2488c3aee999f8df054c1cd7a02fdba2 PIIS030645222300009X.pdf 1f0fe8fdf326f33dbed724c7ca0b2ef516e90db9 PIIS030645222300009X.pdf 78d8094119632c2e073f0e24df266f4324aa23d6e71219649721564537a260fb PIIS030645222300009X.pdf Title: Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats Subject: Neuroscience, 512 (2023) 16-31. doi:10.1016/j.neuroscience.2023.01.005 Author: Irene Puig-Parnau Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Tue Feb 14 07:50:11 2023 CET ModDate: Tue Feb 14 07:52:24 2023 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 4313527 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IFGBNB+AdvArial-b Type 1C Custom yes yes yes 729 0 IFGBNC+AdvPSMP11 Type 1C WinAnsi yes yes no 730 0 IFGBND+AdvArial Type 1C Custom yes yes yes 731 0 IFGBNE+AdvArial-i Type 1C WinAnsi yes yes no 732 0 IFGCCE+AdvPSSym Type 1C Custom yes yes no 733 0 IFGCDE+AdvPSMP13 Type 1C WinAnsi yes yes no 734 0 IFGCEF+AdvBENQ-B Type 1C WinAnsi yes yes no 735 0 IFGDCB+AdvP4C4E74 Type 1C Custom yes yes no 439 0 IFGDCC+AdvPi1 Type 1C WinAnsi yes yes no 443 0 IFGGLM+AdvPSMP10 Type 1C WinAnsi yes yes no 446 0 IFGGLN+AdvPi3 Type 1C WinAnsi yes yes no 450 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-09-21 02:53:45 CEST RepresentationInformation: PIIS030645222300009X.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-09-16 01:43:08 CEST Size: 4313527 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'web64para103' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para122' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para121' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para87' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para102' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para123' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para86' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para120' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para89' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para105' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para124' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para119' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para88' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para104' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para125' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para118' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para109' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para126' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para92' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para107' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para90' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para116' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para114' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para99' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para100' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para128' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para85' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para78' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para71' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para96' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para112' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para76' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para97' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para113' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para110' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para94' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para80' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para111' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para95' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para91' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para127' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para108' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para117' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para106' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para93' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para115' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para84' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para98' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para101' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para95' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para76' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para127' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para108' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para126' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para94' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para109' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para125' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para110' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para78' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para92' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para124' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para111' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para93' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para104' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para80' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para91' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para112' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para105' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para98' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para123' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para102' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para121' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para89' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para96' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para128' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para100' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para107' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para114' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para118' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para85' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para87' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para119' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para84' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para116' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para117' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para86' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para71' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para90' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para113' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para122' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para103' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para99' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para106' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para101' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para88' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para97' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para120' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para115' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-122 Offset: 4285577 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-122 Offset: 4285577 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 849 FreeObjects: 31 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats Destination: 1 Children: Item: Title: Introduction Destination: 1 Item: Title: Experimental procedures Destination: 1 Children: Item: Title: Animals and experimental design Destination: 1 Item: Title: Preparation and assessment of Aβ oligomeric aggregates Destination: 1 Item: Title: Intracerebroventricular injection of amyloid-β Destination: 1 Item: Title: Electrode implantation Destination: 1 Item: Title: Intracranial self-stimulation treatment Destination: 1 Item: Title: Morris water maze Destination: 1 Item: Title: Tissue collection Destination: 1 Item: Title: Ptau and DBN immunostaining Destination: 1 Item: Title: Statistical analyses Destination: 1 Item: Title: Results Destination: 1 Children: Item: Title: Aggregation of Aβ1-42 peptide Destination: 1 Item: Title: Electrode location and ICSS behaviour Destination: 1 Item: Title: Spatial learning and memory Destination: 1 Item: Title: Ptau levels Destination: 1 Item: Title: DBN levels Destination: 1 Item: Title: Discussion Destination: 1 Item: Title: CRediT authorship contribution statement Destination: 1 Item: Title: ack21 Destination: 1 Item: Title: Acknowledgements Destination: 1 Item: Title: Funding Destination: 1 Item: Title: Ethical approval Destination: 1 Item: Title: Author agreement Destination: 1 Item: Title: Conflict of interest Destination: 1 Item: Title: References Destination: 1 Info: Title: Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats Author: Irene Puig-Parnau Subject: Neuroscience, 512 (2023) 16-31. doi:10.1016/j.neuroscience.2023.01.005 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Tue Feb 14 08:20:11 CET 2023 ModDate: Tue Feb 14 08:22:24 CET 2023 ID: 0xd94ddddf89b0c0531f6edc5f11555906, 0xdfc6ca1f34d4e64a9e72604f57635fbc Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 62 ImageHeight: 62 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 14 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 12 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 9 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 12 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 8 ImageHeight: 10 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 19 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 19 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 6 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 7 ImageHeight: 4 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 15 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 4 ImageHeight: 4 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 71 ImageHeight: 71 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 21 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 19 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 37 ImageHeight: 19 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 19 