efc29cded2ce261973c0ac213e4acd7c 319145.pdf 9d618fb72e1601d6e17ccc5dbb8b9d5699c245e2 319145.pdf 1b6b314301b58d16019d9b335e810383c6947d11806a4a9a9a6525ab6df064b9 319145.pdf Title: ABCA3-related interstitial lung disease beyond infancy Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu May 11 12:21:35 2023 CEST ModDate: Sat Nov 15 08:42:08 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 4901783 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WWPKCV+ArialMT CID TrueType Identity-H yes yes yes 343 0 SMOOID+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 8 0 TDQRMB+FrutigerLTPro-Condensed Type 1C Custom yes yes yes 9 0 LUYTOR+FrutigerLTPro-BoldCn Type 1C Custom yes yes yes 10 0 CWPRSJ+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 157 0 HFATAZ+Symbol Type 1C Custom yes yes yes 344 0 FCWHYD+FrutigerLTPro-CondensedIta Type 1C WinAnsi yes yes yes 148 0 Helvetica-Bold Type 1 WinAnsi no no no 438 0 Helvetica Type 1 WinAnsi no no no 439 0 SQMMYD+ClassicalGaramondBT-Roman TrueType WinAnsi yes yes yes 7 0 NOXDGN+ClassicalGaramondBT-Italic TrueType WinAnsi yes yes yes 6 0 SMOOID+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 429 0 CWPRSJ+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 431 0 LUYTOR+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 433 0 SMOOID+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 267 0 CWPRSJ+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 266 0 LUYTOR+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 265 0 SMOOID+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 279 0 CWPRSJ+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 278 0 LUYTOR+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 277 0 JQXFCV+FrutigerLTPro-BoldCnIta Type 1C WinAnsi yes yes yes 98 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-16 04:18:42 CET RepresentationInformation: 319145.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-15 08:42:32 CET Size: 4901783 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 482 FreeObjects: 17 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: ABCA3-­related interstitial lung disease beyond infancy Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Patients Item: Title: Genetic analysis Item: Title: Clinical data Children: Item: Title: High-resolution CT analysis Item: Title: Lung biopsy histology Item: Title: Statistics Item: Title: Results Children: Item: Title: Patient cohort Item: Title: Oxygen supplementation of patients at the last follow-up visit Item: Title: Pulmonary function test results reveal lung function decline over time Item: Title: Chest HR-CT indicated GGO was a common and sustained pattern in all patients Item: Title: Various histology patterns in lung biopsies at the time of diagnosis Item: Title: Correlating survival and location of type of genetic variation in ABCA3 Item: Title: Medication during the course Item: Title: Discussion Item: Title: References Info: Title: ABCA3-related interstitial lung disease beyond infancy Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu May 11 12:51:35 CEST 2023 ModDate: Sat Nov 15 00:42:08 CET 2025 ID: 0x86c3540537309d41ac4dbff8865645fc, 0x6121f099d11db2110a00ed0810000000 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1492 ImageHeight: 852 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1492 ImageHeight: 1278 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1028 ImageHeight: 1207 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1868 ImageHeight: 1547 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 981 