94d13a93d49fb5be906c259abff2f81d atmosphere_14_01016.pdf 0a68398a5f0fb407814d93b44bd269692967002d atmosphere_14_01016.pdf bfb49a746354380e4c12ae4f8df16d0b1bd31b23a01ae0bfa7f235ed973cd0dc atmosphere_14_01016.pdf Title: A Comparison of Models for the Forecast of Daily Concentration Thresholds of Airborne Fungal Spores Subject: Aerobiological predictive model development is of increasing interest, despite the distribution and variability of data and the limitations of statistical methods making it highly challenging. The use of concentration thresholds and models, where a binary response allows one to establish the occurrence or non-occurrence of the threshold, have been proposed to reduce difficulties. In this paper, we use logistic regression (logit) and regression trees to predict the daily concentration thresholds (low, medium, high, and very high) of six airborne fungal spore taxa (Alternaria, Cladosporium, Agaricus, Ganoderma, Leptosphaeria, and Pleospora) in eight localities in Catalonia (NE Spain) using data from 1995 to 2014. The predictive potential of these models was analyzed through sensitivity and specificity. The models showed similar results regarding the relationship and influence of the meteorological parameters and fungal spores. Ascospores showed a strong relationship with precipitation and basidiospores with minimum temperature, while conidiospores did not indicate any preferences. Sensitivity (true-positive) and specificity (false-positive) presented highly satisfactory validation results for both models in all thresholds, with an average of 73%. However, seeing as logit offers greater precision when attempting to establish the exceedance of a concentration threshold and is easier to apply, it is proposed as the best predictive model. Keywords: aerobiology; logistic regression; mycology; prediction; regression tree Author: Andrés M. Vélez-Pereira, Concepción De Linares, Miquel A. Canela and Jordina Belmonte Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 13 07:17:29 2023 CEST ModDate: Tue Jun 13 07:24:51 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1211077 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LLIWAI+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 WRMHYL+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 CXMGHY+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 HJNPOH+VnURWPalladioL Type 1 Custom yes yes no 23 0 HJOMHV+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 IRXXWC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 JCMDJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 78 0 JCMDKB+PalatinoLinotype CID TrueType Identity-H yes yes yes 81 0 JCMDKC+PalatinoLinotype TrueType WinAnsi yes yes no 87 0 JCMDKE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 90 0 JCMEFB+PalatinoLinotype TrueType MacRoman yes yes no 93 0 YTYGMW+CMEX10 Type 1 Builtin yes yes no 100 0 LVXJLX+VnURWPalladioL-Italic Type 1 Custom yes yes no 104 0 VIGPUI+PazoMath-Italic Type 1 Builtin yes yes no 108 0 GIGFZE+CMR10 Type 1 Builtin yes yes no 112 0 QQXUPP+PazoMath Type 1 Builtin yes yes no 116 0 FRIBTL+CMSY10 Type 1 Builtin yes yes no 120 0 JCMDJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 137 0 JCMDKB+PalatinoLinotype CID TrueType Identity-H yes yes yes 140 0 JCMDKC+PalatinoLinotype TrueType WinAnsi yes yes no 146 0 JCMDKE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 149 0 JCMEFB+PalatinoLinotype TrueType MacRoman yes yes no 152 0 JCMDJA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 166 0 JCMDKB+PalatinoLinotype CID TrueType Identity-H yes yes yes 169 0 JCMDKC+PalatinoLinotype TrueType WinAnsi yes yes no 175 0 JCMDKE+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 178 0 JCMEFB+PalatinoLinotype TrueType MacRoman yes yes no 181 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-23 02:30:58 CEST RepresentationInformation: atmosphere_14_01016.