9da11555bf49a06a09b609cb0dd9514a s41531-023-00579-w.pdf 4ea9ba068b45c5c13e7309bc9a5af27310b9c388 s41531-023-00579-w.pdf 368d7fc62d852beadbea7f3918086613720c60b06277280e5ea2ec2b831342c9 s41531-023-00579-w.pdf Title: Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain Subject: npj Parkinson’s Disease, doi:10.1038/s41531-023-00579-w Keywords: Author: Margaux Teil Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Sep 19 10:04:50 2023 CEST ModDate: Sat Nov 18 04:31:37 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 4460164 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JAAHJA+AdvMyriad_I Type 1C WinAnsi yes yes no 779 0 JAAHIN+AdvOT46dcae81+03 Type 1C Custom yes yes yes 76 0 JAAHJB+AdvMyriad_R Type 1C WinAnsi yes yes no 77 0 JAAHIO+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 78 0 JAAHIP+AdvOT46dcae81+fb Type 1C Custom yes yes yes 79 0 JAAGFO+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 780 0 Arial-BoldMT Type 1C WinAnsi yes no no 781 0 JAAGMN+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 471 0 JAAGMO+AdvTT6780a46b Type 1C WinAnsi yes yes no 97 0 JAAHJC+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 84 0 JAAHHL+AdvTT2876772e+27 Type 1C Custom yes yes yes 782 0 JAAHHM+AdvOT46dcae81 Type 1C WinAnsi yes yes no 86 0 JAAIGB+AdvTTab7e17fd Type 1C WinAnsi yes yes no 80 0 JAAIKA+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 81 0 JAAIEP+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 82 0 JAAIFA+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 83 0 JAAIDP+AdvOT3b30f6db.B+03 Type 1C Custom yes yes yes 85 0 JABHJF+AdvOT919a0533.B Type 1C WinAnsi yes yes no 95 0 JABLEA+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 96 0 JACFCE+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 127 0 JAFCFP+AdvTT6780a46b+fb Type 1C Custom yes yes yes 296 0 JAFCLO+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 378 0 JAFDCO+AdvTTab7e17fd+20 Type 1C Custom yes yes yes 435 0 JAFDCP+AdvOT65f8a23b.I+fb Type 1C Custom yes yes yes 436 0 JAFDBN+AdvTTab7e17fd+22 Type 1C Custom yes yes no 437 0 JAFDBO+AdvOT65f8a23b.I+03 Type 1C Custom yes yes yes 438 0 JAFEJI+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 505 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-02 04:08:21 CEST RepresentationInformation: s41531-023-00579-w.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-01 09:24:14 CEST Size: 4460164 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 882 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain Destination: title_link Children: Item: Title: Introduction Destination: A1 Item: Title: Results Destination: A2 Children: Item: Title: Widespread prefrontal phosphorylated α-syn immunoreactivity Destination: B1 Item: Title: Prefrontal neuronal loss Destination: B2 Item: Title: Prefrontal inflammation Destination: B3 Item: Title: Phosphorylated α-syn accumulates in the caudate nucleus but not in the putamen Destination: B4 Item: Title: Striatal dopaminergic function is altered Destination: B5 Item: Title: Lack of striatal and nigral degeneration Destination: B6 Item: Title: Discussion Destination: A3 Item: Title: Methods Destination: A4 Children: Item: Title: Ethics statement Destination: B7 Item: Title: Purification of LBs from human PD brains Destination: B8 Item: Title: Animals and stereotactic injections Destination: B9 Item: Title: Histological analysis Destination: B10 Children: Item: Title: Phosphorylated α-synuclein staining Destination: C1 Item: Title: Neuronal loss Destination: C2 Item: Title: Inflammation Destination: C3 Item: Title: Dopaminergic neurodegeneration assessment Destination: C4 Item: Title: Biochemical analysis Destination: B11 Children: Item: Title: Total protein extraction Destination: C5 Item: Title: Sequential protein extraction Destination: C6 Item: Title: Immunoblotting Destination: C7 Item: Title: Microglial morphology Destination: B12 Item: Title: Statistical analysis Destination: B13 Item: Title: Reporting summary Destination: B14 Item: Title: DATA AVAILABILITY Destination: M2 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: ADDITIONAL INFORMATION Destination: M1 Info: Title: Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain Author: Margaux Teil Subject: npj Parkinson’s Disease, doi:10.1038/s41531-023-00579-w Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Sep 19 10:34:50 CEST 2023 ModDate: Sat Nov 18 04:31:37 CET 2023 ID: 0x3ef01371a8741922ea9918ca0c965d82, 0x8b0198dfc648caf43dd8fd81c420676a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 250 ImageHeight: 80 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 2357 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 1225 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 1702 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 1717 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 937 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 1382 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: JAAHJA+AdvMyriad_I FontSubset: true FirstChar: 68 LastChar: 146 FontDescriptor: FontName: JAAHJA+AdvMyriad_I Flags: Nonsymbolic FontBBox: -104, -239, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAHIN+AdvOT46dcae81+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: JAAHIN+AdvOT46dcae81+03 Flags: Symbolic FontBBox: -31, -208, 739, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAGFO+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: JAAGFO+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAHJB+AdvMyriad_R FontSubset: true FirstChar: 35 LastChar: 146 FontDescriptor: FontName: JAAHJB+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAHIO+AdvOT46dcae81+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: JAAHIO+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAHHL+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAAHHL+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAHIP+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JAAHIP+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAIGB+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: JAAIGB+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAIKA+AdvOT7d2ebc01 FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: JAAIKA+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAIEP+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JAAIEP+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAIFA+AdvOT65f8a23b.