f5d4bb00cf65e7258d8c3ff259260d06 pmc_10056426.pdf b8d20bb21cb88ce06bcc8a6401b520e4093c9205 pmc_10056426.pdf 3d21073ea76771b888846f7bd4616d099514c4ea10dca47dc3f7b28a54ef135c pmc_10056426.pdf Title: Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment Subject: Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment. Nanotechnology has helped to address these questions, making important contributions in the oncological field. The use of nanoparticles has allowed the improvement of the therapeutic index of several conventional drugs and facilitates the tumoral accumulation and intracellular delivery of complex biomolecules, such as genetic material. Among the wide range of nanotechnology-based drug delivery systems (nanoDDS), solid lipid nanoparticles (SLNs) have emerged as promising systems for delivering different types of cargo. Their solid lipid core, at room and body temperature, provides SLNs with higher stability than other formulations. Moreover, SLNs offer other important features, namely the possibility to perform active targeting, sustained and controlled release, and multifunctional therapy. Furthermore, with the possibility to use biocompatible and physiologic materials and easy scale-up and low-cost production methods, SLNs meet the principal requirements of an ideal nanoDDS. The present work aims to summarize the main aspects related to SLNs, including composition, production methods, and administration routes, as well as to show the most recent studies about the use of SLNs for cancer treatment. Keywords: solid lipid nanoparticles; nanomedicine; cancer therapy; cancer diagnostics; drug delivery; targeted therapy Author: Júlia German-Cortés, Mireia Vilar-Hernández, Diana Rafael, Ibane Abasolo and Fernanda Andrade Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 3 10:43:53 2023 CET ModDate: Fri Mar 3 10:48:41 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 28 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3548946 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YUQEMP+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 DGEWUE+VnURWPalladioL Type 1 Custom yes yes no 15 0 BADVAR+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 JAZMTR+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 UFFYTE+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 IAFAOG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 DDLDEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 85 0 DDLDEH+PalatinoLinotype TrueType WinAnsi yes yes no 88 0 DDLDEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 91 0 XLTSSD+CMSY10 Type 1 Builtin yes yes no 101 0 VVSYYB+EURM10 Type 1 Builtin yes yes no 105 0 DDLDEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 128 0 DDLDEH+PalatinoLinotype TrueType WinAnsi yes yes no 131 0 DDLDEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 134 0 DDLDEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 151 0 DDLDEH+PalatinoLinotype TrueType WinAnsi yes yes no 154 0 DDLDEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 157 0 DDLDEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 193 0 DDLDEH+PalatinoLinotype TrueType WinAnsi yes yes no 196 0 DDLDEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 199 0 DDLDEF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 214 0 DDLDEH+PalatinoLinotype TrueType WinAnsi yes yes no 217 0 DDLDEJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 220 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-29 02:32:06 CEST RepresentationInformation: pmc_10056426.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-28 02:23:55 CEST Size: 3548946 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 755 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: SLN Properties Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: SLNs Production Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Hot High-Pressure Homogenization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Cold High-Pressure Homogenization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Microemulsion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Double Microemulsion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: High Shear Homogenization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Solvent Emulsification-Evaporation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Solvent Emulsification-Diffusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Solvent Injection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Solvent Injection Lyophilization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Coacervation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Microwave-Assisted