3f47ab7f04d42719cbfa337c6928c148 319859.pdf ed8ad22eeee797f979ead1ec94a87f3c3aef83f2 319859.pdf aec5355e5eda939c1fd94e3826b708584d18f3857c46850e978df598308771cc 319859.pdf Title: CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation Subject: Panesso M, Uría María Luz, Renedo B, Esperalba J, Benítez-Carabante María Isabel, Mendoza-Palomar N, Alonso L, Oliveras M and Diaz-de-Heredia C (2023) CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation. Front. Pediatr. 11:1197828. doi: 10.3389/fped.2023.1197828 Keywords: cytomegalovirus; hematopoietic stem cell transplantation; children; CMV hyperimmune globulin; salvage therapy Author: Melissa Panesso Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Jul 18 16:23:30 2023 CEST ModDate: Wed Jul 19 03:03:53 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 754170 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IAFLNN+AdvOT2c8ce45a Type 1C WinAnsi yes yes no 303 0 IAFLNO+AdvOT9b12cd41 Type 1C WinAnsi yes yes no 304 0 IAFLOO+AdvOTd3a5f740 Type 1C WinAnsi yes yes no 309 0 IAFLOP+AdvOT9b12cd41+20 Type 1C WinAnsi yes yes no 312 0 IAFLPA+AdvOT9b12cd41+fb Type 1C Custom yes yes yes 313 0 IAFMAB+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 316 0 IAFMCE+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 128 0 IAFMCF+AdvOTd3a5f740+fb Type 1C Custom yes yes yes 129 0 IAFMCG+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 135 0 IAFMCB+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 127 0 IAFMCC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 146 0 IAFMCD+AdvTT5843c571 Type 1C WinAnsi yes yes no 147 0 IAFMDH+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 150 0 IAFMJG+AdvOT46dcae81 Type 1C WinAnsi yes yes no 151 0 IAFMJH+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 156 0 IAFMJI+AdvOT46dcae81+fb Type 1C Custom yes yes yes 152 0 IAFNBG+AdvOTd3a5f740+20 Type 1C WinAnsi yes yes no 159 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-01-23 04:41:50 CET RepresentationInformation: 319859.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-01-22 10:42:56 CET Size: 754170 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 378 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation Destination: head1 Children: Item: Title: Introduction Destination: head2 Item: Title: Methods Destination: head3 Children: Item: Title: Inclusion criteria Destination: head4 Item: Title: Endpoints Destination: head5 Item: Title: Quantification of CMV DNAemia Destination: head6 Item: Title: Definitions Destination: head7 Item: Title: CMV-resistant strains testing Destination: head8 Item: Title: CMVIG dosage Destination: head9 Item: Title: Patient follow up Destination: head10 Item: Title: Statistical analysis Destination: head11 Item: Title: Results Destination: head12 Item: Title: Discussion Destination: head13 Item: Title: Data availability statement Destination: head14 Item: Title: Ethics statement Destination: head15 Item: Title: Author contributions Destination: head16 Item: Title: Funding Destination: head17 Item: Title: Acknowledgments Destination: head18 Item: Title: Conflict of interest Destination: head19 Item: Title: Publisher's note Destination: head20 Item: Title: Supplementary material Destination: head21 Item: Title: References Destination: head22 Info: Title: CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation Author: Melissa Panesso Subject: Panesso M, Uría María Luz, Renedo B, Esperalba J, Benítez-Carabante María Isabel, Mendoza-Palomar N, Alonso L, Oliveras M and Diaz-de-Heredia C (2023) CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation. Front. Pediatr. 