bf3cc8c1ec4a923ff2480f4fb4000180 13063_2023_Article_7787.pdf 98aa7b1d0f7024a55f44d766ee74a9439da22e25 13063_2023_Article_7787.pdf 1c2ac860f4ecff04f5ac65d213b6d3c1e3c3c20268d64ba3e8a7310881d1984e 13063_2023_Article_7787.pdf Title: Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial) Subject: Trials, https://doi.org/10.1186/s13063-023-07787-y Keywords: Lower limb radiculalgia;Pulsed radiofrequency;Dorsal root ganglion;Autologous conditioned serum Author: Marta Homs Riera Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Fri Nov 7 07:19:13 2025 CET ModDate: Mon Nov 10 11:53:11 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none 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RepresentationInformation: 13063_2023_Article_7787.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-26 16:18:46 CET Size: 2980395 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 304 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial) Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Discussion Item: Title: Trial registration {2a}{2b} Item: Title: Introduction {6a} Children: Item: Title: Study design Children: Item: Title: Objectives {7} Item: Title: Methods Children: Item: Title: Setting {9} Item: Title: Study population {10} Item: Title: Recruitment and informed consent Item: Title: Randomization {16a} {16b} {16c} Item: Title: Trial intervention and blinding {11a} {17a} Item: Title: Outcome measures and follow-up {12} Children: Item: Title: Primary outcome Item: Title: Secondary outcomes Item: Title: Data collection {18a} {18b} {19} {27} Item: Title: Monitoring, safety, and quality control Item: Title: Sample size {14} Item: Title: Statistical analysis {20a} {20b} {20c} {18b} Item: Title: Pain management Item: Title: Discussion Item: Title: Conclusions Children: Item: Title: Trial status Item: Title: Acknowledgements Item: Title: References Info: Title: Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial) Author: Marta Homs Riera Subject: Trials, https://doi.org/10.1186/s13063-023-07787-y Keywords: Lower limb radiculalgia;Pulsed radiofrequency;Dorsal root ganglion;Autologous conditioned serum Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Fri Nov 07 07:19:13 CET 2025 ModDate: Mon Nov 10 11:53:11 CET 2025 ID: 0x133a9e939f44944bb8d937b37abda963, 0x73f57b4ba3a76726625fbe669b17cf3b Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 115 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Fonts: Type1: Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: 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conditioned serum Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial) Marta Homs Riera Raimon Milà Ricard Valdés David Blay Rosa Maria Borràs David Parés springer.com springerlink.com springer.com springerlink.com Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 115, 508, 128, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 262, 66, 380, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 58, 321, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 197, 560, 202, 548 Flags: Print AppearanceDictionary: true Destination: 147 Annotation: Subtype: Link Rect: 59, 500, 64, 488 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