Microemulsion Technique Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Solid Lipid Nanoparticles Administration Routes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: Topical and Dermal Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Pulmonary Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Oral Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Ocular Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Intravenous Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Intranasal Administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: SLNs’ Advantages for Cancer Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: SLNs for Drug Delivery Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Targeted SLNs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: SLNs for Gene Delivery Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Other Applications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Immunotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Theragnostic Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Info: Title: Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment Author: Júlia German-Cortés, Mireia Vilar-Hernández, Diana Rafael, Ibane Abasolo and Fernanda Andrade Subject: Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment. Nanotechnology has helped to address these questions, making important contributions in the oncological field. The use of nanoparticles has allowed the improvement of the therapeutic index of several conventional drugs and facilitates the tumoral accumulation and intracellular delivery of complex biomolecules, such as genetic material. Among the wide range of nanotechnology-based drug delivery systems (nanoDDS), solid lipid nanoparticles (SLNs) have emerged as promising systems for delivering different types of cargo. Their solid lipid core, at room and body temperature, provides SLNs with higher stability than other formulations. Moreover, SLNs offer other important features, namely the possibility to perform active targeting, sustained and controlled release, and multifunctional therapy. Furthermore, with the possibility to use biocompatible and physiologic materials and easy scale-up and low-cost production methods, SLNs meet the principal requirements of an ideal nanoDDS. The present work aims to summarize the main aspects related to SLNs, including composition, production methods, and administration routes, as well as to show the most recent studies about the use of SLNs for cancer treatment. Keywords: solid lipid nanoparticles; nanomedicine; cancer therapy; cancer diagnostics; drug delivery; targeted therapy Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Mar 03 10:43:53 CET 2023 ModDate: Fri Mar 03 10:48:41 CET 2023 ID: 0xc32969662f243a606abdfe4788808ee6, 0xc32969662f243a606abdfe4788808ee6 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BADVAR+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 134 FontDescriptor: FontName: BADVAR+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XLTSSD+CMSY10 FontSubset: true FirstChar: 6 LastChar: 48 FontDescriptor: FontName: XLTSSD+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: JAZMTR+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: JAZMTR+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VVSYYB+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: VVSYYB+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: YUQEMP+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 243 FontDescriptor: FontName: YUQEMP+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UFFYTE+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: UFFYTE+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DGEWUE+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: DGEWUE+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 34, 279, 152, 288 Annotation: Subtype: Link Rect: 34, 267, 109, 276 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 168, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 141, 663, 153, 676 Annotation: Subtype: Link Rect: 278, 663, 289, 676 Annotation: Subtype: Link Rect: 379, 663, 390, 676 Annotation: Subtype: Link Rect: 493, 663, 504, 676 Annotation: Subtype: Link Rect: 166, 652, 177, 663 Annotation: Subtype: Link Rect: 131, 17, 307, 28 Annotation: Subtype: Link Rect: 385, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 365, 87, 384 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 265, 723, 272, 732 ActionDest: 225 Annotation: Subtype: Link Rect: 264, 648, 271, 657 