DOI: 10.1002/ski2.224 EDITORIAL Skin cancer special issue in Skin Health and Disease Skin cancer is a major health issue since it is the most believe that a better knowledge of infrequent skin can- common cancer worldwide and its incidence is rising cers is of utmost importance in order to improve the un- year after year.1–4 Although most skin cancers are non‐ derstanding and management of such tumours. lethal, they lead to significant morbidity and high treat- We also aimed to advance understanding of how skin ment costs. Therefore, primary prevention strategies, cancer presents in different ethnicities with a manuscript such as sun prevention, or secondary prevention stra- comparing the melanoma outcomes in black versus tegies, including early detection using dermoscopy or white patients.16 Although most skin cancers are rare in reflectance confocal microscopy, are crucial.1,5–7 non‐white populations, most studies to date have In addition, certain skin cancers, including mela- focussed on white populations resulting in a knowledge noma, squamous cell carcinoma or Merkel cell carci- bias that is essential to address. noma can be very aggressive and result in significant Due to its high incidence and large heterogeneity in mortality.8,9 This has been especially significant during terms of clinical presentation and management, skin the COVID‐19 pandemic where mortality rates related to cancer continues to be a trending topic. In the last skin cancers have increased, potentially due to delayed years, this has resulted in an improved understanding detection resulting in more advanced tumours.10 Hence, of the genetic pathways of skin tumours, the develop- it is crucial to ensure skin cancer screening and surveil- ment of efficacious medical treatments such as immu- lance in order to improve detection and treatment. notherapy and targeted therapies, and the advent of In this special issue of Skin Health and Disease we novel treatment strategies such as neoadjuvant ap- aimed to highlight the complexity of skin cancers by proaches. We hope this issue will reflect this exciting publishing a wide array of manuscripts covering different time in skin cancer research and encourage more aspects related to skin cancers, ranging from primary research to improve patient outcomes. prevention strategies related to sun education,11 ge- netics,12 and epidemiology13–16 to surgical17,18 and non‐ A C K N OW L E D G E M E N T S surgical19–21 treatments. From these papers, we would Not applicable. like to highlight some hot topics such as the paper from Borg et al17 evaluating the impact of the COVID‐19 C ON F L I C T O F I N T E R E S T S T A T E M E N T pandemic in the surgical management of skin cancers Oriol Yélamos is an Associate Editor of SHD. Oriol on the head and neck area in elderly patients. Another Yélamos has received consultancy honoraria from relevant paper evaluates the impact of 3D total photog- Almirall, Bioderma, Isispharma Kiowa Kirin and Leo raphy, a novel system developed to screen populations Pharma, and speakers' honoraria from Almirall, BMS, at high risk for skin cancer, in terms of skin cancers Isispharma, Jannsen‐Cilag, La Roche Posay, Leo excised and the histopathology outcomes.18 We have Pharma, MSD and Pierre Fabre. SG is an Associate left some room for non‐invasive skin imaging such as Editor of SHD. Shamir Geller has received speakers' reflectance confocal microscopy which has been used by honoraria from Takeda and Rafa. Selin Tokez is an Han et al20 to monitor the treatment of lentiginous mel- Associate Editor of SHD. anoma with imiquimod. Additionally, we did not forget to include studies AUTHOR CONTRIBUTIONS describing rare tumours or rare associations such as Oriol Yélamos: Writing – original draft (lead); Writing – cutaneous metastatic endometrial carcinoma,22 a review & editing (lead). Shamir Geller: Writing – original comprehensive review of malignant chondroid syrin- draft (supporting); Writing – review & editing (support- goma,14 or a systematic review about the association ing). Selin Tokez: Writing – original