7b10514a965c4239cb372f66a69d27af  320149.pdf
f1c3f580964dc35e74f12616ab1ce9ce358a296a  320149.pdf
4ce01d9bd6d2b18f4cb0a5c978f3ad4fdae038437153c923341b613f19012d47  320149.pdf

Title:           The international X-linked hypophosphataemia (XLH) registry: first interim analysis of baseline demographic, genetic and clinical data
Subject:         Orphanet Journal of Rare Diseases, https://doi.org/10.1186/s13023-023-02882-4
Keywords:        X-linked hypophosphataemia (XLH);Hypophosphataemic rickets;Rare disease;International;Natural history;Osteomalacia;Patient registry;;Fibroblast growth factor 23 (FGF23)
Author:           Gema Ariceta
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Wed Sep 27 00:07:52 2023 CEST
ModDate:         Mon Nov 20 12:48:39 2023 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           17
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1704064 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     46  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     53  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     48  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  no     457  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     51  0
IQCTMS+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes     50  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     47  0
TRARTP+WarnockPro-It                 Type 1C           WinAnsi          yes yes yes     49  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     52  0
NEDIDO+STIX-Regular                  Type 1C           Custom           yes yes yes     73  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    413  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     97  0
MyriadPro-Regular4                   Type 1C           WinAnsi          yes no  yes    380  0
OBPDLM+OpenSans-Light                Type 1C           Custom           yes yes no     387  0
OBPDLM+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     383  0
OBPDLM+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     393  0
OBPDLM+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     390  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-10-07 04:01:11 CEST
 RepresentationInformation: 320149.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-10-06 09:44:38 CEST
  Size: 1704064
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 567
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusion 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Registry identification
         Item: 
          Title: Registry design
         Item: 
          Title: Ethics
         Item: 
          Title: Participants in the first interim analysis
         Item: 
          Title: Criteria for verifying a diagnosis of XLH
         Item: 
          Title: Data capture and processing
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Registry participant demographics
         Item: 
          Title: Genetic testing and diagnosis
         Item: 
          Title: Clinical presentation
          Children: 
           Item: 
            Title: Bone conditions
           Item: 
            Title: Dental conditions
           Item: 
            Title: Renal conditions
           Item: 
            Title: Joint conditions
           Item: 
            Title: Orthopedic surgery
         Item: 
          Title: Auxological data
          Children: 
           Item: 
            Title: Lengthheight
           Item: 
            Title: Weight
           Item: 
            Title: Body mass index (BMI)
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: The international X-linked hypophosphataemia (XLH) registry: first interim analysis of baseline demographic, genetic and clinical data
    Author:  Gema Ariceta
    Subject: Orphanet Journal of Rare Diseases, https://doi.org/10.1186/s13023-023-02882-4
    Keywords: X-linked hypophosphataemia (XLH);Hypophosphataemic rickets;Rare disease;International;Natural history;Osteomalacia;Patient registry;;Fibroblast growth factor 23 (FGF23)
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Wed Sep 27 00:07:52 CEST 2023
    ModDate: Mon Nov 20 12:48:39 CET 2023
   ID: 0xf32fef464b2f60e2c717d10a232ed4c4, 0x680d43a2cda1d50f46e41aef27744303
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 81
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 74
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1961
      ImageHeight: 1070
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1772
      ImageHeight: 941
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1961
      ImageHeight: 1058
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1961
      ImageHeight: 1096
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1961
      ImageHeight: 1041
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TRARTP+WarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: TRARTP+WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: IQCTMS+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: IQCTMS+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NEDIDO+STIX-Regular
      FontSubset: true
      FirstChar: 30
      LastChar: 62
      FontDescriptor: 
       FontName: NEDIDO+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2023-09-26T22:07:52</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2023-11-20T12:48:39+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2023-11-20T12:48:39+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>X-linked hypophosphataemia (XLH);Hypophosphataemic rickets;Rare disease;International;Natural history;Osteomalacia;Patient registry;;Fibroblast growth factor 23 (FGF23)</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s13023-023-02882-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Orphanet Journal of Rare Diseases, https://doi.org/10.1186/s13023-023-02882-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>X-linked hypophosphataemia (XLH)</rdf:li>
               <rdf:li>Hypophosphataemic rickets</rdf:li>
               <rdf:li>Rare disease</rdf:li>
               <rdf:li>International</rdf:li>
               <rdf:li>Natural history</rdf:li>
               <rdf:li>Osteomalacia</rdf:li>
               <rdf:li>Patient registry</rdf:li>
               <rdf:li>Fibroblast growth factor 23 (FGF23)</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The international X-linked hypophosphataemia (XLH) registry: first interim analysis of baseline demographic, genetic and clinical data</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Gema Ariceta</rdf:li>
               <rdf:li> Signe Sparre Beck-Nielsen</rdf:li>
               <rdf:li> Annemieke M. Boot</rdf:li>
               <rdf:li> Maria Luisa Brandi</rdf:li>
               <rdf:li> Karine Briot</rdf:li>
