636e3aabbdbcc596a8c9614aaf176a1d 1_s2.0_S0048969722067092_main.pdf 871b04079baa69f304c662fcaee9ecc498f0199b 1_s2.0_S0048969722067092_main.pdf 80abbef72912cc636befcdc1b4c74e30c1ca097ffeb3b32eaa87175f01623c9d 1_s2.0_S0048969722067092_main.pdf Title: Impacts of dietary copper on the swine gut microbiome and antibiotic resistome Subject: Science of the Total Environment, 857 (2023) 159609. doi:10.1016/j.scitotenv.2022.159609 Keywords: Antimicrobial resistance; Antibiotic resistance genes; Bacterial community composition; Co-selection; HT-qPCR; Pig microbiome Author: Julius Emil Brinck Creator: Elsevier CreationDate: Thu Oct 27 14:30:17 2022 CEST ModDate: Thu Oct 27 14:30:17 2022 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1129079 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CKKJFO+AdvTTe692faf0 Type 1C WinAnsi yes yes no 512 0 CKKJGP+AdvTT8608a8d1+20 Type 1C Custom yes yes yes 515 0 CKKJHA+AdvTT47f7fe79.I Type 1C WinAnsi yes yes no 516 0 CKKJHB+AdvTTe692faf0+20 Type 1C WinAnsi yes yes no 517 0 CKKJNP+AdvTTe692faf0+fb Type 1C Custom yes yes yes 524 0 CKKJOA+AdvTTe692faf0+03 Type 1C Custom yes yes yes 525 0 CKKJOB+AdvTTe692faf0+22 Type 1C Custom yes yes no 526 0 CKKKBB+AdvTTc8c83e50 Type 1C WinAnsi yes yes no 527 0 CKKKCC+AdvTTc9617e0c.B Type 1C WinAnsi yes yes no 298 0 CKKKDC+AdvTT8608a8d1 Type 1C WinAnsi yes yes no 297 0 CKKKFD+AdvTT47f7fe79.I+fb Type 1C Custom yes yes yes 304 0 CKKKGD+AdvTTdd3b7348.I Type 1C WinAnsi yes yes no 303 0 CKKNFC+ArialMT Type 1C WinAnsi yes yes no 312 0 CKKONK+AdvTTe692faf0+01 Type 1C Custom yes yes yes 313 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-08 02:27:50 CET RepresentationInformation: 1_s2.0_S0048969722067092_main.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-01 01:39:41 CET Size: 1129079 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 588 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: This link is https://doi.org/10.1021/es071916+ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Impacts of dietary copper on the swine gut microbiome and antibiotic resistome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2. Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.1. Description of Cu supplementation swine feeding trial Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.2. Fecal DNA extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.3. 16S rRNA gene amplicon sequencing and data processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.4. High-throughput qPCR and data processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.5. Total and bioavailable Cu in fecal samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.6. Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 3.1. Total and bioavailable Cu in feces Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 3.2. Impacts of dietary Cu and pig growth stage on bacterial community composition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3.3. Impacts of dietary Cu and pig growth stage on ARGs and MGEs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 3.4. Linkage between bacterial community composition and ARGs/MGEs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 4.1. Dietary Cu supplements had a marginal impact on the gut microbiome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 4.2. Does Cu-based feed supplements constitute a risk for co-selection of ARGs in livestock? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 5. Conclusions and perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Impacts of dietary copper on the swine gut microbiome and antibiotic resistome Author: Julius Emil Brinck Subject: Science of the Total Environment, 857 (2023) 159609. doi:10.1016/j.scitotenv.2022.159609 Keywords: Antimicrobial resistance; Antibiotic resistance genes; Bacterial community composition; Co-selection; HT-qPCR; Pig microbiome Creator: Elsevier CreationDate: Thu Oct 27 14:30:17 CEST 2022 ModDate: Thu Oct 27 14:30:17 CEST 2022 ID: 0x91be6fc37d320ec2cc592a9df6c9bb7f, 0xe626d13f360f1741814b89c07b1938b3 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 801 ImageHeight: 526 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 245 ImageHeight: 269 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: CKKJFO+AdvTTe692faf0 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: CKKJFO+AdvTTe692faf0 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 916, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKJGP+AdvTT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CKKJGP+AdvTT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CKKJHA+AdvTT47f7fe79.I FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: CKKJHA+AdvTT47f7fe79.I Flags: Serif, Nonsymbolic FontBBox: -156, -250, 1000, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKJHB+AdvTTe692faf0+20 FontSubset: true FirstChar: 129 LastChar: 150 FontDescriptor: FontName: CKKJHB+AdvTTe692faf0+20 Flags: Nonsymbolic FontBBox: -468, -302, 1093, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKKDC+AdvTT8608a8d1 FontSubset: true FirstChar: 38 LastChar: 62 FontDescriptor: FontName: CKKKDC+AdvTT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKKCC+AdvTTc9617e0c.B FontSubset: true FirstChar: 45 LastChar: 224 FontDescriptor: FontName: CKKKCC+AdvTTc9617e0c.B Flags: Serif, Nonsymbolic FontBBox: -83, -250, 947, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKJNP+AdvTTe692faf0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: CKKJNP+AdvTTe692faf0+fb Flags: Symbolic FontBBox: 19, 0, 916, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CKKJOA+AdvTTe692faf0+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: CKKJOA+AdvTTe692faf0+03 Flags: Symbolic FontBBox: -666, -531, 1062, 1000 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CKKJOB+AdvTTe692faf0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: CKKJOB+AdvTTe692faf0+22 Flags: Nonsymbolic FontBBox: 0, -250, 1177, 1041 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CKKKBB+AdvTTc8c83e50 FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: CKKKBB+AdvTTc8c83e50 Flags: Nonsymbolic FontBBox: -10, -250, 968, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKKGD+AdvTTdd3b7348.I FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: CKKKGD+AdvTTdd3b7348.I Flags: Nonsymbolic FontBBox: -166, -208, 906, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKKFD+AdvTT47f7fe79.I+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: CKKKFD+AdvTT47f7fe79.I+fb Flags: Symbolic FontBBox: -125, -218, 906, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: CKKNFC+ArialMT FontSubset: true FirstChar: 46 LastChar: 122 FontDescriptor: FontName: CKKNFC+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CKKONK+AdvTTe692faf0+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: CKKONK+AdvTTe692faf0+01 Flags: Symbolic FontBBox: -93, -260, 1229, 1197 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.scitotenv.2022.159609 Impacts of dietary copper on the swine gut microbiome and antibiotic resistome