7f6ecb470b5910fc18cb0e7a8b00c143 12862_2023_Article_2172.pdf 2836ca25e0370b859445992cecdc915ae00036ef 12862_2023_Article_2172.pdf a50c0c8cea1ce5fed048bfc7e9bc92e0e497518c796ee86ed0f514d37d370f37 12862_2023_Article_2172.pdf Title: Heat-induced female biased sex ratio during development is not mitigated after prolonged thermal selection Subject: BMC Ecology and Evolution, https://doi.org/10.1186/s12862-023-02172-4 Keywords: Drosophila;Experimental evolution;Global warming;Climate change;Offspring sex ratio;Thermal adaptation;Thermal selection;Heat stress Author: Marta A. Santos Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Nov 2 15:25:54 2023 CET ModDate: Thu Nov 2 16:28:29 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1062887 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 71 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 72 0 MyriadPro-It Type 1C Custom yes no yes 73 0 MyriadPro-Regular2 Type 1C WinAnsi yes no no 277 0 MyriadPro-Light Type 1C Custom yes no yes 112 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 278 0 MyriadPro-Semibold Type 1C Custom yes no yes 113 0 WarnockPro-It Type 1C WinAnsi yes no yes 74 0 WarnockPro-Regular Type 1C Custom yes no yes 75 0 VHJDKI+MyriadPro-SemiboldIt Type 1C Custom yes yes yes 111 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 240 0 MTYAFF+Code2000 CID TrueType Identity-H yes yes yes 161 0 HWJRNP+MTMI Type 1C Custom yes yes no 187 0 HWJRNP+MTSYN Type 1C Custom yes yes no 188 0 HWJRNP+WarnockPro-It2 Type 1C Custom yes yes no 189 0 NYONHI+OpenSans-Extrabold Type 1C WinAnsi yes yes no 215 0 NYONHI+OpenSans-Bold Type 1C WinAnsi yes yes no 222 0 NYONHI+OpenSans-Light Type 1C Custom yes yes no 219 0 NYONHI+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 225 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-06-27 04:36:14 CEST RepresentationInformation: 12862_2023_Article_2172.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-06-26 18:50:48 CEST Size: 1062887 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 361 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Heat-induced female biased sex ratio during development is not mitigated after prolonged thermal selection Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Results Item: Title: Conclusions Item: Title: Background Item: Title: Results Item: Title: Discussion Children: Item: Title: High developmental temperatures can lead to female-biased sex ratios Item: Title: Sex ratio distortion does not respond to thermal selection Item: Title: Conclusions Item: Title: Methods Children: Item: Title: Population maintenance and thermal selection regimes Item: Title: Thermal plasticity assay Item: Title: Statistical methods Item: Title: Anchor 16 Item: Title: Acknowledgements Item: Title: References Info: Title: Heat-induced female biased sex ratio during development is not mitigated after prolonged thermal selection Author: Marta A. Santos Subject: BMC Ecology and Evolution, https://doi.org/10.1186/s12862-023-02172-4 Keywords: Drosophila;Experimental evolution;Global warming;Climate change;Offspring sex ratio;Thermal adaptation;Thermal selection;Heat stress Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Nov 02 15:25:54 CET 2023 ModDate: Thu Nov 02 16:28:29 CET 2023 ID: 0xb78984d419060489ed13ce1de57e8522, 0xf99118515152c6313400fb3079356f90 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 40 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 42 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 82 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 75 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: MTYAFF+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VHJDKI+MyriadPro-SemiboldIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: VHJDKI+MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular2 Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HWJRNP+MTMI FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: HWJRNP+MTMI Flags: Symbolic FontBBox: 0, -188, 637, 458 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HWJRNP+MTSYN FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: HWJRNP+MTSYN Flags: Symbolic FontBBox: 0, -83, 724, 583 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HWJRNP+WarnockPro-It2 FontSubset: true FirstChar: 17 LastChar: 32 FontDescriptor: FontName: HWJRNP+WarnockPro-It2 Flags: Symbolic FontBBox: -88, -221, 783, 709 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true CIDFontType2: Font: BaseFont: MTYAFF+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MTYAFF+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true XMP: 2023-11-02T14:25:54 Adobe InDesign 15.1 (Windows) 2023-11-02T16:28:29+01:00 2023-11-02T16:28:29+01:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Drosophila;Experimental evolution;Global warming;Climate change;Offspring sex ratio;Thermal adaptation;Thermal selection;Heat stress False application/pdf https://doi.org/10.1186/s12862-023-02172-4 BioMed Central BMC Ecology and Evolution, https://doi.org/10.1186/s12862-023-02172-4 Drosophila Experimental evolution Global warming Climate change Offspring sex ratio Thermal adaptation Thermal selection Heat stress Heat-induced female biased sex ratio during development is not mitigated after prolonged thermal selection Marta A. Santos Marta A. Antunes Afonso Grandela Ana Carromeu-Santos Ana S. Quina Mauro Santos Margarida Matos Pedro Simões 10.1186/s12862-023-02172-4 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s12862-023-02172-4 10.1186/s12862-023-02172-4 2730-7182 journal BMC Ecology and Evolution The Author(s) 2010-04-23 true 10.1186/s12862-023-02172-4 noindex springer.com springerlink.com uuid:c04b7a2c-e830-4771-8f4a-d64a0b127c48 uuid:7e112800-46b5-4273-8250-cab77fe66bd5 default 1 converted uuid:c04b7a2c-e830-4771-8f4a-d64a0b127c48 converted to PDF/A-2b pdfToolbox 2023-11-02T14:41:15Z 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 68, 330, 60 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 68, 538, 60 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 60, 270, 52 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 268, 631, 273, 619 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 280, 631, 285, 619 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 207, 607, 212, 595 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 217, 607, 222, 595 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 191, 595, 196, 583 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 203, 595, 208, 583 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 174, 547, 179, 535 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 185, 547, 190, 535 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 196, 547, 205, 535 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 80, 511, 90, 499 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 96, 511, 105, 499 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 188, 487, 193, 475 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 63, 439, 72, 427 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 