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-21 01:34:26 CEST Size: 1211077 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 429 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Area Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Aerobiological and Meteorological Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistical Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Logistic Regression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Regression Trees Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Criteria for the Application of Regression to Modeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Info: Title: A Comparison of Models for the Forecast of Daily Concentration Thresholds of Airborne Fungal Spores Author: Andrés M. Vélez-Pereira, Concepción De Linares, Miquel A. Canela and Jordina Belmonte Subject: Aerobiological predictive model development is of increasing interest, despite the distribution and variability of data and the limitations of statistical methods making it highly challenging. The use of concentration thresholds and models, where a binary response allows one to establish the occurrence or non-occurrence of the threshold, have been proposed to reduce difficulties. In this paper, we use logistic regression (logit) and regression trees to predict the daily concentration thresholds (low, medium, high, and very high) of six airborne fungal spore taxa (Alternaria, Cladosporium, Agaricus, Ganoderma, Leptosphaeria, and Pleospora) in eight localities in Catalonia (NE Spain) using data from 1995 to 2014. The predictive potential of these models was analyzed through sensitivity and specificity. The models showed similar results regarding the relationship and influence of the meteorological parameters and fungal spores. Ascospores showed a strong relationship with precipitation and basidiospores with minimum temperature, while conidiospores did not indicate any preferences. Sensitivity (true-positive) and specificity (false-positive) presented highly satisfactory validation results for both models in all thresholds, with an average of 73%. However, seeing as logit offers greater precision when attempting to establish the exceedance of a concentration threshold and is easier to apply, it is proposed as the best predictive model. Keywords: aerobiology; logistic regression; mycology; prediction; regression tree Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Jun 13 07:17:29 CEST 2023 ModDate: Tue Jun 13 07:24:51 CEST 2023 ID: 0x1adda40947ae9fa60e33598c2c02d448, 0x1adda40947ae9fa60e33598c2c02d448 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GIGFZE+CMR10 FontSubset: true FirstChar: 40 LastChar: 61 FontDescriptor: FontName: GIGFZE+CMR10 Flags: Symbolic FontBBox: -40, -250, 1009, 750 FontFile: true Font: BaseFont: CXMGHY+URWPalladioL-Ital FontSubset: true FirstChar: 44 LastChar: 248 FontDescriptor: FontName: CXMGHY+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YTYGMW+CMEX10 FontSubset: true FirstChar: 20 LastChar: 21 FontDescriptor: FontName: YTYGMW+CMEX10 Flags: Symbolic FontBBox: -24, -2960, 1454, 772 FontFile: true Font: BaseFont: QQXUPP+PazoMath FontSubset: true FirstChar: 229 LastChar: 229 FontDescriptor: FontName: QQXUPP+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: HJNPOH+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 254 FontDescriptor: FontName: HJNPOH+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FRIBTL+CMSY10 FontSubset: true FirstChar: 0 LastChar: 21 FontDescriptor: FontName: FRIBTL+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: LVXJLX+VnURWPalladioL-Italic FontSubset: true FirstChar: 178 LastChar: 226 FontDescriptor: FontName: LVXJLX+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LLIWAI+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 122 FontDescriptor: FontName: LLIWAI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HJOMHV+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 226 FontDescriptor: FontName: HJOMHV+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VIGPUI+PazoMath-Italic FontSubset: true FirstChar: 98 LastChar: 101 FontDescriptor: FontName: VIGPUI+PazoMath-Italic Flags: Symbolic FontBBox: -70, -277, 902, 733 FontFile: true Font: BaseFont: WRMHYL+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: WRMHYL+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 