               <rdf:li> Carmen de Lucas Collantes</rdf:li>
               <rdf:li> Francesco Emma</rdf:li>
               <rdf:li> Sandro Giannini</rdf:li>
               <rdf:li> Dieter Haffner</rdf:li>
               <rdf:li> Richard Keen</rdf:li>
               <rdf:li> Elena Levtchenko</rdf:li>
               <rdf:li> Outi Mӓkitie</rdf:li>
               <rdf:li> M. Zulf Mughal</rdf:li>
               <rdf:li> Ola Nilsson</rdf:li>
               <rdf:li> Dirk Schnabel</rdf:li>
               <rdf:li> Liana Tripto-Shkolnik</rdf:li>
               <rdf:li> Jonathan Liu</rdf:li>
               <rdf:li> Angela Williams</rdf:li>
               <rdf:li> Sue Wood</rdf:li>
               <rdf:li> M. Carola Zillikens</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s13023-023-02882-4</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s13023-023-02882-4</prism:url>
         <prism:doi>10.1186/s13023-023-02882-4</prism:doi>
         <prism:issn>1750-1172</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Orphanet Journal of Rare Diseases</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13023-023-02882-4</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:7d8c33db-96fb-41cb-ad9b-b2464e75541d</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:be5f8968-218e-4302-8028-931af80d00df</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:7d8c33db-96fb-41cb-ad9b-b2464e75541d</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-09-27T02:05:12Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Gema Ariceta</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1763-1098</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 66, 330, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 66, 538, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 58, 270, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 121, 560, 133, 548
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 558, 107, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 140, 546, 145, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 222, 522, 227, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 233, 522, 238, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 179, 474, 184, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 98, 378, 103, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 109, 378, 114, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 157, 306, 162, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 168, 306, 173, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 179, 306, 189, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 220, 270, 224, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 231, 270, 241, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 247, 270, 257, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 59, 174, 69, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 75, 174, 85, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 217, 102, 227, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 232, 102, 242, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 526, 607, 536, 595
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 304, 595, 314, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 320, 595, 330, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 382, 535, 387, 523
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 437, 451, 447, 439
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 403, 391, 413, 379
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 387, 319, 391, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 391, 259, 396, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 499, 139, 504, 127
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 609, 133, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 280, 585, 285, 573
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 152, 513, 157, 501
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 229, 381, 234, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 254, 297, 259, 285
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 200, 237, 205, 225
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 174, 177, 179, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 81, 116, 91, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 96, 116, 106, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 422, 668, 426, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 403, 608, 408, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 280, 320, 285, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 75
      Annotation: 
       Subtype: Link
       Rect: 244, 284, 249, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 522, 324, 527, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 496, 276, 501, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 506, 276, 510, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 515, 276, 520, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 304, 264, 309, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 384, 168, 389, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 84, 98, 89, 86
       Flags: Print
       AppearanceDictionary: true
       Destination: 98
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 84, 560, 89, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 270, 356, 275, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 280, 308, 285, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 123, 152, 128, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 251, 92, 255, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 336, 668, 341, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 411, 212, 416, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 511, 212, 516, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 332, 227, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 75, 320, 79, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 86, 140, 91, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
      Annotation: 
       Subtype: Link
       Rect: 179, 140, 184, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 136
