6e6e76a93a458f2be528e32f803a7431 328630.pdf 2701f736ac2b338286cd48008a55d4fd8cb84264 328630.pdf 59994e9a221037deac513794c947b4fa66155ab30c4c5256dabcef7e980968ea 328630.pdf Title: Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial Subject: This research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 g vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS. Keywords: chronic fatigue syndrome; beta-glucan; zinc; vitamin D3; vitamin B6; myalgic encephalomyelitis; mitochondria; non-restorative sleep; quality of life Author: Marcos Lacasa, Jose Alegre-Martin, Ramon Sanmartin Sentañes, Luisa Varela-Sende, Joanna Jurek and Jesus Castro-Marrero Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Oct 25 12:22:08 2023 CEST ModDate: Wed Oct 25 12:30:14 2023 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1116663 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CIQLLF+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZXDKIP+EURM10 Type 1 Builtin yes yes no 15 0 UQPCPE+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 JYQJSR+URWPalladioL-Roma Type 1 Custom yes yes no 24 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Item: Title: Participants Destination: subsection.2.1 Item: Title: Intervention Protocol Destination: subsection.2.2 Item: Title: Testing of Dietary Supplements Destination: subsection.2.3 Item: Title: Study Design and Procedures Destination: subsection.2.4 Item: Title: Primary Endpoint Destination: subsection.2.5 Item: Title: Secondary Endpoints Destination: subsection.2.6 Children: Item: Title: Sleep Quality Destination: subsubsection.2.6.1 Item: Title: Anxiety and Depression Destination: subsubsection.2.6.2 Item: Title: Health-Related Quality of Life Destination: subsubsection.2.6.3 Item: Title: Sample Size Estimation and Power Analysis Destination: subsection.2.7 Item: Title: Compliance Monitoring and Adverse Events Destination: subsection.2.8 Item: Title: Statistical Analysis Destination: subsection.2.9 Children: Item: Title: Independent Sample Analysis Destination: subsubsection.2.9.1 Item: Title: Paired Data Analysis Destination: subsubsection.2.9.2 Item: Title: Categorical Data Analysis Destination: subsubsection.2.9.3 Item: Title: Results Destination: section.3 Children: Item: Title: Participants’ Characteristics Destination: subsection.3.1 Item: Title: Changes in Fatigue Perception Destination: subsection.3.2 Item: Title: Changes in Sleep Quality, Anxiety/Depression, and Health-Related Quality of Life Destination: subsection.3.3 Children: Item: Title: Sleep Quality Assessment Destination: subsubsection.3.3.1 Item: Title: Anxiety and Depression Destination: subsubsection.3.3.2 Item: Title: Health-Related Quality of Life Destination: subsubsection.3.3.3 Item: Title: Clinical Safety and Intervention Tolerability Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions and Future Directions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial Author: Marcos Lacasa, Jose Alegre-Martin, Ramon Sanmartin Sentañes, Luisa Varela-Sende, Joanna Jurek and Jesus Castro-Marrero Subject: This research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 g vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS. 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