ActionDest: 225 Annotation: Subtype: Link Rect: 438, 622, 445, 631 ActionDest: 225 Annotation: Subtype: Link Rect: 394, 597, 401, 606 ActionDest: 225 Annotation: Subtype: Link Rect: 256, 497, 262, 506 ActionDest: 229 Annotation: Subtype: Link Rect: 246, 456, 253, 468 ActionDest: 72 Annotation: Subtype: Link Rect: 256, 459, 263, 468 ActionDest: 225 Annotation: Subtype: Link Rect: 266, 459, 273, 468 ActionDest: 229 Annotation: Subtype: Link Rect: 544, 434, 551, 443 ActionDest: 229 Annotation: Subtype: Link Rect: 223, 62, 230, 74 ActionDest: 75 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 517, 321, 560, 335 Annotation: Subtype: Link Rect: 165, 307, 184, 320 Annotation: Subtype: Link Rect: 377, 264, 384, 273 ActionDest: 229 Annotation: Subtype: Link Rect: 288, 213, 295, 222 ActionDest: 225 Annotation: Subtype: Link Rect: 295, 213, 302, 222 ActionDest: 229 Annotation: Subtype: Link Rect: 405, 201, 412, 210 ActionDest: 229 Annotation: Subtype: Link Rect: 190, 138, 197, 147 ActionDest: 229 Annotation: Subtype: Link Rect: 525, 75, 532, 84 ActionDest: 225 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 348, 673, 355, 682 ActionDest: 229 Annotation: Subtype: Link Rect: 355, 673, 367, 682 ActionDest: 229 Annotation: Subtype: Link Rect: 544, 648, 556, 657 ActionDest: 229 Annotation: Subtype: Link Rect: 460, 597, 472, 606 ActionDest: 229 Annotation: Subtype: Link Rect: 473, 597, 485, 606 ActionDest: 229 Annotation: Subtype: Link Rect: 267, 522, 278, 531 ActionDest: 229 Annotation: Subtype: Link Rect: 531, 484, 543, 493 ActionDest: 229 Annotation: Subtype: Link Rect: 544, 484, 556, 493 ActionDest: 229 Annotation: Subtype: Link Rect: 212, 396, 224, 405 ActionDest: 229 Annotation: Subtype: Link Rect: 224, 396, 236, 405 ActionDest: 229 Annotation: Subtype: Link Rect: 245, 193, 252, 205 ActionDest: 98 Annotation: Subtype: Link Rect: 270, 183, 282, 192 ActionDest: 229 Annotation: Subtype: Link Rect: 283, 183, 295, 192 ActionDest: 229 Annotation: Subtype: Link Rect: 295, 183, 307, 192 ActionDest: 229 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 426, 305, 438, 314 ActionDest: 229 Annotation: Subtype: Link Rect: 310, 192, 322, 201 ActionDest: 229 Annotation: Subtype: Link Rect: 323, 192, 335, 201 ActionDest: 229 Annotation: Subtype: Link Rect: 527, 78, 534, 87 ActionDest: 229 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 427, 670, 434, 679 ActionDest: 229 Annotation: Subtype: Link Rect: 435, 670, 447, 679 ActionDest: 229 Annotation: Subtype: Link Rect: 223, 556, 235, 565 ActionDest: 229 Annotation: Subtype: Link Rect: 338, 506, 345, 515 ActionDest: 229 Annotation: Subtype: Link Rect: 345, 506, 357, 515 ActionDest: 229 Annotation: Subtype: Link Rect: 246, 405, 258, 415 ActionDest: 229 Annotation: Subtype: Link Rect: 280, 292, 292, 301 ActionDest: 229 Annotation: Subtype: Link Rect: 335, 204, 347, 213 ActionDest: 229 Annotation: Subtype: Link Rect: 217, 128, 229, 137 ActionDest: 229 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 514, 698, 526, 707 ActionDest: 229 Annotation: Subtype: Link Rect: 211, 610, 223, 619 ActionDest: 229 Annotation: Subtype: Link Rect: 404, 559, 416, 568 ActionDest: 229 Annotation: Subtype: Link Rect: 294, 534, 306, 543 ActionDest: 229 Annotation: Subtype: Link Rect: 381, 522, 393, 531 ActionDest: 229 Annotation: Subtype: Link Rect: 494, 522, 506, 531 ActionDest: 229 Annotation: Subtype: Link Rect: 526, 371, 538, 380 ActionDest: 232 Annotation: Subtype: Link Rect: 284, 207, 291, 216 ActionDest: 225 Annotation: Subtype: Link Rect: 291, 207, 298, 216 ActionDest: 229 Annotation: Subtype: Link Rect: 299, 207, 311, 216 ActionDest: 229 Annotation: Subtype: Link Rect: 255, 182, 267, 191 ActionDest: 232 Annotation: Subtype: Link Rect: 268, 182, 280, 191 ActionDest: 232 Annotation: Subtype: Link Rect: 333, 144, 345, 154 ActionDest: 232 Annotation: Subtype: Link Rect: 331, 132, 343, 141 ActionDest: 232 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 346, 698, 358, 707 ActionDest: 229 Annotation: Subtype: Link Rect: 358, 698, 370, 707 ActionDest: 232 Annotation: Subtype: Link Rect: 371, 698, 383, 707 ActionDest: 232 Annotation: Subtype: Link Rect: 493, 673, 505, 682 ActionDest: 232 Annotation: Subtype: Link Rect: 506, 673, 518, 682 ActionDest: 232 Annotation: Subtype: Link Rect: 375, 660, 387, 669 ActionDest: 232 Annotation: Subtype: Link Rect: 468, 660, 480, 669 ActionDest: 232 Annotation: Subtype: Link Rect: 483, 660, 495, 669 ActionDest: 232 Annotation: Subtype: Link Rect: 242, 635, 254, 644 ActionDest: 232 Annotation: Subtype: Link Rect: 341, 635, 353, 644 ActionDest: 