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 480 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 2760 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 2052 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 963 ImageHeight: 1049 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 932 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1412 ImageHeight: 760 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 963 ImageHeight: 719 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1070 ImageHeight: 2532 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 2758 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2049 ImageHeight: 2758 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 963 ImageHeight: 641 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: IFGGLN+AdvPi3 FontSubset: true FirstChar: 34 LastChar: 51 FontDescriptor: FontName: IFGGLN+AdvPi3 Flags: Nonsymbolic FontBBox: -11, -345, 1373, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGDCB+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: IFGDCB+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: IFGBNB+AdvArial-b FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: IFGBNB+AdvArial-b Flags: Symbolic FontBBox: -190, -211, 1001, 778 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IFGBNC+AdvPSMP11 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: IFGBNC+AdvPSMP11 Flags: Nonsymbolic FontBBox: 0, -302, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGBND+AdvArial FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: IFGBND+AdvArial Flags: Symbolic FontBBox: -223, -212, 1002, 784 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IFGDCC+AdvPi1 FontSubset: true FirstChar: 109 LastChar: 109 FontDescriptor: FontName: IFGDCC+AdvPi1 Flags: Nonsymbolic FontBBox: 13, -323, 958, 824 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGBNE+AdvArial-i FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: IFGBNE+AdvArial-i Flags: Serif, Nonsymbolic FontBBox: -213, -211, 1064, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGCCE+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: IFGCCE+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: IFGCDE+AdvPSMP13 FontSubset: true FirstChar: 98 LastChar: 108 FontDescriptor: FontName: IFGCDE+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGGLM+AdvPSMP10 FontSubset: true FirstChar: 113 LastChar: 113 FontDescriptor: FontName: IFGGLM+AdvPSMP10 Flags: Nonsymbolic FontBBox: 0, -302, 989, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IFGCEF+AdvBENQ-B FontSubset: true FirstChar: 67 LastChar: 85 FontDescriptor: FontName: IFGCEF+AdvBENQ-B Flags: Nonsymbolic FontBBox: -125, -239, 1385, 770 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.neuroscience.2023.01.005 Intracranial Self-stimulation of the Medial Forebrain Bundle Ameliorates Memory Disturbances and Pathological Hallmarks in an Alzheimer’s Disease Model by Intracerebral Administration of Amyloid-β in Rats Irene Puig-Parnau Soleil Garcia-Brito Laia Vila-Soles Andrea Riberas Laura Aldavert-Vera Pilar Segura-Torres Elisabet Kádár Gemma Huguet Alzheimer’s disease amyloid-β deep brain stimulation medial forebrain bundle intracranial self-stimulation Neuroscience, 512 (2023) 16-31. doi:10.1016/j.neuroscience.2023.01.005 The Author(s) journal Neuroscience © 2023 The Author(s). Published by Elsevier Ltd on behalf of IBRO. 0306-4522 512 21 February 2023 2023-02-21 16-31 16 31 10.1016/j.neuroscience.2023.01.005 https://doi.org/10.1016/j.neuroscience.2023.01.005 VoR 10.1016/j.neuroscience.2023.01.005 noindex 6.5 Elsevier 2023-02-14T12:20:11+05:30 2023-02-14T12:22:24+05:30 2023-02-14T12:22:24+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:c728b63f-2691-48aa-bbd9-1b48dd26585b uuid:2362e1f2-d278-4425-ab84-8e40c4260db2 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 16 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 51, 645, 51, 659 Destination: null Annotation: Subtype: Link Rect: 51, 576, 51, 585 Destination: null Annotation: Subtype: Link Rect: 127, 580, 131, 588 Destination: 637 Annotation: Subtype: Link Rect: 212, 580, 215, 588 Destination: 637 Annotation: Subtype: Link Rect: 282, 580, 286, 588 Destination: 637 Annotation: Subtype: Link Rect: 355, 580, 359, 588 Destination: 637 Annotation: Subtype: Link Rect: 446, 580, 450, 588 Destination: 637 Annotation: Subtype: Link Rect: 535, 580, 539, 588 Destination: 637 Annotation: Subtype: Link Rect: 539, 575, 542, 588 Destination: 637 Annotation: Subtype: Link Rect: 111, 571, 115, 579 Destination: 637 Annotation: Subtype: Link Rect: 115, 566, 118, 579 Destination: 637 Annotation: Subtype: Link Rect: 204, 571, 207, 579 Destination: 637 Annotation: Subtype: Link Rect: 207, 566, 211, 579 Destination: 637 Annotation: Subtype: Link Rect: 51, 554, 51, 561 Destination: null Annotation: Subtype: Link Rect: 51, 541, 51, 549 Destination: null Annotation: Subtype: Link Rect: 51, 510, 51, 519 Destination: null Annotation: Subtype: Link Rect: 96, 510, 96, 519 Destination: null Annotation: Subtype: Link Rect: 472, 347, 544, 355 Annotation: Subtype: Link Rect: 51, 337, 173, 345 Annotation: Subtype: Link Rect: 127, 282, 128, 292 Destination: null Annotation: Subtype: Link Rect: 51, 265, 51, 274 Destination: null Annotation: Subtype: Link Rect: 137, 222, 228, 231 Destination: 352 Annotation: Subtype: Link Rect: 89, 200, 192, 209 Destination: 281 Annotation: Subtype: Link Rect: 193, 189, 232, 198 Destination: 281 Annotation: Subtype: Link Rect: 193, 189, 283, 198 Destination: 281 Annotation: Subtype: Link Rect: 51, 178, 109, 187 Destination: 281 Annotation: Subtype: Link Rect: 314, 283, 427, 292 Destination: 352 Annotation: Subtype: Link Rect: 326, 261, 326, 270 Destination: null Annotation: Subtype: Link Rect: 383, 250, 506, 259 Destination: 229 Annotation: Subtype: Link Rect: 424, 206, 483, 215 Destination: 281 Annotation: Subtype: Link Rect: 495, 162, 544, 171 Destination: 281 Annotation: Subtype: Link Rect: 311, 151, 544, 160 Destination: 281 Annotation: Subtype: Link Rect: 311, 140, 517, 149 Destination: 281 Annotation: Subtype: Link Rect: 515, 108, 544, 117 Destination: 229 Annotation: Subtype: Link Rect: 311, 97, 424, 106 Destination: 229 Annotation: Subtype: Link Rect: 326, 86, 326, 95 Destination: null Annotation: Subtype: Link Rect: 51, 54, 212, 61 Annotation: Subtype: Link Rect: 251, 38, 406, 45 Annotation: Subtype: Link Rect: 114, 106, 184, 114 Annotation: Subtype: Link Rect: 255, 106, 283, 114 Annotation: Subtype: Link Rect: 51, 98, 105, 105 Annotation: Subtype: Link Rect: 109, 98, 195, 105 Annotation: Subtype: Link Rect: 51, 692, 123, 700 Annotation: Subtype: Link Rect: 51, 692, 127, 700 Annotation: Subtype: Link Rect: 51, 692, 241, 700 Page: Label: 17 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 85, 670, 121, 679 Destination: 229 Annotation: Subtype: Link Rect: 85, 670, 230, 679 Destination: 229 Annotation: Subtype: Link Rect: 85, 670, 283, 679 Destination: 229 Annotation: Subtype: Link Rect: 51, 659, 140, 668 Destination: 229 Annotation: Subtype: Link Rect: 51, 659, 283, 668 Destination: 229 Annotation: Subtype: Link Rect: 51, 659, 283, 668 Destination: 229 Annotation: Subtype: Link Rect: 51, 648, 153, 657 Destination: 229 Annotation: Subtype: Link Rect: 51, 648, 283, 657 Destination: 229 Annotation: Subtype: Link Rect: 51, 637, 170, 646 Destination: 229 Annotation: Subtype: Link Rect: 51, 637, 283, 646 Destination: 229 Annotation: Subtype: Link Rect: 51, 626, 100, 635 Destination: 229 Annotation: Subtype: Link Rect: 253, 604, 283, 613 Destination: 281 Annotation: Subtype: Link Rect: 51, 593, 283, 602 Destination: 281 Annotation: Subtype: Link Rect: 51, 582, 87, 591 Destination: 281 Annotation: Subtype: Link Rect: 51, 582, 165, 591 Destination: 281 Annotation: Subtype: Link Rect: 54, 550, 75, 559 Destination: 352 Annotation: Subtype: Link Rect: 54, 550, 159, 559 Destination: 352 Annotation: Subtype: Link Rect: 65, 495, 65, 504 Destination: null Annotation: Subtype: Link Rect: 146, 473, 283, 482 Destination: 229 Annotation: Subtype: Link Rect: 51, 462, 99, 471 Destination: 229 Annotation: Subtype: Link Rect: 257, 440, 283, 449 Destination: 352 Annotation: Subtype: Link Rect: 51, 429, 97, 438 Destination: 352 Annotation: Subtype: Link Rect: 65, 374, 65, 383 Destination: null Annotation: Subtype: Link Rect: 89, 257, 89, 267 Destination: null Annotation: Subtype: Link Rect: 51, 241, 51, 250 Destination: null Annotation: Subtype: Link Rect: 51, 224, 51, 233 Destination: null Annotation: Subtype: Link Rect: 65, 125, 65, 134 Destination: null Annotation: Subtype: Link Rect: 65, 82, 65, 91 Destination: null Annotation: Subtype: Link Rect: 478, 648, 502, 657 Destination: 39 Annotation: Subtype: Link Rect: 326, 637, 326, 646 Destination: null Annotation: Subtype: Link Rect: 311, 502, 311, 511 Destination: null Annotation: Subtype: Link Rect: 311, 475, 311, 483 Destination: null Annotation: Subtype: Link Rect: 326, 288, 326, 297 Destination: null Annotation: Subtype: Link Rect: 311, 76, 311, 85 Destination: null Annotation: Subtype: Link Rect: 311, 60, 311, 69 Destination: null Page: Label: 18 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 250, 446, 283, 455 Destination: 352 Annotation: Subtype: Link Rect: 51, 435, 130, 444 Destination: 352 Annotation: Subtype: Link Rect: 51, 273, 51, 282 Destination: null Annotation: Subtype: Link Rect: 51, 257, 51, 266 Destination: null Annotation: Subtype: Link Rect: 195, 202, 283, 211 Destination: 352 Annotation: Subtype: Link Rect: 51, 191, 71, 200 Destination: 352 Annotation: Subtype: Link Rect: 65, 49, 65, 58 Destination: null Annotation: Subtype: Link Rect: 311, 489, 311, 498 Destination: null Annotation: Subtype: Link Rect: 311, 472, 311, 481 Destination: null Annotation: Subtype: Link Rect: 326, 352, 326, 360 Destination: null Annotation: Subtype: Link Rect: 311, 230, 311, 239 Destination: null Annotation: Subtype: Link Rect: 311, 213, 311, 222 Destination: null Annotation: Subtype: Link Rect: 358, 104, 473, 112 Destination: 352 Annotation: Subtype: Link Rect: 326, 93, 326, 102 Destination: null Annotation: Subtype: Link Rect: 51, 585, 51, 597 Destination: null Page: Label: 19 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 51, 555, 51, 564 Destination: null Annotation: Subtype: Link Rect: 51, 538, 51, 547 Destination: null Annotation: Subtype: Link Rect: 51, 346, 51, 355 Destination: null Annotation: Subtype: Link Rect: 51, 330, 51, 339 Destination: null Annotation: Subtype: Link Rect: 326, 572, 326, 580 Destination: null Annotation: Subtype: Link Rect: 420, 528, 451, 537 Destination: 58 Annotation: Subtype: Link Rect: 484, 528, 489, 537 Destination: 83 Annotation: Subtype: Link Rect: 326, 495, 326, 504 Destination: null Annotation: Subtype: Link Rect: 461, 462, 489, 471 Destination: 58 Annotation: Subtype: Link Rect: 516, 462, 521, 471 Destination: 83 Annotation: Subtype: Link Rect: 311, 438, 311, 447 Destination: null Annotation: Subtype: Link Rect: 311, 421, 311, 430 Destination: null Annotation: Subtype: Link Rect: 404, 231, 404, 241 Destination: null Annotation: Subtype: Link Rect: 311, 215, 311, 224 Destination: null Annotation: Subtype: Link Rect: 311, 198, 311, 207 Destination: null Annotation: Subtype: Link Rect: 314, 155, 338, 164 Destination: 94 Annotation: Subtype: Link Rect: 51, 122, 51, 134 Destination: null Annotation: Subtype: Link Rect: 226, 72, 321, 80 Destination: 352 Page: Label: 20 Sequence: 5 Page: Label: 21 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 51, 110, 51, 119 Destination: null Annotation: Subtype: Link Rect: 51, 93, 51, 102 Destination: null Annotation: Subtype: Link Rect: 51, 93, 73, 102 Destination: 94 Annotation: Subtype: Link Rect: 326, 110, 326, 119 Destination: null Annotation: Subtype: Link Rect: 51, 207, 51, 219 Destination: null Annotation: Subtype: Link Rect: 198, 166, 292, 174 Destination: 352 Annotation: Subtype: Link Rect: 82, 139, 101, 147 Destination: 94 Page: Label: 22 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 311, 639, 311, 648 Destination: null Annotation: Subtype: Link Rect: 311, 622, 311, 631 Destination: null Annotation: Subtype: Link Rect: 515, 600, 541, 609 Destination: 105 Annotation: Subtype: Link Rect: 326, 458, 326, 467 Destination: null Annotation: Subtype: Link Rect: 51, 448, 51, 460 Destination: null Annotation: Subtype: Link Rect: 51, 108, 51, 120 Destination: null Page: Label: 23 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 65, 203, 65, 212 Destination: null Annotation: Subtype: Link Rect: 159, 115, 184, 124 Destination: 105 Annotation: Subtype: Link Rect: 415, 615, 415, 624 Destination: null Annotation: Subtype: Link Rect: 311, 414, 311, 423 Destination: null Annotation: Subtype: Link Rect: 311, 398, 311, 407 Destination: null Annotation: Subtype: Link Rect: 468, 266, 527, 275 Destination: 122 Annotation: Subtype: Link Rect: 326, 201, 326, 209 Destination: null Annotation: Subtype: Link Rect: 311, 153, 311, 162 Destination: null Annotation: Subtype: Link Rect: 311, 136, 311, 145 Destination: null Annotation: Subtype: Link Rect: 314, 60, 375, 69 Destination: 140 Annotation: Subtype: Link Rect: 51, 518, 51, 530 Destination: null Annotation: Subtype: Link Rect: 51, 283, 51, 295 Destination: null Page: Label: 24 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 455, 692, 487, 701 Destination: 188 Annotation: Subtype: Link Rect: 509, 692, 538, 701 Destination: 188 Annotation: Subtype: Link Rect: 470, 593, 530, 602 Destination: 140 Annotation: Subtype: Link Rect: 333, 582, 333, 591 Destination: null Annotation: Subtype: Link Rect: 476, 462, 538, 471 Destination: 140 Annotation: Subtype: Link Rect: 385, 407, 414, 416 Destination: 188 Annotation: Subtype: Link Rect: 399, 370, 399, 380 Destination: null Annotation: Subtype: Link Rect: 318, 354, 319, 363 Destination: null Annotation: Subtype: Link Rect: 333, 211, 333, 220 Destination: null Annotation: Subtype: Link Rect: 318, 135, 318, 147 Destination: null Page: Label: 25 Sequence: 10 Page: Label: 26 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 65, 703, 65, 712 Destination: null Annotation: Subtype: Link Rect: 51, 626, 130, 635 Destination: 281 Annotation: Subtype: Link Rect: 142, 506, 219, 515 Destination: 281 Annotation: Subtype: Link Rect: 161, 374, 283, 383 Destination: 229 Annotation: Subtype: Link Rect: 51, 363, 215, 372 Destination: 229 Annotation: Subtype: Link Rect: 65, 352, 65, 361 Destination: null Annotation: Subtype: Link Rect: 231, 308, 283, 317 Destination: 281 Annotation: Subtype: Link Rect: 51, 298, 71, 306 Destination: 281 Annotation: Subtype: Link Rect: 65, 287, 65, 296 Destination: null Annotation: Subtype: Link Rect: 249, 210, 283, 219 Destination: 352 Annotation: Subtype: Link Rect: 51, 199, 223, 208 Destination: 352 Annotation: Subtype: Link Rect: 65, 188, 65, 197 Destination: null Annotation: Subtype: Link Rect: 406, 692, 544, 701 Destination: 229 Annotation: Subtype: Link Rect: 311, 681, 332, 690 Destination: 229 Annotation: Subtype: Link Rect: 334, 615, 457, 624 Destination: 281 Annotation: Subtype: Link Rect: 326, 561, 326, 569 Destination: null Annotation: Subtype: Link Rect: 363, 484, 400, 493 Destination: 229 Annotation: Subtype: Link Rect: 363, 484, 521, 493 Destination: 229 Annotation: Subtype: Link Rect: 363, 484, 544, 493 Destination: 229 Annotation: Subtype: Link Rect: 311, 473, 361, 482 Destination: 229 Annotation: Subtype: Link Rect: 314, 407, 345, 416 Destination: 281 Annotation: Subtype: Link Rect: 314, 407, 416, 416 Destination: 281 Annotation: Subtype: Link Rect: 326, 396, 326, 405 