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 345, 261, 350, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 354, 213, 359, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 365, 213, 370, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 374, 213, 379, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 383, 213, 388, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 393, 213, 402, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 407, 213, 417, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 356, 117, 366, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 280, 693, 285, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 248, 621, 258, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 181, 525, 185, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 192, 525, 201, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 257, 513, 262, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 114, 441, 119, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 124, 441, 129, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 134, 441, 144, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 252, 393, 257, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 265, 381, 275, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 204, 213, 214, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 164, 93, 174, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 388, 621, 398, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 475, 477, 486, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 335, 381, 345, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 347, 333, 357, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 481, 309, 491, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 353, 105, 363, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 681, 287, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 125, 657, 135, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 350
      Annotation: 
       Subtype: Link
       Rect: 95, 621, 105, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 350
      Annotation: 
       Subtype: Link
       Rect: 275, 585, 285, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 259, 117, 269, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 275, 117, 285, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 350
      Annotation: 
       Subtype: Link
       Rect: 223, 105, 232, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 461, 441, 471, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 424, 381, 434, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 350
      Annotation: 
       Subtype: Link
       Rect: 397, 345, 407, 332
       Flags: Print
       AppearanceDictionary: true
       Destination: 217
     Thumb: true
    Page: 
     Sequence: 15
     Thumb: true
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 667, 253, 659
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 631, 257, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 172, 604, 279, 596
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 145, 568, 272, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 165, 559, 289, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 550, 175, 542
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 514, 232, 506
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 200, 487, 272, 479
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 478, 128, 470
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 216, 442, 288, 434
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 433, 132, 425
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 207, 406, 285, 398
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 397, 106, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 218, 370, 290, 362
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 361, 128, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 334, 169, 326
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 271, 192, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 198, 244, 270, 236
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 235, 132, 227
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 186, 208, 258, 200
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 199, 132, 191
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 161, 163, 288, 155
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 154, 79, 146
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 136, 277, 128
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 127, 287, 119
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 118, 81, 110
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 100, 274, 92
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 703, 536, 695
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 658, 448, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 369, 622, 497, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 586, 488, 578
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 559, 532, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 550, 366, 542
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 491, 532, 526, 524
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 523, 430, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 505, 529, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 496, 521, 488
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 469, 535, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 460, 430, 452
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 429, 424, 523, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 415, 341, 407
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 379, 531, 371
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 465, 352, 537, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 343, 374, 335
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 307, 480, 299
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 372, 271, 478, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 398, 244, 529, 236
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 480, 208, 535, 200
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 199, 401, 191
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 172, 534, 164
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 136, 425, 128
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 509, 109, 531, 101
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 100, 426, 92
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 199, 703, 271, 695
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 694, 140, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 220, 676, 284, 668
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 667, 169, 659
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 243, 640, 289, 632
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 631, 158, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 259, 595, 281, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 586, 181, 578
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 243, 550, 289, 542
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 541, 158, 533
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 370eabb0
   Type: CRC32
  Checksum: 7b10514a965c4239cb372f66a69d27af
   Type: MD5
  Checksum: f1c3f580964dc35e74f12616ab1ce9ce358a296a
   Type: SHA-1
  Checksum: 4ce01d9bd6d2b18f4cb0a5c978f3ad4fdae038437153c923341b613f19012d47
   Type: SHA-256