b1a8aeae769e764f1e61b280f28d7f07 pathogens-12-01403.pdf 14f86fb72679c1c7943d136cc59f7c9c0068112e pathogens-12-01403.pdf 4d0787133565a151f2bedea063e0c1aeb886d170377ef5ab449f85742613112e pathogens-12-01403.pdf Title: Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies Subject: Background: The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). Methods: The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age 65 years (aOR = 0.3; 95%CI: 0.2–0.6) and a daily exposure of 6 h to the TB index case (aOR = 3.6; 95%CI: 2.6–5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5–1.0) and immigrants (aOR = 0.7; 95%CI: 0.5–0.9). Conclusions: Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI. Keywords: tuberculosis; latent tuberculosis infection; contact tracing; epidemiology Author: Sofia Godoy, Ignasi Parrón, Joan-Pau Millet, Joan A. Caylà, Núria Follia, Mònica Carol, Àngels Orcau, Miquel Alsedà, Diana Toledo, Glòria Ferrús, Pere Plans, Irene Barrabeig, Laura Clotet, Àngela Domínguez, Pere Godoy and the Transmission of Tuberculosis in Catalonia (Spain) Working Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Nov 29 07:26:37 2023 CET ModDate: Wed Nov 29 07:58:19 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 448037 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IIZDOC+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 APWKLL+VnURWPalladioL Type 1 Custom yes yes no 15 0 YOYBZA+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 BZJRIP+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 SFFNAA+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 32 0 UXHOAG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 PalatinoLinotype-Bold TrueType WinAnsi no no no 78 0 PalatinoLinotype-Roman TrueType WinAnsi no no no 81 0 PalatinoLinotype-Italic TrueType WinAnsi no no no 84 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 87 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 97 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-11 02:46:30 CEST RepresentationInformation: pathogens-12-01403.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-07-10 12:07:14 CEST Size: 448037 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 246 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies Author: Sofia Godoy, Ignasi Parrón, Joan-Pau Millet, Joan A. Caylà, Núria Follia, Mònica Carol, Àngels Orcau, Miquel Alsedà, Diana Toledo, Glòria Ferrús, Pere Plans, Irene Barrabeig, Laura Clotet, Àngela Domínguez, Pere Godoy and the Transmission of Tuberculosis in Catalonia (Spain) Working Group Subject: Background: The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). Methods: The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age 65 years (aOR = 0.3; 95%CI: 0.2 0.6) and a daily exposure of 6 h to the TB index case (aOR = 3.6; 95%CI: 2.6 5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5 1.0) and immigrants (aOR = 0.7; 95%CI: 0.5 0.9). Conclusions: Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI. 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