Destination: null Annotation: Subtype: Link Rect: 509, 341, 544, 350 Destination: 352 Annotation: Subtype: Link Rect: 509, 341, 544, 350 Destination: 352 Annotation: Subtype: Link Rect: 311, 330, 430, 339 Destination: 352 Annotation: Subtype: Link Rect: 311, 330, 544, 339 Destination: 352 Annotation: Subtype: Link Rect: 311, 319, 393, 328 Destination: 352 Annotation: Subtype: Link Rect: 311, 319, 460, 328 Destination: 352 Annotation: Subtype: Link Rect: 495, 287, 544, 296 Destination: 352 Annotation: Subtype: Link Rect: 311, 276, 332, 285 Destination: 352 Annotation: Subtype: Link Rect: 503, 243, 544, 252 Destination: 352 Annotation: Subtype: Link Rect: 311, 232, 406, 241 Destination: 352 Annotation: Subtype: Link Rect: 311, 232, 544, 241 Destination: 352 Annotation: Subtype: Link Rect: 311, 221, 332, 230 Destination: 352 Annotation: Subtype: Link Rect: 487, 188, 544, 197 Destination: 352 Annotation: Subtype: Link Rect: 311, 177, 332, 186 Destination: 352 Annotation: Subtype: Link Rect: 491, 144, 544, 153 Destination: 352 Annotation: Subtype: Link Rect: 311, 133, 419, 142 Destination: 352 Annotation: Subtype: Link Rect: 51, 95, 51, 107 Destination: null Page: Label: 27 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 51, 49, 51, 61 Destination: null Page: Label: 28 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 65, 205, 65, 214 Destination: null Annotation: Subtype: Link Rect: 145, 183, 277, 192 Destination: 352 Annotation: Subtype: Link Rect: 54, 150, 126, 159 Destination: 352 Annotation: Subtype: Link Rect: 168, 106, 220, 115 Destination: 352 Annotation: Subtype: Link Rect: 54, 73, 223, 82 Destination: 229 Annotation: Subtype: Link Rect: 251, 63, 283, 72 Destination: 229 Annotation: Subtype: Link Rect: 51, 52, 209, 61 Destination: 229 Annotation: Subtype: Link Rect: 326, 659, 326, 668 Destination: null Annotation: Subtype: Link Rect: 523, 604, 544, 613 Destination: 352 Annotation: Subtype: Link Rect: 311, 593, 361, 602 Destination: 352 Annotation: Subtype: Link Rect: 314, 572, 435, 580 Destination: 281 Annotation: Subtype: Link Rect: 421, 539, 465, 548 Destination: 229 Annotation: Subtype: Link Rect: 421, 539, 538, 548 Destination: 229 Annotation: Subtype: Link Rect: 425, 473, 504, 482 Destination: 281 Annotation: Subtype: Link Rect: 314, 385, 336, 394 Destination: 352 Annotation: Subtype: Link Rect: 314, 385, 416, 394 Destination: 352 Annotation: Subtype: Link Rect: 514, 374, 544, 383 Destination: 281 Annotation: Subtype: Link Rect: 311, 363, 437, 372 Destination: 281 Annotation: Subtype: Link Rect: 473, 352, 544, 361 Destination: 352 Annotation: Subtype: Link Rect: 311, 341, 387, 350 Destination: 352 Annotation: Subtype: Link Rect: 311, 341, 465, 350 Destination: 352 Annotation: Subtype: Link Rect: 314, 330, 544, 339 Destination: 281 Annotation: Subtype: Link Rect: 311, 319, 417, 328 Destination: 281 Annotation: Subtype: Link Rect: 453, 276, 474, 285 Destination: 352 Annotation: Subtype: Link Rect: 453, 276, 544, 285 Destination: 352 Annotation: Subtype: Link Rect: 311, 265, 332, 274 Destination: 352 Annotation: Subtype: Link Rect: 326, 177, 326, 186 Destination: null Annotation: Subtype: Link Rect: 314, 111, 392, 120 Destination: 281 Annotation: Subtype: Link Rect: 398, 67, 495, 76 Destination: 352 Annotation: Subtype: Link Rect: 380, 45, 452, 54 Destination: 352 Annotation: Subtype: Link Rect: 51, 704, 51, 712 Destination: null Annotation: Subtype: Link Rect: 158, 657, 177, 665 Destination: 140 Annotation: Subtype: Link Rect: 51, 321, 51, 333 Destination: null Page: Label: 29 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 74, 703, 99, 712 Destination: 352 Annotation: Subtype: Link Rect: 74, 703, 195, 712 Destination: 352 Annotation: Subtype: Link Rect: 65, 626, 65, 635 Destination: null Annotation: Subtype: Link Rect: 71, 469, 71, 479 Destination: null Annotation: Subtype: Link Rect: 51, 440, 51, 449 Destination: null Annotation: Subtype: Link Rect: 108, 271, 108, 281 Destination: null Annotation: Subtype: Link Rect: 108, 271, 108, 281 Destination: null Annotation: Subtype: Link Rect: 51, 255, 51, 264 Destination: null Annotation: Subtype: Link Rect: 143, 207, 144, 217 Destination: null Annotation: Subtype: Link Rect: 51, 190, 51, 199 Destination: null Annotation: Subtype: Link Rect: 114, 109, 115, 119 Destination: null Annotation: Subtype: Link Rect: 51, 93, 51, 102 Destination: null Annotation: Subtype: Link Rect: 371, 701, 371, 711 Destination: null Annotation: Subtype: Link Rect: 311, 685, 311, 693 Destination: null Annotation: Subtype: Link Rect: 366, 632, 366, 642 Destination: null Annotation: Subtype: Link Rect: 311, 616, 311, 625 Destination: null Annotation: Subtype: Link Rect: 393, 587, 393, 597 Destination: null Annotation: Subtype: Link Rect: 311, 568, 311, 576 Destination: null Annotation: Subtype: Link Rect: 368, 530, 501, 538 Annotation: Subtype: Link Rect: 311, 521, 311, 528 Destination: null Annotation: Subtype: Link Rect: 462, 483, 544, 490 Annotation: Subtype: Link Rect: 323, 474, 379, 481 Annotation: Subtype: Link Rect: 311, 464, 311, 472 Destination: null Annotation: Subtype: Link Rect: 382, 445, 511, 453 Annotation: Subtype: Link Rect: 311, 436, 311, 443 