b4dbbd7d05453db177686180175b05c9 330_2023_Article_9435.pdf 2140160bdbd9ee8a0f51a14884f19548cd02d2fb 330_2023_Article_9435.pdf d58d80919398cb9a5478ca0e6606bdc4404d214aa95790393eea3f6e0db93425 330_2023_Article_9435.pdf Title: Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study Subject: European Radiology, https://doi.org/10.1007/s00330-023-09435-0 Keywords: Multiple system atrophy;Progressive supranuclear palsy;Shape analysis;Neurofilament protein;Parkinsonian disorders Author: C. Painous Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Jun 9 05:22:57 2023 CEST ModDate: Fri Jun 9 06:09:15 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1334358 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 348 0 MyriadPro-Semibold Type 1C Custom yes no yes 349 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 350 0 MyriadPro-Bold Type 1C Custom yes no yes 351 0 GJSVIM+STIX-Regular Type 1C Custom yes yes yes 352 0 STIX-Italic Type 1C Custom yes no yes 369 0 XUADNO+Wingdings-Regular Type 1C WinAnsi yes yes yes 378 0 TJTFUI+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 400 0 Springnew-Regular Type 1C WinAnsi yes no yes 406 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 228 0 Springnew-Regular2 Type 1C WinAnsi yes no yes 220 0 Springnew-Regular3 Type 1C WinAnsi yes no yes 245 0 NQYCPV+STIX-BoldItalic Type 1C Custom yes yes yes 249 0 CGJGAT+STIX-Bold Type 1C WinAnsi yes yes yes 250 0 HXPRMK+SymbolMT CID TrueType Identity-H yes yes yes 270 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-02 03:55:05 CEST RepresentationInformation: 330_2023_Article_9435.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-01 15:43:45 CEST Size: 1334358 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 474 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study Children: Item: Title: Abstract Children: Item: Title: Objectives Item: Title: Methodology Item: Title: Results Item: Title: Conclusion Item: Title: Key Points Item: Title: Introduction Item: Title: Methods Children: Item: Title: Design Item: Title: Participants Item: Title: Clinical procedures Item: Title: CSF collection, storage, and analyses Item: Title: MRI acquisition Item: Title: Morphometric MRI measurements Children: Item: Title: Brainstem automatic measures (Supplementary Fig. 3) Item: Title: Shape analysis Item: Title: Statistics Item: Title: Results Children: Item: Title: Demographic and clinical data Item: Title: CSF biomarkers Item: Title: MRI quantitative measures Item: Title: Shape analysis Children: Item: Title: Comparison of brainstem shape across parkinsonian disorders and control subjects Item: Title: Association of brainstem shape and clinical variables Item: Title: Association of brainstem shape and CSF NfL Item: Title: Discussion Children: Item: Title: Correlations with clinical and CSF variables Item: Title: Anchor 29 Item: Title: Acknowledgements Item: Title: References Info: Title: Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study Author: C. Painous Subject: European Radiology, https://doi.org/10.1007/s00330-023-09435-0 Keywords: Multiple system atrophy;Progressive supranuclear palsy;Shape analysis;Neurofilament protein;Parkinsonian disorders Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Jun 09 05:22:57 CEST 2023 ModDate: Fri Jun 09 06:09:15 CEST 2023 ID: 0x07851d6fb7f0644d91510f2487c34232, 0xfb62a9eadbbac347bdced772c52b3e6c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 781 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 2234 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1138 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 794 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: HXPRMK+SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: GJSVIM+STIX-Regular FontSubset: true FirstChar: 24 LastChar: 252 FontDescriptor: FontName: GJSVIM+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NQYCPV+STIX-BoldItalic FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: NQYCPV+STIX-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -753, -359, 1430, 1004 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XUADNO+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: XUADNO+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CGJGAT+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: CGJGAT+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: HXPRMK+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HXPRMK+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true XMP: 2023-06-09T03:22:57 Adobe InDesign 15.1 (Windows) 2023-06-09T04:09:15Z 2023-06-09T04:09:15Z Adobe PDF Library 15.0 Multiple system atrophy;Progressive supranuclear palsy;Shape analysis;Neurofilament protein;Parkinsonian disorders False application/pdf https://doi.org/10.1007/s00330-023-09435-0 Springer Berlin Heidelberg European Radiology, https://doi.org/10.1007/s00330-023-09435-0 Multiple system atrophy Progressive supranuclear palsy Shape analysis Neurofilament protein Parkinsonian disorders Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study C. Painous S. Pascual-Diaz E. Muñoz-Moreno V. Sánchez JC. Pariente A. Prats-Galino M. Soto M. Fernández A. Pérez-Soriano A. Camara E. Muñoz F. Valldeoriola N. Caballol C. Pont-Sunyer N. Martin M. Basora M. Tio J. Rios MJ. Martí N. Bargalló Y. Compta 10.1007/s00330-023-09435-0 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00330-023-09435-0 10.1007/s00330-023-09435-0 1432-1084 33 7 4540 4551 journal European Radiology The Author(s) 2010-04-23 true 10.1007/s00330-023-09435-0 noindex springer.com springerlink.com uuid:86afb286-f048-4891-97bd-e6915b95c9ae uuid:0f3692e3-6c1d-4dae-b7b2-97fe6d2f0c98 default 1 converted uuid:cba991ae-73b3-40da-9504-084e4061d996 converted to PDF/A-2b pdfToolbox 2023-06-09T04:08:58Z 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Label: 4540 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 513, 726, 546, 694 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4541 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 54, 621, 59, 606 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 64, 621, 69, 606 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 163, 621, 168, 606 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 173, 621, 178, 606 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 210, 596, 215, 581 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 111, 584, 116, 569 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 95, 559, 100, 544 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 192, 559, 197, 544 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 202, 559, 213, 544 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 100, 534, 110, 519 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 114, 534, 124, 519 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 273, 534, 283, 519 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 275, 521, 285, 506 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 255, 509, 260, 494 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 265, 509, 270, 494 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 194, 459, 204, 444 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 111, 421, 122, 406 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 127, 421, 137, 406 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 372, 673, 383, 658 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 388, 673, 398, 658 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 531, 610, 541, 595 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 306, 598, 316, 583 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 415, 573, 426, 558 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 432, 573, 442, 558 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 530, 