Julius Emil Brinck Simon Bo Lassen Asal Forouzandeh Ting Pan Yan-Zi Wang Alessandra Monteiro Laia Blavi David SolĂ -Oriol Hans H. Stein Jian-Qiang Su Kristian K. Brandt Antimicrobial resistance Antibiotic resistance genes Bacterial community composition Co-selection HT-qPCR Pig microbiome Science of the Total Environment, 857 (2023) 159609. doi:10.1016/j.scitotenv.2022.159609 The Authors journal Science of the Total Environment (c) 2022 The Authors All rights reserved 0048-9697 857 Part 3 20 January 2023 2023-01-20 159609 159609 10.1016/j.scitotenv.2022.159609 https://doi.org/10.1016/j.scitotenv.2022.159609 2010-04-23 true 10.1016/j.scitotenv.2022.159609 elsevier.com sciencedirect.com VoR 10.1016/j.scitotenv.2022.159609 noindex 2010-04-23 true elsevier.com sciencedirect.com Elsevier 2022-10-27T12:30:17Z 2022-10-27T12:30:17Z 2022-10-27T12:30:17Z True Antimicrobial resistance; Antibiotic resistance genes; Bacterial community composition; Co-selection; HT-qPCR; Pig microbiome uuid:13fd5a97-641b-4909-adf5-0cd4f5efd363 uuid:8f39b4a9-36fb-4a95-87dd-0de695906799 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 500, 597, 528, 625 Annotation: Subtype: Link Rect: 122, 577, 126, 588 Destination: 446 Annotation: Subtype: Link Rect: 128, 577, 132, 588 Destination: 446 Annotation: Subtype: Link Rect: 216, 577, 220, 588 Destination: 446 Annotation: Subtype: Link Rect: 222, 577, 226, 588 Destination: 446 Annotation: Subtype: Link Rect: 315, 577, 319, 588 Destination: 446 Annotation: Subtype: Link Rect: 321, 577, 325, 588 Destination: 446 Annotation: Subtype: Link Rect: 373, 577, 377, 588 Destination: 446 Annotation: Subtype: Link Rect: 444, 577, 448, 588 Destination: 446 Annotation: Subtype: Link Rect: 550, 577, 554, 588 Destination: 446 Annotation: Subtype: Link Rect: 84, 564, 87, 575 Destination: 446 Annotation: Subtype: Link Rect: 171, 564, 174, 575 Destination: 446 Annotation: Subtype: Link Rect: 244, 564, 246, 575 Destination: 446 Annotation: Subtype: Link Rect: 318, 564, 322, 575 Destination: 446 Annotation: Subtype: Link Rect: 411, 564, 415, 575 Destination: 446 Annotation: Subtype: Link Rect: 417, 564, 421, 575 Destination: 446 Annotation: Subtype: Link Rect: 423, 565, 429, 577 Destination: 446 Annotation: Subtype: Link Rect: 90, 99, 134, 105 Annotation: Subtype: Link Rect: 501, 665, 557, 737 Annotation: Subtype: Link Rect: 37, 666, 96, 730 Annotation: Subtype: Link Rect: 320, 721, 366, 729 Annotation: Subtype: Link Rect: 261, 665, 424, 673 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 63, 626, 103, 634 Destination: 217 Annotation: Subtype: Link Rect: 129, 595, 198, 603 Destination: 174 Annotation: Subtype: Link Rect: 276, 574, 289, 582 Destination: 174 Annotation: Subtype: Link Rect: 37, 564, 55, 572 Destination: 174 Annotation: Subtype: Link Rect: 240, 553, 289, 561 Destination: 217 Annotation: Subtype: Link Rect: 37, 543, 131, 551 Destination: 217 Annotation: Subtype: Link Rect: 136, 543, 215, 551 Destination: 217 Annotation: Subtype: Link Rect: 135, 511, 190, 519 Destination: 217 Annotation: Subtype: Link Rect: 194, 511, 246, 519 Destination: 217 Annotation: Subtype: Link Rect: 250, 511, 289, 519 Destination: 217 Annotation: Subtype: Link Rect: 37, 501, 55, 509 Destination: 217 Annotation: Subtype: Link Rect: 69, 459, 136, 467 Destination: 174 Annotation: Subtype: Link Rect: 141, 459, 224, 467 Destination: 217 Annotation: Subtype: Link Rect: 228, 459, 287, 467 Destination: 217 Annotation: Subtype: Link Rect: 37, 449, 114, 456 Destination: 