9487f1624f17b72a8aad224a9d082114 fimmu-14-1253121.pdf 4163c05e4f57d627348409b7245fb26e723fbdd4 fimmu-14-1253121.pdf 45afc95f0f1738b8e01e07ba5ea5788511c728932e44a7f5a2903d7adfb36ce6 fimmu-14-1253121.pdf Title: Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery Subject: There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Keywords: anti-beta-lactoglobulin, chronic fatigue syndrome, fibromyalgia, intestinal permeability, myalgic encephalomyelitis, zonulin Author: Franz Martín CreationDate: Mon Sep 4 03:16:28 2023 CEST ModDate: Mon Sep 4 03:16:28 2023 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 5004617 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AHDJEA+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 865 0 AHDJFB+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 867 0 AHDEIC+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 835 0 AHDEJD+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 836 0 AHDEJE+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 837 0 AHDEJF+AdvPSA18C Type 1C WinAnsi yes yes no 838 0 AHDEJG+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 839 0 AHDEJH+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 840 0 AHDEJI+AdvPSA323 Type 1C WinAnsi yes yes no 841 0 AHDEJJ+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 842 0 AHDEJK+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 855 0 AHDEKL+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 856 0 AHDEKM+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 857 0 AHDJKA+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 271 0 AHDJKB+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 278 0 AHDJKC+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 279 0 AHDJKD+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 272 0 AHDJND+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 284 0 AHDJNE+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 287 0 AHDJPE+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 288 0 AHDKAF+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 289 0 AHFJND+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 293 0 AHNCBB+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 295 0 AHNCBC+AdvTT58d178b9+03 Type 1C Custom yes yes yes 296 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-12-18 04:33:42 CET RepresentationInformation: fimmu-14-1253121.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-12-17 19:20:58 CET Size: 5004617 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 936 FreeObjects: 4 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery Destination: bmark_-1697401462 Children: Item: Title: Introduction Destination: s1 Item: Title: Methods Destination: s2 Children: Item: Title: Study design and participants Destination: s2_1 Item: Title: Data collection and clinical outcomes measures Destination: s2_2 Item: Title: Fatigue impact scale Destination: s2_3 Item: Title: Composite autonomic symptom score Destination: s2_4 Item: Title: Pittsburgh sleep quality index Destination: s2_5 Item: Title: Short form 36-item health survey Destination: s2_6 Item: Title: Collection of blood samples and processing Destination: s2_7 Item: Title: Quantification of intestinal barrier function biomarkers Destination: s2_8 Item: Title: Detection of human anti-β-lactoglobulin antibody levels Destination: s2_9 Item: Title: Statistical analysis Destination: s2_10 Item: Title: Results Destination: s3 Children: Item: Title: Baseline demographics and clinical characteristics of the study participants Destination: s3_1 Item: Title: Profile of biomarkers of intestinal barrier function and inflammation Destination: s3_2 Item: Title: Correlation analysis between intestinal function biomarkers and self-reported outcome measures Destination: s3_3 Item: Title: ROC analysis for each intestinal barrier function biomarker in FM and ME/CFS Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery Author: Franz Martín Subject: There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Keywords: anti-beta-lactoglobulin, chronic fatigue syndrome, fibromyalgia, intestinal permeability, myalgic encephalomyelitis, zonulin CreationDate: Mon Sep 04 03:16:28 CEST 2023 ModDate: Mon Sep 04 03:16:28 CEST 2023 ID: 0x60c99c58e00671581138e253c2b12ee1, 0xbe770485ff77904aabe01f22ccfc28ba Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 5434 ImageHeight: 1642 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 4685 ImageHeight: 3150 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 4620 ImageHeight: 3036 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: 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Alegre-Martín Beatriz Lobo Ana Maria González-Castro Javier Santos Joan Carles Domingo Joanna Jurek Jesús Castro-Marrero There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Copyright © 2023 Martín, Blanco-Suárez, Zambrano, Cáceres, Almirall, Alegre-Martín, Lobo, González-Castro, Santos, Domingo, Jurek and Castro-Marrero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery anti-beta-lactoglobulin chronic fatigue syndrome fibromyalgia intestinal permeability myalgic encephalomyelitis zonulin anti-beta-lactoglobulin, chronic fatigue syndrome, fibromyalgia, intestinal permeability, myalgic encephalomyelitis, zonulin True https://www.frontiersin.org/legal/copyright-statement 2023-09-04T09:16:28+08:00 2023-09-04T09:16:28+08:00 2023-09-04T09:16:28+08:00 uuid:05af9ac5-09b0-41e2-a708-9ed7101dce0b uuid:63673789-392d-4eb2-b8a0-9a2e057587e1 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 522, 707 Annotation: Subtype: Link Rect: 222, 661, 474, 682 Annotation: Subtype: Link Rect: 222, 636, 540, 657 Annotation: Subtype: Link Rect: 222, 611, 486, 632 Annotation: Subtype: Link Rect: 222, 586, 477, 607 Annotation: Subtype: Link Rect: 222, 561, 526, 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