fda31c03a571ba08f3f6eb173ceae34c pmc_10002558.pdf 642cf26ac314e7c52f0425665a78f30408a95322 pmc_10002558.pdf 6b83a04836409d46bf59a3066b19f082e75c520bf424f50db19d0912f6c82ab8 pmc_10002558.pdf Title: Outcome of Kidney Transplants from Viremic and Non-Viremic Hepatitis C Virus Positive Donors into Negative Recipients: Results of the Spanish Registry Subject: Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8–12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised. Keywords: kidney transplantation; hepatitis C virus; viremic donor; graft outcome; hepatocellular carcinoma Author: Antonio Franco, Francesc Moreso, Eulàlia Solà-Porta, Isabel Beneyto, Núria Esforzado, Francisco Gonzalez-Roncero, Asunción Sancho, Edoardo Melilli, Juan Carlos Ruiz and Cristina Galeano Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 23 07:05:30 2023 CET ModDate: Thu Feb 23 07:10:52 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1529154 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KORLVE+VnURWPalladioL Type 1 Custom yes yes no 10 0 EFQIQA+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 OLCGXY+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 IQNPIU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 FJVPBR+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 77 0 NJAOJC+CMSY10 Type 1 Builtin yes yes no 81 0 GBGPEG+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 91 0 GBGPFG+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 97 0 GBGPFH+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 103 0 GBGPFI+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 109 0 GBGPFJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 112 0 GBGPFK+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 115 0 IEJPMB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 134 0 IEJPMD+PalatinoLinotype TrueType WinAnsi yes yes no 137 0 IEJPMF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 140 0 IEKAEE+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 143 0 GBGPEG+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 158 0 GBGPFG+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 164 0 GBGPFH+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 170 0 GBGPFI+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 176 0 GBGPFJ+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 179 0 GBGPFK+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 182 0 GBHAND+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 185 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-19 02:36:56 CEST RepresentationInformation: pmc_10002558.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-18 02:26:46 CEST Size: 1529154 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 327 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Patients and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Outcome Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Patient Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Outcome Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Outcome of Kidney Transplants from Viremic and Non-Viremic Hepatitis C Virus Positive Donors into Negative Recipients: Results of the Spanish Registry Author: Antonio Franco, Francesc Moreso, Eulàlia Solà-Porta, Isabel Beneyto, Núria Esforzado, Francisco Gonzalez-Roncero, Asunción Sancho, Edoardo Melilli, Juan Carlos Ruiz and Cristina Galeano Subject: Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8 12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised. 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