a3666535386cbc71fa05d19a3d0a3793 pmc_10005429.pdf 8cdfa2d763197f931e00ccba69a46b649e8447ca pmc_10005429.pdf d373c1088d4639a2e2e8e67799da5b1e2b8054e948e411b0d45e13100beeb2b7 pmc_10005429.pdf Title: Low Phase Angle Values Are Associated with Malnutrition according to the Global Leadership Initiative on Malnutrition Criteria in Kidney Transplant Candidates: Preliminary Assessment of Diagnostic Accuracy in the FRAILMar Study Subject: Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard). Of 63 patients (62.9 years old; 76.2% men), 22 (34.9%) had malnutrition. The PhA threshold with the highest accuracy was 4.85 (sensitivity 72.7%, specificity 65.9%, and positive and negative likelihood ratios 2.13 and 0.41, respectively). A PhA 4.85 was associated with a 3.5-fold higher malnutrition risk (OR = 3.53 (CI95% 1.0–12.1)). Considering the GLIM criteria as the reference standard, a PhA 4.85 showed only fair validity for detecting malnutrition, and thus cannot be recommended as a stand-alone screening tool in this population. Keywords: phase angle; malnutrition; GLIM; muscle mass; advanced chronic kidney disease; prehabilitation Author: Elena Muñoz-Redondo, Andrea Morgado-Pérez, María-José Pérez-Sáez, Anna Faura, Dolores Sánchez-Rodríguez, Marta Tejero-Sánchez, Delky Meza-Valderrama, María Dolors Muns, Julio Pascual and Ester Marco Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 10 06:54:13 2023 CET ModDate: Fri Mar 10 07:28:47 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2167852 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QDTNFC+VnURWPalladioL Type 1 Custom yes yes no 10 0 HWMTHU+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 BJFZKE+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 CXXQML+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 NCKHBC+CMSY10 Type 1 Builtin yes yes no 28 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 81 0 MEFFIM+PalatinoLinotype TrueType WinAnsi yes yes no 97 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes no 120 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-21 02:35:56 CEST RepresentationInformation: pmc_10005429.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-20 02:27:26 CEST Size: 2167852 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 310 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Setting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Test Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Other Study Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Study Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Ethics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Low Phase Angle Values Are Associated with Malnutrition according to the Global Leadership Initiative on Malnutrition Criteria in Kidney Transplant Candidates: Preliminary Assessment of Diagnostic Accuracy in the FRAILMar Study Author: Elena Muñoz-Redondo, Andrea Morgado-Pérez, María-José Pérez-Sáez, Anna Faura, Dolores Sánchez-Rodríguez, Marta Tejero-Sánchez, Delky Meza-Valderrama, María Dolors Muns, Julio Pascual and Ester Marco Subject: Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard). Of 63 patients (62.9 years old; 76.2% men), 22 (34.9%) had malnutrition. The PhA threshold with the highest accuracy was 4.85 (sensitivity 72.7%, specificity 65.9%, and positive and negative likelihood ratios 2.13 and 0.41, respectively). A PhA 4.85 was associated with a 3.5-fold higher malnutrition risk (OR = 3.53 (CI95% 1.0 12.1)). Considering the GLIM criteria as the reference standard, a PhA 4.85 showed only fair validity for detecting malnutrition, and thus cannot be recommended as a stand-alone screening tool in this population. 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