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ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mailtoigraupecliniccat' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff19' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'mailtomdcollcliniccat' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found ID: PDF-HUL-122 Offset: 2438764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found ID: PDF-HUL-122 Offset: 2438764 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1085 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Therapeutic targeting of adipose tissue macrophages ameliorates liver fibrosis in non-alcoholic fatty liver disease Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Patients and methods Destination: flink2 Children: Item: Title: Patient cohort Destination: slink1 Item: Title: Isolation and culture of human ATMs Destination: slink2 Item: Title: Flow cytometry analysis Destination: slink3 Item: Title: Mice models Destination: slink4 Item: Title: Hepatic stellate cells and liver spheroids in vitro experiments Destination: slink5 Item: Title: Statistical analysis Destination: slink6 Item: Title: Results Destination: flink3 Children: Item: Title: Human pro-inflammatory ATM are directly associated with fibrosis stage in NAFLD Destination: slink7 Item: Title: Dextran nanocarrier is predominantly captured by macrophages of the inflamed adipose tissue of NASH and obese mice Destination: slink8 Item: Title: Long-term dextran-dexamethasone treatment ameliorates adipose tissue inflammation by modulating ATM phenotype Destination: slink9 Item: Title: ATMs phenotype modulation improves hepatic histological features of NAFLD Destination: slink10 Item: Title: Dextran-dexamethasone treatment alleviates liver fibrosis Destination: slink11 Item: Title: Human ATMs switch their phenotype upon dexamethasone nanocarrier engulfment Destination: slink12 Item: Title: Reduction of ATMs pro-inflammatory phenotype influences HSC activation Destination: slink13 Item: Title: Discussion Destination: flink4 Item: Title: Financial support Destination: flink5 Item: Title: Conflicts of interest Destination: flink6 Item: Title: Authors’ contributions Destination: flink7 Item: Title: Data availability statement Destination: flink8 Item: Title: Supplementary data Destination: applink1 Item: Title: References Destination: blink1 Info: Title: Therapeutic targeting of adipose tissue macrophages ameliorates liver fibrosis in non-alcoholic fatty liver disease Author: Celia Martínez Sánchez Subject: Journal of Hepatology, 5 (2023) 100830. doi:10.1016/j.jhepr.2023.100830 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Oct 04 18:58:00 CEST 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doi:10.1016/j.jhepr.2023.100830 Therapeutic targeting of adipose tissue macrophages ameliorates liver fibrosis in non-alcoholic fatty liver disease Celia Martínez–Sánchez Octavi Bassegoda Hongping Deng Xènia Almodóvar Ainitze Ibarzabal Ana de Hollanda Raquel–Adela Martínez García de la Torre Delia Blaya Silvia Ariño Natalia Jiménez-Esquivel Beatriz Aguilar-Bravo Julia Vallverdú Carla Montironi Oscar Osorio-Conles Yiliam Fundora Francisco Javier Sánchez Moreno Alicia G. Gómez-Valadés Laia Aguilar-Corominas Anna Soria Elisa Pose Adrià Juanola Marta Cervera Martina Perez Virginia Hernández-Gea Silvia Affò Kelly S. Swanson Joana Ferrer-Fàbrega Jose Maria Balibrea Pau Sancho-Bru Josep Vidal Pere Ginès Andrew M. Smith Isabel Graupera Mar Coll Dextran dexamethasone conjugates Non-alcoholic steatohepatitis Liver injury Adipose tissue inflammation Nanoparticle Nanomedicine Targeted therapy Drug delivery Journal of Hepatology, 5 (2023) 100830. doi:10.1016/j.jhepr.2023.100830 The Authors journal Journal of Hepatology © 2023 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). 2589-5559 5 10 October 2023 100830 100830 10.1016/j.jhepr.2023.100830 https://doi.org/10.1016/j.jhepr.2023.100830 2010-04-23 true 10.1016/j.jhepr.2023.100830 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.jhepr.2023.100830 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-10-04T21:58+05:30 2023-10-05T16:46:11+05:30 2023-10-05T16:46:11+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:766d1e5e-9b2d-4e37-a6f3-9a2164cdcb5f uuid:e2f19f91-f4bf-4aac-a75c-68e311e33452 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 42, 503, 124, 513 Destination: null Annotation: Subtype: Link Rect: 191, 503, 270, 513 Destination: null Annotation: Subtype: Link Rect: 520, 630, 548, 657 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 140, 656, 143, 665 Destination: null Annotation: Subtype: Link Rect: 144, 656, 148, 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