5569e7ea33b6cb70323919c0c50e71d9  elife-88008.pdf
2724d20b6edd68872071df2274b983a81cb3430e  elife-88008.pdf
ae15b5ad6f7c031ec03189f8998d46c86fcc3f87d13326ac7dad2c310174dbce  elife-88008.pdf

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    Outlines: 
     Item: 
      Title: Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period
      Children: 
       Item: 
        Title: eLife assessment
       Item: 
        Title: Introduction
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Morphological, molecular, and nanoparticle tracking-mediated identification of endometrial EV populations secreted into the endometrial fluid
         Item: 
          Title: Sequencing of endometrial EV-derived DNA isolated during the periconception period
         Item: 
          Title: Endometrial EVs encapsulate mtDNA while mtDNA levels become reduced in the receptive endometrium
         Item: 
          Title: Vertical transmission of EV-derived DNA from the maternal endometrium to the embryo
         Item: 
          Title: Bioenergetic impact of endometrial EV-derived DNA uptake by the embryo
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Experimental design
         Item: 
          Title: Endometrial fluid sampling
         Item: 
          Title: EV isolation from endometrial fluid
         Item: 
          Title: Transmission electron microscopy
         Item: 
          Title: Western blotting
         Item: 
          Title: Dynamic light scattering
         Item: 
          Title: Nanoparticle tracking analysis
         Item: 
          Title: High throughput sequencing of the DNA cargo from human endometrial EVs
         Item: 
          Title: DNA sequencing analysis
         Item: 
          Title: Endometrial biopsies
         Item: 
          Title: Determination of mitochondrial DNA copy number in biopsies
         Item: 
          Title: Quantitative RNA sequencing in Biopsies
         Item: 
          Title: mtDNA copy number quantification in MVs
         Item: 
          Title: Murine embryo isolation and culture
         Item: 
          Title: Tagged-DNA production and EV internalization by murine embryos
         Item: 
          Title: mtDNA internalization by mouse embryos
         Item: 
          Title: Analysis of embryo ATP level modulation after co-incubation with human EVs
         Item: 
          Title: Mitochondrial function assays in embryos
         Item: 
          Title: Data analysis
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Additional information
        Children: 
         Item: 
          Title: Funding
         Item: 
          Title: Author contributions
         Item: 
          Title: Author ORCIDs
         Item: 
          Title: Ethics
         Item: 
          Title: Peer review material
       Item: 
        Title: Additional files
        Children: 
         Item: 
          Title: Supplementary files
       Item: 
        Title: References
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  Checksum: 5569e7ea33b6cb70323919c0c50e71d9
   Type: MD5
  Checksum: 2724d20b6edd68872071df2274b983a81cb3430e
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  Checksum: ae15b5ad6f7c031ec03189f8998d46c86fcc3f87d13326ac7dad2c310174dbce
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