232 Annotation: Subtype: Link Rect: 291, 560, 298, 568 ActionDest: 225 Annotation: Subtype: Link Rect: 298, 560, 310, 568 ActionDest: 229 Annotation: Subtype: Link Rect: 217, 534, 229, 543 ActionDest: 232 Annotation: Subtype: Link Rect: 410, 534, 422, 543 ActionDest: 232 Annotation: Subtype: Link Rect: 543, 534, 555, 543 ActionDest: 232 Annotation: Subtype: Link Rect: 389, 522, 401, 531 ActionDest: 232 Annotation: Subtype: Link Rect: 543, 408, 555, 417 ActionDest: 232 Annotation: Subtype: Link Rect: 214, 396, 226, 405 ActionDest: 232 Annotation: Subtype: Link Rect: 370, 396, 382, 405 ActionDest: 232 Annotation: Subtype: Link Rect: 533, 257, 545, 267 ActionDest: 232 Annotation: Subtype: Link Rect: 498, 245, 510, 254 ActionDest: 232 Annotation: Subtype: Link Rect: 511, 245, 523, 254 ActionDest: 232 Annotation: Subtype: Link Rect: 413, 169, 425, 178 ActionDest: 235 Annotation: Subtype: Link Rect: 404, 157, 416, 166 ActionDest: 235 Annotation: Subtype: Link Rect: 427, 66, 434, 78 ActionDest: 118 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 256, 670, 263, 682 ActionDest: 118 Annotation: Subtype: Link Rect: 219, 622, 231, 631 ActionDest: 235 Annotation: Subtype: Link Rect: 498, 166, 559, 177 Annotation: Subtype: Link Rect: 423, 97, 435, 106 ActionDest: 235 Annotation: Subtype: Link Rect: 435, 97, 447, 106 ActionDest: 235 Annotation: Subtype: Link Rect: 493, 97, 505, 106 ActionDest: 235 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 544, 698, 556, 707 ActionDest: 235 Annotation: Subtype: Link Rect: 477, 647, 489, 657 ActionDest: 235 Annotation: Subtype: Link Rect: 225, 622, 237, 631 ActionDest: 235 Annotation: Subtype: Link Rect: 209, 585, 220, 594 ActionDest: 235 Annotation: Subtype: Link Rect: 451, 585, 463, 594 ActionDest: 235 Annotation: Subtype: Link Rect: 385, 532, 392, 544 ActionDest: 162 Annotation: Subtype: Link Rect: 302, 484, 314, 493 ActionDest: 235 Annotation: Subtype: Link Rect: 484, 409, 496, 418 ActionDest: 235 Annotation: Subtype: Link Rect: 430, 371, 437, 380 ActionDest: 225 Annotation: Subtype: Link Rect: 437, 371, 449, 380 ActionDest: 235 Annotation: Subtype: Link Rect: 359, 333, 371, 342 ActionDest: 235 Annotation: Subtype: Link Rect: 371, 334, 383, 342 ActionDest: 235 Annotation: Subtype: Link Rect: 227, 321, 239, 330 ActionDest: 235 Annotation: Subtype: Link Rect: 332, 321, 343, 330 ActionDest: 235 Annotation: Subtype: Link Rect: 367, 308, 379, 317 ActionDest: 235 Annotation: Subtype: Link Rect: 374, 283, 386, 292 ActionDest: 235 Annotation: Subtype: Link Rect: 260, 233, 272, 242 ActionDest: 235 Annotation: Subtype: Link Rect: 549, 142, 556, 154 ActionDest: 141 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 544, 368, 555, 376 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 320, 536, 329 ActionDest: 235 Annotation: Subtype: Link Rect: 217, 307, 229, 316 ActionDest: 235 Annotation: Subtype: Link Rect: 392, 295, 404, 304 ActionDest: 235 Annotation: Subtype: Link Rect: 488, 282, 500, 291 ActionDest: 235 Annotation: Subtype: Link Rect: 544, 207, 556, 216 ActionDest: 235 Annotation: Subtype: Link Rect: 514, 144, 526, 153 ActionDest: 235 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 440, 673, 452, 682 ActionDest: 238 Annotation: Subtype: Link Rect: 543, 673, 555, 682 ActionDest: 238 Annotation: Subtype: Link Rect: 353, 622, 365, 631 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 486, 534, 494 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 467, 534, 475 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 443, 534, 451 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 424, 534, 432 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 405, 534, 413 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 386, 534, 394 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 372, 534, 380 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 358, 534, 366 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 339, 534, 347 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 320, 534, 328 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 306, 534, 313 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 291, 534, 299 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 277, 534, 285 ActionDest: 235 Annotation: Subtype: Link Rect: 524, 263, 534, 270 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 244, 534, 251 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 220, 534, 228 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 201, 534, 209 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 182, 534, 190 