59169e2e02d12fbf22ebf9a4cfc50ac8 fendo-14-1181744.pdf 33ad488777f3317c3d074a8e2e3ab9ca055c6447 fendo-14-1181744.pdf 930bad730b2b1613be7f02622ef3e43a2ef9b6977d1cd03d567aee8a9b5a4f1a fendo-14-1181744.pdf Keywords: incretin, microbiota, type 2 diabetes remission, severe obesity, bariatric surgery Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 5378628 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MGCOLF+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 637 0 MGCLFO+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 608 0 MGCLFP+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 609 0 MGCLGA+AdvPSA18C Type 1C WinAnsi yes yes no 610 0 MGCLGB+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 611 0 MGCLGC+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 612 0 MGCLGD+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 613 0 MGCLHE+AdvPSA323 Type 1C WinAnsi yes yes no 614 0 MGCLHF+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 615 0 MGCLHG+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 627 0 MGCLHH+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 628 0 MGCOLE+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 635 0 MGCOPE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 268 0 MGCOPF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 274 0 MGCOPG+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 275 0 MGCOPH+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 276 0 MGCPAI+AdvOTb65e897d.B Type 1C Custom yes yes yes 280 0 MGCPCI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 286 0 MGCPCJ+AdvOTd877c31c Type 1C WinAnsi yes yes no 287 0 MGCPHI+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 290 0 MGCPIJ+AdvTTc8b77491.I Type 1C WinAnsi yes yes no 291 0 MGFKGD+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 298 0 MGFKMB+AdvTT58d178b9+03 Type 1C Custom yes yes yes 305 0 MGFKMC+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 300 0 MGFKPC+AdvOT1ef757c0+22 Type 1C Custom yes yes no 307 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-09-24 03:51:58 CEST RepresentationInformation: fendo-14-1181744.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-09-23 16:25:12 CEST Size: 5378628 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 707 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass Destination: bmark_808170112 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Materials and methods Destination: s2 Children: Item: Title: 2.1 Surgical procedures Destination: s2_1 Item: Title: 2.2 T2D Remission Destination: s2_2 Item: Title: 2.3 Stool sample collection, DNA extraction, and metagenomic sequencing Destination: s2_3 Item: Title: 2.4 Statistical analysis of taxonomical and clinical features Destination: s2_4 Item: Title: 2.5 Statistical analysis Destination: s2_5 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Metabolic profile changes after surgery Destination: s3_1 Item: Title: 3.2 Evaluation of intestinal permeability Destination: s3_2 Item: Title: 3.3 Incretin profile changes with surgery Destination: s3_3 Item: Title: 3.4 Changes in gut microbiota and relationship with anthropometric parameters Destination: s3_4 Item: Title: 3.5 Gut microbiota and incretin response Destination: s3_5 Item: Title: 3.6 T2D remission Destination: s3_6 Item: Title: 4 Discussion Destination: s4 Children: Item: Title: 4.1 Association between gut microbiota, incretin response and metabolic parameters Destination: s4_1 Item: Title: 4.2 Gut permeability Destination: s4_2 Item: Title: 4.3 T2D remission predictors Destination: s4_3 Item: Title: 4.4 Limitations Destination: s4_4 Item: Title: 5 Conclusions Destination: s5 Item: Title: Data availability statement Destination: s6 Item: Title: Ethics statement Destination: s7 Item: Title: Author contributions Destination: s8 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: References Destination: bmark_2090415954 Info: Keywords: incretin, microbiota, type 2 diabetes remission, severe obesity, bariatric surgery ID: 0x3c22829a4f45c9453815804d45808861, 0x60605c1a29cf664da171c5c8c02ceb61 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1730 ImageHeight: 2055 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1448 ImageHeight: 1473 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3685 