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JAAIFA+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAHJC+AdvOT3b30f6db.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JAAHJC+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAIDP+AdvOT3b30f6db.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAAIDP+AdvOT3b30f6db.B+03 Flags: Symbolic FontBBox: -62, -218, 791, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAHHM+AdvOT46dcae81 FontSubset: true FirstChar: 35 LastChar: 243 FontDescriptor: FontName: JAAHHM+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAAGMN+AdvOTa20b42a7 FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JAAGMN+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JABHJF+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 105 FontDescriptor: FontName: JABHJF+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JABLEA+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JABLEA+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAAGMO+AdvTT6780a46b FontSubset: true FirstChar: 37 LastChar: 237 FontDescriptor: FontName: JAAGMO+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAFCFP+AdvTT6780a46b+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAFCFP+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAFDCO+AdvTTab7e17fd+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAFDCO+AdvTTab7e17fd+20 Flags: Symbolic FontBBox: 19, 0, 989, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAFDCP+AdvOT65f8a23b.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAFDCP+AdvOT65f8a23b.I+fb Flags: Symbolic FontBBox: 0, 0, 781, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAFDBN+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: JAFDBN+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JAFDBO+AdvOT65f8a23b.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAFDBO+AdvOT65f8a23b.I+03 Flags: Symbolic FontBBox: -72, -208, 760, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JAFEJI+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: JAFEJI+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JAFCLO+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JAFCLO+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JACFCE+AdvTT6780a46b+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: JACFCE+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41531-023-00579-w Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain Margaux Teil Sandra Dovero Mathieu Bourdenx Marie-Laure Arotcarena Morgane Darricau Gregory Porras Marie-Laure Thiolat Inés Trigo-Damas Celine Perier Cristina Estrada Nuria Garcia-Carrillo María Trinidad Herrero Miquel Vila José A. Obeso Erwan Bezard Benjamin Dehay Springer US npj Parkinson’s Disease, doi:10.1038/s41531-023-00579-w Springer 2023-11-18T04:31:37+01:00 2023-09-19T13:34:50+05:30 2023-11-18T04:31:37+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:bd0f2535-e5e7-44a2-82ce-6d95f60c3471 uuid:100f6c2f-89f7-44b2-acad-c6b77cd56a99 default 1 converted uuid:217c8e4d-6a0d-41a2-a62f-692c8ad9feac converted to PDF/A-2b pdfToolbox 2023-09-19T13:35:43+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 617, 509, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 617, 509, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 518, 617, 519, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 509, 617, 518, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 517, 617, 518, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 79, 606, 80, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 79, 606, 80, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 89, 606, 90, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 80, 606, 89, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 88, 606, 89, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 257, 606, 258, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 257, 606, 258, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 267, 606, 268, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 258, 606, 267, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 266, 606, 267, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 362, 606, 363, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 362, 606, 363, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 606, 373, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 363, 606, 372, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 606, 372, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 246, 386, 413, 395 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 289, 140, 298 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 141, 289, 145, 298 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 161, 269, 164, 278 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 170, 218, 174, 227 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 175, 218, 178, 227 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 99, 188, 103, 197 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 311, 331, 314, 340 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 317, 331, 324, 340 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 368, 290, 375, 299 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 379, 290, 386, 299 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 514, 280, 521, 289 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 461, 249, 467, 258 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 453, 188, 459, 197 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 292, 56, 384, 63 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 454, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 104, 726, 111, 735 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 114, 726, 121, 735 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 77, 585, 84, 594 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 86, 585, 93, 594 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 125, 427, 130, 436 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 234, 410, 241, 419 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 242, 410, 249, 419 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 45, 365, 49, 374 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 165, 368, 172, 377 