dcb0dc0e6e78a5ef1b162c941c9ad24c 320336.pdf 79794d83296e7dab0f005052a8dd6d4b0bf5a597 320336.pdf 312ca18756a4b01438d83898ae3e1417ad6d1d8b869edf3a154d235bbba24805 320336.pdf Title: Oral fosfomycin for treatment of acute bacterial prostatitis caused by multidrug-resistant Enterobacterales Subject: Microbiol Spectr 2023.11:e02136-23 Keywords: fosfomycin-tromethamine, acute prostatitis, multidrug resistance Author: Joaquin Burgos, Yannick Hoyos-Mallecot, Carles Ferre-Losa, Maider Arando, Arnau Monforte, Tomas Pumarola, Ibai Los-Arcos, Vicenç Falcó Creator: Antenna XSL House Formatter V7.3 MR2 Linux : 7.3.3.60933 (2023-04-21T14:08+09) Producer: Antenna House PDF Output Library 7.3.1866; modified using iText 4.2.0 by 1T3XT CreationDate: Tue Oct 10 09:24:12 2023 CEST ModDate: Tue Oct 21 12:33:13 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 585 x 783 pts Page rot: 0 File size: 175034 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XVDRCC+MyriadPro-Regular Type 1C Custom yes yes yes 26 0 XVDRCC+MyriadPro-Semibold Type 1C Custom yes yes yes 27 0 XVDRCC+MyriadPro-Regular Type 1C Custom yes yes yes 28 0 XVDRCC+MyriadPro-It Type 1C Builtin yes yes yes 29 0 XVDRCC+MyriadPro-BoldSemiExt Type 1C Builtin yes yes yes 30 0 XVDRCC+MyriadPro-Light Type 1C Custom yes yes yes 31 0 XVDRCC+MyriadPro-Light Type 1C Custom yes yes yes 32 0 Times-Roman Type 1 WinAnsi no no no 2 0 XVDRCC+MyriadPro-Semibold Type 1C Custom yes yes yes 203 0 XVDRCC+MyriadPro-SemiboldIt Type 1C Builtin yes yes yes 310 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-22 03:54:43 CEST RepresentationInformation: 320336.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-21 12:33:42 CEST Size: 175034 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'table-caption-kriyadocs-T1_0' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 8' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 8' cannot be found ID: PDF-HUL-122 Offset: 172401 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 9' cannot be found ID: PDF-HUL-122 Offset: 172401 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'table-caption-kriyadocs-T1_0' cannot be found ID: PDF-HUL-122 Offset: 172401 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ref-para-kriyadocs-R 12' cannot be found ID: PDF-HUL-122 Offset: 172401 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: EN Outlines: Item: Title: Oral fosfomycin for treatment of acute bacterial prostatitis caused by multidrug-resistant Enterobacterales Children: Item: Title: MATERIALS AND METHODS Children: Item: Title: Study population and setting Item: Title: Outcome measures and definitions Item: Title: Culture, identification, and antibiotic susceptibility Item: Title: RESULTS Children: Item: Title: Baseline characteristics Item: Title: Etiology of acute prostatitis and antibiotic susceptibility Item: Title: Antimicrobial therapy Item: Title: DISCUSSION Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 51 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 796 ImageHeight: 136 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 33 ImageHeight: 32 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: XVDRCC+MyriadPro-Light FontSubset: true FirstChar: 99 LastChar: 128 FontDescriptor: FontName: XVDRCC+MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-SemiboldIt FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: XVDRCC+MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-Regular FontSubset: true FirstChar: 32 LastChar: 147 FontDescriptor: FontName: XVDRCC+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-Semibold FontSubset: true FirstChar: 32 LastChar: 129 FontDescriptor: FontName: XVDRCC+MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 973 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-Semibold FontSubset: true FirstChar: 44 LastChar: 130 FontDescriptor: FontName: XVDRCC+MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 973 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-Regular FontSubset: true FirstChar: 44 LastChar: 136 FontDescriptor: FontName: XVDRCC+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-It FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: XVDRCC+MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-BoldSemiExt