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 163, 534, 171 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 148, 534, 156 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 129, 534, 137 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 106, 534, 113 ActionDest: 235 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 524, 700, 534, 708 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 681, 534, 689 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 657, 534, 665 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 633, 534, 641 ActionDest: 238 Annotation: Subtype: Link Rect: 524, 605, 534, 612 ActionDest: 238 Annotation: Subtype: Link Rect: 385, 377, 392, 387 ActionDest: 171 Annotation: Subtype: Link Rect: 450, 340, 462, 349 ActionDest: 238 Annotation: Subtype: Link Rect: 544, 340, 556, 349 ActionDest: 238 Annotation: Subtype: Link Rect: 231, 327, 242, 336 ActionDest: 238 Annotation: Subtype: Link Rect: 417, 289, 429, 298 ActionDest: 238 Annotation: Subtype: Link Rect: 513, 227, 525, 236 ActionDest: 238 Annotation: Subtype: Link Rect: 459, 151, 471, 160 ActionDest: 238 Annotation: Subtype: Link Rect: 539, 151, 556, 160 ActionDest: 241 Annotation: Subtype: Link Rect: 255, 139, 272, 148 ActionDest: 241 Annotation: Subtype: Link Rect: 467, 139, 483, 148 ActionDest: 241 Annotation: Subtype: Link Rect: 333, 76, 350, 85 ActionDest: 241 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 366, 685, 383, 694 ActionDest: 241 Annotation: Subtype: Link Rect: 490, 660, 507, 669 ActionDest: 241 Annotation: Subtype: Link Rect: 416, 585, 433, 594 ActionDest: 241 Annotation: Subtype: Link Rect: 539, 585, 556, 594 ActionDest: 241 Annotation: Subtype: Link Rect: 506, 572, 523, 581 ActionDest: 241 Annotation: Subtype: Link Rect: 453, 522, 470, 531 ActionDest: 241 Annotation: Subtype: Link Rect: 237, 472, 254, 481 ActionDest: 241 Annotation: Subtype: Link Rect: 489, 334, 506, 343 ActionDest: 241 Annotation: Subtype: Link Rect: 337, 170, 354, 180 ActionDest: 241 Annotation: Subtype: Link Rect: 355, 170, 372, 180 ActionDest: 241 Annotation: Subtype: Link Rect: 471, 170, 488, 180 ActionDest: 241 Annotation: Subtype: Link Rect: 233, 158, 249, 167 ActionDest: 241 Annotation: Subtype: Link Rect: 250, 158, 267, 167 ActionDest: 241 Annotation: Subtype: Link Rect: 394, 120, 411, 129 ActionDest: 241 Annotation: Subtype: Link Rect: 398, 70, 415, 79 ActionDest: 241 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 468, 723, 485, 732 ActionDest: 241 Annotation: Subtype: Link Rect: 530, 583, 541, 592 ActionDest: 238 Annotation: Subtype: Link Rect: 530, 562, 541, 570 ActionDest: 238 Annotation: Subtype: Link Rect: 528, 524, 543, 533 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 492, 543, 500 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 476, 543, 485 ActionDest: 241 Annotation: Subtype: Link Rect: 530, 460, 541, 469 ActionDest: 238 Annotation: Subtype: Link Rect: 528, 445, 543, 453 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 429, 543, 437 ActionDest: 241 Annotation: Subtype: Link Rect: 530, 408, 541, 416 ActionDest: 238 Annotation: Subtype: Link Rect: 528, 387, 543, 395 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 371, 543, 379 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 355, 543, 363 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 334, 543, 342 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 312, 543, 321 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 296, 543, 305 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 280, 543, 289 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 259, 543, 267 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 232, 543, 241 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 206, 543, 214 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 173, 543, 182 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 146, 543, 155 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 125, 543, 133 ActionDest: 241 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 528, 687, 543, 695 ActionDest: 241 Annotation: Subtype: Link Rect: 530, 660, 541, 668 ActionDest: 232 Annotation: Subtype: Link Rect: 528, 644, 543, 652 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 616, 543, 625 ActionDest: 241 Annotation: Subtype: Link Rect: 528, 584, 543, 592 ActionDest: 241 Annotation: Subtype: Link Rect: 389, 421, 406, 430 ActionDest: 241 Annotation: Subtype: Link Rect: 406, 420, 423, 430 ActionDest: 241 Annotation: Subtype: Link Rect: 386, 395, 403, 404 ActionDest: 244 Annotation: Subtype: Link Rect: 234, 333, 251, 342 ActionDest: 244 