ImageHeight: 4739 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: MGCOPE+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: MGCOPE+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCOPF+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: MGCOPF+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCOPG+AdvOT3f84ef53 FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: MGCOPG+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCOPH+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: MGCOPH+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCPAI+AdvOTb65e897d.B FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: MGCPAI+AdvOTb65e897d.B Flags: Symbolic FontBBox: -20, -250, 968, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCPCI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: MGCPCI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCPCJ+AdvOTd877c31c FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: MGCPCJ+AdvOTd877c31c Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCLFO+AdvTTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 241 FontDescriptor: FontName: MGCLFO+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCLFP+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: MGCLFP+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCLGA+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: MGCLGA+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCPHI+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: MGCPHI+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCLGB+AdvTTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: MGCLGB+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCPIJ+AdvTTc8b77491.I FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: MGCPIJ+AdvTTc8b77491.I Flags: Nonsymbolic FontBBox: -145, -208, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCLGC+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: MGCLGC+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: MGCLGD+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: MGCLGD+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCLHE+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: MGCLHE+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGCLHF+AdvTT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: MGCLHF+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGFKGD+AdvTT9b12cd41+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: MGFKGD+AdvTT9b12cd41+22 Flags: Symbolic FontBBox: 0, -156, 552, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGFKMC+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: MGFKMC+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: MGFKMB+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: MGFKMB+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCLHG+AdvTT2c8ce45a FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: MGCLHG+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MGFKPC+AdvOT1ef757c0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: MGFKPC+AdvOT1ef757c0+22 Flags: Nonsymbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MGCLHH+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: MGCLHH+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MGCOLE+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: MGCOLE+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: MGCOLF+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: MGCOLF+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: Laura Hernández-Montoliu M-Mar Rodríguez-Peña Rocío Puig Brenno Astiarraga Fernando Guerrero-Pérez Nuria Virgili Rafael López-Urdiales Javier Osorio Rosa Monseny Claudio Lazzara Lucía Sobrino Manuel Pérez-Maraver María Pérez-Prieto Silvia Pellitero Sonia Fernández-Veledo Joan Vendrell Nuria Vilarrasa Hernández-Montoliu L, Rodríguez-Peña M-M, Puig R, Astiarraga B, Guerrero-Pérez F, Virgili N, López-Urdiales R, Osorio J, Monseny R, Lazzara C, Sobrino L, Pérez-Maraver M, Pérez-Prieto M, Pellitero S, Fernández-Veledo S, Vendrell J and Vilarrasa N (2023) A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass. Front. Endocrinol. 