34, 316, 152, 325 Annotation: Subtype: Link Rect: 34, 306, 83, 313 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 175, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 166, 660, 177, 674 Annotation: Subtype: Link Rect: 299, 660, 311, 674 Annotation: Subtype: Link Rect: 516, 660, 527, 674 Annotation: Subtype: Link Rect: 422, 201, 429, 210 ActionDest: 194 Annotation: Subtype: Link Rect: 495, 176, 502, 185 ActionDest: 194 Annotation: Subtype: Link Rect: 504, 176, 511, 185 ActionDest: 194 Annotation: Subtype: Link Rect: 359, 138, 366, 148 ActionDest: 194 Annotation: Subtype: Link Rect: 243, 113, 250, 122 ActionDest: 194 Annotation: Subtype: Link Rect: 250, 113, 257, 122 ActionDest: 194 Annotation: Subtype: Link Rect: 548, 114, 555, 122 ActionDest: 194 Annotation: Subtype: Link Rect: 394, 101, 401, 110 ActionDest: 194 Annotation: Subtype: Link Rect: 230, 76, 237, 85 ActionDest: 194 Annotation: Subtype: Link Rect: 237, 76, 244, 85 ActionDest: 194 Annotation: Subtype: Link Rect: 127, 17, 272, 28 Annotation: Subtype: Link Rect: 395, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 402, 87, 421 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 506, 723, 518, 732 ActionDest: 194 Annotation: Subtype: Link Rect: 393, 685, 405, 694 ActionDest: 194 Annotation: Subtype: Link Rect: 488, 660, 500, 669 ActionDest: 194 Annotation: Subtype: Link Rect: 435, 635, 442, 644 ActionDest: 194 Annotation: Subtype: Link Rect: 443, 635, 455, 644 ActionDest: 194 Annotation: Subtype: Link Rect: 455, 635, 467, 644 ActionDest: 194 Annotation: Subtype: Link Rect: 272, 610, 279, 619 ActionDest: 194 Annotation: Subtype: Link Rect: 279, 610, 291, 619 ActionDest: 194 Annotation: Subtype: Link Rect: 294, 610, 306, 619 ActionDest: 194 Annotation: Subtype: Link Rect: 315, 572, 322, 581 ActionDest: 194 Annotation: Subtype: Link Rect: 260, 547, 272, 556 ActionDest: 194 Annotation: Subtype: Link Rect: 259, 484, 271, 493 ActionDest: 198 Annotation: Subtype: Link Rect: 285, 472, 297, 481 ActionDest: 198 Annotation: Subtype: Link Rect: 209, 459, 221, 468 ActionDest: 198 Annotation: Subtype: Link Rect: 222, 459, 233, 468 ActionDest: 198 Annotation: Subtype: Link Rect: 458, 447, 470, 456 ActionDest: 198 Annotation: Subtype: Link Rect: 471, 447, 483, 456 ActionDest: 198 Annotation: Subtype: Link Rect: 205, 422, 217, 431 ActionDest: 198 Annotation: Subtype: Link Rect: 219, 422, 231, 431 ActionDest: 198 Annotation: Subtype: Link Rect: 457, 422, 469, 431 ActionDest: 198 Annotation: Subtype: Link Rect: 527, 409, 539, 418 ActionDest: 198 Annotation: Subtype: Link Rect: 524, 334, 536, 343 ActionDest: 194 Annotation: Subtype: Link Rect: 258, 321, 270, 330 ActionDest: 198 Annotation: Subtype: Link Rect: 238, 309, 249, 318 ActionDest: 198 Annotation: Subtype: Link Rect: 253, 309, 265, 318 ActionDest: 198 Annotation: Subtype: Link Rect: 232, 296, 244, 305 ActionDest: 198 Annotation: Subtype: Link Rect: 363, 169, 375, 178 ActionDest: 198 Annotation: Subtype: Link Rect: 432, 91, 439, 103 ActionDest: 68 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 267, 387, 278, 396 ActionDest: 198 Annotation: Subtype: Link Rect: 194, 327, 206, 336 ActionDest: 198 Annotation: Subtype: Link Rect: 504, 327, 516, 336 ActionDest: 198 Annotation: Subtype: Link Rect: 442, 314, 454, 323 ActionDest: 198 Annotation: Subtype: Link Rect: 294, 276, 306, 285 ActionDest: 194 Annotation: Subtype: Link Rect: 499, 201, 511, 210 ActionDest: 194 Annotation: Subtype: Link Rect: 379, 126, 386, 135 ActionDest: 194 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 490, 646, 502, 655 ActionDest: 198 Annotation: Subtype: Link Rect: 458, 634, 470, 643 ActionDest: 198 Annotation: Subtype: Link Rect: 388, 489, 400, 498 ActionDest: 198 Annotation: Subtype: Link Rect: 400, 489, 412, 498 ActionDest: 198 Annotation: Subtype: Link Rect: 232, 451, 244, 460 ActionDest: 194 Annotation: Subtype: Link Rect: 260, 414, 272, 423 ActionDest: 198 Annotation: Subtype: Link Rect: 375, 414, 387, 423 ActionDest: 198 Annotation: Subtype: Link Rect: 254, 364, 266, 372 ActionDest: 198 Annotation: Subtype: Link Rect: 267, 363, 279, 372 ActionDest: 198 