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SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 716 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The challenges of access to innovative medicines with limited evidence in the European Union Destination: titlink1 Children: Item: Title: 1 Introduction Destination: flink1 Item: Title: 2 Actions to accelerate regulatory access to innovative medicines Destination: flink2 Item: Title: 3 Uncertainty and consequences of access to innovative medicines with limited evidence Destination: flink3 Children: Item: Title: 3.1 Uncertainty of benefit at authorization and during the post-marketing period Destination: slink1 Item: Title: 3.2 Uncertainty in pricing and reimbursement process Destination: slink2 Item: Title: 4 Discussion Destination: flink4 Item: Title: 5 Conclusion Destination: flink5 Item: Title: Author contributions Destination: flink6 Item: Title: Conflict of interest Destination: flink7 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