Destination: null Annotation: Subtype: Link Rect: 401, 426, 544, 434 Annotation: Subtype: Link Rect: 323, 417, 455, 424 Annotation: Subtype: Link Rect: 311, 407, 311, 415 Destination: null Annotation: Subtype: Link Rect: 410, 360, 523, 367 Annotation: Subtype: Link Rect: 311, 350, 311, 358 Destination: null Annotation: Subtype: Link Rect: 521, 341, 544, 349 Annotation: Subtype: Link Rect: 323, 332, 473, 339 Annotation: Subtype: Link Rect: 311, 322, 311, 330 Destination: null Annotation: Subtype: Link Rect: 323, 284, 468, 292 Annotation: Subtype: Link Rect: 311, 275, 311, 282 Destination: null Annotation: Subtype: Link Rect: 438, 246, 544, 254 Annotation: Subtype: Link Rect: 323, 237, 362, 244 Annotation: Subtype: Link Rect: 311, 227, 311, 235 Destination: null Annotation: Subtype: Link Rect: 495, 218, 544, 225 Annotation: Subtype: Link Rect: 323, 209, 397, 216 Annotation: Subtype: Link Rect: 311, 199, 311, 207 Destination: null Annotation: Subtype: Link Rect: 378, 180, 508, 188 Annotation: Subtype: Link Rect: 311, 171, 311, 178 Destination: null Annotation: Subtype: Link Rect: 508, 133, 544, 140 Annotation: Subtype: Link Rect: 323, 123, 409, 131 Annotation: Subtype: Link Rect: 311, 114, 311, 121 Destination: null Annotation: Subtype: Link Rect: 495, 76, 544, 84 Annotation: Subtype: Link Rect: 323, 67, 413, 74 Annotation: Subtype: Link Rect: 311, 57, 311, 65 Destination: null Page: Label: 30 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 162, 704, 283, 712 Annotation: Subtype: Link Rect: 62, 695, 90, 702 Annotation: Subtype: Link Rect: 51, 686, 51, 693 Destination: null Annotation: Subtype: Link Rect: 108, 657, 229, 665 Annotation: Subtype: Link Rect: 51, 648, 51, 655 Destination: null Annotation: Subtype: Link Rect: 201, 619, 283, 627 Annotation: Subtype: Link Rect: 62, 610, 118, 617 Annotation: Subtype: Link Rect: 51, 600, 51, 608 Destination: null Annotation: Subtype: Link Rect: 234, 572, 283, 579 Annotation: Subtype: Link Rect: 62, 563, 155, 570 Annotation: Subtype: Link Rect: 51, 553, 51, 561 Destination: null Annotation: Subtype: Link Rect: 62, 525, 225, 532 Annotation: Subtype: Link Rect: 51, 515, 51, 523 Destination: null Annotation: Subtype: Link Rect: 108, 468, 262, 475 Annotation: Subtype: Link Rect: 51, 458, 51, 466 Destination: null Annotation: Subtype: Link Rect: 126, 430, 283, 438 Annotation: Subtype: Link Rect: 62, 421, 67, 428 Annotation: Subtype: Link Rect: 51, 411, 51, 419 Destination: null Annotation: Subtype: Link Rect: 234, 383, 283, 390 Annotation: Subtype: Link Rect: 62, 373, 149, 381 Annotation: Subtype: Link Rect: 51, 364, 51, 371 Destination: null Annotation: Subtype: Link Rect: 205, 335, 283, 343 Annotation: Subtype: Link Rect: 62, 326, 133, 333 Annotation: Subtype: Link Rect: 51, 316, 51, 324 Destination: null Annotation: Subtype: Link Rect: 108, 269, 246, 277 Annotation: Subtype: Link Rect: 51, 260, 51, 267 Destination: null Annotation: Subtype: Link Rect: 205, 222, 283, 229 Annotation: Subtype: Link Rect: 62, 212, 104, 220 Annotation: Subtype: Link Rect: 51, 203, 51, 210 Destination: null Annotation: Subtype: Link Rect: 201, 165, 283, 172 Annotation: Subtype: Link Rect: 62, 156, 152, 163 Annotation: Subtype: Link Rect: 51, 146, 51, 154 Destination: null Annotation: Subtype: Link Rect: 110, 99, 250, 106 Annotation: Subtype: Link Rect: 51, 89, 51, 97 Destination: null Annotation: Subtype: Link Rect: 205, 70, 283, 78 Annotation: Subtype: Link Rect: 62, 61, 128, 68 Annotation: Subtype: Link Rect: 51, 51, 51, 59 Destination: null Annotation: Subtype: Link Rect: 465, 695, 544, 702 Annotation: Subtype: Link Rect: 323, 686, 409, 693 Annotation: Subtype: Link Rect: 311, 676, 311, 684 Destination: null Annotation: Subtype: Link Rect: 465, 648, 544, 655 Annotation: Subtype: Link Rect: 323, 638, 413, 646 Annotation: Subtype: Link Rect: 311, 629, 311, 636 Destination: null Annotation: Subtype: Link Rect: 323, 591, 438, 598 Annotation: Subtype: Link Rect: 311, 581, 311, 589 Destination: null Annotation: Subtype: Link Rect: 462, 553, 544, 561 Annotation: Subtype: Link Rect: 323, 544, 379, 551 Annotation: Subtype: Link Rect: 311, 534, 311, 542 Destination: null Annotation: Subtype: Link Rect: 372, 496, 511, 504 Annotation: Subtype: Link Rect: 311, 487, 311, 494 Destination: null Annotation: Subtype: Link Rect: 383, 449, 527, 456 Annotation: Subtype: Link Rect: 311, 439, 311, 447 Destination: null Annotation: Subtype: Link Rect: 495, 402, 544, 409 Annotation: Subtype: Link Rect: 323, 392, 421, 400 Annotation: Subtype: Link Rect: 311, 383, 311, 390 Destination: null Annotation: Subtype: Link Rect: 323, 345, 429, 352 Annotation: Subtype: Link Rect: 311, 335, 311, 343 Destination: null Annotation: Subtype: Link Rect: 323, 316, 468, 324 Annotation: Subtype: Link Rect: 311, 307, 311, 314 Destination: null Annotation: Subtype: Link Rect: 323, 250, 442, 258 Annotation: Subtype: Link Rect: 311, 241, 311, 248 Destination: null Annotation: Subtype: Link Rect: 368, 174, 489, 182 Annotation: Subtype: Link Rect: 311, 165, 311, 172 Destination: null Annotation: Subtype: Link Rect: 387, 137, 524, 144 Annotation: Subtype: Link Rect: 311, 127, 311, 135 Destination: null Annotation: Subtype: Link Rect: 