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s2_2 Item: Title: 2.3 Ethics statement Destination: s2_3 Item: Title: 2.4 Response criteria Destination: s2_4 Item: Title: 2.5 Viral antibody quantification Destination: s2_5 Item: Title: 2.6 sNfL quantification Destination: s2_6 Item: Title: 2.7 Statistical analysis Destination: s2_7 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Patients recruited according to the inclusion criteria Destination: s3_1 Item: Title: 3.2 Variation of antiviral IgG titers and Nf-L levels after 6 months with teriflunomide Destination: s3_2 Item: Title: 3.3 Clinical and radiological response after 2 years of treatment with teriflunomide Destination: s3_3 Item: Title: 3.4 Demographic, clinical, radiological, and environmental data to identify early biomarkers of response to teriflunomide Destination: s3_4 Item: Title: 4 Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions 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García-Martínez MÁ, Arroyo R and Álvarez-Lafuente R (2023) Teriflunomide and Epstein–Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response. Front. Immunol. 14:1248182 Copyright © 2023 Domínguez-Mozo, González-Suárez, Villar, Costa-Frossard, Villarrubia, Aladro, Pilo, Montalbán, Comabella, Casanova-Peño, Martínez-Ginés, García-Domínguez, García-Martínez, Arroyo and Álvarez-Lafuente. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. multiple sclerosis teriflunomide biomarker EDSS EBV HHV-6 NF-L ELISA Teriflunomide and Epstein–Barr virus in a Spanish multiple sclerosis cohort: in vivo antiviral activity and clinical response multiple sclerosis, teriflunomide, biomarker, EDSS, EBV, HHV-6, NF-L, ELISA True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 530, 707 Annotation: Subtype: Link Rect: 222, 661, 474, 682 Annotation: Subtype: Link Rect: 222, 636, 532, 657 Annotation: Subtype: Link Rect: 222, 611, 500, 632 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 529, 144, 536 Annotation: Subtype: Link Rect: 49, 372, 158, 379 Annotation: Subtype: Link Rect: 49, 286, 168, 293 Annotation: Subtype: Link Rect: 49, 277, 74, 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