2a44df339e10a71c62bdefe7691827ca pmc_10040786.pdf e8cfcf8e5c662f148e07305d8fcd1482159e1f33 pmc_10040786.pdf 8eca4260e9f43c04a99132ade8e4cb087c68311bca4c1a4beb094a26e1e25e6a pmc_10040786.pdf Title: Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients Subject: Background: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized Keywords: atopic dermatitis, CCL27, CLA+ memory T cells, house dust mite, IgE, IL-31, periostin, pruritus Author: Lídia Sans-de San Nicolàs; Ignasi Figueras-Nart; Irene García-Jiménez; Montserrat Bonfill-Ortí; Antonio Guilabert; Laia Curto-Barredo; Marta Bertolín-Colilla; Marta Ferran; Esther Serra-Baldrich; Ramon M. Pujol; Luis F. Santamaria-Babí Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Mar 9 05:04:09 2023 CET ModDate: Thu Mar 9 05:04:22 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 2994746 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BHLMID+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 728 0 BHLMIE+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 729 0 BHLMIF+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 730 0 BHLMIG+AdvPSA18C Type 1C WinAnsi yes yes no 731 0 BHLMIH+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 732 0 BHLMII+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 733 0 BHLMIJ+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 734 0 BHLMIK+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 748 0 BHLMIL+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 749 0 BHLNGG+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 753 0 BHLNGH+AdvPSA323 Type 1C WinAnsi yes yes no 754 0 BHLNLG+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 327 0 BHLNLH+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 311 0 BHLNLI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 324 0 BHLNLJ+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 325 0 BHLNLK+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 317 0 BHMBDE+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 329 0 BHMHGN+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 333 0 BHMKBM+AdvOT46dcae81 Type 1C WinAnsi yes yes no 331 0 BHMKBN+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 332 0 BHMKFM+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 346 0 BHMKFN+AdvTT58d178b9+03 Type 1C Custom yes yes yes 343 0 BHMKFO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 342 0 BHMKGP+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 348 0 BHMKIA+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 347 0 BHMKJA+AdvOTd877c31c+03 Type 1C Custom yes yes yes 349 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-21 02:35:49 CEST RepresentationInformation: pmc_10040786.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-20 02:27:11 CEST Size: 2994746 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B16' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B20' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B31' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B32' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B33' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B34' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B35' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B36' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B36' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B6' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B37' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B38' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B39' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B40' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B35' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B41' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B42' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B43' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B44' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B42' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B45' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B49' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B50' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B51' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B33' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B52' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B53' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B54' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B32' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B55' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B56' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B57' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B61' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B62' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B63' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B64' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B65' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B66' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B67' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 2974331 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 2974331 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 813 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 2.1 Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2.2 Isolation of memory CLA+/- T cells and epidermal cells suspension Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.3 Coculture of CLA+/- memory T cells with epidermal cells and stimulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.4 Transwell culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.5 Cytokine and chemokine quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.6 ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.7 RNA isolation, quantitative real-time PCR and gene-array analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.8 Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 2.8 Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3.2 Patients with memory T-cell IL-31 response to HDM show elevated plasma levels of sp and total IgE and a more inflammatory 瀀爀漀昀椀氀攀 琀栀愀渀 瀀愀琀椀攀渀琀猀 眀椀琀栀 渀漀 䤀䰀ⴀ㌀㄀ 爀攀猀瀀漀渀猀攩㸾൥湤潢樍ㄠ〠潢樼㰯䍲潰䉯硛〠〠㔹㔮㌸㤠㠴ㄮ㘶㍝⽁湮潴獛㈠〠删㌠〠删㐠〠删㔠〠删㘠〠删㜠〠删㠠〠删㤠〠删㄰‰⁒‱ㄠ〠删ㄲ‰⁒‱㌠〠删ㄴ‰⁒‱㔠〠删ㄶ‰⁒‱㜠〠删ㄸ‰⁒‱㤠〠删㈰‰⁒′ㄠ〠删㈲‰⁒′㌠〠删㈴‰⁒′㔠〠删㈶‰⁒′㜠〠删㈸‰⁒′㤠〠删㌰‰⁒″ㄠ〠删㌲‰⁒″㌠〠删㌴‰⁒″㔠〠删㌶‰⁒崯偡牥湴‴㔷‰⁒⽂嬷㈶‰⁒‷㈵‰⁒‷㈴‰⁒‷㈳‰⁒‷㈲‰⁒‷㈱‰⁒‷㈰‰⁒崯䍯湴敮瑳″㠠〠刯副瑡瑥‰⽍敤楡䉯硛〠〠㔹㔮㌸㤠㠴ㄮ㘶㍝⽒敳潵牣敳″㜠〠刯呹灥⽐慧放㸍敮摯扪ല‰扪㰼⽒散瑛ㄹ㌮〹㘠㔶㜮㘶㘠ㄹ㜮㐰㔠㔷㘮㘸崯卵扴祰支䱩湫⽂潲摥牛〠〠そ⽄敳琨B1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.8 Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients Author: Lídia Sans-de San Nicolàs; Ignasi Figueras-Nart; Irene García-Jiménez; Montserrat Bonfill-Ortí; Antonio Guilabert; Laia Curto-Barredo; Marta Bertolín-Colilla; Marta Ferran; Esther Serra-Baldrich; Ramon M. Pujol; Luis F. Santamaria-Babí Subject: Background: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized Keywords: atopic dermatitis, CCL27, CLA+ memory T cells, house dust mite, IgE, IL-31, periostin, pruritus Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Mar 09 05:04:09 CET 2023 ModDate: Thu Mar 09 05:04:22 CET 2023 ID: 0xb1251cc368e4b74a1b4b682b8607b3e8, 0xcd246b5a8f48774fb8979b23251023d5 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2988 ImageHeight: 5140 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3024 ImageHeight: 5008 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3108 ImageHeight: 2628 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: BHLNLI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: BHLNLI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLNLJ+AdvOT7d6df7ab.I FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: BHLNLJ+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLNLG+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: BHLNLG+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMBDE+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 65 LastChar: 71 FontDescriptor: FontName: BHMBDE+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKBM+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 117 FontDescriptor: FontName: BHMKBM+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKBN+AdvOTb65e897d.B FontSubset: true FirstChar: 40 LastChar: 117 FontDescriptor: FontName: BHMKBN+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMHGN+AdvTT749c1f5a.I FontSubset: true FirstChar: 105 LastChar: 118 FontDescriptor: FontName: BHMHGN+AdvTT749c1f5a.I Flags: Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKFO+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: BHMKFO+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKFN+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: BHMKFN+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMID+AdvTTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 224 FontDescriptor: FontName: BHLMID+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLMIE+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BHLMIE+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMIF+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: BHLMIF+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BHMKFM+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: BHMKFM+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BHLMIG+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: BHLMIG+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKIA+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BHMKIA+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMIH+AdvTT9b12cd41 FontSubset: true FirstChar: 40 LastChar: 242 FontDescriptor: FontName: BHLMIH+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKGP+AdvOT1ef757c0+22 FontSubset: true FirstChar: 2 LastChar: 21 FontDescriptor: FontName: BHMKGP+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMII+AdvTT9b12cd41+20 FontSubset: true FirstChar: 129 LastChar: 146 FontDescriptor: FontName: BHLMII+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHMKJA+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BHMKJA+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 0, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMIJ+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BHLMIJ+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLMIK+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: BHLMIK+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLMIL+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: BHLMIL+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLNGG+AdvTT9b12cd41+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: BHLNGG+AdvTT9b12cd41+01 Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: BHLNGH+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: BHLNGH+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BHLNLH+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: BHLNLH+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BHLNLK+AdvOT3f84ef53 FontSubset: true FirstChar: 68 LastChar: 114 FontDescriptor: FontName: BHLNLK+AdvOT3f84ef53 Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1000 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 7.0 (Windows) atopic dermatitis, CCL27, CLA+ memory T cells, house dust mite, IgE, IL-31, periostin, pruritus 2023-03-09T12:04:09+08:00 2023-03-09T12:04:22+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2023-03-09T12:04:22+08:00 application/pdf Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients Lídia Sans-de San Nicolàs; Ignasi Figueras-Nart; Irene García-Jiménez; Montserrat Bonfill-Ortí; Antonio Guilabert; Laia Curto-Barredo; Marta Bertolín-Colilla; Marta Ferran; Esther Serra-Baldrich; Ramon M. Pujol; Luis F. Santamaria-Babí Background: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized uuid:36fcbf61-3ea0-49a7-a323-90c7348334a6 uuid:898f0367-fb92-4e7c-bc43-4d04ff45eb42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 515, 707 Annotation: Subtype: Link Rect: 222, 661, 519, 682 Annotation: Subtype: Link Rect: 222, 636, 541, 657 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 691, 125, 706 Annotation: Subtype: Link Rect: 60, 538, 133, 545 Annotation: Subtype: Link Rect: 49, 338, 158, 345 Annotation: Subtype: Link Rect: 121, 270, 180, 277 Annotation: Subtype: Link Rect: 49, 261, 133, 268 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 471, 793, 518, 800 Annotation: Subtype: Link Rect: 451, 783, 543, 790 Annotation: Subtype: Link Rect: 49, 797, 233, 813 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 193, 567, 197, 576 Destination: 211 Annotation: Subtype: Link Rect: 201, 567, 206, 576 Destination: 211 Annotation: Subtype: Link Rect: 266, 555, 270, 564 Destination: 211 Annotation: Subtype: Link Rect: 94, 530, 98, 539 Destination: 211 Annotation: Subtype: Link Rect: 103, 530, 107, 539 Destination: 211 Annotation: Subtype: Link Rect: 101, 505, 106, 514 Destination: 211 Annotation: Subtype: Link Rect: 110, 505, 119, 514 Destination: null Annotation: Subtype: Link Rect: 107, 467, 111, 476 Destination: 211 Annotation: Subtype: Link Rect: 116, 467, 124, 