, 561, 405 Destination: 126 Annotation: Subtype: Link Rect: 399, 361, 399, 370 Destination: null Annotation: Subtype: Link Rect: 399, 339, 399, 347 Destination: null Annotation: Subtype: Link Rect: 447, 259, 454, 267 Destination: 126 Annotation: Subtype: Link Rect: 411, 88, 411, 96 Destination: null Annotation: Subtype: Link Rect: 507, 44, 510, 52 Destination: 126 Annotation: Subtype: Link Rect: 36, 601, 36, 613 Destination: null Annotation: Subtype: Link Rect: 308, 586, 326, 594 Destination: 21 Annotation: Subtype: Link Rect: 107, 576, 125, 584 Destination: 21 Annotation: Subtype: Link Rect: 384, 566, 403, 574 Destination: 21 Page: Label: 103445 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 173, 689, 177, 698 Destination: 126 Annotation: Subtype: Link Rect: 94, 677, 101, 686 Destination: 126 Annotation: Subtype: Link Rect: 160, 677, 167, 686 Destination: 126 Annotation: Subtype: Link Rect: 72, 665, 79, 674 Destination: 126 Annotation: Subtype: Link Rect: 87, 630, 94, 638 Destination: 126 Annotation: Subtype: Link Rect: 54, 614, 54, 622 Destination: null Annotation: Subtype: Link Rect: 188, 570, 192, 578 Destination: 126 Annotation: Subtype: Link Rect: 75, 534, 82, 542 Destination: 126 Annotation: Subtype: Link Rect: 159, 534, 167, 542 Destination: 126 Annotation: Subtype: Link Rect: 72, 522, 76, 530 Destination: 126 Annotation: Subtype: Link Rect: 164, 522, 171, 530 Destination: 126 Annotation: Subtype: Link Rect: 52, 498, 59, 507 Destination: 126 Annotation: Subtype: Link Rect: 139, 498, 147, 507 Destination: 126 Annotation: Subtype: Link Rect: 208, 498, 212, 507 Destination: 126 Annotation: Subtype: Link Rect: 54, 426, 70, 435 Destination: 126 Annotation: Subtype: Link Rect: 161, 426, 177, 435 Destination: 126 Annotation: Subtype: Link Rect: 203, 414, 207, 423 Destination: 126 Annotation: Subtype: Link Rect: 123, 271, 140, 279 Destination: 126 Annotation: Subtype: Link Rect: 56, 223, 73, 232 Destination: 295 Annotation: Subtype: Link Rect: 202, 187, 210, 196 Destination: 295 Annotation: Subtype: Link Rect: 54, 52, 54, 61 Destination: null Annotation: Subtype: Link Rect: 333, 689, 337, 698 Destination: 126 Annotation: Subtype: Link Rect: 236, 677, 239, 686 Destination: 126 Annotation: Subtype: Link Rect: 279, 590, 317, 598 Destination: 1 Annotation: Subtype: Link Rect: 235, 470, 235, 479 Destination: null Annotation: Subtype: Link Rect: 271, 458, 306, 467 Destination: 1 Annotation: Subtype: Link Rect: 386, 259, 394, 267 Destination: 295 Annotation: Subtype: Link Rect: 442, 594, 459, 602 Destination: 295 Annotation: Subtype: Link Rect: 416, 435, 417, 443 Destination: null Annotation: Subtype: Link Rect: 481, 399, 503, 407 Destination: 21 Annotation: Subtype: Link Rect: 568, 402, 575, 411 Destination: 126 Annotation: Subtype: Link Rect: 500, 139, 508, 148 Destination: 126 Annotation: Subtype: Link Rect: 416, 112, 417, 120 Destination: null Annotation: Subtype: Link Rect: 497, 64, 521, 72 Destination: 111 Page: Label: 103446 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 59, 274, 81, 283 Destination: 111 Annotation: Subtype: Link Rect: 66, 203, 89, 211 Destination: 111 Annotation: Subtype: Link Rect: 129, 47, 151, 56 Destination: 111 Annotation: Subtype: Link Rect: 218, 71, 240, 80 Destination: 