4b7177cf625a105aa980ac3c2d4b5145 pmc_10044575.pdf 82b2b3440e86279d0a2815fa40b073c7e7dcf653 pmc_10044575.pdf c2a4018e03f6d3e3fdd3a19b54b1f0fcb34fe8dcae005da646ba22a2d291cac2 pmc_10044575.pdf Title: Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use:A Cross-Sectional Study Subject: Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin. Keywords: surgical site infection; spine surgery; Cutibacterium spp.; rifampin Author: Susana Núñez-Pereira, Eva Benavent, Marta Ulldemolins, Beatriz Sobrino-Díaz, José A. Iribarren, Rosa Escudero-Sánchez, María Dolores Del Toro, Andrés Nodar, Luisa Sorli, Alberto Bahamonde, Helem H. Vilchez, Oriol Gasch, Elena Muñez, David Rodríguez-Montserrat, María José García-País, Sleiman Haddad, Julia Sellarès-Nadal, Oscar Murillo, Dolors Rodríguez-Pardo and on behalf of GEIO–SEIMC (Group for the Study of Osteoarticular Infections–Spanish Society of Infectious Diseases and Clinical Microbiology) Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Mar 6 02:29:30 2023 CET ModDate: Tue Mar 7 04:54:44 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 289104 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ARIQJE+VnURWPalladioL Type 1 Custom yes yes no 10 0 NKDEYO+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 GPSXIQ+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 LEFEBV+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 MLHCKP+URWPalladioL-BoldItal Type 1 Custom yes yes no 28 0 PXJMKO+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 YYFPCJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 XYPWHM+CMSY10 Type 1 Builtin yes yes no 79 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-28 02:40:43 CEST RepresentationInformation: pmc_10044575.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-27 02:24:57 CEST Size: 289104 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 224 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Infection Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Multivariate Regression Analysis of Risk Factors Associated with Cutibacterium spp. IASIs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Treatment and Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Study Design, Setting, and Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Definitions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Antibiotic Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use:A Cross-Sectional Study Author: Susana Núñez-Pereira, Eva Benavent, Marta Ulldemolins, Beatriz Sobrino-Díaz, José A. Iribarren, Rosa Escudero-Sánchez, María Dolores Del Toro, Andrés Nodar, Luisa Sorli, Alberto Bahamonde, Helem H. Vilchez, Oriol Gasch, Elena Muñez, David Rodríguez-Montserrat, María José García-País, Sleiman Haddad, Julia Sellarès-Nadal, Oscar Murillo, Dolors Rodríguez-Pardo and on behalf of GEIO SEIMC (Group for the Study of Osteoarticular Infections Spanish Society of Infectious Diseases and Clinical Microbiology) Subject: Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin. Keywords: surgical site infection; spine surgery; Cutibacterium spp.; rifampin Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Mar 06 02:29:30 CET 2023 ModDate: Tue Mar 07 04:54:44 CET 2023 ID: 0x0a5894a7bc37d7c55dacd9d31b506340, 0x0a5894a7bc37d7c55dacd9d31b506340 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PXJMKO+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 243 FontDescriptor: FontName: PXJMKO+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GPSXIQ+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: GPSXIQ+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LEFEBV+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: LEFEBV+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ARIQJE+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 243 FontDescriptor: FontName: ARIQJE+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: MLHCKP+URWPalladioL-BoldItal FontSubset: true FirstChar: 67 LastChar: 117 FontDescriptor: FontName: MLHCKP+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NKDEYO+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: NKDEYO+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XYPWHM+CMSY10 FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: XYPWHM+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 34, 279, 152, 288 Annotation: Subtype: Link Rect: 34, 269, 96, 276 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 167, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 222, 642, 233, 655 Annotation: Subtype: Link Rect: 288, 630, 299, 643 Annotation: Subtype: Link Rect: 236, 604, 247, 617 Annotation: Subtype: Link Rect: 362, 604, 373, 617 Annotation: Subtype: Link Rect: 180, 591, 191, 605 Annotation: Subtype: Link Rect: 120, 17, 281, 28 Annotation: Subtype: Link Rect: 400, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 412, 87, 431 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 497, 568, 504, 576 ActionDest: 95 Annotation: Subtype: Link Rect: 502, 542, 509, 551 ActionDest: 95 Annotation: Subtype: Link Rect: 279, 492, 286, 501 ActionDest: 95 Annotation: Subtype: Link Rect: 476, 455, 483, 464 ActionDest: 95 Annotation: Subtype: Link Rect: 404, 429, 411, 438 ActionDest: 95 Annotation: Subtype: Link Rect: 