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Title:           Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling
Subject:         CellReports, 42 (2023) 112375. doi:10.1016/j.celrep.2023.112375
Author:          Estibaliz Barrio-Alonso
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     Item: 
      Title: Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: TIMELESS displays a circadian pattern of expression in the mouse brain
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         Item: 
          Title: Conditional deletion of Timeless disrupts hippocampal-dependent memory in adult mice
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         Item: 
          Title: Timeless deficiency attenuates long-term potentiation and elevates basal neurotransmission in hippocampus
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         Item: 
          Title: ChIP-seq identifies TIMELESS as a potential transcription activator of hippocampal synaptic plasticity pathways
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         Item: 
          Title: TIMELESS positively regulates Pde4b expression that modulates cAMP levels and synaptic function in hippocampus
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         Item: 
          Title: Timeless deletion alters AMPA receptor function and spine densities in hippocampus
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         Item: 
          Title: PDE4B supplementation rescues fear memory and spine density phenotypes by modulating cAMP levels in Timeless CKO mice
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        Title: Discussion
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         Item: 
          Title: Limitations of the study
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        Title: Supplemental information
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        Title: Acknowledgments
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        Title: Declaration of interests
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            Title: Immunohistochemistry
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            Title: Western blotting
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            Title: Quantitative RT-PCR
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            Title: EEG/EMG wireless transmitter implantation
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            Title: Behavioral assays
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            Title: Stereotaxic surgery and hippocampal spine density analysis
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            Title: Chromatin immunoprecipitation (ChIP)
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            Title: Cyclic AMP ELISA measurement
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            Title: Hippocampal slice preparation
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            Title: Electrophysiology
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            Title: Chemicals
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          Title: Quantification and statistical analysis
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   Type: CRC32
  Checksum: 452365e72c494f24aca5c56c432d1c8f
   Type: MD5
  Checksum: 36691c1da39c5950e171bffeb9497abfa8b39995
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   Type: SHA-256