14:1181744 Copyright © 2023 Hernández-Montoliu, Rodríguez-Peña, Puig, Astiarraga, Guerrero-Pérez, Virgili, López-Urdiales, Osorio, Monseny, Lazzara, Sobrino, Pérez-Maraver, Pérez-Prieto, Pellitero, Fernández-Veledo, Vendrell and Vilarrasa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. incretin microbiota type 2 diabetes remission severe obesity bariatric surgery A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass incretin, microbiota, type 2 diabetes remission, severe obesity, bariatric surgery True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 464, 707 Annotation: Subtype: Link Rect: 222, 661, 518, 682 Annotation: Subtype: Link Rect: 222, 636, 492, 657 Annotation: Subtype: Link Rect: 222, 611, 452, 632 Annotation: Subtype: Link Rect: 222, 586, 502, 607 Annotation: Subtype: Link Rect: 222, 561, 469, 582 Annotation: Subtype: Link Rect: 222, 536, 436, 557 Annotation: Subtype: Link Rect: 222, 511, 358, 532 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 520, 116, 527 Annotation: Subtype: Link Rect: 60, 500, 135, 507 Annotation: Subtype: Link Rect: 49, 251, 155, 258 Annotation: Subtype: Link Rect: 121, 165, 180, 172 Annotation: Subtype: Link Rect: 49, 156, 133, 163 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 470, 793, 524, 800 Annotation: Subtype: Link Rect: 450, 783, 540, 790 Annotation: Subtype: Link Rect: 49, 797, 240, 813 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 281, 378, 285, 387 Destination: 165 Annotation: Subtype: Link Rect: 197, 290, 202, 299 Destination: 165 Annotation: Subtype: Link Rect: 213, 290, 217, 299 Destination: 165 Annotation: Subtype: Link Rect: 228, 290, 233, 299 Destination: 165 Annotation: Subtype: Link Rect: 240, 228, 245, 237 Destination: 165 Annotation: Subtype: Link Rect: 255, 228, 259, 237 Destination: 165 Annotation: Subtype: Link Rect: 269, 228, 273, 237 Destination: 165 Annotation: Subtype: Link Rect: 283, 228, 287, 237 Destination: 165 Annotation: Subtype: Link Rect: 52, 215, 57, 224 Destination: 165 Annotation: Subtype: Link Rect: 248, 203, 256, 212 Destination: 165 Annotation: Subtype: Link Rect: 265, 203, 274, 212 Destination: 165 Annotation: Subtype: Link Rect: 341, 431, 349, 440 Destination: 165 Annotation: Subtype: Link Rect: 360, 431, 369, 440 Destination: 165 Annotation: Subtype: Link Rect: 379, 431, 388, 440 Destination: 165 Annotation: Subtype: Link Rect: 399, 431, 407, 440 Destination: 165 Annotation: Subtype: Link Rect: 468, 431, 476, 440 Destination: 165 Annotation: Subtype: Link Rect: 487, 431, 496, 440 Destination: 165 Annotation: Subtype: Link Rect: 506, 431, 515, 440 Destination: 165 Annotation: Subtype: Link Rect: 417, 356, 426, 365 Destination: 165 Annotation: Subtype: Link Rect: 431, 318, 440, 327 Destination: 165 Annotation: Subtype: Link Rect: 534, 293, 542, 302 Destination: 165 Annotation: Subtype: Link Rect: 451, 181, 460, 190 Destination: 165 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 197, 231, 205, 240 Destination: 165 Annotation: Subtype: Link Rect: 519, 456, 527, 465 Destination: 165 Annotation: Subtype: Link Rect: 420, 119, 428, 128 Destination: 165 Annotation: Subtype: Link Rect: 355, 69, 527, 78 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 52, 644, 60, 653 Destination: 165 Annotation: Subtype: Link Rect: 146, 644, 154, 653 Destination: 165 Annotation: Subtype: Link Rect: 279, 644, 287, 653 Destination: 165 Annotation: Subtype: Link Rect: 206, 594, 215, 603 Destination: 165 Annotation: Subtype: Link Rect: 170, 506, 179, 515 Destination: 165 Annotation: Subtype: Link Rect: 123, 431, 131, 440 Destination: 165 Annotation: Subtype: Link Rect: 184, 419, 193, 428 Destination: 165 Annotation: Subtype: Link Rect: 126, 219, 134, 228 Destination: 165 Annotation: Subtype: Link Rect: 143, 219, 152, 228 Destination: 165 Annotation: Subtype: Link Rect: 160, 219, 169, 228 Destination: 165 Annotation: Subtype: Link Rect: 403, 669, 411, 678 Destination: 165 Annotation: Subtype: Link Rect: 446, 406, 477, 415 Destination: 62 Annotation: Subtype: Link Rect: 307, 269, 334, 278 Destination: 62 Annotation: Subtype: Link Rect: 380, 219, 411, 228 Destination: 74 Annotation: Subtype: Link Rect: 486, 69, 494, 78 Destination: 165 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 100, 210, 109, 219 Destination: 165 Annotation: Subtype: Link Rect: 185, 68, 215, 77 Destination: 84 Annotation: Subtype: Link Rect: 368, 444, 