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      Title: Study protocol of a randomised, double-­blind, placebo-­controlled, two-­arm parallel-­group, multi-­centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with seps
      Children: 
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        Title: Abstract
       Item: 
        Title: Introduction
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         Item: 
          Title: Recombinant human ALP (recAP and ilofotase alfa)
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          Title: Trial objectives
       Item: 
        Title: Methods and analysis
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         Item: 
          Title: Patients
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          Title: Trial oversight
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          Title: Patient and public involvement statement
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          Title: Trial design
         Item: 
          Title: Statistical considerations
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          Title: Safety endpoints
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          Title: Population PK
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          Title: Sensitivity analyses and secondary endpoints
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        Title: Ethics and dissemination
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