111 Annotation: Subtype: Link Rect: 399, 195, 406, 203 Destination: 295 Annotation: Subtype: Link Rect: 411, 167, 411, 175 Destination: null Annotation: Subtype: Link Rect: 518, 123, 525, 131 Destination: 126 Annotation: Subtype: Link Rect: 36, 516, 36, 528 Destination: null Annotation: Subtype: Link Rect: 401, 501, 420, 509 Destination: 21 Annotation: Subtype: Link Rect: 408, 474, 414, 482 Destination: 126 Annotation: Subtype: Link Rect: 551, 325, 557, 333 Destination: 126 Page: Label: 103447 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 77, 689, 84, 698 Destination: 126 Annotation: Subtype: Link Rect: 205, 606, 212, 614 Destination: 126 Annotation: Subtype: Link Rect: 54, 590, 54, 598 Destination: null Annotation: Subtype: Link Rect: 42, 291, 42, 300 Destination: null Annotation: Subtype: Link Rect: 42, 279, 42, 288 Destination: null Annotation: Subtype: Link Rect: 205, 92, 212, 100 Destination: 295 Annotation: Subtype: Link Rect: 223, 681, 224, 690 Destination: null Annotation: Subtype: Link Rect: 223, 669, 224, 677 Destination: null Annotation: Subtype: Link Rect: 223, 486, 224, 495 Destination: null Annotation: Subtype: Link Rect: 223, 474, 224, 483 Destination: null Annotation: Subtype: Link Rect: 223, 437, 224, 445 Destination: null Annotation: Subtype: Link Rect: 227, 426, 227, 433 Destination: null Annotation: Subtype: Link Rect: 234, 426, 394, 433 Annotation: Subtype: Link Rect: 234, 417, 394, 424 Annotation: Subtype: Link Rect: 234, 408, 290, 415 Annotation: Subtype: Link Rect: 227, 399, 227, 406 Destination: null Annotation: Subtype: Link Rect: 234, 399, 394, 406 Annotation: Subtype: Link Rect: 234, 390, 394, 397 Annotation: Subtype: Link Rect: 234, 381, 394, 388 Annotation: Subtype: Link Rect: 234, 372, 280, 379 Annotation: Subtype: Link Rect: 227, 363, 227, 370 Destination: null Annotation: Subtype: Link Rect: 234, 363, 394, 370 Annotation: Subtype: Link Rect: 234, 354, 394, 361 Annotation: Subtype: Link Rect: 234, 345, 335, 352 Annotation: Subtype: Link Rect: 227, 336, 227, 343 Destination: null Annotation: Subtype: Link Rect: 234, 336, 394, 343 Annotation: Subtype: Link Rect: 234, 327, 394, 334 Annotation: Subtype: Link Rect: 234, 318, 317, 325 Annotation: Subtype: Link Rect: 227, 309, 227, 316 Destination: null Annotation: Subtype: Link Rect: 234, 309, 394, 316 Annotation: Subtype: Link Rect: 234, 300, 394, 307 Annotation: Subtype: Link Rect: 234, 291, 297, 298 Annotation: Subtype: Link Rect: 227, 282, 227, 289 Destination: null Annotation: Subtype: Link Rect: 234, 282, 394, 289 Annotation: Subtype: Link Rect: 234, 273, 394, 280 Annotation: Subtype: Link Rect: 234, 264, 394, 271 Annotation: Subtype: Link Rect: 234, 255, 351, 262 Annotation: Subtype: Link Rect: 227, 247, 227, 253 Destination: null Annotation: Subtype: Link Rect: 234, 247, 394, 253 Annotation: Subtype: Link Rect: 234, 238, 394, 245 Annotation: Subtype: Link Rect: 234, 229, 394, 236 Annotation: Subtype: Link Rect: 234, 220, 394, 227 Annotation: Subtype: Link Rect: 234, 211, 331, 218 Annotation: Subtype: Link Rect: 227, 202, 227, 209 Destination: null Annotation: Subtype: Link Rect: 234, 202, 394, 209 Annotation: Subtype: Link Rect: 234, 193, 394, 200 Annotation: Subtype: Link Rect: 234, 184, 388, 191 Annotation: Subtype: Link Rect: 227, 175, 227, 182 Destination: null Annotation: Subtype: Link Rect: 234, 175, 394, 182 Annotation: Subtype: Link Rect: 234, 166, 394, 173 Annotation: Subtype: Link Rect: 234, 157, 394, 164 Annotation: Subtype: Link Rect: 234, 148, 394, 155 Annotation: Subtype: Link Rect: 234, 139, 326, 146 Annotation: Subtype: Link Rect: 223, 130, 223, 137 Destination: null Annotation: Subtype: Link Rect: 234, 130, 394, 137 Annotation: Subtype: Link Rect: 234, 121, 394, 128 Annotation: Subtype: Link Rect: 234, 112, 380, 119 Annotation: Subtype: Link Rect: 223, 103, 223, 110 Destination: null Annotation: Subtype: Link Rect: 234, 103, 394, 110 Annotation: Subtype: Link Rect: 234, 94, 394, 101 Annotation: Subtype: Link Rect: 234, 85, 394, 92 Annotation: Subtype: Link Rect: 234, 76, 267, 83 Annotation: Subtype: Link Rect: 223, 67, 223, 74 Destination: null Annotation: Subtype: Link Rect: 234, 67, 394, 74 Annotation: Subtype: Link Rect: 234, 58, 394, 65 Annotation: Subtype: Link Rect: 234, 49, 394, 56 Annotation: Subtype: Link Rect: 234, 40, 342, 47 Annotation: Subtype: Link Rect: 405, 723, 405, 730 Destination: null Annotation: Subtype: Link Rect: 415, 723, 575, 730 Annotation: Subtype: Link Rect: 415, 714, 575, 721 Annotation: Subtype: Link Rect: 415, 705, 575, 712 Annotation: Subtype: Link Rect: 415, 696, 575, 703 Annotation: Subtype: Link Rect: 415, 687, 483, 694 Annotation: Subtype: Link Rect: 405, 678, 405, 685 Destination: null Annotation: Subtype: Link Rect: 415, 678, 575, 685 Annotation: Subtype: Link Rect: 415, 669, 575, 676 Annotation: Subtype: Link Rect: 415, 660, 538, 667 Annotation: Subtype: Link Rect: 538, 660, 575, 667 Annotation: Subtype: Link Rect: 415, 651, 540, 658 Annotation: Subtype: Link Rect: 540, 651, 575, 658 Annotation: Subtype: Link Rect: 415, 642, 510, 649 Annotation: Subtype: Link Rect: 405, 633, 405, 640 Destination: null Annotation: Subtype: Link Rect: 415, 633, 575, 640 Annotation: Subtype: Link Rect: 415, 624, 575, 631 Annotation: Subtype: Link Rect: 415, 615, 575, 622 Annotation: Subtype: Link Rect: 415, 606, 448, 613 Annotation: Subtype: Link Rect: 405, 597, 405, 604 Destination: null Annotation: Subtype: Link Rect: 415, 597, 575, 604 Annotation: Subtype: Link Rect: 415, 588, 575, 595 Annotation: Subtype: Link Rect: 415, 580, 574, 586 Annotation: Subtype: Link Rect: 405, 571, 405, 578 Destination: null Annotation: Subtype: Link Rect: 415, 571, 575, 578 Annotation: Subtype: Link Rect: 415, 562, 575, 569 Annotation: Subtype: Link Rect: 415, 553, 575, 560 Annotation: Subtype: Link Rect: 415, 544, 575, 551 Annotation: Subtype: Link Rect: 415, 535, 575, 542 Annotation: Subtype: Link Rect: 415, 526, 455, 533 Annotation: Subtype: Link Rect: 405, 517, 405, 524 Destination: null Annotation: Subtype: Link Rect: 415, 517, 575, 524 Annotation: Subtype: Link Rect: 415, 508, 575, 515 Annotation: Subtype: Link Rect: 415, 499, 575, 506 Annotation: Subtype: Link Rect: 415, 490, 575, 497 Annotation: Subtype: Link Rect: 415, 481, 527, 488 Annotation: Subtype: Link Rect: 405, 472, 405, 479 Destination: null Annotation: Subtype: Link Rect: 415, 472, 575, 479 Annotation: Subtype: Link Rect: 415, 463, 575, 470 Annotation: Subtype: Link Rect: 415, 454, 575, 461 Annotation: Subtype: Link Rect: 415, 445, 575, 