217 Annotation: Subtype: Link Rect: 223, 407, 289, 415 Destination: 174 Annotation: Subtype: Link Rect: 37, 396, 55, 404 Destination: 174 Annotation: Subtype: Link Rect: 59, 396, 100, 404 Destination: 217 Annotation: Subtype: Link Rect: 214, 365, 287, 373 Destination: 174 Annotation: Subtype: Link Rect: 37, 354, 108, 362 Destination: 217 Annotation: Subtype: Link Rect: 112, 354, 191, 362 Destination: 217 Annotation: Subtype: Link Rect: 65, 333, 96, 341 Destination: 174 Annotation: Subtype: Link Rect: 158, 281, 242, 289 Destination: 174 Annotation: Subtype: Link Rect: 37, 260, 145, 268 Destination: 217 Annotation: Subtype: Link Rect: 171, 250, 239, 258 Destination: 217 Annotation: Subtype: Link Rect: 40, 229, 107, 237 Destination: 174 Annotation: Subtype: Link Rect: 112, 229, 201, 237 Destination: 174 Annotation: Subtype: Link Rect: 248, 229, 289, 237 Destination: 174 Annotation: Subtype: Link Rect: 37, 218, 55, 226 Destination: 174 Annotation: Subtype: Link Rect: 58, 218, 141, 226 Destination: 174 Annotation: Subtype: Link Rect: 161, 156, 219, 164 Destination: 174 Annotation: Subtype: Link Rect: 223, 156, 289, 164 Destination: 174 Annotation: Subtype: Link Rect: 37, 145, 54, 153 Destination: 174 Annotation: Subtype: Link Rect: 409, 553, 465, 561 Destination: 174 Annotation: Subtype: Link Rect: 469, 553, 552, 561 Destination: 174 Annotation: Subtype: Link Rect: 470, 302, 513, 310 Destination: 1 Annotation: Subtype: Link Rect: 370, 292, 407, 299 Destination: 1 Annotation: Subtype: Link Rect: 473, 229, 544, 237 Destination: 217 Annotation: Subtype: Link Rect: 366, 187, 436, 195 Destination: 174 Annotation: Subtype: Link Rect: 326, 135, 395, 142 Destination: 174 Annotation: Subtype: Link Rect: 354, 124, 399, 132 Destination: 217 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 190, 731, 260, 739 Destination: 217 Annotation: Subtype: Link Rect: 78, 605, 136, 613 Destination: 217 Annotation: Subtype: Link Rect: 40, 553, 124, 561 Destination: 217 Annotation: Subtype: Link Rect: 40, 490, 98, 498 Destination: 174 Annotation: Subtype: Link Rect: 104, 448, 197, 456 Destination: 217 Annotation: Subtype: Link Rect: 203, 448, 273, 456 Destination: 217 Annotation: Subtype: Link Rect: 265, 375, 289, 383 Destination: 174 Annotation: Subtype: Link Rect: 37, 365, 76, 373 Destination: 174 Annotation: Subtype: Link Rect: 172, 333, 235, 341 Destination: 174 Annotation: Subtype: Link Rect: 238, 250, 289, 257 Destination: 174 Annotation: Subtype: Link Rect: 37, 239, 55, 247 Destination: 174 Annotation: Subtype: Link Rect: 60, 239, 115, 247 Destination: 217 Annotation: Subtype: Link Rect: 218, 166, 286, 174 Destination: 217 Annotation: Subtype: Link Rect: 37, 155, 115, 163 Destination: 217 Annotation: Subtype: Link Rect: 119, 155, 184, 163 Destination: 217 Annotation: Subtype: Link Rect: 48, 114, 130, 122 Destination: 217 Annotation: Subtype: Link Rect: 146, 82, 200, 90 Destination: 174 Annotation: Subtype: Link Rect: 157, 72, 226, 80 Destination: 217 Annotation: Subtype: Link Rect: 364, 678, 468, 686 Destination: 217 Annotation: Subtype: Link Rect: 444, 626, 494, 634 Destination: 174 Annotation: Subtype: Link Rect: 345, 574, 429, 582 Destination: 217 Annotation: Subtype: Link Rect: 389, 490, 439, 498 Destination: 217 Annotation: Subtype: Link Rect: 346, 375, 371, 383 Destination: 44 Annotation: Subtype: Link Rect: 500, 365, 526, 373 Destination: 44 Annotation: Subtype: Link Rect: 439, 302, 466, 310 Destination: 44 Annotation: Subtype: Link Rect: 391, 85, 393, 