Annotation: Subtype: Link Rect: 402, 320, 419, 329 ActionDest: 244 Annotation: Subtype: Link Rect: 207, 295, 224, 304 ActionDest: 244 Annotation: Subtype: Link Rect: 281, 282, 298, 291 ActionDest: 244 Annotation: Subtype: Link Rect: 298, 282, 315, 291 ActionDest: 244 Annotation: Subtype: Link Rect: 521, 207, 538, 216 ActionDest: 244 Annotation: Subtype: Link Rect: 538, 207, 555, 216 ActionDest: 244 Annotation: Subtype: Link Rect: 463, 195, 475, 204 ActionDest: 229 Annotation: Subtype: Link Rect: 495, 117, 502, 129 ActionDest: 180 Annotation: Subtype: Link Rect: 350, 94, 367, 103 ActionDest: 244 Annotation: Subtype: Link Rect: 481, 69, 497, 78 ActionDest: 244 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 307, 685, 324, 694 ActionDest: 244 Annotation: Subtype: Link Rect: 230, 622, 247, 631 ActionDest: 244 Annotation: Subtype: Link Rect: 461, 597, 478, 606 ActionDest: 244 Annotation: Subtype: Link Rect: 541, 597, 558, 606 ActionDest: 244 Annotation: Subtype: Link Rect: 228, 585, 244, 594 ActionDest: 244 Annotation: Subtype: Link Rect: 483, 585, 500, 594 ActionDest: 244 Annotation: Subtype: Link Rect: 272, 522, 289, 531 ActionDest: 244 Annotation: Subtype: Link Rect: 357, 522, 374, 531 ActionDest: 244 Annotation: Subtype: Link Rect: 249, 497, 266, 506 ActionDest: 244 Annotation: Subtype: Link Rect: 539, 409, 556, 418 ActionDest: 244 Annotation: Subtype: Link Rect: 306, 321, 323, 330 ActionDest: 244 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 524, 684, 540, 693 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 663, 540, 671 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 636, 540, 645 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 615, 540, 623 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 599, 540, 608 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 578, 540, 586 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 551, 540, 560 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 524, 540, 533 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 503, 540, 512 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 487, 540, 496 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 472, 540, 480 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 445, 540, 453 ActionDest: 244 Annotation: Subtype: Link Rect: 524, 407, 540, 416 ActionDest: 244 Annotation: Subtype: Link Rect: 272, 132, 289, 142 ActionDest: 244 Annotation: Subtype: Link Rect: 287, 107, 304, 116 ActionDest: 244 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 404, 720, 411, 732 ActionDest: 204 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 260, 302, 275, 311 ActionDest: 244 Annotation: Subtype: Link Rect: 261, 229, 278, 238 ActionDest: 244 Annotation: Subtype: Link Rect: 327, 191, 339, 200 ActionDest: 232 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 190, 735, 207, 744 ActionDest: 244 Annotation: Subtype: Link Rect: 207, 735, 224, 744 ActionDest: 247 Annotation: Subtype: Link Rect: 310, 735, 327, 744 ActionDest: 247 Annotation: Subtype: Link Rect: 419, 735, 436, 744 ActionDest: 247 Annotation: Subtype: Link Rect: 310, 723, 327, 732 ActionDest: 247 Annotation: Subtype: Link Rect: 275, 673, 292, 682 ActionDest: 247 Annotation: Subtype: Link Rect: 432, 647, 449, 657 ActionDest: 247 Annotation: Subtype: Link Rect: 104, 152, 142, 162 Annotation: Subtype: Link Rect: 148, 152, 184, 162 Annotation: Subtype: Link Rect: 164, 129, 202, 139 Annotation: Subtype: Link Rect: 208, 129, 244, 139 Annotation: Subtype: Link Rect: 208, 105, 246, 116 Annotation: Subtype: Link Rect: 329, 82, 366, 93 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 95, 699, 132, 710 Annotation: Subtype: Link Rect: 138, 699, 174, 710 Annotation: Subtype: Link Rect: 244, 641, 282, 652 Annotation: Subtype: Link Rect: 288, 641, 324, 652 Annotation: Subtype: Link Rect: 382, 618, 419, 629 Annotation: Subtype: Link Rect: 376, 596, 414, 606 Annotation: Subtype: Link Rect: 337, 549, 375, 560 Annotation: Subtype: Link Rect: 381, 549, 417, 560 Annotation: Subtype: Link Rect: 520, 526, 557, 537 Annotation: Subtype: Link Rect: 59, 504, 96, 514 Annotation: Subtype: Link Rect: 102, 504, 138, 514 Annotation: Subtype: Link Rect: 519, 480, 557, 491 Annotation: Subtype: Link Rect: 59, 469, 95, 479 Annotation: Subtype: Link Rect: 255, 445, 293, 456 Annotation: Subtype: Link Rect: 326, 423, 364, 433 Annotation: Subtype: Link Rect: 328, 399, 366, 410 Annotation: Subtype: Link Rect: 277, 376, 315, 387 Annotation: Subtype: Link Rect: 275, 353, 313, 364 Annotation: Subtype: Link Rect: 184, 331, 222, 341 Annotation: Subtype: Link Rect: 