412, 429, 419, 438 ActionDest: 98 Annotation: Subtype: Link Rect: 237, 367, 244, 376 ActionDest: 98 Annotation: Subtype: Link Rect: 245, 367, 252, 376 ActionDest: 98 Annotation: Subtype: Link Rect: 306, 342, 313, 351 ActionDest: 98 Annotation: Subtype: Link Rect: 316, 341, 323, 351 ActionDest: 98 Annotation: Subtype: Link Rect: 213, 329, 220, 338 ActionDest: 98 Annotation: Subtype: Link Rect: 220, 329, 232, 338 ActionDest: 98 Annotation: Subtype: Link Rect: 362, 317, 374, 325 ActionDest: 98 Annotation: Subtype: Link Rect: 271, 304, 283, 313 ActionDest: 98 Annotation: Subtype: Link Rect: 458, 254, 470, 263 ActionDest: 98 Annotation: Subtype: Link Rect: 473, 254, 485, 263 ActionDest: 98 Annotation: Subtype: Link Rect: 486, 241, 498, 250 ActionDest: 98 Annotation: Subtype: Link Rect: 210, 103, 222, 112 ActionDest: 98 Annotation: Subtype: Link Rect: 313, 91, 325, 99 ActionDest: 98 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 523, 481, 530, 493 ActionDest: 73 Annotation: Subtype: Link Rect: 187, 318, 193, 328 ActionDest: 73 Annotation: Subtype: Link Rect: 202, 270, 209, 282 ActionDest: 76 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 306, 357, 312, 369 ActionDest: 76 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 375, 569, 382, 581 ActionDest: 83 Annotation: Subtype: Link Rect: 286, 92, 298, 102 ActionDest: 98 Annotation: Subtype: Link Rect: 298, 92, 310, 102 ActionDest: 98 Annotation: Subtype: Link Rect: 444, 80, 456, 89 ActionDest: 98 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 445, 736, 452, 744 ActionDest: 95 Annotation: Subtype: Link Rect: 508, 685, 515, 694 ActionDest: 95 Annotation: Subtype: Link Rect: 544, 635, 556, 644 ActionDest: 98 Annotation: Subtype: Link Rect: 531, 623, 543, 631 ActionDest: 98 Annotation: Subtype: Link Rect: 543, 622, 555, 631 ActionDest: 98 Annotation: Subtype: Link Rect: 352, 522, 364, 531 ActionDest: 98 Annotation: Subtype: Link Rect: 364, 497, 376, 506 ActionDest: 98 Annotation: Subtype: Link Rect: 213, 447, 225, 456 ActionDest: 98 Annotation: Subtype: Link Rect: 226, 447, 238, 456 ActionDest: 98 Annotation: Subtype: Link Rect: 240, 384, 247, 393 ActionDest: 98 Annotation: Subtype: Link Rect: 247, 384, 259, 393 ActionDest: 98 Annotation: Subtype: Link Rect: 194, 221, 205, 230 ActionDest: 98 Annotation: Subtype: Link Rect: 361, 208, 373, 217 ActionDest: 98 Annotation: Subtype: Link Rect: 177, 95, 189, 104 ActionDest: 98 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 218, 660, 230, 669 ActionDest: 98 Annotation: Subtype: Link Rect: 279, 635, 291, 644 ActionDest: 98 Annotation: Subtype: Link Rect: 292, 635, 303, 644 ActionDest: 98 Annotation: Subtype: Link Rect: 395, 484, 407, 493 ActionDest: 98 Annotation: Subtype: Link Rect: 544, 320, 556, 329 ActionDest: 98 Annotation: Subtype: Link Rect: 409, 94, 421, 103 ActionDest: 98 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 306, 660, 318, 669 ActionDest: 98 Annotation: Subtype: Link Rect: 319, 660, 331, 669 ActionDest: 98 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 536, 684, 560, 695 Annotation: Subtype: Link Rect: 165, 672, 406, 683 Annotation: Subtype: Link Rect: 303, 169, 341, 180 Annotation: Subtype: Link Rect: 242, 147, 280, 157 Annotation: Subtype: Link Rect: 286, 147, 322, 157 Annotation: Subtype: Link Rect: 301, 123, 338, 134 Annotation: Subtype: Link Rect: 263, 100, 301, 111 Annotation: Subtype: Link Rect: 307, 100, 343, 111 Annotation: Subtype: Link Rect: 243, 77, 281, 88 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 59, 722, 96, 733 Annotation: Subtype: Link Rect: 108, 688, 146, 698 Annotation: Subtype: Link Rect: 95, 665, 133, 675 Annotation: Subtype: Link Rect: 139, 665, 175, 675 Annotation: Subtype: Link Rect: 201, 630, 238, 640 Annotation: Subtype: Link Rect: 244, 630, 280, 640 Annotation: Subtype: Link Rect: 394, 618, 432, 629 Annotation: Subtype: Link Rect: 443, 595, 480, 606 Annotation: Subtype: Link Rect: 338, 560, 375, 571 Annotation: Subtype: Link Rect: 312, 537, 349, 548 Annotation: Subtype: Link Rect: 356, 537, 392, 548 Annotation: Subtype: Link Rect: 95, 504, 133, 514 Annotation: Subtype: Link Rect: 104, 469, 142, 479 Annotation: Subtype: Link Rect: 148, 469, 184, 479 Annotation: Subtype: Link Rect: 473, 445, 511, 456 Annotation: Subtype: Link Rect: 517, 445, 553, 456 Annotation: Subtype: Link Rect: 259, 411, 297, 422 Annotation: Subtype: Link Rect: 303, 411, 339, 422 Annotation: Subtype: Link Rect: 467, 388, 505, 399 Annotation: Subtype: Link Rect: 408, 353, 446, 364 Annotation: Subtype: Link Rect: 379, 330, 417, 341 Annotation: Subtype: Link Rect: 157, 296, 194, 307 Annotation: Subtype: Link Rect: 200, 296, 236, 307 Annotation: Subtype: Link Rect: 383, 284, 420, 295 Annotation: Subtype: Link Rect: 426, 284, 462, 295 Annotation: Subtype: Link Rect: 456, 261, 493, 272 Annotation: Subtype: Link Rect: 500, 261, 536, 272 Annotation: Subtype: Link Rect: 140, 228, 177, 238 Annotation: Subtype: Link Rect: 95, 193, 133, 203 Annotation: Subtype: Link Rect: 139, 193, 175, 203 Annotation: Subtype: Link Rect: 520, 181, 557, 192 Checksum: 612c0fe7 Type: CRC32 Checksum: 4b7177cf625a105aa980ac3c2d4b5145 Type: MD5 Checksum: 82b2b3440e86279d0a2815fa40b073c7e7dcf653 Type: SHA-1