de4d7ce05c80f58de04700f1777213ca 2023_CellGenomics_Marletaz_etal.pdf 63254475e936a73adb67512a584454aec1125ab0 2023_CellGenomics_Marletaz_etal.pdf ef7c95177f353475180303c47b0706834729296005dd4f504483fe8368ce7631 2023_CellGenomics_Marletaz_etal.pdf Title: Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes Subject: Cell Genomics, 3 (2023) 100295. doi:10.1016/j.xgen.2023.100295 Author: Ferdinand Marlétaz Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Apr 14 01:51:08 2023 CEST ModDate: Tue Apr 18 09:13:26 2023 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 6585448 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AIKLHK+AdvPSHN-H Type 1C WinAnsi yes yes no 1415 0 AIKLMJ+AdvPSHN-HI Type 1C WinAnsi yes yes no 1419 0 AIKLMK+AdvPSHN-M Type 1C WinAnsi yes yes no 1421 0 AIKLML+AdvPSMPi6 Type 1C WinAnsi yes yes no 1423 0 AIKPHG+AdvPSHN-MI Type 1C WinAnsi yes yes no 1426 0 AIKPHH+AdvPSSym Type 1C WinAnsi yes yes no 1428 0 AIKPJH+Helvetica-Bold Type 1C WinAnsi yes yes no 1431 0 AIKLHK+AdvPSHN-H Type 1C WinAnsi yes yes no 1277 0 AECJOL+AdvPSA189 Type 1C WinAnsi yes yes no 1231 0 AECJOM+Advhelvneue-bi Type 1C WinAnsi yes yes no 1220 0 AIKLMK+AdvPSHN-M Type 1C Custom yes yes no 1221 0 AECJPN+AdvPSA183 Type 1C Custom yes yes no 1218 0 AECKAO+AdvP4C4E59 Type 1C Custom yes yes yes 1219 0 AIKPHG+AdvPSHN-MI Type 1C WinAnsi yes yes no 1262 0 AECKCA+Advhelvneue-italic Type 1C MacRoman yes yes no 1257 0 AIKPHH+AdvPSSym Type 1C WinAnsi yes yes no 1223 0 AIKPJH+Helvetica-Bold Type 1C WinAnsi yes yes no 1224 0 AIKLMJ+AdvPSHN-HI Type 1C WinAnsi yes yes no 1286 0 AECKPA+AdvP7DED Type 1C WinAnsi yes yes no 1290 0 AECKOO+AdvP4C4E74 Type 1C Custom yes yes yes 1281 0 AEDEGH+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1302 0 AEEGNG+AdvPS480274 Type 1C WinAnsi yes yes no 1320 0 AIKLML+AdvPSMPi6 Type 1C WinAnsi yes yes no 1318 0 AEEHBH+AdvTimes Type 1C WinAnsi yes yes no 1325 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-01-29 03:09:14 CET RepresentationInformation: 2023_CellGenomics_Marletaz_etal.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-01-28 06:16:17 CET Size: 6585448 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1502 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: The genome and developmental regulatory landscape of P. lividus Destination: slink3 Item: Title: Opposite trends of genomic architectural changes in sea urchins and vertebrates Destination: slink4 Item: Title: The expression of recently evolved sea urchin genes Destination: slink5 Item: Title: The origin of pmar/hbox12 genes Destination: slink6 Item: Title: Conservation and divergence of gene expression modules across deuterostomes Destination: slink7 Item: Title: Regulatory landmarks during sea urchin development Destination: slink8 Item: Title: Discussion Destination: flink9 Children: Item: Title: Limitations of the study Destination: slink10 Item: Title: Supplemental information Destination: falink11 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: acklink2 Item: Title: Declaration of interests Destination: acklink3 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink12 Children: Item: Title: Key resources table Destination: slink13 Item: Title: Resource availability Destination: slink14 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Method details Destination: slink15 Children: Item: Title: DNA extraction and sequencing Destination: tlink4 Item: Title: Genome assembly Destination: tlink5 Item: Title: Annotation Destination: tlink6 Item: Title: Long non-coding RNAs Destination: tlink7 Item: Title: Synteny and gene family reconstruction Destination: tlink8 Item: Title: Gene expression analyses Destination: tlink9 Item: Title: ATAC-seq Destination: tlink10 Item: Title: Cut&Tag Destination: tlink11 Item: Title: In situ hybridization Destination: tlink12 Item: Title: Overexpression of mRNA Destination: tlink13 Item: Title: Quantification and statistical analysis Destination: slink16 Info: Title: Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes Author: Ferdinand Marlétaz Subject: Cell Genomics, 3 (2023) 100295. doi:10.1016/j.xgen.2023.100295 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Apr 14 02:21:08 CEST 2023 ModDate: Tue Apr 18 09:43:26 CEST 2023 ID: 0x40da7fdefeb376bd675121843a995e6c, 0x41b8bd068919c7479dffd4b0056f2e9b Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1191 ImageHeight: 1191 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 68 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 68 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 325 ImageHeight: 325 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 376 ImageHeight: 324 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 296 ImageHeight: 281 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 325 ImageHeight: 377 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 376 ImageHeight: 376 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 849 ImageHeight: 782 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: AECKOO+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 48 FontDescriptor: FontName: AECKOO+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AECJPN+AdvPSA183 FontSubset: true FirstChar: 25 LastChar: 184 FontDescriptor: FontName: AECJPN+AdvPSA183 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 791 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AECKAO+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 128 FontDescriptor: FontName: AECKAO+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: AECJOM+Advhelvneue-bi FontSubset: true FirstChar: 45 LastChar: 120 FontDescriptor: FontName: AECJOM+Advhelvneue-bi Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLMK+AdvPSHN-M FontSubset: true FirstChar: 30 LastChar: 180 FontDescriptor: FontName: AIKLMK+AdvPSHN-M Flags: Nonsymbolic FontBBox: -156, -218, 1062, 802 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AIKLMJ+AdvPSHN-HI FontSubset: true FirstChar: 46 LastChar: 120 FontDescriptor: FontName: AIKLMJ+AdvPSHN-HI Flags: Nonsymbolic FontBBox: -156, -218, 1135, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLML+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: AIKLML+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLHK+AdvPSHN-H FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: AIKLHK+AdvPSHN-H Flags: Nonsymbolic FontBBox: -166, -229, 1093, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPHH+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: AIKPHH+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPJH+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 108 FontDescriptor: FontName: AIKPJH+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AEEGNG+AdvPS480274 FontSubset: true FirstChar: 43 LastChar: 66 FontDescriptor: FontName: AEEGNG+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AECKCA+Advhelvneue-italic FontSubset: true FirstChar: 40 LastChar: 223 FontDescriptor: FontName: AECKCA+Advhelvneue-italic Flags: Nonsymbolic FontBBox: -156, -208, 1104, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: AECKPA+AdvP7DED FontSubset: true FirstChar: 51 LastChar: 51 FontDescriptor: FontName: AECKPA+AdvP7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLMJ+AdvPSHN-HI FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: AIKLMJ+AdvPSHN-HI Flags: Nonsymbolic FontBBox: -156, -218, 1135, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLMK+AdvPSHN-M FontSubset: true FirstChar: 40 LastChar: 180 FontDescriptor: FontName: AIKLMK+AdvPSHN-M Flags: Nonsymbolic FontBBox: -156, -218, 1062, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AEEHBH+AdvTimes FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: AEEHBH+AdvTimes Flags: Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPHG+AdvPSHN-MI FontSubset: true FirstChar: 80 LastChar: 118 FontDescriptor: FontName: AIKPHG+AdvPSHN-MI Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLML+AdvPSMPi6 FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: AIKLML+AdvPSMPi6 Flags: Nonsymbolic FontBBox: 0, -177, 989, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AECJOL+AdvPSA189 FontSubset: true FirstChar: 46 LastChar: 122 FontDescriptor: FontName: AECJOL+AdvPSA189 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPHG+AdvPSHN-MI FontSubset: true FirstChar: 51 LastChar: 51 FontDescriptor: FontName: AIKPHG+AdvPSHN-MI Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPHH+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: AIKPHH+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AEDEGH+AdvPS3F4C13 FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: AEDEGH+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKPJH+Helvetica-Bold FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: AIKPJH+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: AIKLHK+AdvPSHN-H FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: AIKLHK+AdvPSHN-H Flags: Nonsymbolic FontBBox: -166, -229, 1093, 812 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.xgen.2023.100295 Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes Ferdinand Marlétaz Arnaud Couloux Julie Poulain Karine Labadie Corinne Da Silva Sophie Mangenot Benjamin Noel Albert J. Poustka Philippe Dru Cinta Pegueroles Marco Borra Elijah K. Lowe Guy Lhomond Lydia Besnardeau Stéphanie Le Gras Tao Ye Daria Gavriouchkina Roberta Russo Caterina Costa Francesca Zito Letizia Anello Aldo Nicosia Maria Antonietta Ragusa Marta Pascual M. Dolores Molina Aline Chessel Marta Di Carlo Xavier Turon Richard R. Copley Jean-Yves Exposito Pedro Martinez Vincenzo Cavalieri Smadar Ben Tabou de Leon Jenifer Croce Paola Oliveri Valeria Matranga Maria Di Bernardo Julia Morales Patrick Cormier Anne-Marie Geneviève Jean Marc Aury Valérie Barbe Patrick Wincker Maria Ina Arnone Christian Gache Thierry Lepage Cell Genomics, 3 (2023) 100295. doi:10.1016/j.xgen.2023.100295 The Author(s) journal Cell Genomics © 2023 The Author(s). 2666-979X 3 4 12 April 2023 2023-04-12 100295 100295 10.1016/j.xgen.2023.100295 https://doi.org/10.1016/j.xgen.2023.100295 2010-04-23 true 10.1016/j.xgen.2023.100295 elsevier.com sciencedirect.com VoR 10.1016/j.xgen.2023.100295 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-04-14T05:21:08+05:30 2023-04-18T12:43:26+05:30 2023-04-18T12:43:26+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:ec546c8b-6d37-4e19-bbaf-56caae70affe uuid:651ef9a0-e0bb-44f0-bcb8-526fcb6f156c http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 354, 510, 449, 520 Annotation: Subtype: Link Rect: 354, 498, 460, 508 Annotation: Subtype: Link Rect: 100, 48, 268, 56 Annotation: Subtype: Link Rect: 53, 58, 69, 74 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 135, 584, 141, 593 Destination: 1 Annotation: Subtype: Link Rect: 141, 584, 150, 593 Destination: 1 Annotation: Subtype: Link Rect: 150, 584, 153, 593 Destination: 1 Annotation: Subtype: Link Rect: 225, 584, 229, 593 Destination: 1 Annotation: Subtype: Link Rect: 286, 584, 290, 593 Destination: 1 Annotation: Subtype: Link Rect: 357, 584, 361, 593 Destination: 1 Annotation: Subtype: Link Rect: 435, 584, 438, 593 Destination: 1 Annotation: Subtype: Link Rect: 516, 584, 520, 593 Destination: 1 Annotation: Subtype: Link Rect: 115, 574, 119, 583 Destination: 1 Annotation: Subtype: Link Rect: 195, 574, 201, 583 Destination: 1 Annotation: Subtype: Link Rect: 201, 574, 204, 583 Destination: 1 Annotation: Subtype: Link Rect: 260, 574, 264, 583 Destination: 1 Annotation: Subtype: Link Rect: 340, 574, 343, 583 Destination: 1 Annotation: Subtype: Link Rect: 400, 574, 404, 583 Destination: 1 Annotation: Subtype: Link Rect: 467, 574, 471, 583 Destination: 1 Annotation: Subtype: Link Rect: 534, 574, 538, 583 Destination: 1 Annotation: Subtype: Link Rect: 130, 564, 134, 573 Destination: 1 Annotation: Subtype: Link Rect: 215, 564, 219, 573 Destination: 1 Annotation: Subtype: Link Rect: 252, 564, 256, 573 Destination: 1 Annotation: Subtype: Link Rect: 345, 564, 352, 573 Destination: 1 Annotation: Subtype: Link Rect: 419, 564, 427, 573 Destination: 1 Annotation: Subtype: Link Rect: 493, 564, 501, 573 Destination: 1 Annotation: Subtype: Link Rect: 117, 554, 124, 563 Destination: 1 Annotation: Subtype: Link Rect: 184, 554, 192, 563 Destination: 1 Annotation: Subtype: Link Rect: 249, 554, 256, 563 Destination: 1 Annotation: Subtype: Link Rect: 363, 554, 371, 563 Destination: 1 Annotation: Subtype: Link Rect: 435, 554, 439, 563 Destination: 1 Annotation: Subtype: Link Rect: 519, 554, 528, 563 Destination: 1 Annotation: Subtype: Link Rect: 528, 554, 536, 563 Destination: 1 Annotation: Subtype: Link Rect: 111, 544, 118, 553 Destination: 1 Annotation: Subtype: Link Rect: 183, 544, 190, 553 Destination: 1 Annotation: Subtype: Link Rect: 248, 544, 255, 553 Destination: 1 Annotation: Subtype: Link Rect: 335, 544, 339, 553 Destination: 1 Annotation: Subtype: Link Rect: 427, 544, 434, 553 Destination: 1 Annotation: Subtype: Link Rect: 502, 544, 512, 553 Destination: 1 Annotation: Subtype: Link Rect: 512, 544, 519, 553 Destination: 1 Annotation: Subtype: Link Rect: 131, 534, 138, 543 Destination: 1 Annotation: Subtype: Link Rect: 259, 534, 267, 543 Destination: 1 Annotation: Subtype: Link Rect: 327, 534, 331, 543 Destination: 1 Annotation: Subtype: Link Rect: 388, 534, 391, 543 Destination: 1 Annotation: Subtype: Link Rect: 466, 534, 474, 543 Destination: 1 Annotation: Subtype: Link Rect: 130, 524, 138, 533 Destination: 1 Annotation: Subtype: Link Rect: 198, 524, 205, 533 Destination: 1 Annotation: Subtype: Link Rect: 275, 524, 282, 533 Destination: 1 Annotation: Subtype: Link Rect: 381, 524, 388, 533 Destination: 1 Annotation: Subtype: Link Rect: 458, 524, 462, 533 Destination: 1 Annotation: Subtype: Link Rect: 522, 524, 526, 533 Destination: 1 Annotation: Subtype: Link Rect: 120, 514, 124, 523 Destination: 1 Annotation: Subtype: Link Rect: 200, 514, 203, 523 Destination: 1 Annotation: Subtype: Link Rect: 274, 514, 278, 523 Destination: 1 Annotation: Subtype: Link Rect: 361, 514, 370, 523 Destination: 1 Annotation: Subtype: Link Rect: 370, 514, 373, 523 Destination: 1 Annotation: Subtype: Link Rect: 119, 236, 193, 243 Annotation: Subtype: Link Rect: 220, 236, 301, 243 Annotation: Subtype: Link Rect: 53, 226, 207, 233 Annotation: Subtype: Link Rect: 53, 16, 69, 32 Annotation: Subtype: Link Rect: 380, 10, 538, 18 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 198, 644, 201, 652 Destination: 506 Annotation: Subtype: Link Rect: 252, 589, 256, 597 Destination: 506 Annotation: Subtype: Link Rect: 258, 589, 261, 597 Destination: 506 Annotation: Subtype: Link Rect: 98, 545, 102, 553 Destination: 506 Annotation: Subtype: Link Rect: 103, 545, 107, 553 Destination: 506 Annotation: Subtype: Link Rect: 111, 523, 115, 531 Destination: 506 Annotation: Subtype: Link Rect: 208, 490, 211, 499 Destination: 506 Annotation: Subtype: Link Rect: 133, 435, 137, 444 Destination: 544 Annotation: Subtype: Link Rect: 138, 435, 142, 444 Destination: 544 Annotation: Subtype: Link Rect: 90, 381, 97, 389 Destination: 544 Annotation: Subtype: Link Rect: 244, 370, 251, 378 Destination: 544 Annotation: Subtype: Link Rect: 253, 370, 260, 378 Destination: 544 Annotation: Subtype: Link Rect: 180, 326, 187, 334 Destination: 544 Annotation: Subtype: Link Rect: 133, 304, 140, 312 Destination: 544 Annotation: Subtype: Link Rect: 80, 249, 97, 258 Destination: 544 Annotation: Subtype: Link Rect: 106, 238, 113, 247 Destination: 544 Annotation: Subtype: Link Rect: 190, 238, 197, 247 Destination: 544 Annotation: Subtype: Link Rect: 142, 216, 149, 225 Destination: 544 Annotation: Subtype: Link Rect: 135, 194, 142, 203 Destination: 544 Annotation: Subtype: Link Rect: 144, 194, 151, 203 Destination: 544 Annotation: Subtype: Link Rect: 281, 139, 298, 148 Destination: 544 Annotation: Subtype: Link Rect: 85, 96, 92, 104 Destination: 544 Annotation: Subtype: Link Rect: 167, 85, 174, 93 Destination: 544 Annotation: Subtype: Link Rect: 197, 74, 204, 82 Destination: 544 Annotation: Subtype: Link Rect: 504, 665, 511, 674 Destination: 544 Annotation: Subtype: Link Rect: 513, 665, 520, 674 Destination: 544 Annotation: Subtype: Link Rect: 534, 545, 541, 553 Destination: 544 Annotation: Subtype: Link Rect: 542, 545, 549, 553 Destination: 544 Annotation: Subtype: Link Rect: 332, 512, 339, 521 Destination: 544 Annotation: Subtype: Link Rect: 441, 490, 448, 499 Destination: 544 Annotation: Subtype: Link Rect: 542, 468, 549, 477 Destination: 544 Annotation: Subtype: Link Rect: 357, 435, 364, 444 Destination: 544 Annotation: Subtype: Link Rect: 342, 402, 349, 411 Destination: 544 Annotation: Subtype: Link Rect: 460, 348, 467, 356 Destination: 544 Annotation: Subtype: Link Rect: 440, 158, 475, 166 Destination: 506 Annotation: Subtype: Link Rect: 503, 125, 539, 133 Destination: 506 Annotation: Subtype: Link Rect: 487, 70, 545, 78 Destination: 972 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 142, 70, 172, 78 Destination: 144 Annotation: Subtype: Link Rect: 182, 70, 215, 78 Destination: 506 Annotation: Subtype: Link Rect: 80, 52, 87, 60 Destination: 645 Annotation: Subtype: Link Rect: 90, 48, 120, 56 Destination: 144 Annotation: Subtype: Link Rect: 504, 74, 511, 82 Destination: 645 Annotation: Subtype: Link Rect: 357, 63, 364, 71 Destination: 544 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 125, 665, 132, 674 Destination: 544 Annotation: Subtype: Link Rect: 134, 665, 141, 674 Destination: 544 Annotation: Subtype: Link Rect: 145, 662, 181, 670 Destination: 506 Annotation: Subtype: Link Rect: 104, 629, 139, 637 Destination: 506 Annotation: Subtype: Link Rect: 123, 563, 163, 572 Destination: 506 Annotation: Subtype: Link Rect: 148, 519, 184, 528 Destination: 506 Annotation: Subtype: Link Rect: 194, 519, 227, 528 Destination: 506 Annotation: Subtype: Link Rect: 155, 486, 185, 495 Destination: 144 Annotation: Subtype: Link Rect: 126, 475, 157, 484 Destination: 144 Annotation: Subtype: Link Rect: 111, 432, 145, 440 Destination: 144 