Annotation: Subtype: Link Rect: 203, 225, 215, 234 ActionDest: 201 Annotation: Subtype: Link Rect: 216, 225, 228, 234 ActionDest: 201 Annotation: Subtype: Link Rect: 375, 188, 387, 196 ActionDest: 201 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 208, 735, 220, 744 ActionDest: 201 Annotation: Subtype: Link Rect: 199, 660, 211, 669 ActionDest: 201 Annotation: Subtype: Link Rect: 278, 610, 290, 619 ActionDest: 201 Annotation: Subtype: Link Rect: 291, 610, 303, 619 ActionDest: 201 Annotation: Subtype: Link Rect: 499, 572, 511, 581 ActionDest: 201 Annotation: Subtype: Link Rect: 514, 572, 526, 581 ActionDest: 201 Annotation: Subtype: Link Rect: 425, 510, 437, 519 ActionDest: 201 Annotation: Subtype: Link Rect: 473, 396, 485, 405 ActionDest: 201 Annotation: Subtype: Link Rect: 525, 271, 537, 280 ActionDest: 194 Annotation: Subtype: Link Rect: 255, 258, 267, 267 ActionDest: 198 Annotation: Subtype: Link Rect: 218, 79, 225, 91 ActionDest: 127 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 325, 720, 332, 732 ActionDest: 156 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 211, 733, 218, 745 ActionDest: 185 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 373, 559, 380, 568 ActionDest: 194 Annotation: Subtype: Link Rect: 381, 559, 393, 568 ActionDest: 201 Annotation: Subtype: Link Rect: 396, 559, 408, 568 ActionDest: 201 Annotation: Subtype: Link Rect: 189, 534, 201, 543 ActionDest: 201 Annotation: Subtype: Link Rect: 204, 534, 216, 543 ActionDest: 201 Annotation: Subtype: Link Rect: 491, 534, 503, 543 ActionDest: 201 Annotation: Subtype: Link Rect: 456, 509, 468, 518 ActionDest: 201 Annotation: Subtype: Link Rect: 239, 471, 251, 481 ActionDest: 201 Annotation: Subtype: Link Rect: 251, 471, 263, 481 ActionDest: 201 Annotation: Subtype: Link Rect: 266, 471, 278, 481 ActionDest: 201 Annotation: Subtype: Link Rect: 497, 471, 509, 481 ActionDest: 201 Annotation: Subtype: Link Rect: 504, 434, 515, 443 ActionDest: 201 Annotation: Subtype: Link Rect: 462, 384, 474, 393 ActionDest: 201 Annotation: Subtype: Link Rect: 475, 384, 487, 393 ActionDest: 201 Annotation: Subtype: Link Rect: 399, 371, 410, 380 ActionDest: 201 Annotation: Subtype: Link Rect: 475, 321, 487, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 487, 321, 498, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 498, 321, 510, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 510, 321, 521, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 522, 321, 533, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 533, 321, 545, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 545, 321, 556, 330 ActionDest: 201 Annotation: Subtype: Link Rect: 231, 308, 242, 317 ActionDest: 201 Annotation: Subtype: Link Rect: 334, 308, 345, 317 ActionDest: 201 Annotation: Subtype: Link Rect: 343, 283, 354, 292 ActionDest: 201 Annotation: Subtype: Link Rect: 361, 271, 372, 280 ActionDest: 201 Annotation: Subtype: Link Rect: 459, 271, 471, 280 ActionDest: 201 Annotation: Subtype: Link Rect: 528, 246, 540, 255 ActionDest: 204 Annotation: Subtype: Link Rect: 543, 245, 555, 255 ActionDest: 204 Annotation: Subtype: Link Rect: 276, 208, 288, 217 ActionDest: 204 Annotation: Subtype: Link Rect: 291, 208, 303, 217 ActionDest: 204 Annotation: Subtype: Link Rect: 518, 195, 530, 204 ActionDest: 204 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 536, 382, 560, 393 Annotation: Subtype: Link Rect: 165, 370, 378, 381 Annotation: Subtype: Link Rect: 365, 337, 375, 345 ActionDest: 198 Annotation: Subtype: Link Rect: 268, 313, 275, 321 ActionDest: 194 Annotation: Subtype: Link Rect: 275, 313, 286, 321 ActionDest: 194 Annotation: Subtype: Link Rect: 286, 313, 297, 321 ActionDest: 204 Annotation: Subtype: Link Rect: 299, 313, 310, 321 ActionDest: 204 Annotation: Subtype: Link Rect: 180, 288, 187, 297 ActionDest: 194 Annotation: Subtype: Link Rect: 187, 288, 198, 297 ActionDest: 198 Annotation: Subtype: Link Rect: 198, 288, 209, 297 ActionDest: 201 Annotation: Subtype: Link Rect: 209, 288, 220, 297 ActionDest: 201 Annotation: Subtype: Link Rect: 220, 288, 231, 297 ActionDest: 204 Annotation: Subtype: Link Rect: 