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 173, 368, 180, 377 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 182, 368, 189, 377 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 263, 344, 267, 353 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 270, 303, 275, 312 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 45, 252, 49, 261 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 183, 241, 188, 250 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 241, 231, 245, 240 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 63, 221, 68, 230 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 45, 148, 49, 157 Flags: Print AppearanceDictionary: true Destination: 103 Annotation: Subtype: Link Rect: 130, 142, 137, 150 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 441, 704, 448, 713 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 451, 704, 458, 713 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 407, 681, 412, 690 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 311, 660, 315, 669 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 322, 664, 329, 673 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 420, 640, 425, 649 Flags: Print AppearanceDictionary: true Destination: 135 Annotation: Subtype: Link Rect: 546, 525, 550, 533 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 434, 494, 438, 503 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 398, 467, 405, 476 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 406, 467, 413, 476 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 367, 444, 372, 453 Flags: Print AppearanceDictionary: true Destination: 158 Annotation: Subtype: Link Rect: 366, 146, 371, 155 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 404, 126, 409, 135 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 397, 96, 402, 105 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 60, 179, 66, 188 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 68, 179, 75, 188 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 132, 145, 136, 154 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 198, 115, 202, 124 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 206, 85, 210, 94 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 136, 65, 140, 74 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 462, 300, 466, 309 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 413, 280, 418, 289 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 514, 214, 521, 223 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 446, 174, 452, 183 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 54, 223, 59, 232 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 188, 184, 195, 193 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 196, 184, 203, 193 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 212, 143, 219, 152 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 220, 143, 228, 152 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 67, 111, 74, 120 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 54, 66, 59, 75 Flags: Print AppearanceDictionary: true Destination: 262 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 82, 228, 89, 237 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 90, 228, 97, 237 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 284, 198, 291, 207 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 241, 168, 248, 177 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 249, 168, 256, 177 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 257, 168, 264, 177 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 237, 139, 244, 148 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 199, 79, 206, 88 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 207, 79, 214, 88 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 98, 59, 105, 68 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 491, 188, 498, 197 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 339, 158, 346, 167 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 347, 158, 354, 167 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 356, 158, 362, 167 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 333, 139, 339, 148 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 465, 119, 472, 128 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 473, 89, 480, 98 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 522, 79, 529, 88 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 205, 318, 211, 327 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 213, 318, 220, 327 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 164, 258, 171, 267 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 172, 258, 179, 267 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 181, 258, 187, 267 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 209, 149, 216, 158 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 50, 109, 57, 118 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 58, 109, 65, 118 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 244, 89, 251, 98 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 254, 89, 261, 98 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 125, 59, 132, 68 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 136, 59, 142, 68 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 442, 398, 449, 407 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 524, 338, 531, 347 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 337, 318, 344, 327 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 345, 318, 352, 327 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 516, 298, 523, 307 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 445, 149, 452, 158 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 394, 139, 401, 148 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 320, 109, 327, 118 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 330, 109, 337, 118 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 330, 89, 337, 98 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 338, 89, 345, 98 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 441, 69, 448, 78 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 450, 69, 456, 78 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 74, 268, 81, 277 