ImageHeight: 1430 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1921 ImageHeight: 2561 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: WWPKCV+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: JQXFCV+FrutigerLTPro-BoldCnIta FontSubset: true FirstChar: 51 LastChar: 67 FontDescriptor: FontName: JQXFCV+FrutigerLTPro-BoldCnIta Flags: Nonsymbolic FontBBox: -173, -250, 1012, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: FCWHYD+FrutigerLTPro-CondensedIta FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: FCWHYD+FrutigerLTPro-CondensedIta Flags: Nonsymbolic, Italic FontBBox: -166, -250, 992, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Helvetica-Bold Encoding: WinAnsiEncoding Font: BaseFont: Helvetica Encoding: WinAnsiEncoding Font: BaseFont: HFATAZ+Symbol FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: HFATAZ+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SMOOID+FrutigerLTPro-LightCn FontSubset: true FirstChar: 28 LastChar: 252 FontDescriptor: FontName: SMOOID+FrutigerLTPro-LightCn Flags: Nonsymbolic FontBBox: -100, -250, 1000, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TDQRMB+FrutigerLTPro-Condensed FontSubset: true FirstChar: 29 LastChar: 233 FontDescriptor: FontName: TDQRMB+FrutigerLTPro-Condensed Flags: Nonsymbolic FontBBox: -105, -250, 1000, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LUYTOR+FrutigerLTPro-BoldCn FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: LUYTOR+FrutigerLTPro-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CWPRSJ+FrutigerLTPro-LightCnIta FontSubset: true FirstChar: 30 LastChar: 121 FontDescriptor: FontName: CWPRSJ+FrutigerLTPro-LightCnIta Flags: Nonsymbolic FontBBox: -161, -250, 991, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: NOXDGN+ClassicalGaramondBT-Italic FontSubset: true FirstChar: 51 LastChar: 67 FontDescriptor: FontName: NOXDGN+ClassicalGaramondBT-Italic Flags: Serif, Nonsymbolic FontBBox: -167, -237, 1275, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SQMMYD+ClassicalGaramondBT-Roman FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: SQMMYD+ClassicalGaramondBT-Roman Flags: Serif, Nonsymbolic FontBBox: -166, -237, 1261, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: WWPKCV+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WWPKCV+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true XMP: doi:thorax-2022-219434 application/pdf 2023-05-11T15:51:35+05:30 2025-11-14T23:42:08-08:00 2025-11-14T23:42:08-08:00 Adobe InDesign 15.1 (Windows) uuid:99f0228e-1dd1-11b2-0a00-8800e886c8ff xmp.did:AC6A3D891B2068118C14E2BA4B787437 xmp.id:70defc67-3e63-a64c-b481-afd6746dfba2 proof:pdf xmp.iid:be80d376-f2c0-7d40-83cc-9a00b5939666 xmp.did:5714b5b0-42f3-f944-b162-120476d2f751 xmp.did:AC6A3D891B2068118C14E2BA4B787437 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2023-05-11T15:51:35+05:30 3bafb44b-725f-4a34-a197-dc1a752a2167 Adobe PDF Library 15.0 False Pages: Page: Label: 587 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 255, 671, 264, 655 Annotation: Subtype: Link Rect: 420, 610, 429, 595 Annotation: Subtype: Link Rect: 253, 594, 262, 579 Annotation: Subtype: Link Rect: 226, 519, 235, 504 Annotation: Subtype: Link Rect: 85, 461, 122, 451 Annotation: Subtype: Link Rect: 42, 452, 119, 442 Annotation: Subtype: Link Rect: 42, 443, 65, 433 Annotation: Subtype: Link Rect: 40, 162, 136, 139 Annotation: Subtype: Link Rect: 51, 183, 127, 174 Annotation: Subtype: Link Rect: 42, 174, 103, 165 Annotation: Subtype: Link Rect: 408, 197, 411, 186 ActionDest: 156 Annotation: Subtype: Link Rect: 430, 131, 438, 120 ActionDest: 156 Annotation: Subtype: Link Rect: 373, 98, 382, 87 ActionDest: 156 Annotation: Subtype: Link Rect: 513, 36, 531, 18 Annotation: Subtype: Link Rect: 40, 34, 65, 18 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 588 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 262, 454, 266, 443 ActionDest: 156 Annotation: Subtype: Link Rect: 164, 410, 172, 399 ActionDest: 156 Annotation: Subtype: Link Rect: 65, 377, 78, 366 ActionDest: 156 Annotation: Subtype: Link Rect: 215, 199, 227, 188 ActionDest: 156 Annotation: Subtype: Link Rect: 211, 155, 288, 144 Annotation: Subtype: Link Rect: 42, 144, 73, 133 Annotation: Subtype: Link Rect: 74, 133, 185, 122 Annotation: Subtype: Link Rect: 159, 76, 165, 65 ActionDest: 230 Annotation: Subtype: Link Rect: 207, 65, 214, 54 ActionDest: 230 Annotation: Subtype: Link Rect: 336, 476, 342, 465 ActionDest: 230 Annotation: Subtype: Link Rect: 390, 476, 396, 465 ActionDest: 230 Annotation: Subtype: Link Rect: 450, 476, 456, 465 ActionDest: 230 Annotation: Subtype: Link Rect: 491, 199, 498, 188 ActionDest: 156 Annotation: Subtype: Link Rect: 388, 131, 394, 120 ActionDest: 230 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 589 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 201, 232, 208, 221 ActionDest: 230 Annotation: Subtype: Link Rect: 281, 76, 288, 65 ActionDest: 156 Annotation: Subtype: Link Rect: 438, 199, 550, 189 Annotation: Subtype: Link Rect: 309, 110, 347, 99 ActionDest: 1 Annotation: Subtype: Link Rect: 338, 77, 375, 66 ActionDest: 1 Annotation: Subtype: Link Rect: 469, 65, 508, 55 ActionDest: 43 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 590 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 119, 276, 264, 265 Annotation: Subtype: Link Rect: 184, 232, 288, 221 Annotation: Subtype: Link Rect: 42, 221, 51, 210 Annotation: Subtype: Link Rect: 173, 210, 286, 199 Annotation: Subtype: Link Rect: 42, 199, 78, 188 ActionDest: 1 Annotation: Subtype: Link Rect: 66, 87, 102, 76 ActionDest: 43 Annotation: Subtype: Link Rect: 79, 54, 116, 43 ActionDest: 43 Annotation: Subtype: Link Rect: 396, 703, 434, 692 ActionDest: 43 Annotation: Subtype: Link Rect: 436, 670, 473, 659 ActionDest: 43 Annotation: Subtype: Link Rect: 422, 611, 453, 601 ActionDest: 61 Annotation: Subtype: Link Rect: 427, 468, 471, 458 ActionDest: 61 Annotation: Subtype: Link Rect: 393, 300, 430, 289 ActionDest: 96 Annotation: Subtype: Link Rect: 446, 278, 481, 267 ActionDest: 96 Annotation: Subtype: Link Rect: 509, 109, 547, 98 ActionDest: 125 Annotation: Subtype: Link Rect: 467, 76, 503, 65 ActionDest: 125 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 591 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 145, 366, 182, 355 ActionDest: 125 Annotation: Subtype: Link Rect: 220, 309, 257, 298 ActionDest: 146 Annotation: Subtype: Link Rect: 44, 243, 89, 232 ActionDest: 146 Annotation: Subtype: Link Rect: 81, 188, 118, 177 ActionDest: 146 Annotation: Subtype: Link Rect: 231, 122, 288, 111 Annotation: Subtype: Link Rect: 42, 111, 101, 100 Annotation: Subtype: Link Rect: 181, 54, 288, 43 Annotation: Subtype: Link Rect: 306, 377, 322, 366 Annotation: Subtype: Link Rect: 309, 366, 433, 355 Annotation: Subtype: Link Rect: 549, 142, 553, 131 ActionDest: 156 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 592 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 142, 274, 149, 263 ActionDest: 230 Annotation: Subtype: Link Rect: 149, 87, 156, 76 ActionDest: 156 Annotation: Subtype: Link Rect: 114, 76, 120, 65 