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Title:          Association of biological sex with clinical outcomes and biomarkers of Alzheimer’s disease in adults with Down syndrome
Subject:        DOI: 10.1093/braincomms/fcad074; Brain Communications, 5, 2, 2023-3-17.; Abstract: The study of sex differences in Alzheimer’s disease is increasingly recognized as a key priority in research and clinical development. People with Down syndrome represent the largest population with a genetic link to Alzheimer’s disease (>90% in the 7th decade). Yet, sex differences in Alzheimer’s disease manifestations have not been fully investigated in these individuals, who are key candidates for preventive clinical trials. In this double-centre, cross-sectional study of 628 adults with Down syndrome [46% female, 44.4 (34.6; 50.7) years], we compared Alzheimer’s disease prevalence, as well as cognitive outcomes and AT(N) biomarkers across age and sex. Participants were recruited from a population-based health plan in Barcelona, Spain, and from a convenience sample recruited via services for people with intellectual disabilities in England and Scotland. They underwent assessment with the Cambridge C
Keywords:       Down syndrome; Alzheimer’s disease; sex; gender; precision medicine
Author:         M. Florencia Iulita
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  Checksum: 613dce3a
   Type: CRC32
  Checksum: 8742eea0fb3899933e7c6c417db41e82
   Type: MD5
  Checksum: 090b544b90086fd8164be0955f7910da4761bc5e
   Type: SHA-1