91 Destination: 44 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 55, 129, 539, 722 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 72, 595, 91, 603 Destination: 72 Annotation: Subtype: Link Rect: 263, 574, 283, 582 Destination: 79 Annotation: Subtype: Link Rect: 65, 511, 84, 519 Destination: 79 Annotation: Subtype: Link Rect: 229, 459, 247, 467 Destination: 79 Annotation: Subtype: Link Rect: 137, 438, 174, 446 Destination: 44 Annotation: Subtype: Link Rect: 222, 417, 241, 425 Destination: 95 Annotation: Subtype: Link Rect: 533, 541, 552, 549 Destination: 108 Annotation: Subtype: Link Rect: 308, 500, 328, 508 Destination: 117 Annotation: Subtype: Link Rect: 346, 479, 365, 487 Destination: 117 Annotation: Subtype: Link Rect: 139, 100, 456, 338 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 134, 93, 153, 101 Destination: 140 Annotation: Subtype: Link Rect: 221, 61, 241, 69 Destination: 140 Annotation: Subtype: Link Rect: 378, 710, 396, 718 Destination: 140 Annotation: Subtype: Link Rect: 323, 51, 382, 59 Destination: 217 Annotation: Subtype: Link Rect: 387, 51, 473, 59 Destination: 217 Annotation: Subtype: Link Rect: 478, 51, 536, 59 Destination: 217 Annotation: Subtype: Link Rect: 39, 323, 287, 743 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 59, 110, 535, 709 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 161, 197, 217, 205 Destination: 217 Annotation: Subtype: Link Rect: 221, 197, 272, 205 Destination: 217 Annotation: Subtype: Link Rect: 276, 197, 289, 205 Destination: 217 Annotation: Subtype: Link Rect: 37, 187, 75, 195 Destination: 217 Annotation: Subtype: Link Rect: 247, 145, 289, 153 Destination: 217 Annotation: Subtype: Link Rect: 37, 134, 55, 142 Destination: 217 Annotation: Subtype: Link Rect: 58, 134, 117, 142 Destination: 217 Annotation: Subtype: Link Rect: 205, 114, 276, 122 Destination: 217 Annotation: Subtype: Link Rect: 166, 103, 240, 111 Destination: 217 Annotation: Subtype: Link Rect: 260, 72, 289, 80 Destination: 217 Annotation: Subtype: Link Rect: 37, 61, 77, 69 Destination: 217 Annotation: Subtype: Link Rect: 82, 61, 147, 69 Destination: 217 Annotation: Subtype: Link Rect: 432, 218, 507, 226 Destination: 217 Annotation: Subtype: Link Rect: 487, 134, 555, 142 Destination: 174 Annotation: Subtype: Link Rect: 306, 124, 392, 132 Destination: 174 Annotation: Subtype: Link Rect: 407, 72, 491, 80 Destination: 174 Annotation: Subtype: Link Rect: 62, 302, 532, 743 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 40, 501, 106, 509 Destination: 217 Annotation: Subtype: Link Rect: 110, 501, 172, 509 Destination: 217 Annotation: Subtype: Link Rect: 87, 270, 158, 278 Destination: 174 Annotation: Subtype: Link Rect: 163, 270, 241, 278 Destination: 217 Annotation: Subtype: Link Rect: 245, 270, 289, 278 Destination: 217 Annotation: Subtype: Link Rect: 37, 260, 75, 268 Destination: 217 Annotation: Subtype: Link Rect: 109, 229, 172, 237 Destination: 174 Annotation: Subtype: Link Rect: 40, 176, 114, 184 Destination: 217 Annotation: Subtype: Link Rect: 160, 124, 247, 132 Destination: 217 Annotation: Subtype: Link Rect: 252, 124, 289, 132 Destination: 217 Annotation: Subtype: Link Rect: 37, 114, 85, 122 Destination: 217 Annotation: Subtype: Link Rect: 92, 114, 136, 122 Destination: 217 Annotation: Subtype: Link Rect: 233, 72, 286, 80 Destination: 217 Annotation: Subtype: Link Rect: 37, 61, 99, 69 Destination: 174 Annotation: Subtype: Link Rect: 393, 491, 440, 499 Destination: 217 Annotation: Subtype: Link