452 Annotation: Subtype: Link Rect: 415, 436, 566, 443 Annotation: Subtype: Link Rect: 405, 427, 405, 434 Destination: null Annotation: Subtype: Link Rect: 415, 427, 575, 434 Annotation: Subtype: Link Rect: 415, 418, 575, 425 Annotation: Subtype: Link Rect: 415, 409, 575, 416 Annotation: Subtype: Link Rect: 415, 400, 575, 407 Annotation: Subtype: Link Rect: 415, 391, 441, 398 Annotation: Subtype: Link Rect: 405, 382, 405, 389 Destination: null Annotation: Subtype: Link Rect: 415, 382, 575, 389 Annotation: Subtype: Link Rect: 415, 373, 575, 380 Annotation: Subtype: Link Rect: 415, 364, 575, 371 Annotation: Subtype: Link Rect: 415, 355, 575, 362 Annotation: Subtype: Link Rect: 415, 346, 430, 353 Annotation: Subtype: Link Rect: 405, 337, 405, 344 Destination: null Annotation: Subtype: Link Rect: 415, 337, 575, 344 Annotation: Subtype: Link Rect: 415, 328, 575, 335 Annotation: Subtype: Link Rect: 415, 319, 575, 326 Annotation: Subtype: Link Rect: 415, 311, 575, 317 Annotation: Subtype: Link Rect: 415, 302, 462, 309 Annotation: Subtype: Link Rect: 405, 293, 405, 300 Destination: null Annotation: Subtype: Link Rect: 415, 293, 575, 300 Annotation: Subtype: Link Rect: 415, 284, 575, 291 Annotation: Subtype: Link Rect: 415, 275, 575, 282 Annotation: Subtype: Link Rect: 415, 266, 575, 273 Annotation: Subtype: Link Rect: 415, 257, 475, 264 Annotation: Subtype: Link Rect: 405, 248, 405, 255 Destination: null Annotation: Subtype: Link Rect: 415, 248, 575, 255 Annotation: Subtype: Link Rect: 415, 239, 575, 246 Annotation: Subtype: Link Rect: 415, 230, 575, 237 Annotation: Subtype: Link Rect: 415, 221, 504, 228 Annotation: Subtype: Link Rect: 405, 212, 405, 219 Destination: null Annotation: Subtype: Link Rect: 415, 212, 575, 219 Annotation: Subtype: Link Rect: 415, 203, 575, 210 Annotation: Subtype: Link Rect: 415, 194, 575, 201 Annotation: Subtype: Link Rect: 415, 185, 560, 192 Annotation: Subtype: Link Rect: 405, 176, 405, 183 Destination: null Annotation: Subtype: Link Rect: 415, 176, 575, 183 Annotation: Subtype: Link Rect: 415, 167, 575, 174 Annotation: Subtype: Link Rect: 415, 158, 575, 165 Annotation: Subtype: Link Rect: 415, 149, 575, 156 Annotation: Subtype: Link Rect: 415, 140, 469, 147 Annotation: Subtype: Link Rect: 405, 131, 405, 138 Destination: null Annotation: Subtype: Link Rect: 415, 131, 575, 138 Annotation: Subtype: Link Rect: 415, 122, 575, 129 Annotation: Subtype: Link Rect: 415, 113, 575, 120 Annotation: Subtype: Link Rect: 415, 104, 554, 111 Annotation: Subtype: Link Rect: 405, 95, 405, 102 Destination: null Annotation: Subtype: Link Rect: 415, 95, 575, 102 Annotation: Subtype: Link Rect: 415, 86, 575, 93 Annotation: Subtype: Link Rect: 415, 77, 529, 84 Annotation: Subtype: Link Rect: 405, 68, 405, 75 Destination: null Annotation: Subtype: Link Rect: 415, 68, 575, 75 Annotation: Subtype: Link Rect: 415, 59, 575, 66 Annotation: Subtype: Link Rect: 415, 51, 517, 57 Page: Label: 103448 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 36, 723, 36, 730 Destination: null Annotation: Subtype: Link Rect: 47, 723, 206, 730 Annotation: Subtype: Link Rect: 47, 714, 206, 721 Annotation: Subtype: Link Rect: 47, 705, 206, 712 Annotation: Subtype: Link Rect: 47, 696, 80, 703 Annotation: Subtype: Link Rect: 36, 687, 