346aaef7ea24222f1f381643f5293715 fnins-17-1205065.pdf c7d8f0e7a74e4ff0549488a0137afcd2ad2a0a52 fnins-17-1205065.pdf 8a79e44495cbe3cf8935dead6dcb29d2a87f185ca63d410e6ca2cb16ce03267e fnins-17-1205065.pdf Title: Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report Subject: Midaglia L, Felipe-Rucián A, Delgado Alvarez I, Montalban X and Tintoré M (2023) Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report. Front. Neurosci. 17:1205065. doi: 10.3389/fnins.2023.1205065 Keywords: acquired demyelinating syndrome (ADS); myelin oligodendrocyte glycoprotein (MOG); MOG antibody-associated disease (MOGAD); neuromyelitis optica spectrum disorder (NMOSD); multiple sclerosis (MS); pediatric onset multiple sclerosis (POMS) Author: Luciana Midaglia Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jul 15 13:42:28 2023 CEST ModDate: Sat Jul 15 13:57:50 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 595.26 x 842.116 pts (A4) Page rot: 0 File size: 613794 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MRXPXD+MuseoSans-300Italic Type 1C WinAnsi yes yes no 38 0 WUIMOG+MinionPro-Regular Type 1C Custom yes yes no 41 0 LEUBXB+MuseoSans-500 Type 1C Custom yes yes yes 48 0 RMYGTC+MuseoSans-700 Type 1C Custom yes yes yes 22 0 YYULGO+MuseoSans-300 Type 1C Custom yes yes yes 25 0 GTBWQN+MTSY Type 1C Custom yes yes no 64 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 91 0 JAGPYM+MinionPro-It Type 1C Custom yes yes no 131 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-15 03:55:03 CEST RepresentationInformation: fnins-17-1205065.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-14 19:28:19 CEST Size: 613794 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 182 FreeObjects: 11 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Case report Destination: section*.3 Item: Title: Discussion Destination: section*.4 Item: Title: Data availability statement Destination: section*.5 Item: Title: Ethics statement Destination: section*.6 Item: Title: Author contributions Destination: section*.7 Item: Title: Conflict of interest Destination: section*.8 Item: Title: Publisher's note Destination: section*.9 Item: Title: References Destination: section*.10 Info: Title: Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report Author: Luciana Midaglia Subject: Midaglia L, Felipe-Rucián A, Delgado Alvarez I, Montalban X and Tintoré M (2023) Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report. Front. Neurosci. 17:1205065. doi: 10.3389/fnins.2023.1205065 Keywords: acquired demyelinating syndrome (ADS); myelin oligodendrocyte glycoprotein (MOG); MOG antibody-associated disease (MOGAD); neuromyelitis optica spectrum disorder (NMOSD); multiple sclerosis (MS); pediatric onset multiple sclerosis (POMS) Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Sat Jul 15 14:12:28 CEST 2023 ModDate: Sat Jul 15 14:27:50 CEST 2023 ID: 0x993bdf151b3078bc50bcf79d7359bdb0, 0xd35b1bc3cb847e4daf0c3f3c05807a7a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 128 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1020 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 542 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: LEUBXB+MuseoSans-500 FontSubset: true FirstChar: 3 LastChar: 233 FontDescriptor: FontName: LEUBXB+MuseoSans-500 Flags: Symbolic FontBBox: 2, -210, 845, 744 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GTBWQN+MTSY FontSubset: true FirstChar: 2 LastChar: 25 FontDescriptor: FontName: GTBWQN+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 538 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JAGPYM+MinionPro-It FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: JAGPYM+MinionPro-It Flags: Symbolic FontBBox: -136, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RMYGTC+MuseoSans-700 FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: RMYGTC+MuseoSans-700 Flags: Symbolic FontBBox: -8, -210, 941, 741 