Rect: 509, 428, 557, 436 Destination: 217 Annotation: Subtype: Link Rect: 306, 417, 323, 425 Destination: 217 Annotation: Subtype: Link Rect: 327, 417, 394, 425 Destination: 217 Annotation: Subtype: Link Rect: 386, 355, 446, 363 Destination: 174 Annotation: Subtype: Link Rect: 445, 261, 497, 268 Destination: 217 Annotation: Subtype: Link Rect: 309, 177, 403, 185 Destination: 217 Annotation: Subtype: Link Rect: 410, 177, 475, 185 Destination: 217 Annotation: Subtype: Link Rect: 482, 177, 555, 185 Destination: 217 Annotation: Subtype: Link Rect: 306, 166, 382, 174 Destination: 217 Annotation: Subtype: Link Rect: 344, 104, 436, 112 Destination: 217 Annotation: Subtype: Link Rect: 440, 104, 505, 112 Destination: 217 Annotation: Subtype: Link Rect: 344, 62, 445, 70 Destination: 174 Annotation: Subtype: Link Rect: 112, 601, 482, 743 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 112, 720, 212, 728 Destination: 174 Annotation: Subtype: Link Rect: 195, 678, 284, 686 Destination: 217 Annotation: Subtype: Link Rect: 40, 605, 99, 613 Destination: 217 Annotation: Subtype: Link Rect: 102, 605, 158, 613 Destination: 217 Annotation: Subtype: Link Rect: 198, 480, 268, 488 Destination: 217 Annotation: Subtype: Link Rect: 272, 480, 289, 488 Destination: 217 Annotation: Subtype: Link Rect: 37, 469, 74, 477 Destination: 217 Annotation: Subtype: Link Rect: 223, 135, 268, 143 Destination: 174 Annotation: Subtype: Link Rect: 517, 710, 557, 718 Annotation: Subtype: Link Rect: 306, 699, 435, 707 Annotation: Subtype: Link Rect: 345, 617, 491, 623 Annotation: Subtype: Link Rect: 385, 601, 537, 607 Annotation: Subtype: Link Rect: 453, 585, 557, 592 Annotation: Subtype: Link Rect: 384, 553, 515, 560 Annotation: Subtype: Link Rect: 450, 513, 555, 520 Annotation: Subtype: Link Rect: 474, 497, 557, 504 Annotation: Subtype: Link Rect: 318, 489, 352, 496 Annotation: Subtype: Link Rect: 371, 458, 473, 464 Annotation: Subtype: Link Rect: 388, 426, 489, 432 Destination: 446 Annotation: Subtype: Link Rect: 356, 394, 482, 400 Annotation: Subtype: Link Rect: 356, 370, 458, 376 Annotation: Subtype: Link Rect: 536, 354, 557, 360 Annotation: Subtype: Link Rect: 318, 346, 407, 352 Annotation: Subtype: Link Rect: 348, 330, 557, 336 Annotation: Subtype: Link Rect: 318, 322, 432, 329 Annotation: Subtype: Link Rect: 443, 306, 557, 313 Annotation: Subtype: Link Rect: 318, 298, 345, 305 Annotation: Subtype: Link Rect: 465, 274, 557, 281 Annotation: Subtype: Link Rect: 318, 266, 353, 273 Annotation: Subtype: Link Rect: 348, 250, 504, 257 Annotation: Subtype: Link Rect: 334, 234, 557, 241 Annotation: Subtype: Link Rect: 318, 226, 557, 233 Annotation: Subtype: Link Rect: 318, 219, 557, 225 Annotation: Subtype: Link Rect: 318, 211, 508, 217 Annotation: Subtype: Link Rect: 364, 187, 461, 193 Annotation: Subtype: Link Rect: 318, 155, 436, 161 Annotation: Subtype: Link Rect: 525, 123, 557, 129 Annotation: Subtype: Link Rect: 318, 115, 388, 121 Annotation: Subtype: Link Rect: 483, 91, 557, 97 Annotation: Subtype: Link Rect: 318, 83, 381, 89 Annotation: Subtype: Link Rect: 392, 51, 502, 58 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 162, 710, 289, 716 Annotation: Subtype: Link Rect: 49, 702, 72, 708 Annotation: Subtype: Link Rect: 175, 678, 289, 684 Annotation: Subtype: Link Rect: 49, 670, 79, 676 Annotation: Subtype: Link Rect: 78, 646, 202, 652 Annotation: Subtype: Link Rect: 107, 606, 218, 612 Annotation: Subtype: Link Rect: 198, 582, 289, 589 Annotation: Subtype: Link Rect: 49, 