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 82, 268, 89, 277 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 90, 268, 97, 277 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 99, 268, 105, 277 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 107, 268, 114, 277 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 78, 198, 85, 207 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 88, 198, 95, 207 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 120, 168, 127, 177 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 128, 168, 135, 177 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 156, 149, 163, 158 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 81, 99, 88, 108 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 89, 99, 96, 108 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 284, 79, 291, 88 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 425, 258, 432, 267 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 530, 158, 537, 167 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 184, 686, 191, 695 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 192, 686, 199, 695 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 201, 686, 208, 695 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 108, 666, 115, 675 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 116, 666, 123, 675 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 55, 616, 62, 625 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 64, 616, 70, 625 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 72, 616, 79, 625 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 80, 616, 87, 625 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 87, 556, 94, 565 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 140, 516, 147, 525 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 223, 456, 230, 465 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 240, 179, 247, 188 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 250, 179, 257, 188 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 258, 179, 265, 188 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 77, 149, 84, 158 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 318, 626, 325, 635 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 419, 576, 426, 585 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 395, 536, 402, 545 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 407, 485, 414, 494 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 463, 465, 470, 474 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 500, 400, 507, 409 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 508, 400, 515, 409 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 516, 400, 523, 409 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 372, 290, 378, 299 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 380, 290, 386, 299 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 388, 290, 395, 299 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 334, 240, 340, 249 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 342, 240, 349, 249 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 403, 220, 410, 228 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 456, 179, 463, 188 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 464, 179, 471, 188 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 360, 59, 367, 68 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 368, 59, 375, 68 Flags: Print AppearanceDictionary: true Destination: 458 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 81, 647, 88, 656 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 89, 647, 96, 656 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 97, 647, 104, 656 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 238, 572, 245, 581 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 246, 572, 253, 581 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 254, 572, 261, 581 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 134, 173, 140, 182 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 185, 144, 191, 153 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 193, 144, 200, 153 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 201, 144, 208, 153 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 435, 587, 442, 596 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 443, 587, 450, 596 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 451, 587, 458, 596 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 434, 338, 441, 347 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 443, 338, 450, 347 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 451, 338, 458, 347 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 477, 243, 484, 252 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 485, 243, 492, 252 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 493, 243, 500, 252 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 491, 74, 498, 83 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 499, 74, 506, 83 Flags: Print AppearanceDictionary: true Destination: 479 Annotation: Subtype: Link Rect: 508, 74, 515, 83 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 224, 623, 231, 632 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 232, 623, 239, 632 Flags: Print AppearanceDictionary: true Destination: 458 Annotation: Subtype: Link Rect: 84, 278, 186, 287 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 162, 175, 169, 184 Flags: Print AppearanceDictionary: true Destination: 479 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 538, 383, 559, 390 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 374, 425, 381 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 71, 472, 201, 479 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 706, 549, 713 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 697, 324, 704 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 553, 549, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 301, 544, 412, 551 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 430c3416 Type: CRC32 Checksum: 9da11555bf49a06a09b609cb0dd9514a Type: MD5 Checksum: 4ea9ba068b45c5c13e7309bc9a5af27310b9c388 Type: SHA-1 Checksum: 368d7fc62d852beadbea7f3918086613720c60b06277280e5ea2ec2b831342c9 Type: SHA-256