ActionDest: 230 Annotation: Subtype: Link Rect: 521, 681, 525, 670 ActionDest: 156 Annotation: Subtype: Link Rect: 443, 362, 454, 351 ActionDest: 156 Annotation: Subtype: Link Rect: 354, 285, 467, 274 Annotation: Subtype: Link Rect: 453, 252, 553, 241 Annotation: Subtype: Link Rect: 306, 241, 316, 230 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 593 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 50, 148, 56, 138 ActionDest: 230 Annotation: Subtype: Link Rect: 240, 126, 339, 116 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 594 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 261, 680, 268, 670 ActionDest: 230 Annotation: Subtype: Link Rect: 270, 223, 288, 214 Annotation: Subtype: Link Rect: 42, 214, 131, 204 Annotation: Subtype: Link Rect: 376, 661, 511, 652 Annotation: Subtype: Link Rect: 337, 635, 451, 626 Annotation: Subtype: Link Rect: 376, 626, 490, 617 Annotation: Subtype: Link Rect: 371, 617, 485, 608 Annotation: Subtype: Link Rect: 354, 608, 469, 599 Annotation: Subtype: Link Rect: 450, 559, 486, 550 Annotation: Subtype: Link Rect: 530, 550, 549, 541 Annotation: Subtype: Link Rect: 449, 523, 520, 514 Annotation: Subtype: Link Rect: 510, 495, 536, 487 Annotation: Subtype: Link Rect: 432, 468, 450, 460 Annotation: Subtype: Link Rect: 433, 450, 467, 441 Annotation: Subtype: Link Rect: 384, 432, 399, 423 Annotation: Subtype: Link Rect: 446, 414, 499, 405 Annotation: Subtype: Link Rect: 540, 396, 553, 387 Annotation: Subtype: Link Rect: 319, 387, 347, 378 Annotation: Subtype: Link Rect: 504, 369, 535, 360 Annotation: Subtype: Link Rect: 455, 342, 489, 333 Annotation: Subtype: Link Rect: 390, 324, 436, 315 Annotation: Subtype: Link Rect: 495, 306, 533, 297 Annotation: Subtype: Link Rect: 353, 278, 392, 270 Annotation: Subtype: Link Rect: 388, 260, 418, 252 Annotation: Subtype: Link Rect: 442, 242, 474, 234 Annotation: Subtype: Link Rect: 387, 224, 420, 215 Annotation: Subtype: Link Rect: 370, 206, 417, 197 Annotation: Subtype: Link Rect: 393, 188, 420, 179 Annotation: Subtype: Link Rect: 340, 161, 384, 152 Annotation: Subtype: Link Rect: 456, 143, 502, 134 Annotation: Subtype: Link Rect: 438, 125, 485, 116 Annotation: Subtype: Link Rect: 400, 107, 447, 98 Annotation: Subtype: Link Rect: 508, 89, 540, 80 Annotation: Subtype: Link Rect: 319, 80, 344, 71 Annotation: Subtype: Link Rect: 473, 62, 509, 53 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Page: Label: 595 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 187, 737, 235, 729 Annotation: Subtype: Link Rect: 233, 719, 277, 711 Annotation: Subtype: Link Rect: 54, 710, 66, 702 Annotation: Subtype: Link Rect: 133, 692, 161, 684 Annotation: Subtype: Link Rect: 201, 674, 229, 666 Annotation: Subtype: Link Rect: 234, 629, 265, 621 Annotation: Subtype: Link Rect: 54, 593, 83, 585 Annotation: Subtype: Link Rect: 399, 737, 438, 729 Annotation: Subtype: Link Rect: 375, 719, 411, 711 Annotation: Subtype: Link Rect: 319, 701, 366, 693 Annotation: Subtype: Link Rect: 367, 683, 394, 675 Annotation: Subtype: Link Rect: 426, 665, 457, 657 Annotation: Subtype: Link Rect: 485, 647, 544, 639 Annotation: Subtype: Link Rect: 319, 638, 331, 630 Annotation: Subtype: Link Rect: 413, 620, 444, 612 Annotation: Subtype: Link Rect: 343, 593, 376, 585 Annotation: Subtype: Link Rect: 576, 215, 587, 312 Checksum: 58e44fbb Type: CRC32 Checksum: efc29cded2ce261973c0ac213e4acd7c Type: MD5 Checksum: 9d618fb72e1601d6e17ccc5dbb8b9d5699c245e2 Type: SHA-1 Checksum: 1b6b314301b58d16019d9b335e810383c6947d11806a4a9a9a6525ab6df064b9 Type: SHA-256