draft (supporting); between melanoma and genital lichen sclerosus.13 We Writing – review & editing (supporting). - This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2023 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. Skin Health Dis. 2023;3:e224. wileyonlinelibrary.com/journal/ski2 1 of 2 https://doi.org/10.1002/ski2.224 2 of 2 - EDITORIAL FU NDIN G I NF OR MAT I ON 7. Pérez‐Anker J, Ribero S, Yélamos O, Garcia‐Herrera A, Alos L, This editorial received no specific grant from any Alejo B, et al. Basal cell carcinoma characterization using fusion funding agency in the public, commercial, or not‐for‐ ex vivo confocal microscopy: a promising change in conventional skin histopathology. Br J Dermatol. 2020;182(2):468–76. https:// profit sectors. doi.org/10.1111/bjd.18239 8. Tokez S, Wakkee M, Kan W, Venables ZC, Mooyaart AL, Oriol Yélamos1,2 Louwman M, et al. Cumulative incidence and disease‐specific Shamir Geller3,4 survival of metastatic cutaneous squamous cell carcinoma: a Selin Tokez5 nationwide cancer registry study. J Am Acad Dermatol. 2022; 86(2):331–8. https://doi.org/10.1016/j.jaad.2021.09.067 1 9. Karia PS, Han J, Schmults CD. Cutaneous squamous cell car- Dermatology Department, Hospital de la Santa cinoma: estimated incidence of disease, nodal metastasis, and Creu i Sant Pau, Universitat Autònoma de deaths from disease in the United States, 2012. J Am Acad Barcelona, Barcelona, Spain Dermatol. 2013;68(6):957–66. https://doi.org/10.1016/j.jaad. 2 2012.11.037 Institut d’Investigació Biomèdica Sant Pau 10. Tejera‐Vaquerizo A, Paradela S, Toll A, Santos‐Juanes J, Jaka (IIB SANT PAU), Barcelona, Spain A, Lopez A, et al. Effects of COVID‐19 lockdown on tumour 3 Department of Medicine, Dermatology Service, burden of melanoma and cutaneous squamous cell carcinoma. Memorial Sloan Kettering Cancer Center, Acta Derm Venereol. 2021;101(8):adv00525. https://doi.org/10. New York, New York, USA 2340/00015555‐3890 4 Department of Dermatology, Tel Aviv Sourasky 11. Peconi J, Fegan G, Abbott R. Sun safety education in a mari- time climate. Skin Health Dis. 2022. https://doi.org/10.1002/ Medical Center, Sackler Faculty of Medicine, Tel ski2.137 Aviv University, Tel Aviv, Israel 12. Turner LD, Zarkovic A, Lee Siew Hua J, Chan W, Ogra S, 5 Department of Dermatology, Erasmus Medical Brettell D, et al. Does the histopathological subtype of primary Center Cancer Institute, University Medical basal cell carcinoma predict the subtype of secondary tumours? What role do genetic mutations play? Skin Health Dis. 2022. Center Rotterdam, Rotterdam, The Netherlands https://doi.org/10.1002/ski2.123 13. Sim SJY, Dear K, Mastoraki E, James M, Haider A, Ellery P, Correspondence et al. Genital lichen sclerosus and melanoma; A systematic Oriol Yélamos. review. Skin Health Dis. 2022. https://doi.org/10.1002/ski2.198 Email: oyelamos@gmail.com 14. Zufall AG, Mark EJ, Gru AA. Malignant chondroid syringoma ‐ a systemic review. Skin Health Dis. 2022. https://doi.org/10.1002/ ski2.144 DATA AVAI LAB I LI TY ST AT EME NT 15. Win Myint TT, Selak V, Elwood M. The risk of subsequent Data sharing is not applicable to this article as no new invasive melanoma after a primary in situ or invasive melanoma data were created or analysed in this study. in a high incidence country (New Zealand). Skin Health Dis; 2022. https://doi.org/10.1002/ski2.116 ETHI CS ST ATE ME N T 16. Edmonds N, Miller B, Saavedra A. Retrospective chart review of melanoma outcomes in non‐hispanic black patients and case‐ Not applicable. matched non‐hispanic white patients. Skin Health Dis. 2023. https://doi.org/10.1002/ski2.204 17. Borg T.‐M, Eisold J, Miyanjo M, Pappa E. The effect of COVID‐19 REFE RENCES on surgical management of skin cancers of the head, face and 1. Perez M, Abisaad JA, Rojas KD, Marchetti MA, Jaimes N. Skin neck in elderly patients. Skin Health Dis. 2023. https://doi.org/10. cancer: primary, secondary, and tertiary prevention. Part I. J Am 1002/ski2.XXX Acad Dermatol. 2022;87(2):255–68. https://doi.org/10.1016/j. 18. 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