Annotation: Subtype: Link Rect: 99, 402, 106, 411 Destination: 645 Annotation: Subtype: Link Rect: 108, 402, 115, 411 Destination: 645 Annotation: Subtype: Link Rect: 120, 399, 161, 407 Destination: 506 Annotation: Subtype: Link Rect: 61, 377, 97, 385 Destination: 506 Annotation: Subtype: Link Rect: 108, 381, 115, 389 Destination: 645 Annotation: Subtype: Link Rect: 239, 366, 273, 374 Destination: 506 Annotation: Subtype: Link Rect: 78, 348, 85, 356 Destination: 645 Annotation: Subtype: Link Rect: 90, 344, 121, 352 Destination: 144 Annotation: Subtype: Link Rect: 177, 326, 184, 334 Destination: 544 Annotation: Subtype: Link Rect: 190, 322, 227, 330 Destination: 144 Annotation: Subtype: Link Rect: 190, 293, 197, 301 Destination: 645 Annotation: Subtype: Link Rect: 103, 256, 134, 265 Destination: 144 Annotation: Subtype: Link Rect: 144, 260, 151, 268 Destination: 544 Annotation: Subtype: Link Rect: 222, 234, 257, 243 Destination: 144 Annotation: Subtype: Link Rect: 189, 158, 220, 166 Destination: 144 Annotation: Subtype: Link Rect: 231, 158, 264, 166 Destination: 506 Annotation: Subtype: Link Rect: 284, 114, 298, 122 Destination: 506 Annotation: Subtype: Link Rect: 59, 103, 83, 111 Destination: 506 Annotation: Subtype: Link Rect: 255, 96, 262, 104 Destination: 645 Annotation: Subtype: Link Rect: 291, 74, 298, 82 Destination: 645 Annotation: Subtype: Link Rect: 61, 59, 96, 67 Destination: 144 Annotation: Subtype: Link Rect: 167, 48, 202, 56 Destination: 506 Annotation: Subtype: Link Rect: 440, 654, 447, 663 Destination: 645 Annotation: Subtype: Link Rect: 415, 589, 422, 597 Destination: 645 Annotation: Subtype: Link Rect: 351, 556, 358, 564 Destination: 544 Annotation: Subtype: Link Rect: 341, 497, 376, 506 Destination: 237 Annotation: Subtype: Link Rect: 417, 501, 424, 510 Destination: 544 Annotation: Subtype: Link Rect: 425, 501, 432, 510 Destination: 544 Annotation: Subtype: Link Rect: 542, 446, 549, 455 Destination: 544 Annotation: Subtype: Link Rect: 313, 432, 355, 440 Destination: 506 Annotation: Subtype: Link Rect: 379, 377, 410, 385 Destination: 237 Annotation: Subtype: Link Rect: 441, 355, 484, 363 Destination: 506 Annotation: Subtype: Link Rect: 502, 322, 532, 330 Destination: 237 Annotation: Subtype: Link Rect: 337, 282, 344, 290 Destination: 544 Annotation: Subtype: Link Rect: 346, 282, 353, 290 Destination: 544 Annotation: Subtype: Link Rect: 359, 278, 390, 287 Destination: 237 Annotation: Subtype: Link Rect: 397, 216, 404, 225 Destination: 544 Annotation: Subtype: Link Rect: 405, 216, 412, 225 Destination: 645 Annotation: Subtype: Link Rect: 313, 114, 347, 122 Destination: 237 Annotation: Subtype: Link Rect: 358, 114, 368, 122 Destination: 506 Annotation: Subtype: Link Rect: 436, 96, 443, 104 Destination: 544 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 55, 125, 90, 133 Destination: 258 Annotation: Subtype: Link Rect: 86, 92, 117, 100 Destination: 258 Annotation: Subtype: Link Rect: 125, 96, 132, 104 Destination: 645 Annotation: Subtype: Link Rect: 173, 70, 204, 78 Destination: 258 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 89, 457, 96, 466 Destination: 645 Annotation: Subtype: Link Rect: 61, 442, 97, 451 Destination: 506 Annotation: Subtype: Link Rect: 135, 432, 166, 440 Destination: 302 Annotation: Subtype: Link Rect: 105, 402, 112, 411 Destination: 645 Annotation: Subtype: Link Rect: 116, 399, 146, 407 Destination: 302 Annotation: Subtype: Link Rect: 165, 388, 198, 396 Destination: 506 Annotation: Subtype: Link Rect: 145, 359, 152, 367 Destination: 645 Annotation: Subtype: Link Rect: 226, 315, 233, 323 Destination: 645 Annotation: Subtype: Link Rect: 251, 260, 258, 268 Destination: 645 Annotation: Subtype: Link Rect: 124, 212, 154, 221 Destination: 302 Annotation: Subtype: Link Rect: 91, 190, 121, 199 Destination: 302 Annotation: Subtype: Link Rect: 222, 169, 255, 177 Destination: 506 Annotation: Subtype: Link Rect: 291, 161, 298, 170 Destination: 645 Annotation: Subtype: Link Rect: 79, 139, 86, 148 Destination: 645 Annotation: Subtype: Link Rect: 134, 128, 141, 137 Destination: 645 Annotation: Subtype: Link Rect: 61, 92, 102, 100 Destination: 506 Annotation: Subtype: Link Rect: 272, 63, 279, 71 Destination: 645 Annotation: Subtype: Link Rect: 284, 59, 298, 67 Destination: 506 Annotation: Subtype: Link Rect: 59, 48, 86, 56 Destination: 506 Annotation: Subtype: Link Rect: 387, 432, 417, 440 Destination: 302 Annotation: Subtype: Link Rect: 341, 322, 371, 330 Destination: 302 Annotation: Subtype: Link Rect: 425, 278, 458, 287 Destination: 302 Annotation: Subtype: Link Rect: 338, 245, 369, 254 Destination: 302 Annotation: Subtype: Link Rect: 423, 223, 454, 232 Destination: 302 Annotation: Subtype: Link Rect: 399, 205, 406, 214 Destination: 645 Annotation: Subtype: Link Rect: 310, 158, 344, 166 Destination: 506 Annotation: Subtype: Link Rect: 313, 103, 343, 111 Destination: 302 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 156, 304, 163, 312 Destination: 645 Annotation: Subtype: Link Rect: 120, 293, 127, 301 Destination: 645 Annotation: Subtype: Link Rect: 151, 205, 158, 214 Destination: 645 Annotation: Subtype: Link Rect: 169, 179, 201, 188 Destination: 333 Annotation: Subtype: Link Rect: 211, 183, 218, 192 Destination: 645 Annotation: Subtype: Link Rect: 244, 161, 251, 170 Destination: 544 Annotation: Subtype: Link Rect: 76, 128, 83, 137 Destination: 645 Annotation: Subtype: Link Rect: 99, 85, 102, 93 Destination: 544 Annotation: Subtype: Link Rect: 104, 85, 111, 93 Destination: 645 Annotation: Subtype: Link Rect: 261, 52, 264, 60 Destination: 544 Annotation: Subtype: Link Rect: 329, 293, 333, 301 Destination: 544 Annotation: Subtype: Link Rect: 334, 293, 341, 301 Destination: 645 Annotation: Subtype: Link Rect: 434, 223, 470, 232 Destination: 506 Annotation: Subtype: Link Rect: 378, 158, 408, 166 Destination: 333 Page: Label: 9 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 55, 640, 89, 648 Destination: 333 Annotation: Subtype: Link Rect: 193, 596, 223, 604 Destination: 333 Annotation: Subtype: Link Rect: 118, 567, 125, 575 Destination: 645 Annotation: Subtype: Link Rect: 155, 468, 162, 477 Destination: 645 Annotation: Subtype: Link Rect: 228, 413, 235, 422 Destination: 645 Annotation: Subtype: Link Rect: 216, 377, 246, 385 Destination: 414 Annotation: Subtype: Link Rect: 80, 366, 113, 374 Destination: 414 Annotation: Subtype: Link Rect: 195, 348, 201, 356 Destination: 544 Annotation: Subtype: Link Rect: 250, 348, 257, 356 Destination: 645 Annotation: Subtype: Link Rect: 79, 322, 116, 330 Destination: 414 Annotation: Subtype: Link Rect: 120, 256, 155, 265 Destination: 414 Annotation: Subtype: Link Rect: 135, 190, 165, 199 Destination: 414 Annotation: Subtype: Link Rect: 176, 194, 183, 203 Destination: 756 Annotation: Subtype: Link Rect: 395, 640, 428, 648 Destination: 414 Annotation: Subtype: Link Rect: 386, 611, 393, 619 Destination: 756 Annotation: Subtype: Link Rect: 455, 464, 485, 473 Destination: 144 Annotation: Subtype: Link Rect: 496, 468, 503, 477 Destination: 756 Annotation: Subtype: Link Rect: 439, 442, 469, 451 Destination: 450 Annotation: Subtype: Link Rect: 428, 402, 435, 411 Destination: 544 Annotation: Subtype: Link Rect: 441, 399, 477, 407 Destination: 450 Annotation: Subtype: Link Rect: 505, 399, 515, 407 Destination: 506 Annotation: Subtype: Link Rect: 436, 344, 468, 352 Destination: 450 Annotation: Subtype: Link Rect: 478, 348, 485, 356 Destination: 544 Annotation: Subtype: Link Rect: 487, 348, 494, 356 Destination: 645 Annotation: Subtype: Link Rect: 496, 348, 503, 356 Destination: 756 Annotation: Subtype: Link Rect: 357, 322, 391, 330 Destination: 450 Annotation: Subtype: Link Rect: 415, 322, 425, 330 Destination: 506 Annotation: Subtype: Link Rect: 394, 304, 401, 312 Destination: 544 Annotation: Subtype: Link Rect: 424, 238, 431, 247 Destination: 756 Annotation: Subtype: Link Rect: 436, 234, 467, 243 Destination: 450 Annotation: Subtype: Link Rect: 393, 190, 423, 199 Destination: 450 Annotation: Subtype: Link Rect: 433, 190, 471, 199 Destination: 506 Annotation: Subtype: Link Rect: 306, 169, 342, 177 Destination: 506 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 275, 260, 282, 268 Destination: 756 Annotation: Subtype: Link Rect: 203, 212, 240, 221 Destination: 450 Annotation: Subtype: Link Rect: 248, 216, 255, 225 Destination: 544 Annotation: Subtype: Link Rect: 140, 201, 180, 210 Destination: 506 Annotation: Subtype: Link Rect: 187, 205, 194, 214 Destination: 544 Annotation: Subtype: Link Rect: 142, 158, 180, 166 Destination: 506 Annotation: Subtype: Link Rect: 85, 128, 92, 137 Destination: 756 Annotation: Subtype: Link Rect: 99, 125, 136, 133 Destination: 450 Annotation: Subtype: Link Rect: 166, 125, 176, 133 Destination: 506 Annotation: Subtype: Link Rect: 200, 81, 236, 89 Destination: 506 Annotation: Subtype: Link Rect: 61, 48, 98, 56 Destination: 506 Annotation: Subtype: Link Rect: 406, 256, 437, 265 Destination: 144 Annotation: Subtype: Link Rect: 313, 234, 350, 243 Destination: 506 Annotation: Subtype: Link Rect: 336, 223, 370, 232 Destination: 450 Annotation: Subtype: Link Rect: 420, 201, 457, 210 Destination: 506 Annotation: Subtype: Link Rect: 381, 147, 418, 155 Destination: 450 Annotation: Subtype: Link Rect: 447, 147, 457, 155 Destination: 506 Annotation: Subtype: Link Rect: 440, 96, 457, 104 Destination: 756 Annotation: Subtype: Link Rect: 366, 70, 397, 78 Destination: 450 Page: Label: 12 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 196, 640, 227, 648 Destination: 144 Annotation: Subtype: Link Rect: 83, 556, 90, 564 Destination: 756 Annotation: Subtype: Link Rect: 248, 497, 279, 506 Destination: 144 Annotation: Subtype: Link Rect: 125, 410, 156, 418 Destination: 450 Annotation: Subtype: Link Rect: 187, 337, 194, 345 Destination: 544 Annotation: Subtype: Link Rect: 283, 249, 290, 257 Destination: 544 Annotation: Subtype: Link Rect: 291, 249, 298, 257 Destination: 544 Annotation: Subtype: Link Rect: 283, 205, 290, 214 Destination: 544 Annotation: Subtype: Link Rect: 291, 205, 298, 214 Destination: 544 Annotation: Subtype: Link Rect: 264, 147, 294, 155 Destination: 258 Annotation: Subtype: Link Rect: 482, 644, 489, 652 Destination: 645 Annotation: Subtype: Link Rect: 491, 644, 498, 652 Destination: 756 Annotation: Subtype: Link Rect: 397, 552, 428, 561 Destination: 333 Annotation: Subtype: Link Rect: 500, 490, 507, 499 Destination: 645 Annotation: Subtype: Link Rect: 330, 479, 337, 488 Destination: 756 Annotation: Subtype: Link Rect: 496, 457, 503, 466 Destination: 544 Annotation: Subtype: Link Rect: 504, 457, 511, 466 Destination: 645 Annotation: Subtype: Link Rect: 338, 424, 345, 433 Destination: 645 Annotation: Subtype: Link Rect: 442, 359, 449, 367 Destination: 756 Annotation: Subtype: Link Rect: 499, 359, 506, 367 Destination: 756 Annotation: Subtype: Link Rect: 514, 278, 545, 287 Destination: 414 Annotation: Subtype: Link Rect: 390, 238, 397, 247 Destination: 756 Annotation: Subtype: Link Rect: 399, 238, 406, 247 Destination: 756 Annotation: Subtype: Link Rect: 427, 190, 457, 199 Destination: 450 Annotation: Subtype: Link Rect: 462, 194, 469, 203 Destination: 544 Annotation: Subtype: Link Rect: 313, 158, 343, 166 Destination: 450 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 285, 589, 292, 597 Destination: 756 Annotation: Subtype: Link Rect: 74, 333, 173, 341 Destination: 972 Annotation: Subtype: Link Rect: 74, 322, 176, 330 Destination: 1045 Annotation: Subtype: Link Rect: 74, 278, 146, 287 Destination: 1045 Annotation: Subtype: Link Rect: 74, 158, 260, 166 Destination: 1205 Annotation: Subtype: Link Rect: 214, 116, 292, 123 Annotation: Subtype: Link Rect: 53, 107, 110, 114 Annotation: Subtype: Link Rect: 320, 216, 543, 223 Annotation: Subtype: Link Rect: 320, 207, 538, 214 Annotation: Subtype: Link Rect: 455, 185, 543, 192 Annotation: Subtype: Link Rect: 320, 176, 344, 183 Annotation: Subtype: Link Rect: 320, 154, 456, 161 Annotation: Subtype: Link Rect: 343, 123, 528, 130 Annotation: Subtype: Link Rect: 320, 111, 535, 118 Annotation: Subtype: Link Rect: 363, 70, 487, 77 Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 184, 624, 298, 631 Annotation: Subtype: Link Rect: 76, 614, 98, 621 Annotation: Subtype: Link Rect: 137, 573, 267, 580 Annotation: Subtype: Link Rect: 76, 522, 203, 529 Annotation: Subtype: Link Rect: 95, 481, 222, 488 Annotation: Subtype: Link Rect: 130, 450, 260, 457 Annotation: Subtype: Link Rect: 106, 418, 218, 425 Annotation: Subtype: Link Rect: 106, 386, 206, 393 Annotation: Subtype: Link Rect: 142, 355, 264, 362 Annotation: Subtype: Link Rect: 214, 314, 298, 321 Annotation: Subtype: Link Rect: 76, 304, 101, 311 Annotation: Subtype: Link Rect: 156, 273, 282, 280 Annotation: Subtype: Link Rect: 106, 232, 214, 239 Annotation: Subtype: Link Rect: 138, 190, 278, 197 Annotation: Subtype: Link Rect: 242, 159, 298, 166 Annotation: Subtype: Link Rect: 76, 149, 127, 156 Annotation: Subtype: Link Rect: 143, 99, 258, 106 Annotation: Subtype: Link Rect: 184, 58, 298, 65 Annotation: Subtype: Link Rect: 76, 48, 98, 55 Annotation: Subtype: Link Rect: 448, 665, 549, 672 Annotation: Subtype: Link Rect: 327, 655, 348, 662 Annotation: Subtype: Link Rect: 421, 614, 534, 621 Annotation: Subtype: Link Rect: 475, 573, 549, 580 Annotation: Subtype: Link Rect: 327, 564, 389, 571 Annotation: Subtype: Link Rect: 400, 522, 535, 529 Annotation: Subtype: Link Rect: 389, 481, 535, 488 Annotation: Subtype: Link Rect: 358, 440, 471, 447 Annotation: Subtype: Link Rect: 453, 399, 549, 406 Annotation: Subtype: Link Rect: 327, 390, 352, 397 Annotation: Subtype: Link Rect: 450, 349, 549, 356 Annotation: Subtype: Link Rect: 327, 339, 367, 346 Annotation: Subtype: Link Rect: 327, 327, 549, 333 Annotation: Subtype: Link Rect: 327, 317, 360, 324 Annotation: Subtype: Link Rect: 412, 295, 542, 302 Annotation: Subtype: Link Rect: 327, 282, 549, 289 Annotation: Subtype: Link Rect: 327, 273, 499, 280 Annotation: Subtype: Link Rect: 327, 260, 549, 267 Annotation: Subtype: Link Rect: 327, 251, 549, 258 Annotation: Subtype: Link Rect: 327, 241, 526, 248 Annotation: Subtype: Link Rect: 358, 200, 509, 207 Annotation: Subtype: Link Rect: 397, 159, 530, 166 Annotation: Subtype: Link Rect: 463, 108, 549, 115 Annotation: Subtype: Link Rect: 327, 99, 346, 106 Annotation: Subtype: Link Rect: 354, 48, 464, 55 Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 69, 646, 180, 653 Annotation: Subtype: Link Rect: 131, 605, 257, 612 Annotation: Subtype: Link Rect: 89, 564, 228, 571 Annotation: Subtype: Link Rect: 115, 541, 244, 548 Annotation: Subtype: Link Rect: 258, 519, 292, 526 Annotation: Subtype: Link Rect: 69, 510, 175, 517 Annotation: Subtype: Link Rect: 123, 469, 234, 476 Annotation: Subtype: Link Rect: 129, 428, 243, 435 Annotation: Subtype: Link Rect: 258, 396, 292, 403 Annotation: Subtype: Link Rect: 69, 386, 148, 393 Annotation: Subtype: Link Rect: 181, 345, 292, 352 Annotation: Subtype: Link Rect: 69, 336, 92, 343 Annotation: Subtype: Link Rect: 204, 295, 292, 302 Annotation: Subtype: Link Rect: 69, 285, 120, 292 Annotation: Subtype: Link Rect: 235, 244, 292, 251 Annotation: Subtype: Link Rect: 69, 235, 140, 242 Annotation: Subtype: Link Rect: 190, 194, 292, 201 Annotation: Subtype: Link Rect: 69, 184, 102, 191 Annotation: Subtype: Link Rect: 204, 162, 292, 169 Annotation: Subtype: Link Rect: 69, 153, 108, 160 Annotation: Subtype: Link Rect: 133, 112, 254, 119 Annotation: Subtype: Link Rect: 98, 70, 228, 77 Annotation: Subtype: Link Rect: 366, 665, 502, 672 Annotation: Subtype: Link Rect: 496, 643, 543, 650 Annotation: Subtype: Link Rect: 320, 633, 395, 640 Annotation: Subtype: Link Rect: 486, 592, 543, 599 Annotation: Subtype: Link Rect: 320, 583, 404, 590 Annotation: Subtype: Link Rect: 320, 542, 456, 549 Annotation: Subtype: Link Rect: 417, 511, 528, 518 Annotation: Subtype: Link Rect: 520, 470, 543, 477 Annotation: Subtype: Link Rect: 320, 460, 424, 467 Annotation: Subtype: Link Rect: 320, 429, 449, 436 Annotation: Subtype: Link Rect: 520, 397, 543, 404 Annotation: Subtype: Link Rect: 320, 388, 437, 395 Annotation: Subtype: Link Rect: 320, 375, 403, 382 Annotation: Subtype: Link Rect: 406, 375, 543, 382 Annotation: Subtype: Link Rect: 320, 366, 435, 373 Annotation: Subtype: Link Rect: 320, 325, 444, 332 Annotation: Subtype: Link Rect: 398, 294, 521, 301 Annotation: Subtype: Link Rect: 509, 262, 543, 269 Annotation: Subtype: Link Rect: 320, 253, 428, 260 Annotation: Subtype: Link Rect: 509, 212, 543, 219 Annotation: Subtype: Link Rect: 320, 202, 397, 209 Annotation: Subtype: Link Rect: 509, 180, 543, 187 Annotation: Subtype: Link Rect: 320, 171, 442, 178 Annotation: Subtype: Link Rect: 355, 130, 497, 137 Annotation: Subtype: Link Rect: 351, 99, 490, 106 Annotation: Subtype: Link Rect: 486, 58, 543, 65 Annotation: Subtype: Link Rect: 320, 48, 404, 55 Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 76, 636, 207, 643 Annotation: Subtype: Link Rect: 126, 604, 262, 611 Annotation: Subtype: Link Rect: 252, 562, 298, 569 Annotation: Subtype: Link Rect: 76, 552, 158, 559 Annotation: Subtype: Link Rect: 99, 520, 216, 527 Annotation: Subtype: Link Rect: 264, 478, 298, 485 Annotation: Subtype: Link Rect: 76, 468, 182, 475 Annotation: Subtype: Link Rect: 76, 417, 190, 424 Annotation: Subtype: Link Rect: 76, 403, 298, 410 Annotation: Subtype: Link Rect: 76, 394, 134, 401 Annotation: Subtype: Link Rect: 76, 380, 298, 387 Annotation: Subtype: Link Rect: 76, 371, 298, 378 Annotation: Subtype: Link Rect: 76, 361, 298, 368 Annotation: Subtype: Link Rect: 76, 352, 126, 359 Annotation: Subtype: Link Rect: 264, 319, 298, 326 Annotation: Subtype: Link Rect: 76, 310, 165, 317 Annotation: Subtype: Link Rect: 99, 268, 261, 275 Annotation: Subtype: Link Rect: 252, 235, 298, 242 Annotation: Subtype: Link Rect: 76, 226, 168, 233 Annotation: Subtype: Link Rect: 106, 174, 242, 181 Annotation: Subtype: Link Rect: 252, 142, 298, 149 Annotation: Subtype: Link Rect: 76, 132, 165, 139 Annotation: Subtype: Link Rect: 184, 90, 298, 97 Annotation: Subtype: Link Rect: 76, 81, 98, 88 Annotation: Subtype: Link Rect: 139, 48, 275, 55 Annotation: Subtype: Link Rect: 515, 665, 549, 672 Annotation: Subtype: Link Rect: 327, 655, 414, 662 Annotation: Subtype: Link Rect: 377, 614, 504, 621 Annotation: Subtype: Link Rect: 358, 573, 471, 580 Annotation: Subtype: Link Rect: 406, 541, 538, 548 Annotation: Subtype: Link Rect: 449, 510, 549, 517 Annotation: Subtype: Link Rect: 327, 500, 372, 507 Annotation: Subtype: Link Rect: 435, 459, 549, 466 Annotation: Subtype: Link Rect: 327, 450, 354, 457 Annotation: Subtype: Link Rect: 493, 409, 549, 416 Annotation: Subtype: Link Rect: 327, 399, 390, 406 Annotation: Subtype: Link Rect: 365, 358, 507, 365 Annotation: Subtype: Link Rect: 493, 317, 549, 324 Annotation: Subtype: Link Rect: 327, 308, 372, 315 Annotation: Subtype: Link Rect: 365, 276, 505, 283 Annotation: Subtype: Link Rect: 436, 244, 549, 251 Annotation: Subtype: Link Rect: 327, 235, 348, 242 Annotation: Subtype: Link Rect: 527, 203, 549, 210 Annotation: Subtype: Link Rect: 327, 194, 439, 201 Annotation: Subtype: Link Rect: 475, 162, 549, 169 Annotation: Subtype: Link Rect: 327, 153, 360, 160 Annotation: Subtype: Link Rect: 433, 112, 547, 119 Annotation: Subtype: Link Rect: 404, 80, 505, 87 Annotation: Subtype: Link Rect: 394, 48, 522, 55 Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 107, 655, 233, 662 Annotation: Subtype: Link Rect: 269, 625, 292, 632 Annotation: Subtype: Link Rect: 69, 615, 189, 622 Annotation: Subtype: Link Rect: 269, 585, 292, 592 Annotation: Subtype: Link Rect: 69, 575, 171, 582 Annotation: Subtype: Link Rect: 152, 536, 280, 543 Annotation: Subtype: Link Rect: 171, 505, 292, 512 Annotation: Subtype: Link Rect: 69, 496, 89, 503 Annotation: Subtype: Link Rect: 235, 465, 292, 472 Annotation: Subtype: Link Rect: 69, 456, 155, 463 Annotation: Subtype: Link Rect: 69, 416, 171, 423 Annotation: Subtype: Link Rect: 217, 386, 292, 393 Annotation: Subtype: Link Rect: 69, 376, 106, 383 Annotation: Subtype: Link Rect: 235, 346, 292, 353 Annotation: Subtype: Link Rect: 69, 336, 122, 343 Annotation: Subtype: Link Rect: 235, 297, 292, 303 Annotation: Subtype: Link Rect: 69, 287, 122, 294 Annotation: Subtype: Link Rect: 147, 257, 283, 264 Annotation: Subtype: Link Rect: 69, 207, 211, 214 Annotation: Subtype: Link Rect: 100, 177, 241, 184 Annotation: Subtype: Link Rect: 177, 147, 292, 154 Annotation: Subtype: Link Rect: 69, 137, 96, 144 Annotation: Subtype: Link Rect: 358, 646, 478, 653 Annotation: Subtype: Link Rect: 454, 615, 543, 622 Annotation: Subtype: Link Rect: 320, 605, 348, 612 Annotation: Subtype: Link Rect: 320, 565, 466, 572 Annotation: Subtype: Link Rect: 320, 553, 543, 560 Annotation: Subtype: Link Rect: 320, 543, 516, 550 Annotation: Subtype: Link Rect: 320, 513, 463, 520 Annotation: Subtype: Link Rect: 320, 482, 431, 489 Annotation: Subtype: Link Rect: 486, 451, 543, 458 Annotation: Subtype: Link Rect: 320, 441, 400, 448 Annotation: Subtype: Link Rect: 469, 410, 543, 417 Annotation: Subtype: Link Rect: 320, 401, 389, 408 Annotation: Subtype: Link Rect: 486, 370, 543, 377 Annotation: Subtype: Link Rect: 320, 361, 404, 367 Annotation: Subtype: Link Rect: 402, 339, 527, 346 Annotation: Subtype: Link Rect: 469, 299, 543, 306 Annotation: Subtype: Link Rect: 320, 289, 357, 296 Annotation: Subtype: Link Rect: 469, 268, 543, 275 Annotation: Subtype: Link Rect: 320, 258, 357, 265 Annotation: Subtype: Link Rect: 520, 237, 543, 244 Annotation: Subtype: Link Rect: 320, 227, 440, 234 Annotation: Subtype: Link Rect: 486, 187, 543, 194 Annotation: Subtype: Link Rect: 320, 178, 403, 184 Annotation: Subtype: Link Rect: 391, 137, 502, 144 Page: Label: 17.e1 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 271, 312, 277, 320 Destination: 756 Annotation: Subtype: Link Rect: 367, 309, 482, 316 Annotation: Subtype: Link Rect: 367, 299, 459, 306 Annotation: Subtype: Link Rect: 260, 290, 266, 298 Destination: 756 Annotation: Subtype: Link Rect: 367, 287, 521, 294 Annotation: Subtype: Link Rect: 262, 278, 268, 285 Destination: 756 Annotation: Subtype: Link Rect: 367, 274, 502, 282 Annotation: Subtype: Link Rect: 264, 265, 270, 273 Destination: 756 Annotation: Subtype: Link Rect: 367, 262, 494, 270 Annotation: Subtype: Link Rect: 367, 252, 436, 260 Annotation: Subtype: Link Rect: 259, 243, 266, 251 Destination: 756 Annotation: Subtype: Link Rect: 367, 240, 447, 247 Annotation: Subtype: Link Rect: 268, 231, 274, 238 Destination: 756 Annotation: Subtype: Link Rect: 367, 228, 516, 235 Annotation: Subtype: Link Rect: 249, 218, 255, 226 Destination: 756 Annotation: Subtype: Link Rect: 367, 215, 492, 223 Annotation: Subtype: Link Rect: 271, 206, 277, 214 Destination: 756 Annotation: Subtype: Link Rect: 367, 203, 537, 210 Annotation: Subtype: Link Rect: 267, 194, 273, 201 Destination: 756 Annotation: Subtype: Link Rect: 367, 190, 532, 198 Annotation: Subtype: Link Rect: 261, 182, 268, 189 Destination: 756 Annotation: Subtype: Link Rect: 367, 178, 518, 186 Annotation: Subtype: Link Rect: 264, 169, 270, 177 Destination: 756 Annotation: Subtype: Link Rect: 367, 166, 485, 173 Annotation: Subtype: Link Rect: 274, 157, 284, 164 Destination: 756 Annotation: Subtype: Link Rect: 367, 154, 499, 161 Annotation: Subtype: Link Rect: 261, 144, 271, 152 Destination: 756 Annotation: Subtype: Link Rect: 367, 141, 493, 149 Annotation: Subtype: Link Rect: 285, 132, 294, 140 Destination: 867 Annotation: Subtype: Link Rect: 367, 129, 433, 136 Annotation: Subtype: Link Rect: 248, 120, 257, 127 Destination: 867 Annotation: Subtype: Link Rect: 367, 116, 482, 124 Annotation: Subtype: Link Rect: 367, 106, 417, 114 Annotation: Subtype: Link Rect: 264, 98, 273, 105 Destination: 867 Annotation: Subtype: Link Rect: 367, 94, 441, 102 Annotation: Subtype: Link Rect: 257, 85, 266, 93 Destination: 867 Annotation: Subtype: Link Rect: 367, 82, 505, 89 Annotation: Subtype: Link Rect: 253, 73, 262, 80 Destination: 867 Annotation: Subtype: Link Rect: 367, 70, 481, 77 Page: Label: 17.e2 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 499, 296, 543, 305 Annotation: Subtype: Link Rect: 53, 285, 87, 294 Annotation: Subtype: Link Rect: 429, 253, 520, 261 Annotation: Subtype: Link Rect: 383, 154, 536, 162 Annotation: Subtype: Link Rect: 260, 143, 419, 151 Annotation: Subtype: Link Rect: 251, 647, 261, 654 Destination: 867 Annotation: Subtype: Link Rect: 360, 643, 478, 651 Annotation: Subtype: Link Rect: 253, 635, 262, 642 Destination: 867 Annotation: Subtype: Link Rect: 360, 631, 486, 639 Annotation: Subtype: Link Rect: 256, 622, 266, 630 Destination: 867 Annotation: Subtype: Link Rect: 360, 619, 443, 626 Annotation: Subtype: Link Rect: 261, 610, 267, 617 Destination: 756 Annotation: Subtype: Link Rect: 360, 607, 512, 614 Annotation: Subtype: Link Rect: 246, 597, 255, 605 Destination: 867 Annotation: Subtype: Link Rect: 360, 594, 469, 602 Annotation: Subtype: Link Rect: 267, 585, 273, 593 Destination: 645 Annotation: Subtype: Link Rect: 360, 582, 497, 589 Annotation: Subtype: Link Rect: 360, 572, 391, 579 Annotation: Subtype: Link Rect: 260, 563, 266, 570 Destination: 645 Annotation: Subtype: Link Rect: 360, 560, 491, 567 Annotation: Subtype: Link Rect: 360, 547, 471, 555 Annotation: Subtype: Link Rect: 252, 538, 261, 546 Destination: 867 Annotation: Subtype: Link Rect: 360, 535, 466, 542 Annotation: Subtype: Link Rect: 360, 523, 457, 530 Annotation: Subtype: Link Rect: 259, 514, 265, 521 Destination: 756 Annotation: Subtype: Link Rect: 360, 510, 482, 518 Annotation: Subtype: Link Rect: 240, 501, 246, 509 Destination: 756 Annotation: Subtype: Link Rect: 360, 498, 485, 505 Annotation: Subtype: Link Rect: 360, 488, 390, 496 Annotation: Subtype: Link Rect: 240, 418, 249, 425 Destination: 867 Annotation: Subtype: Link Rect: 260, 406, 266, 414 Destination: 544 Annotation: Subtype: Link Rect: 314, 384, 320, 392 Destination: 544 Annotation: Subtype: Link Rect: 263, 372, 269, 380 Destination: 544 Page: Label: 17.e3 Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 59, 651, 92, 659 Destination: 506 Annotation: Subtype: Link Rect: 365, 600, 376, 608 Destination: 867 Annotation: Subtype: Link Rect: 170, 589, 181, 597 Destination: 867 Annotation: Subtype: Link Rect: 264, 556, 275, 564 Destination: 867 Annotation: Subtype: Link Rect: 437, 519, 471, 528 Destination: 506 Annotation: Subtype: Link Rect: 542, 512, 549, 521 Destination: 756 Annotation: Subtype: Link Rect: 153, 442, 186, 451 Destination: 506 Annotation: Subtype: Link Rect: 447, 424, 457, 433 Destination: 867 Annotation: Subtype: Link Rect: 219, 337, 226, 345 Destination: 756 Annotation: Subtype: Link Rect: 539, 315, 549, 323 Destination: 867 Annotation: Subtype: Link Rect: 459, 216, 469, 225 Destination: 867 Annotation: Subtype: Link Rect: 511, 205, 518, 214 Destination: 756 Annotation: Subtype: Link Rect: 469, 194, 476, 203 Destination: 756 Annotation: Subtype: Link Rect: 87, 52, 98, 60 Destination: 867 Page: Label: 17.e4 Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 150, 676, 161, 685 Destination: 867 Annotation: Subtype: Link Rect: 419, 676, 429, 685 Destination: 867 Annotation: Subtype: Link Rect: 236, 665, 246, 674 Destination: 867 Annotation: Subtype: Link Rect: 414, 644, 421, 652 Destination: 756 Annotation: Subtype: Link Rect: 91, 545, 102, 553 Destination: 867 Annotation: Subtype: Link Rect: 532, 545, 543, 553 Destination: 867 Annotation: Subtype: Link Rect: 209, 442, 239, 451 Destination: 258 Annotation: Subtype: Link Rect: 417, 442, 543, 451 Annotation: Subtype: Link Rect: 53, 432, 97, 440 Annotation: Subtype: Link Rect: 373, 421, 407, 429 Destination: 506 Annotation: Subtype: Link Rect: 408, 424, 419, 433 Destination: 756 Annotation: Subtype: Link Rect: 468, 413, 478, 422 Destination: 867 Annotation: Subtype: Link Rect: 235, 391, 246, 400 Destination: 867 Annotation: Subtype: Link Rect: 477, 391, 488, 400 Destination: 867 Annotation: Subtype: Link Rect: 383, 370, 393, 378 Destination: 867 Annotation: Subtype: Link Rect: 326, 333, 359, 341 Destination: 506 Annotation: Subtype: Link Rect: 71, 304, 82, 312 Destination: 867 Annotation: Subtype: Link Rect: 355, 304, 366, 312 Destination: 867 Annotation: Subtype: Link Rect: 149, 293, 159, 301 Destination: 867 Annotation: Subtype: Link Rect: 444, 293, 451, 301 Destination: 756 Annotation: Subtype: Link Rect: 80, 271, 91, 279 Destination: 867 Annotation: Subtype: Link Rect: 522, 238, 529, 247 Destination: 645 Annotation: Subtype: Link Rect: 173, 205, 180, 214 Destination: 544 Annotation: Subtype: Link Rect: 145, 139, 155, 148 Destination: 867 Annotation: Subtype: Link Rect: 399, 128, 406, 137 Destination: 544 Page: Label: 17.e5 Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 173, 662, 205, 670 Destination: 506 Annotation: Subtype: Link Rect: 420, 644, 431, 652 Destination: 867 Annotation: Subtype: Link Rect: 502, 611, 513, 619 Destination: 867 Annotation: Subtype: Link Rect: 376, 596, 502, 604 Annotation: Subtype: Link Rect: 163, 519, 193, 528 Destination: 144 Annotation: Subtype: Link Rect: 450, 519, 486, 528 Destination: 506 Annotation: Subtype: Link Rect: 491, 512, 502, 521 Destination: 867 Annotation: Subtype: Link Rect: 394, 453, 429, 462 Destination: 506 Annotation: Subtype: Link Rect: 483, 453, 513, 462 Destination: 333 Annotation: Subtype: Link Rect: 401, 410, 439, 418 Destination: 506 Annotation: Subtype: Link Rect: 106, 377, 139, 385 Destination: 506 Annotation: Subtype: Link Rect: 276, 370, 283, 378 Destination: 756 Annotation: Subtype: Link Rect: 394, 117, 405, 126 Destination: 867 Annotation: Subtype: Link Rect: 365, 107, 376, 115 Destination: 867 Page: Label: 17.e6 Sequence: 24 Checksum: e930ac38 Type: CRC32 Checksum: de4d7ce05c80f58de04700f1777213ca Type: MD5 Checksum: 63254475e936a73adb67512a584454aec1125ab0 Type: SHA-1 Checksum: ef7c95177f353475180303c47b0706834729296005dd4f504483fe8368ce7631 Type: SHA-256