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Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Patients and methods Destination: flink2 Children: Item: Title: Study design, data sources and setting Destination: slink1 Item: Title: Exposure Destination: slink2 Item: Title: Outcomes Destination: slink3 Item: Title: Statistical analyses Destination: slink4 Item: Title: Interrupted time series (ITS) analysis Destination: slink5 Item: Title: Data management and quality assessment Destination: slink6 Item: Title: Results Destination: flink3 Children: Item: Title: Use and discontinuation patterns of oral retinoids Destination: slink7 Item: Title: Contraception use while retinoid exposure and 90 days prior retinoid start Destination: slink8 Item: Title: Pregnancy testing prior and during retinoid exposure Destination: slink9 Item: Title: Pregnancy occurrence overall and relating to retinoid exposure Destination: slink10 Item: Title: Discussion Destination: flink4 Children: Item: Title: Strengths 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