231, 288, 242, 297 ActionDest: 204 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 213, 445, 250, 455 Annotation: Subtype: Link Rect: 257, 445, 293, 455 Annotation: Subtype: Link Rect: 131, 399, 168, 409 Annotation: Subtype: Link Rect: 175, 399, 211, 409 Annotation: Subtype: Link Rect: 298, 375, 335, 386 Annotation: Subtype: Link Rect: 433, 352, 470, 363 Annotation: Subtype: Link Rect: 477, 352, 513, 363 Annotation: Subtype: Link Rect: 165, 330, 203, 340 Annotation: Subtype: Link Rect: 364, 306, 401, 317 Annotation: Subtype: Link Rect: 323, 283, 361, 294 Annotation: Subtype: Link Rect: 284, 260, 322, 271 Annotation: Subtype: Link Rect: 372, 237, 409, 248 Annotation: Subtype: Link Rect: 225, 214, 262, 225 Annotation: Subtype: Link Rect: 462, 202, 500, 213 Annotation: Subtype: Link Rect: 346, 179, 384, 190 Annotation: Subtype: Link Rect: 276, 156, 313, 167 Annotation: Subtype: Link Rect: 59, 134, 96, 144 Annotation: Subtype: Link Rect: 59, 100, 96, 110 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 253, 722, 290, 733 Annotation: Subtype: Link Rect: 462, 699, 499, 710 Annotation: Subtype: Link Rect: 218, 653, 256, 664 Annotation: Subtype: Link Rect: 360, 606, 397, 617 Annotation: Subtype: Link Rect: 403, 606, 439, 617 Annotation: Subtype: Link Rect: 398, 583, 435, 594 Annotation: Subtype: Link Rect: 442, 583, 478, 594 Annotation: Subtype: Link Rect: 366, 560, 404, 571 Annotation: Subtype: Link Rect: 410, 560, 446, 571 Annotation: Subtype: Link Rect: 169, 537, 207, 548 Annotation: Subtype: Link Rect: 436, 514, 473, 525 Annotation: Subtype: Link Rect: 468, 491, 506, 502 Annotation: Subtype: Link Rect: 178, 469, 216, 479 Annotation: Subtype: Link Rect: 253, 434, 291, 445 Annotation: Subtype: Link Rect: 345, 411, 383, 422 Annotation: Subtype: Link Rect: 449, 388, 486, 399 Annotation: Subtype: Link Rect: 59, 354, 96, 364 Annotation: Subtype: Link Rect: 202, 319, 239, 330 Annotation: Subtype: Link Rect: 178, 284, 216, 295 Annotation: Subtype: Link Rect: 391, 227, 428, 238 Annotation: Subtype: Link Rect: 397, 181, 434, 192 Annotation: Subtype: Link Rect: 131, 136, 168, 146 Annotation: Subtype: Link Rect: 285, 112, 323, 123 Annotation: Subtype: Link Rect: 380, 66, 417, 77 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 95, 722, 133, 733 Annotation: Subtype: Link Rect: 95, 676, 133, 687 Annotation: Subtype: Link Rect: 131, 619, 168, 629 Annotation: Subtype: Link Rect: 393, 595, 431, 606 Annotation: Subtype: Link Rect: 169, 572, 207, 583 Annotation: Subtype: Link Rect: 273, 526, 310, 537 Annotation: Subtype: Link Rect: 394, 491, 431, 502 Annotation: Subtype: Link Rect: 77, 469, 114, 479 Annotation: Subtype: Link Rect: 357, 445, 394, 456 Annotation: Subtype: Link Rect: 59, 412, 96, 422 Annotation: Subtype: Link Rect: 160, 388, 198, 399 Annotation: Subtype: Link Rect: 394, 365, 432, 376 Annotation: Subtype: Link Rect: 520, 342, 557, 353 Annotation: Subtype: Link Rect: 441, 330, 478, 341 Annotation: Subtype: Link Rect: 309, 307, 346, 318 Annotation: Subtype: Link Rect: 252, 261, 290, 272 Annotation: Subtype: Link Rect: 216, 238, 253, 249 Annotation: Subtype: Link Rect: 210, 215, 248, 226 Annotation: Subtype: Link Rect: 400, 192, 437, 203 Annotation: Subtype: Link Rect: 245, 169, 282, 180 Annotation: Subtype: Link Rect: 418, 146, 455, 157 Annotation: Subtype: Link Rect: 520, 123, 557, 134 Annotation: Subtype: Link Rect: 504, 89, 541, 100 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 202, 711, 239, 721 Annotation: Subtype: Link Rect: 415, 687, 452, 698 Annotation: Subtype: Link Rect: 371, 664, 408, 675 Annotation: Subtype: Link Rect: 178, 642, 216, 652 Annotation: Subtype: Link Rect: 387, 618, 425, 629 Annotation: Subtype: Link Rect: 122, 596, 160, 606 Annotation: Subtype: Link Rect: 224, 572, 261, 583 Annotation: Subtype: Link Rect: 95, 538, 133, 548 Annotation: Subtype: Link Rect: 360, 514, 398, 525 Annotation: Subtype: Link Rect: 97, 481, 135, 491 Annotation: Subtype: Link Rect: 277, 457, 314, 468 Checksum: 17b25d02 Type: CRC32 Checksum: 94d13a93d49fb5be906c259abff2f81d Type: MD5 Checksum: 0a68398a5f0fb407814d93b44bd269692967002d Type: SHA-1