476 Destination: null Annotation: Subtype: Link Rect: 129, 467, 138, 476 Destination: null Annotation: Subtype: Link Rect: 161, 430, 169, 439 Destination: null Annotation: Subtype: Link Rect: 77, 392, 86, 401 Destination: null Annotation: Subtype: Link Rect: 90, 392, 99, 401 Destination: null Annotation: Subtype: Link Rect: 169, 367, 173, 376 Destination: 211 Annotation: Subtype: Link Rect: 179, 367, 188, 376 Destination: null Annotation: Subtype: Link Rect: 143, 342, 152, 351 Destination: null Annotation: Subtype: Link Rect: 156, 342, 165, 351 Destination: null Annotation: Subtype: Link Rect: 119, 305, 127, 314 Destination: null Annotation: Subtype: Link Rect: 132, 305, 140, 314 Destination: null Annotation: Subtype: Link Rect: 145, 305, 154, 314 Destination: null Annotation: Subtype: Link Rect: 158, 305, 167, 314 Destination: null Annotation: Subtype: Link Rect: 172, 305, 180, 314 Destination: null Annotation: Subtype: Link Rect: 185, 305, 194, 314 Destination: null Annotation: Subtype: Link Rect: 203, 280, 211, 289 Destination: null Annotation: Subtype: Link Rect: 215, 280, 224, 289 Destination: null Annotation: Subtype: Link Rect: 243, 217, 248, 226 Destination: 211 Annotation: Subtype: Link Rect: 253, 217, 262, 226 Destination: null Annotation: Subtype: Link Rect: 277, 192, 285, 201 Destination: null Annotation: Subtype: Link Rect: 276, 167, 285, 176 Destination: null Annotation: Subtype: Link Rect: 499, 317, 529, 326 Destination: 192 Annotation: Subtype: Link Rect: 486, 205, 494, 214 Destination: null Annotation: Subtype: Link Rect: 495, 130, 504, 139 Destination: null Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 268, 473, 272, 482 Destination: null Annotation: Subtype: Link Rect: 277, 473, 285, 482 Destination: null Annotation: Subtype: Link Rect: 179, 423, 187, 432 Destination: null Annotation: Subtype: Link Rect: 406, 454, 439, 463 Destination: 192 Annotation: Subtype: Link Rect: 392, 367, 401, 376 Destination: null Annotation: Subtype: Link Rect: 476, 204, 545, 213 Annotation: Subtype: Link Rect: 304, 192, 356, 201 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 185, 472, 223, 481 Destination: 88 Annotation: Subtype: Link Rect: 87, 447, 128, 456 Destination: 192 Annotation: Subtype: Link Rect: 83, 435, 122, 444 Destination: 192 Annotation: Subtype: Link Rect: 128, 372, 164, 381 Destination: 88 Annotation: Subtype: Link Rect: 251, 347, 287, 356 Destination: 88 Annotation: Subtype: Link Rect: 234, 335, 270, 344 Destination: 88 Annotation: Subtype: Link Rect: 149, 322, 184, 331 Destination: 88 Annotation: Subtype: Link Rect: 213, 297, 249, 306 Destination: 88 Annotation: Subtype: Link Rect: 251, 210, 285, 219 Destination: 192 Annotation: Subtype: Link Rect: 52, 172, 90, 181 Destination: 88 Annotation: Subtype: Link Rect: 95, 172, 110, 181 Destination: 192 Annotation: Subtype: Link Rect: 146, 160, 204, 169 Destination: 192 Annotation: Subtype: Link Rect: 235, 135, 271, 144 Destination: 88 Annotation: Subtype: Link Rect: 110, 72, 150, 81 Destination: 192 Annotation: Subtype: Link Rect: 442, 744, 481, 753 Destination: 99 Annotation: Subtype: Link Rect: 485, 744, 499, 753 Destination: 192 Annotation: Subtype: Link Rect: 447, 694, 481, 703 Destination: 99 Annotation: Subtype: Link Rect: 400, 644, 435, 653 Destination: 192 Annotation: Subtype: Link Rect: 307, 569, 347, 578 Destination: 192 Annotation: Subtype: Link Rect: 502, 556, 540, 565 Destination: 192 Annotation: Subtype: Link Rect: 493, 423, 524, 432 Destination: 110 Annotation: Subtype: Link Rect: 307, 261, 347, 270 Destination: 192 Annotation: Subtype: Link Rect: 351, 261, 381, 270 Destination: 192 Annotation: Subtype: Link Rect: 307, 186, 348, 195 Destination: 192 Annotation: Subtype: Link Rect: 355, 186, 387, 195 Destination: 192 Annotation: Subtype: Link Rect: 462, 173, 502, 182 Destination: 192 Annotation: Subtype: Link Rect: 507, 173, 538, 182 Destination: 192 Annotation: Subtype: Link Rect: 346, 136, 387, 145 Destination: 192 Annotation: Subtype: Link Rect: 523, 98, 545, 107 Destination: 192 Annotation: Subtype: Link Rect: 304, 86, 319, 95 Destination: 192 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 209, 287, 243, 296 Destination: 110 Annotation: Subtype: Link Rect: 152, 237, 185, 246 Destination: 110 Annotation: Subtype: Link Rect: 214, 212, 239, 