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Destination: titlink1 Children: Item: Title: 1 Introduction Destination: flink1 Item: Title: 2 Materials and methods Destination: flink2 Item: Title: 3 Results Destination: flink3 Children: Item: Title: 3.1 Identification of unknown ADRs and characteristics of population Destination: slink1 Item: Title: 3.2 Description of unknown ADRs Destination: slink2 Item: Title: 3.3 Outcome of unknown ADRs at the report and follow-up Destination: slink3 Item: Title: 3.4 Actions made by regulatory agencies based on unknown ADRs Destination: slink4 Item: Title: 4 Discussion Destination: flink4 Item: Title: 5 Strengths and limitations Destination: flink5 Item: Title: 6 Conclusion Destination: flink6 Item: Title: Data availability statement Destination: flink7 Item: Title: Ethics statement Destination: flink8 Item: Title: Author contributions Destination: flink9 Item: Title: Conflict of interest Destination: flink10 Item: Title: Publisher’s note Destination: flink11 Item: Title: Supplementary material 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