376, 453 Destination: 165 Annotation: Subtype: Link Rect: 359, 219, 389, 228 Destination: 93 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 128, 229, 158, 238 Destination: 93 Annotation: Subtype: Link Rect: 511, 104, 540, 113 Destination: 93 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 129, 287, 159, 296 Destination: 93 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 339, 159, 348, 168 Destination: 165 Annotation: Subtype: Link Rect: 357, 159, 365, 168 Destination: 165 Annotation: Subtype: Link Rect: 413, 147, 422, 156 Destination: 165 Annotation: Subtype: Link Rect: 433, 147, 441, 156 Destination: 165 Annotation: Subtype: Link Rect: 385, 122, 394, 131 Destination: 165 Annotation: Subtype: Link Rect: 403, 122, 412, 131 Destination: 165 Annotation: Subtype: Link Rect: 422, 122, 430, 131 Destination: 165 Annotation: Subtype: Link Rect: 440, 122, 448, 131 Destination: 165 Annotation: Subtype: Link Rect: 458, 122, 466, 131 Destination: 165 Annotation: Subtype: Link Rect: 476, 122, 485, 131 Destination: 165 Annotation: Subtype: Link Rect: 494, 122, 503, 131 Destination: 165 Annotation: Subtype: Link Rect: 337, 84, 345, 93 Destination: 165 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 130, 694, 139, 703 Destination: 230 Annotation: Subtype: Link Rect: 236, 669, 245, 678 Destination: 230 Annotation: Subtype: Link Rect: 52, 644, 62, 653 Destination: 230 Annotation: Subtype: Link Rect: 232, 619, 241, 628 Destination: 230 Annotation: Subtype: Link Rect: 97, 606, 105, 615 Destination: 230 Annotation: Subtype: Link Rect: 113, 606, 122, 615 Destination: 230 Annotation: Subtype: Link Rect: 130, 606, 138, 615 Destination: 230 Annotation: Subtype: Link Rect: 146, 606, 154, 615 Destination: 230 Annotation: Subtype: Link Rect: 279, 606, 287, 615 Destination: 230 Annotation: Subtype: Link Rect: 52, 594, 60, 603 Destination: 230 Annotation: Subtype: Link Rect: 89, 519, 97, 528 Destination: 230 Annotation: Subtype: Link Rect: 160, 469, 169, 478 Destination: 230 Annotation: Subtype: Link Rect: 153, 419, 161, 428 Destination: 230 Annotation: Subtype: Link Rect: 266, 381, 275, 390 Destination: 230 Annotation: Subtype: Link Rect: 131, 319, 140, 328 Destination: 230 Annotation: Subtype: Link Rect: 149, 319, 157, 328 Destination: 230 Annotation: Subtype: Link Rect: 277, 294, 285, 303 Destination: 230 Annotation: Subtype: Link Rect: 278, 269, 287, 278 Destination: 230 Annotation: Subtype: Link Rect: 52, 256, 61, 265 Destination: 230 Annotation: Subtype: Link Rect: 112, 256, 121, 265 Destination: 230 Annotation: Subtype: Link Rect: 275, 219, 285, 228 Destination: 230 Annotation: Subtype: Link Rect: 245, 81, 254, 90 Destination: 230 Annotation: Subtype: Link Rect: 329, 744, 337, 753 Destination: 230 Annotation: Subtype: Link Rect: 532, 694, 540, 703 Destination: 230 Annotation: Subtype: Link Rect: 531, 594, 540, 603 Destination: 230 Annotation: Subtype: Link Rect: 423, 556, 431, 565 Destination: 165 Annotation: Subtype: Link Rect: 524, 481, 532, 490 Destination: 230 Annotation: Subtype: Link Rect: 336, 394, 345, 403 Destination: 165 Annotation: Subtype: Link Rect: 353, 394, 362, 403 Destination: 165 Annotation: Subtype: Link Rect: 462, 381, 471, 390 Destination: 165 Annotation: Subtype: Link Rect: 480, 381, 488, 390 Destination: 230 Annotation: Subtype: Link Rect: 365, 94, 374, 103 Destination: 165 Annotation: Subtype: Link Rect: 383, 94, 392, 103 Destination: 230 Annotation: Subtype: Link Rect: 401, 94, 410, 103 Destination: 230 Annotation: Subtype: Link Rect: 419, 94, 427, 103 Destination: 230 Annotation: Subtype: Link Rect: 437, 94, 445, 103 Destination: 230 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 127, 354, 288, 363 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 266, 712, 290, 719 Annotation: Subtype: Link Rect: 49, 704, 103, 711 Annotation: Subtype: Link Rect: 178, 669, 231, 676 Annotation: Subtype: Link Rect: 151, 642, 231, 649 Annotation: Subtype: Link Rect: 141, 607, 221, 614 Annotation: Subtype: Link Rect: 263, 588, 290, 595 Annotation: Subtype: Link Rect: 49, 580, 108, 587 Annotation: Subtype: Link Rect: 155, 553, 208, 560 Annotation: Subtype: Link Rect: 62, 526, 139, 533 Annotation: Subtype: Link Rect: 251, 507, 290, 514 Annotation: Subtype: Link