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Title:           Patient-reported outcome measures and surgery for Crohn’s disease: systematic review
Subject:         DOI: 10.1093/bjsopen/zrad098; BJS Open, 7, 5, 2023-10-26.; Abstract:  Background/Aims: Crohn’s disease is an inflammatory bowel disease with up to 50 per cent of patients requiring surgery within 10 years of diagnosis. Patient-reported outcome measures (PROMs) are vital to monitor and assess patient health-related quality of life (HRQoL). This systematic review aims to evaluate PROMs within studies for perioperative Crohn's disease patients. Methods: Articles from MEDLINE, Embase, Emcare and CINAHL databases were searched to find studies relating to the assessment of HRQoL in perioperative Crohn's disease patients using PROMs and patient-reported experience measures (PREMs) from 1st January 2015 to 22nd October 2023. Bias was assessed using the ROBINS-I tool was used for non-randomized interventional studies and the Cochrane RoB2 tool was used for randomized trials. Results: 1714 journal articles were filtered down to eight studies. Six studies focused on ileocaecal resection, one on perianal fistulas and one on the effects of cholecystectomy on patients with Crohn's disease. Within these articles, ten different PROM tools were identified (8 measures of HRQoL and 2 measures of functional outcome). Overall improvements in patient HRQoL pre- to postoperative for ileocaecal Crohn's disease were found in both paediatric and adult patients. Outcomes were comparable in patients in remission, with or without stoma, but were worse in patients with a stoma and active disease. Conclusion: There are significant variations in how PROMs are used to evaluate perioperative Crohn's disease outcomes and a need for consensus on how tools are used. Routine assessments using an internationally accepted online platform can be used to monitor patients and support areas of treatment pathways that require further support to ensure high standards of care. They also enable future statistical comparisons in quantitative reviews and meta-analyses.
Keywords:        
Author:          Whei J. Kim
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        Title: Introduction
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        Title: Methods
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          Title: Search strategy and article selection
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          Title: Data of interest
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          Title: Inclusion and exclusion
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          Title: Search results
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          Title: Ileal/ileocaecal disease
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          Title: Perianal disease
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          Title: Abdominal surgery secondary to Crohn’s disease
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  Checksum: 17d8af26
   Type: CRC32
  Checksum: c8d36127e044694c60f50b44fd6dabf5
   Type: MD5
  Checksum: 0e3f2e9e11250a354d738bb2a801e4a6c38fb13a
   Type: SHA-1
  Checksum: 30fc891206a40f6fdb08a5c258db4d7e2d58a8c7827a99fae7c0261550a779ae
   Type: SHA-256