217b728bf98e549067954f2beffb08aa jcm-12-02339.pdf 73a6022f20985d5b7c9f625543dfcbd63232cf64 jcm-12-02339.pdf b54aec44bca46b68258e87488b0f33bbbd9aa3ac6fdc173974909d3adfd24a8f jcm-12-02339.pdf Title: Characteristics of Patients with Heart Failure and Advanced Chronic Kidney Disease (Stages 4–5) Not Undergoing Renal Replacement Therapy (ERCA-IC Study) Subject: Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Results: Forty percent of patients had a history of HF. The mean age was 78.2 8.8 years and the mean eGFR was 18.4 5.5 mL/min/1.73 m2. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04–2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up. Keywords: advanced chronic kidney disease; cardiorenal; heart failure; kidney dysfunction; prognosis; mortality Author: Sandra Valdivielso Moré, Miren Vicente Elcano, Anna García Alonso, Sergi Pascual Sanchez, Isabel Galceran Herrera, Francesc Barbosa Puig, Laia C. Belarte-Tornero, Sonia Ruiz-Bustillo, Ronald O. Morales Murillo, Clara Barrios, Joan Vime-Jubany and Nuria Farre Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 17 06:38:43 2023 CET ModDate: Fri Mar 17 06:40:30 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 559853 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 KPTLHL+VnURWPalladioL Type 1 Custom yes yes no 15 0 SFLJWE+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 UGUZDA+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 MOVSXD+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 GQWIGS+CMSY10 Type 1 Builtin yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 78 0 VOABOX+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 95 0 TTZKMB+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 103 0 IKOBOX+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 107 0 BFAGUL+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 111 0 JEZCCV+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes yes 115 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 132 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-03-07 04:51:28 CET RepresentationInformation: jcm-12-02339.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-03-06 15:21:04 CET Size: 559853 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 235 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Baseline Characteristics Destination: subsection.3.1 Item: Title: Outcomes Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Characteristics of Patients with Heart Failure and Advanced Chronic Kidney Disease (Stages 4 5) Not Undergoing Renal Replacement Therapy (ERCA-IC Study) Author: Sandra Valdivielso Moré, Miren Vicente Elcano, Anna García Alonso, Sergi Pascual Sanchez, Isabel Galceran Herrera, Francesc Barbosa Puig, Laia C. Belarte-Tornero, Sonia Ruiz-Bustillo, Ronald O. Morales Murillo, Clara Barrios, Joan Vime-Jubany and Nuria Farre Subject: Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Results: Forty percent of patients had a history of HF. The mean age was 78.2 8.8 years and the mean eGFR was 18.4 5.5 mL/min/1.73 m2. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04 2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up. 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