6e26e14f10c308116fab0981dcdcf90c 1-s2.0-S0048969723051811-main.pdf 733fac74ca746a5b45d257785b117eedaa4f916c 1-s2.0-S0048969723051811-main.pdf 6a7b868178085d79ab574396cacbfd93960be1f406b67e4a2c7a4ec9881ed5dd 1-s2.0-S0048969723051811-main.pdf Title: Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila Subject: Science of the Total Environment, 904 (2023) 166556. doi:10.1016/j.scitotenv.2023.166556 Keywords: Caspase,Drosophila melanogaster,Single-cell gel electrophoresis,Somatic mutation and recombination,DNA repair,Gene expression Author: Merve Güneş Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Sep 1 17:17:39 2023 CEST ModDate: Sat Sep 2 05:45:42 2023 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 9663650 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.4 Rod form of nano hydroxyapatite Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.5 Nanoparticle characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: 2.5.1 Transmission electron microscopy and zeta potential analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.5.2 Fourier transform infrared spectroscopy analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.6 Drosophila strains and exposure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.7 The Drosophila wing somatic mutation and recombination test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 2.8 The Drosophila single cell gel electrophoresis/comet test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 2.9 Caspase activity as indicator of apoptosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 2.10 The gene expression analysis array Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 2.11 Gene ontology and pathway enrichment analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 2.12 Gene-interactions network construction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 2.13 The gene pathway Visualizer tool Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 2.14 Data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Children: Item: Title: 3.1 Synthesis and characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 3.2 The induction of somatic mutation and recombination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 3.3 The induction of DNA strand breaks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 3.4 Caspase activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 3.5 Results from the gene expression analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 3.6 Gene ontology and pathway enrichment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: 3.7 Gene-interaction network construction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 3.8 Gene pathway visualizer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: 5 Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Info: Title: Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila Author: Merve Güneş Subject: Science of the Total Environment, 904 (2023) 166556. doi:10.1016/j.scitotenv.2023.166556 Keywords: Caspase,Drosophila 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1759, 1320 FontFile2: true XMP: application/pdf 10.1016/j.scitotenv.2023.166556 Elsevier B.V. Science of the Total Environment, 904 (2023) 166556. doi:10.1016/j.scitotenv.2023.166556 Caspase Drosophila melanogaster Single-cell gel electrophoresis Somatic mutation and recombination DNA repair Gene expression Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila Merve Güneş Burçin Yalçın Ayşen Yağmur Burgazlı Ghada Tagorti Emre Yavuz Esin Akarsu Nuray Kaya Ricard Marcos Bülent Kaya journal Science of the Total Environment © 2023 The Authors. Published by Elsevier B.V. 0048-9697 904 15 December 2023 2023-12-15 166556 166556 10.1016/j.scitotenv.2023.166556 https://doi.org/10.1016/j.scitotenv.2023.166556 2010-04-23 true 10.1016/j.scitotenv.2023.166556 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.scitotenv.2023.166556 noindex 2010-04-23 true 2nd September 2023 sciencedirect.com elsevier.com Elsevier 2023-09-02T03:45:42 2023-09-01T15:17:39 2023-09-02T03:45:42 True 2nd September 2023 Acrobat Distiller 8.1.0 (Windows) Caspase,Drosophila melanogaster,Single-cell gel electrophoresis,Somatic mutation and recombination,DNA repair,Gene expression uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 100, 571, 447, 582 Flags: Print Destination: 1011 Annotation: Subtype: Link Rect: 447, 571, 455, 582 Flags: Print Destination: 1011 Annotation: Subtype: Link Rect: 94, 558, 162, 569 Flags: Print 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