b86902ae48dfa9bb40f04ae41dc7f85d cancers-15-03329.pdf 66349eb532b5f63178f7a82469585fbec66f987d cancers-15-03329.pdf dc4f0236538a23ccedd87cb919f7e580d83afc4142184389fb5c930c3fcb4969 cancers-15-03329.pdf Title: A Systematic Review of the Current Status of Magnetic Resonance–Ultrasound Images Fusion Software Platforms for Transperineal Prostate Biopsies Subject: Given this new context, our objective is to recognize the suitability of the currently available software for image fusion and the reported series using the transperineal route, as well as to generate new evidence on the complementarity of the directed and systematic biopsies, which has been established through the transrectal approach. Evidence acquisition: This systematic review, registered in Prospero (CRD42022375619), began with a bibliographic search that was carried out in PubMed, Cochrane, and Google Scholar databases. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria and the studied eligibility based on the Participants, Intervention, Comparator, and Outcomes (PICO) strategy were followed. Warp analysis of selected studies was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. In addition, a Google search of all currently available fusion platforms was performed. Our Google search found 11 different commercially available robots to perform transperineal image fusion biopsies, of which 10 devices have published articles supporting their diagnostic effectiveness in transperineal prostate biopsies. Results: A total of 30 articles were selected and the characteristics and results of the biopsies of 11,313 patients were analyzed. The pooled mean age was 66.5 years (63–69). The mean pooled PSA level was 7.8 ng/mL (5.7–10.8). The mean pooled prostate volume was 45.4 cc. (34–56). The mean pooled PSA density was 0.17 (0.12–0.27). The overall cancer detection rate for all prostate cancers was 61.4%, while for csPCa it was 47.8%. PCa detection rate was more effective than that demonstrated in the systematic transrectal biopsy. However, the detection of csPCa in the systematic biopsy was only 9.5% in the reported series. To standardize our review, we grouped prostate cancer screening results according to the population studied and the software used. When the same populations were compared between elastic and rigid software, we found that rigid biopsies had a higher csPCa detection rate than biopsies with elastic fusion systems. Conclusion: Platforms performing prostate biopsy using transperineal image fusion have better detection rates of csPCa than systematic transrectal biopsies. Rigid fusion systems have a better csPCa detection rate than elastic ones. We found no diagnostic differences between the different types of robotic systems currently available. The complementarity of systematic biopsy has also been demonstrated in transperineal imaging fusion biopsies. Keywords: systematic review; robot-assisted prostate biopsy; MR-target transperineal biopsy; software-assisted MRI–TRUS fusion platforms; prostate cancer Author: Nahuel Paesano, Violeta Catalá, Larisa Tcholakian, Enric Trilla and Juan Morote Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jun 24 13:28:26 2023 CEST ModDate: Sat Jun 24 13:31:34 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 936610 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NUMTKF+VnURWPalladioL Type 1 Custom yes yes no 10 0 DXVVLJ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 IUTAIO+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 NYTXXG+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 HNNBOL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 78 0 HNNBOM+PalatinoLinotype CID TrueType Identity-H yes yes yes 81 0 HNNBON+PalatinoLinotype TrueType WinAnsi yes yes no 87 0 HNNBOP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 90 0 HNNCHM+PalatinoLinotype TrueType MacRoman yes yes no 93 0 JVNVXE+wasy9 Type 1 Builtin yes yes no 101 0 AHSHLD+CMSY10 Type 1 Builtin yes yes no 105 0 XJVDWW+wasy8 Type 1 Builtin yes yes no 109 0 HNNBOL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 123 0 HNNBOM+PalatinoLinotype CID TrueType Identity-H yes yes yes 126 0 HNNBON+PalatinoLinotype TrueType WinAnsi yes yes no 132 0 HNNBOP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 135 0 HNNCHM+PalatinoLinotype TrueType MacRoman yes yes no 138 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-04 04:09:19 CEST RepresentationInformation: cancers-15-03329.