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Title:           MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists
Subject:         Cell Death and Disease, doi:10.1038/s41419-023-06229-6
Keywords:        
Author:          Sergio Espinosa-Gil
Creator:         Springer
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     Item: 
      Title: MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists
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       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: ERK5 kinase activity modulates sensitivity of cancer cell to DR agonists
          Destination: B1
         Item: 
          Title: ERK5 inhibition does not affect apoptosis-related transcriptional programs
          Destination: B2
         Item: 
          Title: ERK5 inhibition or genetic deletion induces TP53INP2 protein levels to sensitize cancer cells to DR agonists
          Destination: B3
         Item: 
          Title: ERK5 phosphorylates and modulates TP53INP2 protein stability
          Destination: B4
         Item: 
          Title: ERK5 inhibition or its genetic deletion sensitize EC cells to TRAIL/FasL expressed by natural killer’cells
          Destination: B5
         Item: 
          Title: ERK5 inhibition sensitizes EC patient-derived xenograft organoids (PDXOs) to TRAIL-induced toxicity
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       Item: 
        Title: Discussion
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       Item: 
        Title: Materials and methods
        Destination: A4
        Children: 
         Item: 
          Title: Reagents
          Destination: B7
         Item: 
          Title: DNA constructs
          Destination: B8
         Item: 
          Title: Cells, cell culture and transfection
          Destination: B9
         Item: 
          Title: Generation of MEK5, ERK5 and TP53INP2 knockout cells by CRISPR/Cas9 technology
          Destination: B10
         Item: 
          Title: Cell lysis, immunoblotting and immunoprecipitation
          Destination: B11
         Item: 
          Title: Cell viability and clonogenic’assays
          Destination: B12
         Item: 
          Title: Flow cytometry analysis of apoptosis
          Destination: B13
         Item: 
          Title: Caspase-8 activity’assay
          Destination: B14
         Item: 
          Title: In vitro radiochemical ERK5 kinase activity’assay
          Destination: B15
         Item: 
          Title: In vivo TP53INP2 ubiquitination’assay
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         Item: 
          Title: Phosphoproteomic analysis
          Destination: B17
         Item: 
          Title: Generation of EC patient-derived xenograft organoids (PDXOs)
          Destination: B18
         Item: 
          Title: Viability assays in 3D cultures and EC’PDXOs
          Destination: B19
         Item: 
          Title: EC PDXOs immunofluorescence microscopy
          Destination: B20
         Item: 
          Title: RNA-seq analysis
          Destination: B21
         Item: 
          Title: Natural killer cell amplification and immunophenotyping characterization
          Destination: B22
         Item: 
          Title: Natural killer cell cytotoxicity’assay
          Destination: B23
         Item: 
          Title: Schematics and statistical analysis
          Destination: B24
       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Funding
        Destination: A8
       Item: 
        Title: Competing interests
        Destination: A9
       Item: 
        Title: Ethics approval and consent to participate
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       Item: 
        Title: ADDITIONAL INFORMATION
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    Subject: Cell Death and Disease, doi:10.1038/s41419-023-06229-6
    Keywords: 
    Creator: Springer
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