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Title:           Distinct signatures on d‐galactose‐induced aging and preventive/protective potency of two low‐dose vitamin D supplementation regimens on working memory, muscular damage, cardiac and cerebral oxidative stress, and SIRT1 and calstabin2 downregulation
Subject:         Food Science & Nutrition 2023.11:5050-5062
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     Item: 
      Title: Distinct signatures on d-­galactose-­induced aging and preventive/protective potency of two low-­dose vitamin D supplementation regimens on working memory, muscular damage, cardiac and cerebral oxidative stress, and SIRT1 and calstabin2 downregulation
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: 1|INTRODUCTION
       Item: 
        Title: 2|MATERIALS AND METHODS
        Children: 
         Item: 
          Title: 2.1|Animals and treatments
         Item: 
          Title: 2.2|Cognitive function
         Item: 
          Title: 2.3|Harvesting and sample preparation
         Item: 
          Title: 2.4|Cardiac and brain histopathological study
         Item: 
          Title: 2.5|Muscle damage—­serologic assay
         Item: 
          Title: 2.6|Oxidative stress evaluation
         Item: 
          Title: 2.7|Real-­time polymerase chain reaction (quantitative polymerase chain reaction (qPCR))
         Item: 
          Title: 2.8|Statistical analysis
       Item: 
        Title: 3|RESULTS
        Children: 
         Item: 
          Title: 3.1|Impaired working memory induced by d-­gal was prevented by vitamin D more efficiently when animals were pre-­treated
         Item: 
          Title: 3.2|d-­gal increased LDH and CK levels in the serum and Vit D was more effective in CK than LDH
         Item: 
          Title: 3.3|d-­gal-­induced histopathological changes in the brain but they were prevented and slightly counteracted by vitamin D
         Item: 
          Title: 3.4|Histopathological changes in the heart
         Item: 
          Title: 3.5|D-­gal increased markers of oxidative stress but its effects were prevented and counteracted by Vit D
         Item: 
          Title: 3.6|d-­gal downregulated SIRT1 and calstabin2 expression but the effects were prevented and counteracted by vitamin D
       Item: 
        Title: 4|DISCUSSION
       Item: 
        Title: AUTHOR CONTRIBUTIONS
       Item: 
        Title: ACKNOWLEDGMENTS
       Item: 
        Title: FUNDING INFORMATION
       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
        Children: 
         Item: 
          Title: DATA AVAILABILITY STATEMENT
       Item: 
        Title: REFERENCES
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