11:1197828. doi: 10.3389/fped.2023.1197828 Keywords: cytomegalovirus; hematopoietic stem cell transplantation; children; CMV hyperimmune globulin; salvage therapy Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Jul 18 16:53:30 CEST 2023 ModDate: Wed Jul 19 03:33:53 CEST 2023 ID: 0x07ebe1504dfeaef0423d3774e1203c85, 0x9bb5b53ac26b204fb3fac95df687cbda Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: IAFMCE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: IAFMCE+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -218, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMCF+AdvOTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IAFMCF+AdvOTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFMCG+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: IAFMCG+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFLNN+AdvOT2c8ce45a FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: IAFLNN+AdvOT2c8ce45a Flags: Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFLNO+AdvOT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: IAFLNO+AdvOT9b12cd41 Flags: Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMCC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IAFMCC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFMCD+AdvTT5843c571 FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: IAFMCD+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFLOO+AdvOTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 237 FontDescriptor: FontName: IAFLOO+AdvOTd3a5f740 Flags: Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMDH+AdvOTb65e897d.B FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: IAFMDH+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMJG+AdvOT46dcae81 FontSubset: true FirstChar: 40 LastChar: 215 FontDescriptor: FontName: IAFMJG+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFLOP+AdvOT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: IAFLOP+AdvOT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMJI+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IAFMJI+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFLPA+AdvOT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: IAFLPA+AdvOT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IAFMAB+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: IAFMAB+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMJH+AdvOT65f8a23b.I FontSubset: true FirstChar: 69 LastChar: 120 FontDescriptor: FontName: IAFMJH+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFMCB+AdvOT7d6df7ab.I FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: IAFMCB+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IAFNBG+AdvOTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: IAFNBG+AdvOTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf 10.3389/fped.2023.1197828 en Melissa Panesso María Luz Uría Berta Renedo Juliana Esperalba María Isabel Benítez-Carabante Natalia Mendoza-Palomar Laura Alonso Maria Oliveras Cristina Diaz-de-Heredia CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation Panesso M, Uría María Luz, Renedo B, Esperalba J, Benítez-Carabante María Isabel, Mendoza-Palomar N, Alonso L, Oliveras M and Diaz-de-Heredia C (2023) CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation. Front. Pediatr. 11:1197828. doi: 10.3389/fped.2023.1197828 Copyright © 2023 Panesso, Uría, Renedo, Esperalba, Benítez-Carabante, Mendoza-Palomar, Alonso, Oliveras and Diaz-de-Heredia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. cytomegalovirus hematopoietic stem cell transplantation children CMV hyperimmune globulin salvage therapy 2023-07-18T19:53:30+05:30 Arbortext Advanced Print Publisher 10.0.1465/W Unicode 2023-07-19T06:33:53+05:30 2023-07-19T06:33:53+05:30 Acrobat Distiller 8.1.0 (Windows) cytomegalovirus; hematopoietic stem cell transplantation; children; CMV hyperimmune globulin; salvage therapy uuid:bfbc0ed4-b8eb-4686-bda9-40b9e1363750 uuid:b4f76c00-9a15-4a38-a3e1-95eada667957 Journal © 2023 Panesso, Uría, Renedo, Esperalba, Benítez-Carabante, Mendoza-Palomar, Alonso, Oliveras and Diaz-de-Heredia. 10.3389/fped.2023.1197828 https://doi.org/10.3389/fped.2023.1197828 True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 49, 701, 125, 715 Annotation: Subtype: Link Rect: 64, 413, 152, 420 Annotation: Subtype: Link Rect: 71, 354, 194, 361 Annotation: Subtype: Link Rect: 49, 345, 73, 352 Annotation: Subtype: Link Rect: 214, 695, 514, 716 Annotation: Subtype: Link Rect: 214, 670, 524, 691 Annotation: Subtype: Link Rect: 214, 645, 478, 666 Annotation: Subtype: Link Rect: 214, 620, 411, 641 Annotation: Subtype: Link Rect: 214, 595, 448, 616 Annotation: Subtype: Link Rect: 214, 570, 359, 591 Annotation: Subtype: Link Rect: 377, 120, 381, 129 Destination: 78 Annotation: Subtype: Link