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MRXPXD+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: MRXPXD+MuseoSans-300Italic Flags: Nonsymbolic, SmallCap FontBBox: -53, -12, 724, 703 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: YYULGO+MuseoSans-300 FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: YYULGO+MuseoSans-300 Flags: Symbolic FontBBox: -55, -210, 890, 742 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WUIMOG+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 237 FontDescriptor: FontName: WUIMOG+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 811 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding XMP: True https://www.frontiersin.org/legal/copyright-statement 2023-07-15T17:12:28+05:30 LaTeX with hyperref package + hypdvips 2023-07-15T17:27:50+05:30 2023-07-15T17:27:50+05:30 acquired demyelinating syndrome (ADS); myelin oligodendrocyte glycoprotein (MOG); MOG antibody-associated disease (MOGAD); neuromyelitis optica spectrum disorder (NMOSD); multiple sclerosis (MS); pediatric onset multiple sclerosis (POMS) dvips + MiKTeX GPL Ghostscript 9.0 application/pdf Copyright © 2023 Midaglia, Felipe-Rucián, Delgado Alvarez, Montalban and Tintoré. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Midaglia L, Felipe-Rucián A, Delgado Alvarez I, Montalban X and Tintoré M (2023) Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report. Front. Neurosci. 17:1205065. doi: 10.3389/fnins.2023.1205065 Luciana Midaglia Ana Felipe-Rucián Ignacio Delgado Alvarez Xavier Montalban Mar Tintoré Diagnostic challenge in children with an acquired demyelinating syndrome: an illustrative case report acquired demyelinating syndrome (ADS) myelin oligodendrocyte glycoprotein (MOG) MOG antibody-associated disease (MOGAD) neuromyelitis optica spectrum disorder (NMOSD) multiple sclerosis (MS) pediatric onset multiple sclerosis (POMS) uuid:3869fa15-5881-4423-89c0-9f509d9a688c uuid:5734658d-e48e-474a-8115-133eceb5bd85 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 48, 790, 238, 806 Annotation: Subtype: Link Rect: 457, 800, 498, 808 Annotation: Subtype: Link Rect: 474, 791, 484, 799 Annotation: Subtype: Link Rect: 484, 791, 499, 799 Annotation: Subtype: Link Rect: 499, 791, 516, 799 Annotation: Subtype: Link Rect: 454, 782, 546, 790 Annotation: Subtype: Link Rect: 48, 700, 124, 717 Annotation: Subtype: Link Rect: 57, 524, 133, 532 Annotation: Subtype: Link Rect: 62, 426, 154, 434 Annotation: Subtype: Link Rect: 69, 377, 97, 384 Annotation: Subtype: Link Rect: 97, 377, 133, 384 Annotation: Subtype: Link Rect: 133, 377, 168, 384 Annotation: Subtype: Link Rect: 168, 377, 194, 384 Annotation: Subtype: Link Rect: 48, 367, 75, 375 Annotation: Subtype: Link Rect: 214, 621, 546, 717 Annotation: Subtype: Link Rect: 516, 89, 232, 89 Destination: External Annotation: Subtype: Link Rect: 235, 77, 254, 89 Destination: External Annotation: Subtype: Link Rect: 48, 34, 132, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 452, 800, 546, 807 Annotation: Subtype: Link Rect: 51, 680, 125, 692 Destination: External Annotation: Subtype: Link Rect: 127, 680, 147, 692 Destination: External Annotation: Subtype: Link Rect: 95, 596, 139, 608 Destination: External Annotation: Subtype: Link Rect: 142, 596, 161, 608 Destination: External Annotation: Subtype: Link Rect: 163, 596, 192, 608 Destination: External Annotation: Subtype: Link Rect: 194, 596, 213, 608 Destination: External Annotation: Subtype: Link Rect: 194, 188, 226, 198 Destination: External Annotation: Subtype: Link Rect: 418, 248, 450, 258 Destination: External Annotation: Subtype: Link Rect: 48, 34, 132, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 452, 800, 546, 807 Annotation: Subtype: Link Rect: 138, 99, 173, 111 Destination: External Annotation: Subtype: Link Rect: 175, 99, 195, 111 Destination: External Annotation: Subtype: Link Rect: 197, 99, 245, 111 Destination: External Annotation: Subtype: Link Rect: 