221 Destination: 129 Annotation: Subtype: Link Rect: 134, 149, 175, 158 Destination: 192 Annotation: Subtype: Link Rect: 222, 124, 264, 133 Destination: 110 Annotation: Subtype: Link Rect: 271, 124, 285, 133 Destination: 192 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 95, 364, 135, 373 Destination: 192 Annotation: Subtype: Link Rect: 176, 339, 217, 348 Destination: 192 Annotation: Subtype: Link Rect: 280, 189, 288, 198 Destination: null Annotation: Subtype: Link Rect: 49, 177, 58, 186 Destination: null Annotation: Subtype: Link Rect: 199, 139, 203, 148 Destination: 211 Annotation: Subtype: Link Rect: 208, 139, 217, 148 Destination: null Annotation: Subtype: Link Rect: 222, 139, 231, 148 Destination: null Annotation: Subtype: Link Rect: 236, 139, 244, 148 Destination: null Annotation: Subtype: Link Rect: 250, 139, 258, 148 Destination: null Annotation: Subtype: Link Rect: 488, 364, 492, 373 Destination: 211 Annotation: Subtype: Link Rect: 377, 252, 381, 261 Destination: 211 Annotation: Subtype: Link Rect: 307, 214, 316, 223 Destination: null Annotation: Subtype: Link Rect: 320, 214, 329, 223 Destination: null Annotation: Subtype: Link Rect: 333, 214, 342, 223 Destination: null Annotation: Subtype: Link Rect: 496, 139, 505, 148 Destination: null Annotation: Subtype: Link Rect: 512, 139, 521, 148 Destination: null Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 124, 744, 133, 753 Destination: null Annotation: Subtype: Link Rect: 97, 656, 105, 665 Destination: null Annotation: Subtype: Link Rect: 110, 656, 119, 665 Destination: null Annotation: Subtype: Link Rect: 167, 631, 175, 640 Destination: null Annotation: Subtype: Link Rect: 277, 581, 285, 590 Destination: null Annotation: Subtype: Link Rect: 52, 506, 56, 515 Destination: 211 Annotation: Subtype: Link Rect: 248, 456, 256, 465 Destination: null Annotation: Subtype: Link Rect: 248, 444, 256, 453 Destination: null Annotation: Subtype: Link Rect: 112, 269, 120, 278 Destination: null Annotation: Subtype: Link Rect: 250, 256, 258, 265 Destination: null Annotation: Subtype: Link Rect: 262, 256, 271, 265 Destination: null Annotation: Subtype: Link Rect: 81, 219, 90, 228 Destination: null Annotation: Subtype: Link Rect: 94, 219, 103, 228 Destination: null Annotation: Subtype: Link Rect: 151, 181, 160, 190 Destination: null Annotation: Subtype: Link Rect: 151, 144, 159, 153 Destination: null Annotation: Subtype: Link Rect: 232, 106, 241, 115 Destination: null Annotation: Subtype: Link Rect: 307, 706, 316, 715 Destination: null Annotation: Subtype: Link Rect: 457, 669, 498, 678 Destination: 192 Annotation: Subtype: Link Rect: 523, 656, 545, 665 Destination: 192 Annotation: Subtype: Link Rect: 304, 644, 318, 653 Destination: 192 Annotation: Subtype: Link Rect: 355, 631, 398, 640 Destination: 192 Annotation: Subtype: Link Rect: 519, 531, 527, 540 Destination: null Annotation: Subtype: Link Rect: 532, 531, 540, 540 Destination: null Annotation: Subtype: Link Rect: 341, 481, 349, 490 Destination: null Annotation: Subtype: Link Rect: 356, 481, 365, 490 Destination: null Annotation: Subtype: Link Rect: 378, 456, 386, 465 Destination: null Annotation: Subtype: Link Rect: 484, 419, 494, 428 Destination: null Annotation: Subtype: Link Rect: 420, 394, 428, 403 Destination: null Annotation: Subtype: Link Rect: 307, 231, 316, 240 Destination: null Annotation: Subtype: Link Rect: 397, 194, 406, 203 Destination: null Annotation: Subtype: Link Rect: 469, 131, 474, 140 Destination: 211 Annotation: Subtype: Link Rect: 478, 131, 487, 140 Destination: null Annotation: Subtype: Link Rect: 441, 119, 449, 128 Destination: null Annotation: Subtype: Link Rect: 532, 94, 540, 103 Destination: 268 Annotation: Subtype: Link Rect: 414, 69, 422, 78 Destination: null Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 206, 731, 215, 740 Destination: null Annotation: Subtype: Link Rect: 220, 731, 229, 740 Destination: 268 Annotation: Subtype: Link Rect: 107, 694, 111, 703 Destination: 211 Annotation: Subtype: Link Rect: 52, 669, 61, 678 Destination: null Annotation: Subtype: Link Rect: 264, 656, 272, 665 Destination: 268 Annotation: Subtype: Link Rect: 277, 656, 285, 665 Destination: 268 Annotation: Subtype: Link Rect: 231, 631, 239, 640 Destination: null Annotation: Subtype: Link Rect: 126, 506, 130, 515 