63b0ade4c2616aac64e790bf711b7a4d pmc_10045471.pdf 03863e24e306648c7918e73b24d6816cf15b073d pmc_10045471.pdf 59228072cc39935de51f43624f38ff6b41d2b06bd62787b66f05ca6805d1f44c pmc_10045471.pdf Title: Effect of monovalency on anti-contactin-1 IgG4 Subject: Introduction: Autoimmune nodopathies (AN) have been diagnosed in a subset of patients fulfilling criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who display no or poor response to intravenous immunoglobulins Keywords: "immunoglobulin, demyelination, GBS, auto-immune, myelin, Schwann, axon" Author: Guillaume Taieb; Alexandre Jentzer; Elisa Vegezzi; Cinta Lleixà; Isabel Illa; Luis Querol; Jérôme J. Devaux Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue Mar 14 08:50:26 2023 CET ModDate: Tue Mar 14 09:36:13 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 3166250 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PLOCNN+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 507 0 PLOCNO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 508 0 PLOCNP+AdvPSA18C Type 1C WinAnsi yes yes no 509 0 PLOCOA+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 510 0 PLOCOB+AdvPSA323 Type 1C WinAnsi yes yes no 511 0 PLOCPC+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 512 0 PLOCPD+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 513 0 PLOCPE+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 524 0 PLOFKE+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 527 0 PLOFOG+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 165 0 PLOFOH+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 157 0 PLOFPH+AdvTT58d178b9+03 Type 1C Custom yes yes yes 160 0 PLOFPI+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 152 0 PLOFPJ+AdvOTd877c31c+21 Type 1C WinAnsi yes yes no 153 0 PLOFOE+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 148 0 PLOFOF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 143 0 PLOGAK+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 166 0 PLOGCK+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 167 0 PLOGDL+AdvOT46dcae81 Type 1C WinAnsi yes yes no 169 0 PLOGDM+AdvOT46dcae81+fb Type 1C Custom yes yes yes 168 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 171 0 PMBLIG+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 172 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-21 02:35:45 CEST RepresentationInformation: pmc_10045471.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-20 02:27:09 CEST Size: 3166250 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B14' cannot be found Offset: 3146652 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 3146652 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 3146652 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B16' cannot be found Offset: 3146652 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 3146652 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 3146652 MIMEtype: application/pdf PDFMetadata: Objects: 586 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Effect of monovalency on anti-contactin-1 IgG4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Material and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Antibody purification and cleavage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Monospecificity ELISA assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Cell aggregation assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Intraneural injections and quantification of antibody infiltration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Standard protocol approvals, registrations, and patient consents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Characteristics of patients with AN related to anti-CNTN1 IgG4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Anti-CNTN1 IgG4 have majorly undergone FAE in situ Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Monovalent anti-CNTN1 IgG4 blocks CNTN1/CASPR1-Nfasc155 interaction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Anti-CNTN1 fab penetrates paranodal regions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Effect of monovalency on anti-contactin-1 IgG4 Author: Guillaume Taieb; Alexandre Jentzer; Elisa Vegezzi; Cinta Lleixà; Isabel Illa; Luis Querol; Jérôme J. 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Devaux Introduction: Autoimmune nodopathies (AN) have been diagnosed in a subset of patients fulfilling criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who display no or poor response to intravenous immunoglobulins immunoglobulin, demyelination, GBS, auto-immune, myelin, Schwann, axon uuid:4c77d5c0-4e5b-4e36-94f6-0177348c4c77 uuid:01dab2aa-f856-4df8-91ed-6cdc79e30493 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 656, 477, 677 Annotation: Subtype: Link Rect: 222, 631, 432, 652 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 661, 125, 676 Annotation: Subtype: Link Rect: 60, 481, 141, 488 Annotation: Subtype: Link Rect: 49, 321, 157, 328 Annotation: Subtype: Link Rect: 49, 271, 168, 278 Annotation: Subtype: Link Rect: 49, 262, 74, 269 Annotation: Subtype: Link Rect: 454, 802, 510, 809 Annotation: Subtype: Link Rect: 471, 793, 518, 800 Annotation: 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