247, 99, 266, 111 Destination: External Annotation: Subtype: Link Rect: 406, 160, 460, 172 Destination: External Annotation: Subtype: Link Rect: 463, 160, 482, 172 Destination: External Annotation: Subtype: Link Rect: 465, 88, 519, 100 Destination: External Annotation: Subtype: Link Rect: 522, 88, 541, 100 Destination: External Annotation: Subtype: Link Rect: 48, 34, 132, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 452, 800, 546, 807 Annotation: Subtype: Link Rect: 107, 740, 155, 752 Destination: External Annotation: Subtype: Link Rect: 160, 740, 184, 752 Destination: External Annotation: Subtype: Link Rect: 79, 692, 140, 704 Destination: External Annotation: Subtype: Link Rect: 142, 692, 161, 704 Destination: External Annotation: Subtype: Link Rect: 263, 632, 68, 632 Destination: External Annotation: Subtype: Link Rect: 72, 620, 91, 632 Destination: External Annotation: Subtype: Link Rect: 94, 620, 140, 632 Destination: External Annotation: Subtype: Link Rect: 143, 620, 167, 632 Destination: External Annotation: Subtype: Link Rect: 170, 620, 213, 632 Destination: External Annotation: Subtype: Link Rect: 216, 620, 235, 632 Destination: External Annotation: Subtype: Link Rect: 51, 536, 97, 548 Destination: External Annotation: Subtype: Link Rect: 102, 536, 121, 548 Destination: External Annotation: Subtype: Link Rect: 271, 524, 68, 524 Destination: External Annotation: Subtype: Link Rect: 72, 512, 91, 524 Destination: External Annotation: Subtype: Link Rect: 226, 500, 289, 512 Destination: External Annotation: Subtype: Link Rect: 48, 488, 67, 500 Destination: External Annotation: Subtype: Link Rect: 261, 404, 68, 404 Destination: External Annotation: Subtype: Link Rect: 72, 392, 91, 404 Destination: External Annotation: Subtype: Link Rect: 217, 380, 265, 392 Destination: External Annotation: Subtype: Link Rect: 267, 380, 286, 392 Destination: External Annotation: Subtype: Link Rect: 244, 356, 289, 368 Destination: External Annotation: Subtype: Link Rect: 48, 344, 71, 356 Destination: External Annotation: Subtype: Link Rect: 92, 308, 138, 320 Destination: External Annotation: Subtype: Link Rect: 142, 308, 165, 320 Destination: External Annotation: Subtype: Link Rect: 149, 272, 204, 284 Destination: External Annotation: Subtype: Link Rect: 207, 272, 226, 284 Destination: External Annotation: Subtype: Link Rect: 229, 272, 289, 284 Destination: External Annotation: Subtype: Link Rect: 48, 260, 67, 272 Destination: External Annotation: Subtype: Link Rect: 87, 168, 160, 175 Annotation: Subtype: Link Rect: 201, 140, 281, 147 Annotation: Subtype: Link Rect: 197, 103, 290, 112 Annotation: Subtype: Link Rect: 113, 76, 210, 83 Annotation: Subtype: Link Rect: 547, 167, 302, 184 Annotation: Subtype: Link Rect: 315, 131, 408, 140 Annotation: Subtype: Link Rect: 408, 104, 463, 111 Annotation: Subtype: Link Rect: 336, 75, 424, 84 Annotation: Subtype: Link Rect: 48, 33, 132, 40 Annotation: Subtype: Link Rect: 498, 32, 546, 40 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 452, 800, 546, 807 Annotation: Subtype: Link Rect: 60, 728, 121, 735 Annotation: Subtype: Link Rect: 60, 684, 140, 691 Annotation: Subtype: Link Rect: 292, 646, 47, 663 Annotation: Subtype: Link Rect: 126, 618, 202, 625 Annotation: Subtype: Link Rect: 80, 581, 173, 588 Annotation: Subtype: Link Rect: 315, 728, 393, 735 Annotation: Subtype: Link Rect: 315, 698, 388, 707 Annotation: Subtype: Link Rect: 394, 671, 487, 679 Annotation: Subtype: Link Rect: 315, 635, 403, 643 Annotation: Subtype: Link Rect: 315, 599, 399, 608 Annotation: Subtype: Link Rect: 449, 582, 546, 589 Annotation: Subtype: Link Rect: 48, 34, 132, 41 Annotation: Subtype: Link Rect: 498, 33, 546, 41 Checksum: 44ce2b0b Type: CRC32 Checksum: 346aaef7ea24222f1f381643f5293715 Type: MD5 Checksum: c7d8f0e7a74e4ff0549488a0137afcd2ad2a0a52 Type: SHA-1 Checksum: 8a79e44495cbe3cf8935dead6dcb29d2a87f185ca63d410e6ca2cb16ce03267e Type: SHA-256