FontSubset: true FirstChar: 49 LastChar: 53 FontDescriptor: FontName: XVDRCC+MyriadPro-BoldSemiExt Flags: Nonsymbolic FontBBox: -168, -250, 1362, 999 FontFile3: true ToUnicode: true Font: BaseFont: XVDRCC+MyriadPro-Light FontSubset: true FirstChar: 32 LastChar: 129 FontDescriptor: FontName: XVDRCC+MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdfOral fosfomycin for treatment of acute bacterial prostatitis caused by multidrug-resistant EnterobacteralesSpectrum02136-23Joaquin BurgosYannick Hoyos-MallecotCarles Ferre-LosaMaider ArandoArnau MonforteTomas PumarolaIbai Los-ArcosVicenç FalcóJoaquin BurgosYannick Hoyos-MallecotCarles Ferre-LosaMaider ArandoArnau MonforteTomas PumarolaIbai Los-ArcosVicenç FalcóAmerican Society for MicrobiologyCopyright © 2023 Burgos et al.This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.20232023To assess the feasibility of oral fosfomycin-tromethamine (FT) for the management of acute bacterial prostatitis (ABP) caused by multidrug-resistant (MDR) Enterobacterales. An observational study of adult patients diagnosed with ABP from Vall d’Hebron University Hospital (Barcelona, Spain), treated with oral FT. The primary outcome was clinical cure defined as symptom relief at the control visit, 2–4 weeks post-end of treatment. Secondary outcomes included microbiological cure, relapse, and adverse events related to the treatment. Eighteen patients with ABP caused by Enterobacterales (15 Escherichia coli and three Klebsiella pneumoniae) were included. Microorganisms were MDR bacteria [14 extended-spectrum beta-lactamase (ESBL) producers and two carbapenemase producing K. pneumoniae]. Patients received treatment with FT 3 g/48 hours during a median of 14 days (Q25–Q75, 12–17.75). Fifteen patients received a lead-in phase of intravenous suitable antimicrobial during a median of 7 days (Q25–Q75, 3.75–8). No patient had to stop treatment due to adverse events, and the only side effect reported in two patients was diarrhea. Clinical cure was achieved in all (18/18) patients and microbiological cure in 11/12 patients. After a median of follow-up of 5 months (Q25–Q75, 2–11), 2/18 patients relapsed with an orchitis and a new episode of ABP. FT is an attractive step-down therapy for ABP in patients with resistance or side effects to first-line drugs. The availability of oral treatment could reduce the use of the carbapenems, with a benefit in the quality of life of the patient, health costs, and an ecological impact.We present a brief but largest and interesting experience in which we use fosfomycin-tromethamine (FT) for the treatment of acute bacterial prostatitis (ABP) due to multiresistant bacteria. Our study provides new data that help to consider FT as a plausible alternative for treating ABP in patients with resistance or side effects to first-line drugs. The availability of an alternative oral treatment to avoid the use of the carbapenems could have important benefits in terms of quality of life of the patient, health costs, and an ecological impact.20230522202307122165-0497uuid:586c6948-ff73-4ad1-9992-7f5f27c9413fuuid:f4c13087-0920-486b-96a1-116368087f91 Antenna House PDF Output Library 7.3.1866; modified using iText 4.2.0 by 1T3XT Antenna XSL House Formatter V7.3 MR2 Linux : 7.3.3.60933 (2023-04-21T14:08+09) 2023-10-10T12:54:12+05:30 2025-10-21T03:33:13-07:00 2025-10-21T03:33:13-07:00 f117514b-e784-4b7e-8b64-f4da8613c185 1 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: CHECK_FOR_UPDATE_LOGO Rect: 505, 701, 544, 742 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: 10.1128/spectrum.02136-23 Rect: 450, 23, 534, 32 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: Commons Attribution 4.0 International license Rect: 391, 47, 530, 65 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: 1 Rect: 105, 579, 110, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 2 Rect: 208, 579, 213, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 3 Rect: 285, 579, 290, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 1 Rect: 354, 579, 359, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 1 Rect: 427, 579, 432, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 2 Rect: 502, 579, 507, 590 