535, 540, 520 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 340, 473, 350, 458 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 476, 335, 486, 320 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 397, 323, 407, 308 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 363, 310, 373, 295 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 309, 285, 319, 270 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 530, 285, 540, 270 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 435, 260, 445, 245 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 513, 248, 523, 233 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 373, 210, 383, 195 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 506, 98, 516, 83 Flags: Print AppearanceDictionary: true Destination: 150 Thumb: true Page: Label: 4542 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 168, 374, 178, 359 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 117, 224, 127, 209 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 54, 86, 131, 71 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 140, 86, 150, 71 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 155, 86, 165, 71 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 350, 699, 359, 684 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 507, 674, 517, 659 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 474, 286, 485, 271 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 383, 249, 393, 234 Flags: Print AppearanceDictionary: true Destination: 150 Thumb: true Page: Label: 4543 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 433, 736, 438, 721 Flags: Print AppearanceDictionary: true Destination: 54 Thumb: true Page: Label: 4544 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 129, 336, 134, 321 Flags: Print AppearanceDictionary: true Destination: 66 Annotation: Subtype: Link Rect: 510, 511, 516, 496 Flags: Print AppearanceDictionary: true Destination: 74 Thumb: true Page: Label: 4545 Sequence: 6 Thumb: true Page: Label: 4546 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 92, 424, 97, 409 Flags: Print AppearanceDictionary: true Destination: 79 Annotation: Subtype: Link Rect: 202, 287, 212, 272 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 217, 287, 227, 272 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 80, 274, 90, 259 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 54, 187, 65, 172 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 161, 187, 171, 172 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 256, 187, 266, 172 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 272, 187, 283, 172 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 173, 149, 184, 134 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 189, 149, 199, 134 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 456, 424, 466, 409 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 376, 324, 381, 309 Flags: Print AppearanceDictionary: true Destination: 66 Annotation: Subtype: Link Rect: 428, 124, 438, 109 Flags: Print AppearanceDictionary: true Destination: 137 Thumb: true Page: Label: 4547 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 194, 474, 205, 459 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 210, 474, 221, 459 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 163, 449, 173, 434 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 131, 399, 136, 384 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 178, 361, 183, 346 Flags: Print AppearanceDictionary: true Destination: 98 Annotation: Subtype: Link Rect: 122, 336, 132, 321 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 234, 236, 239, 221 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 245, 236, 255, 221 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 356, 511, 367, 496 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 433, 361, 443, 346 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 309, 349, 320, 334 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 415, 349, 426, 334 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 309, 261, 320, 246 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 325, 261, 336, 246 Flags: Print AppearanceDictionary: true Destination: 150 Thumb: true Page: Label: 4548 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 54, 674, 65, 659 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 70, 674, 81, 659 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 87, 674, 97, 659 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 96, 624, 106, 609 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 112, 624, 122, 609 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 86, 424, 91, 409 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 96, 424, 106, 409 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 111, 424, 122, 409 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 138, 349, 148, 334 Flags: Print AppearanceDictionary: true Destination: 137 Annotation: Subtype: Link Rect: 153, 349, 164, 334 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 54, 324, 65, 309 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 255, 199, 266, 184 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 222, 161, 232, 146 Flags: Print AppearanceDictionary: true Destination: 150 Annotation: Subtype: Link Rect: 391, 607, 542, 594 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4549 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 137, 566, 287, 553 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 496, 544, 483 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 486, 437, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 236, 544, 223 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 226, 544, 213 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 216, 390, 203 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4550 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 145, 506, 287, 493 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 166, 266, 286, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 246, 289, 233 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 236, 289, 223 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 226, 120, 213 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 716, 544, 703 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 696, 544, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 686, 408, 673 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 381, 646, 511, 633 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 382, 606, 520, 593 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 566, 451, 553 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 335, 536, 521, 523 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 506, 544, 493 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 496, 418, 483 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 466, 544, 453 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 436, 544, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 426, 392, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 440, 386, 544, 373 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 376, 379, 363 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 336, 544, 323 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 326, 389, 313 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 460, 266, 544, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 256, 390, 243 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4551 Sequence: 12 Thumb: true Checksum: 58642932 Type: CRC32 Checksum: b4dbbd7d05453db177686180175b05c9 Type: MD5 Checksum: 2140160bdbd9ee8a0f51a14884f19548cd02d2fb Type: SHA-1 Checksum: d58d80919398cb9a5478ca0e6606bdc4404d214aa95790393eea3f6e0db93425 Type: SHA-256