Rect: 49, 499, 63, 506 Annotation: Subtype: Link Rect: 72, 472, 144, 479 Annotation: Subtype: Link Rect: 62, 445, 121, 452 Annotation: Subtype: Link Rect: 154, 426, 247, 433 Annotation: Subtype: Link Rect: 203, 399, 284, 406 Annotation: Subtype: Link Rect: 99, 353, 168, 360 Annotation: Subtype: Link Rect: 62, 318, 120, 325 Annotation: Subtype: Link Rect: 264, 291, 290, 298 Annotation: Subtype: Link Rect: 49, 283, 109, 290 Annotation: Subtype: Link Rect: 126, 256, 203, 263 Annotation: Subtype: Link Rect: 244, 229, 290, 236 Annotation: Subtype: Link Rect: 49, 221, 84, 228 Annotation: Subtype: Link Rect: 213, 194, 290, 201 Annotation: Subtype: Link Rect: 62, 167, 143, 174 Annotation: Subtype: Link Rect: 62, 124, 111, 131 Annotation: Subtype: Link Rect: 62, 89, 143, 96 Annotation: Subtype: Link Rect: 411, 720, 489, 727 Annotation: Subtype: Link Rect: 506, 701, 545, 708 Annotation: Subtype: Link Rect: 304, 693, 318, 700 Annotation: Subtype: Link Rect: 479, 674, 543, 681 Annotation: Subtype: Link Rect: 317, 647, 401, 654 Annotation: Subtype: Link Rect: 470, 628, 545, 635 Annotation: Subtype: Link Rect: 304, 620, 331, 627 Annotation: Subtype: Link Rect: 521, 601, 545, 608 Annotation: Subtype: Link Rect: 304, 593, 338, 600 Annotation: Subtype: Link Rect: 446, 566, 524, 573 Annotation: Subtype: Link Rect: 446, 547, 494, 554 Annotation: Subtype: Link Rect: 437, 528, 541, 535 Annotation: Subtype: Link Rect: 522, 509, 545, 516 Annotation: Subtype: Link Rect: 304, 501, 363, 508 Annotation: Subtype: Link Rect: 374, 482, 430, 489 Annotation: Subtype: Link Rect: 317, 455, 361, 462 Annotation: Subtype: Link Rect: 317, 428, 378, 435 Annotation: Subtype: Link Rect: 398, 401, 489, 408 Annotation: Subtype: Link Rect: 317, 374, 396, 381 Annotation: Subtype: Link Rect: 347, 339, 416, 346 Annotation: Subtype: Link Rect: 381, 312, 462, 319 Annotation: Subtype: Link Rect: 415, 277, 492, 284 Annotation: Subtype: Link Rect: 439, 242, 494, 249 Annotation: Subtype: Link Rect: 500, 213, 545, 220 Annotation: Subtype: Link Rect: 304, 205, 336, 212 Annotation: Subtype: Link Rect: 522, 178, 545, 185 Annotation: Subtype: Link Rect: 304, 170, 345, 177 Annotation: Subtype: Link Rect: 317, 135, 394, 142 Annotation: Subtype: Link Rect: 317, 98, 372, 105 Annotation: Subtype: Link Rect: 399, 71, 457, 78 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 266, 742, 290, 749 Annotation: Subtype: Link Rect: 49, 734, 87, 741 Annotation: Subtype: Link Rect: 89, 699, 140, 706 Annotation: Subtype: Link Rect: 155, 672, 214, 679 Annotation: Subtype: Link Rect: 85, 637, 170, 644 Annotation: Subtype: Link Rect: 261, 610, 290, 617 Annotation: Subtype: Link Rect: 49, 602, 116, 609 Annotation: Subtype: Link Rect: 62, 567, 138, 574 Annotation: Subtype: Link Rect: 95, 532, 167, 539 Annotation: Subtype: Link Rect: 62, 497, 126, 504 Annotation: Subtype: Link Rect: 62, 470, 140, 477 Annotation: Subtype: Link Rect: 102, 435, 181, 442 Annotation: Subtype: Link Rect: 89, 400, 170, 407 Annotation: Subtype: Link Rect: 95, 365, 173, 372 Annotation: Subtype: Link Rect: 362, 750, 439, 757 Annotation: Subtype: Link Rect: 445, 731, 508, 738 Annotation: Subtype: Link Rect: 317, 696, 386, 703 Annotation: Subtype: Link Rect: 324, 669, 392, 676 Annotation: Subtype: Link Rect: 317, 634, 400, 641 Annotation: Subtype: Link Rect: 364, 607, 427, 614 Annotation: Subtype: Link Rect: 454, 580, 523, 587 Annotation: Subtype: Link Rect: 500, 553, 545, 560 Annotation: Subtype: Link Rect: 304, 545, 339, 552 Annotation: Subtype: Link Rect: 327, 510, 408, 517 Annotation: Subtype: Link Rect: 411, 483, 463, 490 Annotation: Subtype: Link Rect: 518, 464, 545, 471 Annotation: Subtype: Link Rect: 304, 456, 368, 463 Annotation: Subtype: Link Rect: 522, 437, 545, 444 Annotation: Subtype: Link Rect: 304, 429, 361, 436 Annotation: Subtype: Link Rect: 434, 402, 512, 409 Annotation: Subtype: Link Rect: 428, 375, 506, 382 Annotation: Subtype: Link Rect: 438, 346, 491, 353 Annotation: Subtype: Link Rect: 452, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 898100de Type: CRC32 Checksum: 59169e2e02d12fbf22ebf9a4cfc50ac8 Type: MD5 Checksum: 33ad488777f3317c3d074a8e2e3ab9ca055c6447 Type: SHA-1 Checksum: 930bad730b2b1613be7f02622ef3e43a2ef9b6977d1cd03d567aee8a9b5a4f1a Type: SHA-256