495, 89, 544, 97 Annotation: Subtype: Link Rect: 323, 80, 447, 87 Annotation: Subtype: Link Rect: 311, 70, 311, 78 Destination: null Page: Label: 31 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 234, 704, 283, 712 Annotation: Subtype: Link Rect: 62, 695, 135, 702 Annotation: Subtype: Link Rect: 51, 686, 51, 693 Destination: null Annotation: Subtype: Link Rect: 51, 686, 283, 693 Annotation: Subtype: Link Rect: 62, 676, 129, 684 Annotation: Subtype: Link Rect: 51, 667, 51, 674 Destination: null Annotation: Subtype: Link Rect: 51, 667, 283, 674 Annotation: Subtype: Link Rect: 62, 657, 208, 665 Annotation: Subtype: Link Rect: 51, 648, 51, 655 Destination: null Annotation: Subtype: Link Rect: 205, 629, 283, 636 Annotation: Subtype: Link Rect: 62, 619, 127, 627 Annotation: Subtype: Link Rect: 51, 610, 51, 617 Destination: null Annotation: Subtype: Link Rect: 248, 581, 283, 589 Annotation: Subtype: Link Rect: 62, 572, 147, 579 Annotation: Subtype: Link Rect: 51, 563, 51, 570 Destination: null Annotation: Subtype: Link Rect: 62, 525, 213, 532 Annotation: Subtype: Link Rect: 51, 515, 51, 523 Destination: null Annotation: Subtype: Link Rect: 97, 477, 259, 485 Annotation: Subtype: Link Rect: 51, 468, 51, 475 Destination: null Annotation: Subtype: Link Rect: 234, 430, 283, 438 Annotation: Subtype: Link Rect: 62, 421, 165, 428 Annotation: Subtype: Link Rect: 51, 411, 51, 419 Destination: null Annotation: Subtype: Link Rect: 248, 402, 283, 409 Annotation: Subtype: Link Rect: 62, 392, 189, 400 Annotation: Subtype: Link Rect: 51, 383, 51, 390 Destination: null Annotation: Subtype: Link Rect: 201, 354, 283, 362 Annotation: Subtype: Link Rect: 62, 345, 147, 352 Annotation: Subtype: Link Rect: 51, 335, 51, 343 Destination: null Annotation: Subtype: Link Rect: 201, 307, 283, 314 Annotation: Subtype: Link Rect: 62, 298, 152, 305 Annotation: Subtype: Link Rect: 51, 288, 51, 295 Destination: null Annotation: Subtype: Link Rect: 127, 260, 266, 267 Annotation: Subtype: Link Rect: 51, 250, 51, 258 Destination: null Annotation: Subtype: Link Rect: 62, 222, 201, 229 Annotation: Subtype: Link Rect: 51, 212, 51, 220 Destination: null Annotation: Subtype: Link Rect: 51, 212, 283, 220 Annotation: Subtype: Link Rect: 62, 203, 283, 210 Annotation: Subtype: Link Rect: 62, 193, 283, 201 Annotation: Subtype: Link Rect: 62, 184, 88, 191 Annotation: Subtype: Link Rect: 51, 174, 51, 182 Destination: null Annotation: Subtype: Link Rect: 117, 146, 273, 154 Annotation: Subtype: Link Rect: 51, 137, 51, 144 Destination: null Annotation: Subtype: Link Rect: 462, 704, 544, 712 Annotation: Subtype: Link Rect: 323, 695, 380, 702 Annotation: Subtype: Link Rect: 311, 686, 311, 693 Destination: null Annotation: Subtype: Link Rect: 369, 657, 489, 665 Annotation: Subtype: Link Rect: 311, 648, 311, 655 Destination: null Annotation: Subtype: Link Rect: 394, 638, 530, 646 Annotation: Subtype: Link Rect: 311, 629, 311, 636 Destination: null Annotation: Subtype: Link Rect: 402, 610, 542, 617 Annotation: Subtype: Link Rect: 311, 600, 311, 608 Destination: null Annotation: Subtype: Link Rect: 372, 572, 510, 579 Annotation: Subtype: Link Rect: 311, 563, 311, 570 Destination: null Annotation: Subtype: Link Rect: 495, 553, 544, 561 Annotation: Subtype: Link Rect: 323, 544, 408, 551 Annotation: Subtype: Link Rect: 311, 534, 311, 542 Destination: null Annotation: Subtype: Link Rect: 382, 506, 532, 513 Annotation: Subtype: Link Rect: 311, 496, 311, 504 Destination: null Annotation: Subtype: Link Rect: 398, 477, 528, 485 Annotation: Subtype: Link Rect: 311, 468, 311, 475 Destination: null Annotation: Subtype: Link Rect: 412, 449, 544, 456 Annotation: Subtype: Link Rect: 323, 439, 345, 447 Annotation: Subtype: Link Rect: 311, 430, 311, 438 Destination: null Annotation: Subtype: Link Rect: 438, 402, 544, 409 Annotation: Subtype: Link Rect: 323, 392, 362, 400 Annotation: Subtype: Link Rect: 311, 383, 311, 390 Destination: null Annotation: Subtype: Link Rect: 421, 354, 544, 362 Annotation: Subtype: Link Rect: 323, 345, 351, 352 Annotation: Subtype: Link Rect: 311, 335, 311, 343 Destination: null Annotation: Subtype: Link Rect: 422, 316, 544, 324 Annotation: Subtype: Link Rect: 323, 307, 353, 314 Annotation: Subtype: Link Rect: 311, 298, 311, 305 Destination: null Annotation: Subtype: Link Rect: 495, 279, 544, 286 Annotation: Subtype: Link Rect: 323, 269, 436, 277 Annotation: Subtype: Link Rect: 311, 260, 311, 267 Destination: null Annotation: Subtype: Link Rect: 323, 222, 442, 229 Annotation: Subtype: Link Rect: 311, 212, 311, 220 Destination: null Annotation: Subtype: Link Rect: 424, 193, 544, 201 Annotation: Subtype: Link Rect: 323, 184, 365, 191 Annotation: Subtype: Link Rect: 311, 174, 311, 182 Destination: null Annotation: Subtype: Link Rect: 495, 156, 544, 163 Annotation: Subtype: Link Rect: 323, 146, 420, 154 Annotation: Subtype: Link Rect: 311, 137, 311, 144 Destination: null Annotation: Subtype: Link Rect: 418, 118, 534, 125 Checksum: 8182f5c1 Type: CRC32 Checksum: 2488c3aee999f8df054c1cd7a02fdba2 Type: MD5 Checksum: 1f0fe8fdf326f33dbed724c7ca0b2ef516e90db9 Type: SHA-1 Checksum: 78d8094119632c2e073f0e24df266f4324aa23d6e71219649721564537a260fb Type: SHA-256