Destination: 211 Annotation: Subtype: Link Rect: 153, 281, 162, 290 Destination: null Annotation: Subtype: Link Rect: 353, 97, 545, 106 Annotation: Subtype: Link Rect: 304, 85, 489, 94 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 157, 707, 228, 714 Annotation: Subtype: Link Rect: 129, 680, 178, 687 Annotation: Subtype: Link Rect: 164, 653, 239, 660 Annotation: Subtype: Link Rect: 92, 626, 164, 633 Annotation: Subtype: Link Rect: 167, 599, 239, 606 Annotation: Subtype: Link Rect: 214, 572, 257, 579 Annotation: Subtype: Link Rect: 86, 537, 170, 544 Annotation: Subtype: Link Rect: 266, 510, 290, 517 Annotation: Subtype: Link Rect: 49, 502, 94, 509 Annotation: Subtype: Link Rect: 266, 475, 290, 482 Annotation: Subtype: Link Rect: 49, 467, 97, 474 Annotation: Subtype: Link Rect: 126, 440, 177, 447 Annotation: Subtype: Link Rect: 72, 405, 149, 412 Annotation: Subtype: Link Rect: 95, 378, 167, 385 Annotation: Subtype: Link Rect: 189, 343, 261, 350 Annotation: Subtype: Link Rect: 72, 308, 130, 315 Annotation: Subtype: Link Rect: 72, 281, 167, 288 Annotation: Subtype: Link Rect: 95, 254, 147, 261 Annotation: Subtype: Link Rect: 154, 227, 225, 234 Annotation: Subtype: Link Rect: 217, 200, 288, 207 Annotation: Subtype: Link Rect: 188, 173, 264, 180 Annotation: Subtype: Link Rect: 62, 130, 131, 137 Annotation: Subtype: Link Rect: 150, 103, 222, 110 Annotation: Subtype: Link Rect: 347, 715, 431, 722 Annotation: Subtype: Link Rect: 317, 680, 389, 687 Annotation: Subtype: Link Rect: 441, 653, 512, 660 Annotation: Subtype: Link Rect: 449, 618, 499, 625 Annotation: Subtype: Link Rect: 317, 583, 386, 590 Annotation: Subtype: Link Rect: 317, 547, 389, 554 Annotation: Subtype: Link Rect: 317, 511, 394, 518 Annotation: Subtype: Link Rect: 317, 475, 412, 482 Annotation: Subtype: Link Rect: 317, 440, 385, 447 Annotation: Subtype: Link Rect: 317, 405, 401, 412 Annotation: Subtype: Link Rect: 461, 378, 545, 385 Annotation: Subtype: Link Rect: 324, 343, 391, 350 Annotation: Subtype: Link Rect: 334, 316, 386, 323 Annotation: Subtype: Link Rect: 471, 289, 523, 296 Annotation: Subtype: Link Rect: 521, 262, 545, 269 Annotation: Subtype: Link Rect: 304, 254, 337, 261 Annotation: Subtype: Link Rect: 456, 219, 518, 226 Annotation: Subtype: Link Rect: 357, 184, 420, 191 Annotation: Subtype: Link Rect: 441, 157, 528, 164 Annotation: Subtype: Link Rect: 430, 103, 525, 110 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 62, 750, 143, 757 Annotation: Subtype: Link Rect: 129, 715, 212, 722 Annotation: Subtype: Link Rect: 95, 688, 155, 695 Annotation: Subtype: Link Rect: 156, 661, 206, 668 Annotation: Subtype: Link Rect: 95, 626, 167, 633 Annotation: Subtype: Link Rect: 220, 607, 287, 614 Annotation: Subtype: Link Rect: 62, 572, 111, 579 Annotation: Subtype: Link Rect: 266, 545, 290, 552 Annotation: Subtype: Link Rect: 49, 537, 94, 544 Annotation: Subtype: Link Rect: 122, 510, 186, 517 Annotation: Subtype: Link Rect: 95, 491, 183, 498 Annotation: Subtype: Link Rect: 247, 472, 290, 479 Annotation: Subtype: Link Rect: 49, 464, 101, 471 Annotation: Subtype: Link Rect: 108, 437, 188, 444 Annotation: Subtype: Link Rect: 62, 410, 128, 417 Annotation: Subtype: Link Rect: 83, 375, 155, 382 Annotation: Subtype: Link Rect: 520, 758, 545, 765 Annotation: Subtype: Link Rect: 304, 750, 350, 757 Annotation: Subtype: Link Rect: 520, 730, 545, 737 Annotation: Subtype: Link Rect: 304, 722, 375, 729 Annotation: Subtype: Link Rect: 405, 694, 454, 701 Annotation: Subtype: Link Rect: 397, 658, 476, 665 Annotation: Subtype: Link Rect: 364, 638, 455, 645 Annotation: Subtype: Link Rect: 441, 618, 501, 625 Annotation: Subtype: Link Rect: 431, 583, 500, 590 Annotation: Subtype: Link Rect: 384, 556, 454, 563 Annotation: Subtype: Link Rect: 470, 529, 519, 536 Annotation: Subtype: Link Rect: 357, 494, 406, 501 Annotation: Subtype: Link Rect: 378, 459, 449, 466 Annotation: Subtype: Link Rect: 521, 422, 545, 429 Annotation: Subtype: Link Rect: 304, 414, 352, 421 Annotation: Subtype: Link Rect: 485, 393, 539, 400 Annotation: Subtype: Link Rect: 426, 356, 499, 363 Annotation: Subtype: Link Rect: 449, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Checksum: 7fe058e1 Type: CRC32 Checksum: 2a44df339e10a71c62bdefe7691827ca Type: MD5 Checksum: e8cfcf8e5c662f148e07305d8fcd1482159e1f33 Type: SHA-1