Rect: 536, 95, 540, 104 Destination: 78 Annotation: Subtype: Link Rect: 49, 793, 219, 807 Annotation: Subtype: Link Rect: 439, 781, 528, 788 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 192, 688, 196, 697 Destination: 78 Annotation: Subtype: Link Rect: 204, 651, 208, 660 Destination: 78 Annotation: Subtype: Link Rect: 281, 513, 285, 522 Destination: 78 Annotation: Subtype: Link Rect: 161, 488, 165, 497 Destination: 78 Annotation: Subtype: Link Rect: 281, 426, 285, 435 Destination: 78 Annotation: Subtype: Link Rect: 257, 376, 261, 385 Destination: 78 Annotation: Subtype: Link Rect: 119, 326, 123, 335 Destination: 78 Annotation: Subtype: Link Rect: 222, 251, 226, 260 Destination: 78 Annotation: Subtype: Link Rect: 52, 238, 60, 247 Destination: 78 Annotation: Subtype: Link Rect: 173, 151, 182, 160 Destination: 78 Annotation: Subtype: Link Rect: 247, 76, 256, 85 Destination: 78 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 136, 438, 144, 447 Destination: 78 Annotation: Subtype: Link Rect: 219, 351, 227, 360 Destination: 78 Annotation: Subtype: Link Rect: 453, 551, 487, 560 Destination: 30 Annotation: Subtype: Link Rect: 496, 538, 527, 547 Destination: 46 Annotation: Subtype: Link Rect: 318, 163, 403, 172 Destination: 78 Annotation: Subtype: Link Rect: 307, 76, 345, 85 Destination: 54 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 190, 303, 231, 312 Destination: 30 Annotation: Subtype: Link Rect: 261, 203, 288, 212 Destination: 72 Annotation: Subtype: Link Rect: 234, 113, 242, 122 Destination: 78 Annotation: Subtype: Link Rect: 474, 165, 482, 174 Destination: 106 Annotation: Subtype: Link Rect: 502, 103, 510, 112 Destination: 106 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 85, 457, 94, 466 Destination: 106 Annotation: Subtype: Link Rect: 176, 395, 184, 404 Destination: 78 Annotation: Subtype: Link Rect: 52, 220, 61, 229 Destination: 106 Annotation: Subtype: Link Rect: 307, 195, 316, 204 Destination: 106 Annotation: Subtype: Link Rect: 320, 195, 329, 204 Destination: 106 Annotation: Subtype: Link Rect: 410, 182, 419, 191 Destination: 106 Annotation: Subtype: Link Rect: 424, 182, 433, 191 Destination: 106 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 101, 638, 194, 647 Destination: 78 Annotation: Subtype: Link Rect: 349, 363, 545, 372 Annotation: Subtype: Link Rect: 304, 351, 439, 360 Annotation: Subtype: Link Rect: 221, 261, 283, 268 Annotation: Subtype: Link Rect: 189, 241, 268, 248 Annotation: Subtype: Link Rect: 49, 205, 136, 212 Annotation: Subtype: Link Rect: 110, 177, 206, 184 Annotation: Subtype: Link Rect: 208, 157, 290, 164 Annotation: Subtype: Link Rect: 49, 149, 69, 156 Annotation: Subtype: Link Rect: 173, 113, 263, 120 Annotation: Subtype: Link Rect: 49, 69, 124, 76 Annotation: Subtype: Link Rect: 338, 261, 395, 268 Annotation: Subtype: Link Rect: 473, 233, 538, 240 Annotation: Subtype: Link Rect: 523, 205, 545, 212 Annotation: Subtype: Link Rect: 304, 197, 360, 204 Annotation: Subtype: Link Rect: 432, 169, 533, 176 Annotation: Subtype: Link Rect: 431, 133, 522, 140 Annotation: Subtype: Link Rect: 304, 113, 530, 120 Annotation: Subtype: Link Rect: 304, 105, 340, 112 Annotation: Subtype: Link Rect: 372, 69, 466, 76 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 114, 728, 183, 735 Annotation: Subtype: Link Rect: 49, 701, 140, 708 Annotation: Subtype: Link Rect: 253, 674, 290, 681 Annotation: Subtype: Link Rect: 49, 666, 120, 673 Annotation: Subtype: Link Rect: 49, 631, 134, 638 Annotation: Subtype: Link Rect: 304, 736, 391, 743 Annotation: Subtype: Link Rect: 508, 700, 545, 707 Annotation: Subtype: Link Rect: 304, 692, 339, 699 Annotation: Subtype: Link Rect: 335, 656, 436, 663 Annotation: Subtype: Link Rect: 490, 620, 545, 627 Annotation: Subtype: Link Rect: 304, 612, 329, 619 Annotation: Subtype: Link Rect: 455, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 119, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Thumb: true Checksum: 8708a0fc Type: CRC32 Checksum: 3f47ab7f04d42719cbfa337c6928c148 Type: MD5 Checksum: ed8ad22eeee797f979ead1ec94a87f3c3aef83f2 Type: SHA-1 Checksum: aec5355e5eda939c1fd94e3826b708584d18f3857c46850e978df598308771cc Type: SHA-256