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 1 Rect: 64, 567, 69, 578 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 1 Rect: 116, 567, 121, 578 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 4 Rect: 220, 543, 226, 554 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: 1 Rect: 252, 135, 258, 146 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 2 Rect: 161, 111, 168, 122 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Contents: 10.1128/spectrum.02136-23 Rect: 450, 23, 534, 32 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: 3 Rect: 43, 699, 50, 710 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 4 Rect: 364, 663, 371, 674 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 5 Rect: 265, 639, 272, 650 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 6 Rect: 272, 627, 279, 638 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 7 Rect: 84, 147, 91, 158 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Contents: 10.1128/spectrum.02136-23 Rect: 450, 23, 534, 32 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: Table 1 Rect: 215, 621, 243, 632 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: null Annotation: Subtype: Link Contents: Table 1 Rect: 90, 383, 118, 394 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: null Annotation: Subtype: Link Contents: 5, Rect: 82, 329, 91, 340 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 8, Rect: 89, 329, 99, 340 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: null Annotation: Subtype: Link Contents: 9 Rect: 97, 329, 106, 340 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: null Annotation: Subtype: Link Contents: 10 Rect: 278, 281, 290, 292 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 11 Rect: 313, 257, 324, 268 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 12 Rect: 256, 221, 267, 232 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 4, Rect: 85, 149, 93, 160 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 12 Rect: 91, 149, 106, 160 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: null Annotation: Subtype: Link Contents: 5 Rect: 43, 125, 50, 136 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Annotation: Subtype: Link Contents: 10 Rect: 360, 113, 371, 124 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 24 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Contents: 10.1128/spectrum.02136-23 Rect: 450, 23, 534, 32 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: c Rect: 368, 701, 372, 711 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: a Rect: 287, 660, 291, 669 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Annotation: Subtype: Link Contents: b Rect: 125, 647, 129, 656 LastModified: D:20231010125412+05'30' Flags: Print ActionDest: 23 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1086/‌652861 Rect: 137, 527, 237, 537 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1128/‌Spectrum.‌00534-‌21 Rect: 98, 490, 237, 499 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1093/‌cid/‌cit704 Rect: 117, 406, 225, 415 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1016/‌j.‌ijantimicag.‌2017.‌01.‌020 Rect: 122, 368, 276, 378 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: EUCAST_‌files/‌Breakpoint_‌tables/‌v_‌13.‌0_‌Breakpoint_‌Tables.‌pdf Rect: 59, 340, 287, 358 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: org/‌10.‌1093/‌jac/‌dkaa126 Rect: 318, 548, 546, 567 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: 2021.‌37277 Rect: 318, 439, 546, 457 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1128/‌AAC.‌02611-‌15 Rect: 422, 401, 544, 411 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: https:‌/‌/‌doi.‌org/‌10.‌1093/‌jac/‌dkz015 Rect: 318, 364, 429, 373 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: ics11020198 Rect: 318, 317, 546, 336 LastModified: D:20231010125412+05'30' Flags: Print Annotation: Subtype: Link Contents: 10.1128/spectrum.02136-23 Rect: 450, 23, 534, 32 LastModified: D:20231010125412+05'30' Flags: Print Checksum: b351ff50 Type: CRC32 Checksum: dcb0dc0e6e78a5ef1b162c941c9ad24c Type: MD5 Checksum: 79794d83296e7dab0f005052a8dd6d4b0bf5a597 Type: SHA-1 Checksum: 312ca18756a4b01438d83898ae3e1417ad6d1d8b869edf3a154d235bbba24805 Type: SHA-256