574, 73, 581 Annotation: Subtype: Link Rect: 130, 550, 241, 557 Annotation: Subtype: Link Rect: 205, 534, 289, 541 Annotation: Subtype: Link Rect: 49, 526, 75, 533 Annotation: Subtype: Link Rect: 147, 502, 274, 509 Annotation: Subtype: Link Rect: 234, 487, 289, 493 Annotation: Subtype: Link Rect: 49, 479, 106, 485 Annotation: Subtype: Link Rect: 245, 455, 289, 461 Annotation: Subtype: Link Rect: 49, 447, 113, 453 Annotation: Subtype: Link Rect: 106, 431, 248, 437 Annotation: Subtype: Link Rect: 106, 407, 261, 413 Annotation: Subtype: Link Rect: 128, 399, 246, 405 Annotation: Subtype: Link Rect: 234, 375, 289, 381 Annotation: Subtype: Link Rect: 49, 367, 131, 373 Annotation: Subtype: Link Rect: 118, 351, 244, 357 Annotation: Subtype: Link Rect: 86, 335, 193, 341 Annotation: Subtype: Link Rect: 193, 311, 289, 318 Annotation: Subtype: Link Rect: 49, 303, 84, 310 Annotation: Subtype: Link Rect: 105, 271, 226, 278 Annotation: Subtype: Link Rect: 127, 247, 284, 254 Annotation: Subtype: Link Rect: 124, 216, 234, 222 Annotation: Subtype: Link Rect: 153, 184, 262, 190 Annotation: Subtype: Link Rect: 256, 120, 289, 126 Annotation: Subtype: Link Rect: 49, 112, 140, 118 Annotation: Subtype: Link Rect: 130, 88, 256, 94 Annotation: Subtype: Link Rect: 84, 64, 223, 70 Annotation: Subtype: Link Rect: 400, 718, 504, 724 Annotation: Subtype: Link Rect: 383, 686, 481, 692 Annotation: Subtype: Link Rect: 451, 662, 545, 668 Annotation: Subtype: Link Rect: 335, 646, 503, 652 Annotation: Subtype: Link Rect: 449, 622, 557, 628 Annotation: Subtype: Link Rect: 318, 614, 337, 620 Annotation: Subtype: Link Rect: 385, 598, 506, 605 Annotation: Subtype: Link Rect: 513, 582, 557, 589 Annotation: Subtype: Link Rect: 318, 574, 378, 581 Annotation: Subtype: Link Rect: 513, 550, 557, 557 Annotation: Subtype: Link Rect: 318, 542, 400, 549 Annotation: Subtype: Link Rect: 473, 526, 557, 533 Annotation: Subtype: Link Rect: 318, 518, 352, 525 Annotation: Subtype: Link Rect: 345, 495, 471, 501 Annotation: Subtype: Link Rect: 385, 471, 543, 477 Annotation: Subtype: Link Rect: 484, 439, 557, 445 Annotation: Subtype: Link Rect: 318, 431, 375, 437 Annotation: Subtype: Link Rect: 488, 407, 557, 413 Annotation: Subtype: Link Rect: 318, 399, 368, 405 Annotation: Subtype: Link Rect: 484, 367, 557, 373 Annotation: Subtype: Link Rect: 318, 359, 363, 365 Annotation: Subtype: Link Rect: 431, 335, 557, 341 Annotation: Subtype: Link Rect: 318, 327, 345, 334 Annotation: Subtype: Link Rect: 423, 319, 557, 326 Annotation: Subtype: Link Rect: 318, 311, 424, 318 Annotation: Subtype: Link Rect: 525, 295, 557, 302 Annotation: Subtype: Link Rect: 318, 287, 408, 294 Annotation: Subtype: Link Rect: 488, 255, 557, 262 Annotation: Subtype: Link Rect: 318, 247, 486, 254 Annotation: Subtype: Link Rect: 341, 239, 557, 246 Annotation: Subtype: Link Rect: 318, 231, 405, 238 Annotation: Subtype: Link Rect: 439, 224, 557, 230 Annotation: Subtype: Link Rect: 318, 216, 327, 222 Annotation: Subtype: Link Rect: 463, 200, 557, 206 Annotation: Subtype: Link Rect: 318, 192, 384, 198 Annotation: Subtype: Link Rect: 371, 168, 486, 174 Annotation: Subtype: Link Rect: 502, 144, 557, 150 Annotation: Subtype: Link Rect: 318, 136, 385, 142 Annotation: Subtype: Link Rect: 379, 112, 522, 118 Annotation: Subtype: Link Rect: 484, 88, 557, 94 Annotation: Subtype: Link Rect: 318, 80, 387, 86 Checksum: 8a62d677 Type: CRC32 Checksum: 636e3aabbdbcc596a8c9614aaf176a1d Type: MD5 Checksum: 871b04079baa69f304c662fcaee9ecc498f0199b Type: SHA-1