315, 307, 353, 318 Annotation: Subtype: Link Rect: 479, 284, 516, 295 Annotation: Subtype: Link Rect: 521, 284, 557, 295 Annotation: Subtype: Link Rect: 373, 261, 411, 272 Annotation: Subtype: Link Rect: 417, 261, 453, 272 Annotation: Subtype: Link Rect: 520, 238, 557, 249 Annotation: Subtype: Link Rect: 59, 228, 95, 238 Annotation: Subtype: Link Rect: 181, 204, 218, 215 Annotation: Subtype: Link Rect: 113, 159, 151, 169 Annotation: Subtype: Link Rect: 505, 135, 543, 146 Annotation: Subtype: Link Rect: 360, 100, 397, 111 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 230, 722, 267, 733 Annotation: Subtype: Link Rect: 165, 699, 202, 710 Annotation: Subtype: Link Rect: 216, 676, 253, 687 Annotation: Subtype: Link Rect: 259, 676, 295, 687 Annotation: Subtype: Link Rect: 59, 653, 96, 664 Annotation: Subtype: Link Rect: 102, 653, 138, 664 Annotation: Subtype: Link Rect: 181, 619, 219, 629 Annotation: Subtype: Link Rect: 225, 619, 261, 629 Annotation: Subtype: Link Rect: 282, 549, 320, 560 Annotation: Subtype: Link Rect: 326, 549, 362, 560 Annotation: Subtype: Link Rect: 59, 515, 96, 525 Annotation: Subtype: Link Rect: 102, 515, 138, 525 Annotation: Subtype: Link Rect: 339, 492, 377, 502 Annotation: Subtype: Link Rect: 383, 492, 419, 502 Annotation: Subtype: Link Rect: 214, 468, 251, 479 Annotation: Subtype: Link Rect: 435, 445, 473, 456 Annotation: Subtype: Link Rect: 268, 422, 305, 433 Annotation: Subtype: Link Rect: 312, 422, 348, 433 Annotation: Subtype: Link Rect: 395, 399, 433, 410 Annotation: Subtype: Link Rect: 478, 376, 515, 387 Annotation: Subtype: Link Rect: 521, 376, 557, 387 Annotation: Subtype: Link Rect: 427, 353, 464, 364 Annotation: Subtype: Link Rect: 366, 330, 404, 341 Annotation: Subtype: Link Rect: 410, 330, 446, 341 Annotation: Subtype: Link Rect: 505, 296, 543, 307 Annotation: Subtype: Link Rect: 59, 262, 96, 272 Annotation: Subtype: Link Rect: 222, 227, 260, 238 Annotation: Subtype: Link Rect: 312, 192, 350, 203 Annotation: Subtype: Link Rect: 196, 170, 234, 180 Annotation: Subtype: Link Rect: 176, 147, 213, 157 Annotation: Subtype: Link Rect: 220, 147, 256, 157 Annotation: Subtype: Link Rect: 292, 112, 329, 123 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 357, 711, 395, 721 Annotation: Subtype: Link Rect: 401, 711, 437, 721 Annotation: Subtype: Link Rect: 380, 688, 418, 698 Annotation: Subtype: Link Rect: 482, 664, 520, 675 Annotation: Subtype: Link Rect: 59, 630, 96, 640 Annotation: Subtype: Link Rect: 102, 630, 138, 640 Annotation: Subtype: Link Rect: 56, 606, 186, 617 Annotation: Subtype: Link Rect: 155, 572, 193, 583 Annotation: Subtype: Link Rect: 199, 572, 235, 583 Annotation: Subtype: Link Rect: 380, 560, 560, 571 Annotation: Subtype: Link Rect: 56, 549, 254, 560 Annotation: Subtype: Link Rect: 193, 526, 418, 537 Annotation: Subtype: Link Rect: 340, 503, 560, 514 Annotation: Subtype: Link Rect: 274, 468, 505, 479 Annotation: Subtype: Link Rect: 233, 434, 270, 445 Annotation: Subtype: Link Rect: 240, 399, 277, 410 Annotation: Subtype: Link Rect: 207, 365, 244, 376 Annotation: Subtype: Link Rect: 177, 343, 215, 353 Annotation: Subtype: Link Rect: 221, 343, 257, 353 Annotation: Subtype: Link Rect: 174, 320, 211, 330 Annotation: Subtype: Link Rect: 217, 320, 253, 330 Annotation: Subtype: Link Rect: 59, 285, 96, 295 Annotation: Subtype: Link Rect: 102, 285, 138, 295 Annotation: Subtype: Link Rect: 363, 261, 401, 272 Annotation: Subtype: Link Rect: 407, 261, 443, 272 Annotation: Subtype: Link Rect: 59, 228, 96, 238 Annotation: Subtype: Link Rect: 59, 193, 96, 203 Annotation: Subtype: Link Rect: 336, 169, 374, 180 Annotation: Subtype: Link Rect: 380, 169, 416, 180 Annotation: Subtype: Link Rect: 59, 136, 96, 146 Annotation: Subtype: Link Rect: 102, 136, 138, 146 Annotation: Subtype: Link Rect: 336, 101, 374, 111 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 225, 722, 262, 733 Annotation: Subtype: Link Rect: 411, 699, 449, 710 Annotation: Subtype: Link Rect: 455, 699, 491, 710 Annotation: Subtype: Link Rect: 389, 676, 427, 687 Annotation: Subtype: Link Rect: 433, 676, 469, 687 Annotation: Subtype: Link Rect: 229, 642, 267, 652 Annotation: Subtype: Link Rect: 273, 642, 309, 652 Annotation: Subtype: Link Rect: 149, 607, 187, 617 Annotation: Subtype: Link Rect: 316, 573, 353, 583 Annotation: Subtype: Link Rect: 399, 549, 437, 560 Annotation: Subtype: Link Rect: 360, 526, 397, 537 Annotation: Subtype: Link Rect: 59, 492, 96, 502 Annotation: Subtype: Link Rect: 398, 468, 435, 479 Annotation: Subtype: Link Rect: 277, 445, 315, 456 Annotation: Subtype: Link Rect: 