51ffc56fd35f919c65c69226dba0b0e5 pmc_10009161.pdf 119aa4a043d94057e5d95a61e2949b2ea0a166cd pmc_10009161.pdf 7961f099203280a1bfabe7a19c4b4418203da74e03e84dcc74e312e168bbb720 pmc_10009161.pdf Title: The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles Subject: The long quest for efficient drug administration has been looking for a universal carrier that can precisely transport traditional drugs, new genomic and proteic therapeutic agents Keywords: ionizable lipid nanoparticles, RNA-loading, drug delivery carriers, pharmacokinetics, biodistribution and clearance  Author: Ramon González-Rioja; Vivian A. Salazar; Neus G. Bastús; Victor Puntes Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Feb 23 05:42:17 2023 CET ModDate: Thu Feb 23 05:42:17 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 1707363 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FECGGL+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 623 0 FECGHM+AdvPSA18C Type 1C WinAnsi yes yes no 624 0 FECGHN+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 625 0 FECGHO+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 626 0 FECGHP+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 627 0 FECGIA+AdvPSA323 Type 1C WinAnsi yes yes no 628 0 FECGIB+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 629 0 FECGIC+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 641 0 FECGID+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 644 0 FECJIE+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 378 0 FECJIF+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 383 0 FECJIG+AdvOTd877c31c Type 1C WinAnsi yes yes no 370 0 FECJJG+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 373 0 FECJHC+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 377 0 FECJHD+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 387 0 FECJOF+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 390 0 FEDEGG+AdvTT58d178b9+03 Type 1C Custom yes yes yes 393 0 FEDEGH+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 394 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-18 02:23:24 CEST RepresentationInformation: pmc_10009161.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-22 02:19:45 CEST Size: 1707363 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B122' cannot be found Offset: 1683431 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B123' cannot be found Offset: 1683431 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B124' cannot be found Offset: 1683431 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 695 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Ionizable lipid nanoparticles: Structure, composition and characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Ionizable lipid nanoparticles: Pharmacokinetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Transformations and metabolization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Degradation and disintegration of iLNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Biodistribution and fate of iLNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Excretion of iLNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Current challenges for ionizable lipid nanoparticles to be used in medicine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Oral ingestion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Ocular applications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Cutaneous application Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Conclusions and future perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Info: Title: The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles Author: Ramon González-Rioja; Vivian A. Salazar; Neus G. 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