36, 694 Destination: null Annotation: Subtype: Link Rect: 47, 687, 206, 694 Annotation: Subtype: Link Rect: 47, 678, 206, 685 Annotation: Subtype: Link Rect: 47, 669, 187, 676 Annotation: Subtype: Link Rect: 36, 660, 36, 667 Destination: null Annotation: Subtype: Link Rect: 47, 660, 206, 667 Annotation: Subtype: Link Rect: 47, 651, 206, 658 Annotation: Subtype: Link Rect: 47, 642, 93, 649 Annotation: Subtype: Link Rect: 36, 633, 36, 640 Destination: null Annotation: Subtype: Link Rect: 47, 633, 206, 640 Annotation: Subtype: Link Rect: 47, 624, 206, 631 Annotation: Subtype: Link Rect: 47, 615, 206, 622 Annotation: Subtype: Link Rect: 47, 606, 148, 613 Annotation: Subtype: Link Rect: 218, 723, 218, 730 Destination: null Annotation: Subtype: Link Rect: 228, 723, 388, 730 Annotation: Subtype: Link Rect: 228, 714, 388, 721 Annotation: Subtype: Link Rect: 228, 705, 388, 712 Annotation: Subtype: Link Rect: 228, 696, 308, 703 Annotation: Subtype: Link Rect: 218, 687, 218, 694 Destination: null Annotation: Subtype: Link Rect: 228, 687, 388, 694 Annotation: Subtype: Link Rect: 228, 678, 388, 685 Annotation: Subtype: Link Rect: 228, 669, 308, 676 Annotation: Subtype: Link Rect: 218, 660, 218, 667 Destination: null Annotation: Subtype: Link Rect: 228, 660, 388, 667 Annotation: Subtype: Link Rect: 228, 651, 388, 658 Annotation: Subtype: Link Rect: 228, 642, 281, 649 Annotation: Subtype: Link Rect: 218, 633, 218, 640 Destination: null Annotation: Subtype: Link Rect: 228, 633, 388, 640 Annotation: Subtype: Link Rect: 228, 624, 388, 631 Annotation: Subtype: Link Rect: 228, 615, 352, 622 Annotation: Subtype: Link Rect: 399, 718, 399, 726 Destination: null Annotation: Subtype: Link Rect: 438, 721, 442, 729 Destination: 295 Annotation: Subtype: Link Rect: 443, 721, 447, 729 Destination: 295 Annotation: Subtype: Link Rect: 448, 721, 451, 729 Destination: 295 Annotation: Subtype: Link Rect: 505, 721, 508, 729 Destination: 295 Annotation: Subtype: Link Rect: 509, 721, 513, 729 Destination: 295 Annotation: Subtype: Link Rect: 451, 711, 455, 719 Destination: 295 Annotation: Subtype: Link Rect: 456, 711, 459, 719 Destination: 295 Annotation: Subtype: Link Rect: 461, 711, 464, 719 Destination: 295 Annotation: Subtype: Link Rect: 521, 711, 524, 719 Destination: 295 Annotation: Subtype: Link Rect: 464, 702, 467, 709 Destination: 295 Annotation: Subtype: Link Rect: 468, 702, 472, 709 Destination: 295 Annotation: Subtype: Link Rect: 525, 702, 529, 709 Destination: 295 Annotation: Subtype: Link Rect: 530, 702, 533, 709 Destination: 295 Annotation: Subtype: Link Rect: 535, 702, 538, 709 Destination: 295 Annotation: Subtype: Link Rect: 540, 701, 545, 714 Destination: 295 Annotation: Subtype: Link Rect: 399, 678, 399, 686 Destination: null Annotation: Subtype: Link Rect: 399, 638, 399, 646 Destination: null Annotation: Subtype: Link Rect: 399, 608, 399, 616 Destination: null Annotation: Subtype: Link Rect: 399, 568, 399, 576 Destination: null Annotation: Subtype: Link Rect: 399, 548, 399, 556 Destination: null Checksum: 8358f9fd Type: CRC32 Checksum: fe5d5a0a8869bd19b05b97838c2e8f9e Type: MD5 Checksum: 006f63f7b4cf4d1a574c326e763e09f201892e84 Type: SHA-1 Checksum: e42f682eb85e8ed0fbbdb7e18ff94236d26362f8edbe75f66ece82dc7d515d78 Type: SHA-256