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-03 15:56:41 CEST Size: 936610 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 604 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Evidence Acquisition Destination: section.2 Children: Item: Title: Systematic Review Destination: subsection.2.1 Item: Title: Quality Assessment of Selected Studies Destination: subsection.2.2 Item: Title: Data Extraction in the Selected Studies Destination: subsection.2.3 Item: Title: Searching Devices for MRI TRUS Fusion Prostate Biopsies in Google and Their Characteristics Destination: subsection.2.4 Item: Title: Evidence Synthesis Destination: section.3 Children: Item: Title: Demographics Destination: subsection.3.1 Item: Title: Characteristics of the Biopsies and MRI Destination: subsection.3.2 Item: Title: Significant Clinically Prostate Cancer Definition Destination: subsection.3.3 Item: Title: Cancer Detection Rates (CDR) Destination: subsection.3.4 Item: Title: Cancer Detection according to Population and Software Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: A Systematic Review of the Current Status of Magnetic Resonance Ultrasound Images Fusion Software Platforms for Transperineal Prostate Biopsies Author: Nahuel Paesano, Violeta Catalá, Larisa Tcholakian, Enric Trilla and Juan Morote Subject: Given this new context, our objective is to recognize the suitability of the currently available software for image fusion and the reported series using the transperineal route, as well as to generate new evidence on the complementarity of the directed and systematic biopsies, which has been established through the transrectal approach. Evidence acquisition: This systematic review, registered in Prospero (CRD42022375619), began with a bibliographic search that was carried out in PubMed, Cochrane, and Google Scholar databases. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria and the studied eligibility based on the Participants, Intervention, Comparator, and Outcomes (PICO) strategy were followed. Warp analysis of selected studies was performed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. In addition, a Google search of all currently available fusion platforms was performed. Our Google search found 11 different commercially available robots to perform transperineal image fusion biopsies, of which 10 devices have published articles supporting their diagnostic effectiveness in transperineal prostate biopsies. Results: A total of 30 articles were selected and the characteristics and results of the biopsies of 11,313 patients were analyzed. The pooled mean age was 66.5 years (63 69). The mean pooled PSA level was 7.8 ng/mL (5.7 10.8). The mean pooled prostate volume was 45.4 cc. (34 56). The mean pooled PSA density was 0.17 (0.12 0.27). The overall cancer detection rate for all prostate cancers was 61.4%, while for csPCa it was 47.8%. PCa detection rate was more effective than that demonstrated in the systematic transrectal biopsy. However, the detection of csPCa in the systematic biopsy was only 9.5% in the reported series. To standardize our review, we grouped prostate cancer screening results according to the population studied and the software used. When the same populations were compared between elastic and rigid software, we found that rigid biopsies had a higher csPCa detection rate than biopsies with elastic fusion systems. Conclusion: Platforms performing prostate biopsy using transperineal image fusion have better detection rates of csPCa than systematic transrectal biopsies. Rigid fusion systems have a better csPCa detection rate than elastic ones. We found no diagnostic differences between the different types of robotic systems currently available. The complementarity of systematic biopsy has also been demonstrated in transperineal imaging fusion biopsies. Keywords: systematic review; robot-assisted prostate biopsy; MR-target transperineal biopsy; software-assisted MRI TRUS fusion platforms; prostate cancer Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jun 24 13:28:26 CEST 2023 ModDate: Sat Jun 24 13:31:34 CEST 2023 ID: 0xbf7e6f136339af2dd38834a95d26d675, 0xbf7e6f136339af2dd38834a95d26d675 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: IUTAIO+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: IUTAIO+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JVNVXE+wasy9 FontSubset: true FirstChar: 44 LastChar: 47 FontDescriptor: FontName: JVNVXE+wasy9 Flags: Symbolic FontBBox: -21, -1667, 1768, 753 FontFile: true Font: BaseFont: NYTXXG+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: NYTXXG+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, 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