519, 422, 557, 433 Annotation: Subtype: Link Rect: 59, 412, 95, 422 Annotation: Subtype: Link Rect: 205, 377, 243, 387 Annotation: Subtype: Link Rect: 249, 377, 285, 387 Annotation: Subtype: Link Rect: 228, 342, 266, 353 Annotation: Subtype: Link Rect: 272, 342, 308, 353 Annotation: Subtype: Link Rect: 519, 319, 557, 330 Annotation: Subtype: Link Rect: 59, 308, 95, 318 Annotation: Subtype: Link Rect: 511, 284, 548, 295 Annotation: Subtype: Link Rect: 59, 251, 96, 261 Annotation: Subtype: Link Rect: 410, 215, 448, 226 Annotation: Subtype: Link Rect: 476, 192, 513, 203 Annotation: Subtype: Link Rect: 209, 158, 246, 169 Annotation: Subtype: Link Rect: 234, 124, 271, 134 Annotation: Subtype: Link Rect: 326, 89, 363, 100 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 453, 722, 491, 733 Annotation: Subtype: Link Rect: 497, 722, 533, 733 Annotation: Subtype: Link Rect: 472, 699, 510, 710 Annotation: Subtype: Link Rect: 516, 699, 552, 710 Annotation: Subtype: Link Rect: 59, 665, 96, 675 Annotation: Subtype: Link Rect: 472, 641, 509, 652 Annotation: Subtype: Link Rect: 516, 641, 552, 652 Annotation: Subtype: Link Rect: 135, 607, 173, 617 Annotation: Subtype: Link Rect: 237, 573, 275, 583 Annotation: Subtype: Link Rect: 483, 549, 520, 560 Annotation: Subtype: Link Rect: 257, 526, 295, 537 Annotation: Subtype: Link Rect: 520, 503, 557, 514 Annotation: Subtype: Link Rect: 183, 468, 220, 479 Annotation: Subtype: Link Rect: 227, 468, 263, 479 Annotation: Subtype: Link Rect: 185, 435, 223, 445 Annotation: Subtype: Link Rect: 229, 435, 265, 445 Annotation: Subtype: Link Rect: 135, 400, 173, 410 Annotation: Subtype: Link Rect: 179, 400, 215, 410 Annotation: Subtype: Link Rect: 59, 366, 96, 376 Annotation: Subtype: Link Rect: 454, 342, 492, 353 Annotation: Subtype: Link Rect: 202, 307, 240, 318 Annotation: Subtype: Link Rect: 104, 274, 142, 284 Annotation: Subtype: Link Rect: 219, 238, 256, 249 Annotation: Subtype: Link Rect: 491, 215, 529, 226 Annotation: Subtype: Link Rect: 339, 193, 376, 203 Annotation: Subtype: Link Rect: 382, 193, 419, 203 Annotation: Subtype: Link Rect: 248, 169, 286, 180 Annotation: Subtype: Link Rect: 292, 169, 328, 180 Annotation: Subtype: Link Rect: 454, 146, 492, 157 Annotation: Subtype: Link Rect: 498, 146, 534, 157 Annotation: Subtype: Link Rect: 268, 124, 306, 134 Annotation: Subtype: Link Rect: 59, 101, 96, 111 Annotation: Subtype: Link Rect: 102, 101, 138, 111 Annotation: Subtype: Link Rect: 344, 77, 382, 88 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 476, 733, 514, 744 Annotation: Subtype: Link Rect: 262, 711, 300, 721 Annotation: Subtype: Link Rect: 449, 699, 487, 710 Annotation: Subtype: Link Rect: 179, 676, 217, 687 Annotation: Subtype: Link Rect: 150, 653, 188, 664 Annotation: Subtype: Link Rect: 520, 629, 557, 640 Annotation: Subtype: Link Rect: 59, 619, 95, 629 Annotation: Subtype: Link Rect: 259, 595, 296, 606 Annotation: Subtype: Link Rect: 302, 595, 338, 606 Annotation: Subtype: Link Rect: 126, 573, 163, 583 Annotation: Subtype: Link Rect: 477, 549, 514, 560 Annotation: Subtype: Link Rect: 521, 549, 557, 560 Annotation: Subtype: Link Rect: 191, 515, 228, 525 Annotation: Subtype: Link Rect: 235, 515, 271, 525 Annotation: Subtype: Link Rect: 519, 491, 556, 502 Annotation: Subtype: Link Rect: 337, 468, 374, 479 Annotation: Subtype: Link Rect: 135, 435, 173, 445 Annotation: Subtype: Link Rect: 463, 411, 500, 422 Annotation: Subtype: Link Rect: 462, 388, 500, 399 Annotation: Subtype: Link Rect: 442, 365, 479, 376 Annotation: Subtype: Link Rect: 485, 365, 521, 376 Annotation: Subtype: Link Rect: 410, 343, 447, 353 Annotation: Subtype: Link Rect: 454, 343, 490, 353 Annotation: Subtype: Link Rect: 59, 308, 96, 318 Annotation: Subtype: Link Rect: 102, 308, 138, 318 Annotation: Subtype: Link Rect: 520, 284, 557, 295 Annotation: Subtype: Link Rect: 59, 274, 95, 284 Annotation: Subtype: Link Rect: 135, 239, 172, 249 Annotation: Subtype: Link Rect: 179, 239, 215, 249 Annotation: Subtype: Link Rect: 59, 205, 96, 215 Annotation: Subtype: Link Rect: 59, 170, 96, 180 Annotation: Subtype: Link Rect: 268, 146, 306, 157 Annotation: Subtype: Link Rect: 329, 135, 367, 146 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 199, 676, 237, 687 Annotation: Subtype: Link Rect: 59, 642, 96, 652 Annotation: Subtype: Link Rect: 102, 642, 138, 652 Annotation: Subtype: Link Rect: 455, 618, 493, 629 Annotation: Subtype: Link Rect: 499, 618, 535, 629 Checksum: aff8adf1 Type: CRC32 Checksum: f5d4bb00cf65e7258d8c3ff259260d06 Type: MD5 Checksum: b8d20bb21cb88ce06bcc8a6401b520e4093c9205 Type: SHA-1