116, 439, 126, 427 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 174, 403, 179, 391 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 59, 307, 69, 295 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 123, 247, 133, 235 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 138, 247, 148, 235 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 252, 247, 262, 235 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 241, 139, 251, 127 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 196, 103, 206, 91 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 482, 704, 492, 692 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 361, 656, 371, 644 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 496, 632, 506, 620 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 413, 524, 418, 512 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 380, 512, 390, 500 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 395, 512, 405, 500 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 378, 488, 388, 476 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 394, 488, 403, 476 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 333, 428, 343, 416 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 388, 380, 398, 368 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 404, 380, 414, 368 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 382, 356, 392, 344 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 398, 356, 408, 344 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 413, 356, 423, 344 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 429, 356, 439, 344 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 308, 344, 318, 332 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 323, 344, 333, 332 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 418, 320, 428, 308 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 525, 320, 535, 308 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 441, 308, 451, 296 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 394, 260, 404, 248 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 408, 260, 418, 248 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 482, 248, 491, 236 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 523, 212, 533, 200 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 509, 152, 518, 140 Flags: Print AppearanceDictionary: true Destination: 208 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 148, 571, 153, 559 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 92, 547, 97, 535 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 97, 511, 102, 499 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 280, 499, 285, 487 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 223, 475, 228, 463 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 82, 427, 87, 415 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 161, 391, 170, 379 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 277, 367, 287, 355 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 82, 307, 91, 295 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 131, 307, 136, 295 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 368, 467, 378, 455 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 500, 443, 505, 431 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 396, 419, 401, 407 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 469, 407, 474, 395 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 424, 383, 434, 371 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 500, 359, 505, 347 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 406, 335, 411, 323 Flags: Print AppearanceDictionary: true Destination: 77 Annotation: Subtype: Link Rect: 370, 311, 380, 299 Flags: Print AppearanceDictionary: true Destination: 168 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 233, 681, 243, 668 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 247, 681, 257, 668 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 268, 633, 278, 620 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 154, 573, 159, 560 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 224, 525, 228, 512 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 235, 525, 240, 512 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 85, 501, 95, 488 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 248, 489, 258, 476 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 230, 381, 240, 368 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 259, 345, 269, 332 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 275, 345, 285, 332 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 145, 321, 155, 308 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 280, 285, 285, 272 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 157, 201, 162, 188 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 168, 201, 173, 188 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 163, 177, 167, 164 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 163, 129, 173, 116 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 177, 129, 187, 116 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 264, 93, 275, 80 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 502, 561, 512, 548 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 363, 297, 373, 284 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 378, 177, 383, 164 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 308, 129, 318, 116 Flags: Print AppearanceDictionary: true Destination: 208 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 207, 603, 217, 590 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 216, 357, 225, 345 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 59, 321, 69, 309 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 473, 645, 483, 633 Flags: Print AppearanceDictionary: true Destination: 208 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 154, 693, 164, 680 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 81, 609, 91, 596 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 232, 609, 242, 596 Flags: Print AppearanceDictionary: true Destination: 168 Annotation: Subtype: Link Rect: 88, 585, 98, 572 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 105, 585, 115, 572 Flags: Print AppearanceDictionary: true Destination: 201 Annotation: Subtype: Link Rect: 90, 525, 100, 512 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 410, 561, 420, 548 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 414, 549, 424, 536 Flags: Print AppearanceDictionary: true Destination: 208 Annotation: Subtype: Link Rect: 496, 510, 529, 501 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 501, 404, 492 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 7 Thumb: true Page: Sequence: 8 Thumb: true Checksum: 73fe024e Type: CRC32 Checksum: 7f6ecb470b5910fc18cb0e7a8b00c143 Type: MD5 Checksum: 2836ca25e0370b859445992cecdc915ae00036ef Type: SHA-1 Checksum: a50c0c8cea1ce5fed048bfc7e9bc92e0e497518c796ee86ed0f514d37d370f37 Type: SHA-256